公开(公告)号：US20070076217A1

公开(公告)日：2007-04-05

申请号：US11243665

申请日：2005-10-05

申请人： Chris Baker ,  Matthew Everett ,  Yan Zhou ,  Keith O'Hara

发明人： Chris Baker ,  Matthew Everett ,  Yan Zhou ,  Keith O'Hara

IPC分类号： G01B11/02

CPC分类号： A61B3/102 ,  A61B3/1005 ,  A61B5/0066

摘要： An accurate measure of eye length can be obtained using concurrent OCT measurements. A position OCT device can be used to continually monitor the position of the front surface of the cornea, while a distance OCT device can determine the apparent distance between the front surface of the cornea and the front surface of the retina. Since the eye is likely to move during the period of time between measurements of the cornea and retina, the monitored position of the cornea can be used to correct the apparent length measurement by the amount of eye movement over that period of time, in order to obtain an accurate measure of eye length. In some embodiments a single OCT device can serve the dual role of monitoring eye position while making eye length measurements

摘要翻译： 使用并行OCT测量可以获得眼睛长度的精确测量。 位置OCT装置可以用于连续监视角膜前表面的位置，而距离OCT装置可以确定角膜前表面和视网膜的前表面之间的表观距离。 由于眼睛可能在角膜和视网膜的测量之间的时间段期间移动，所以可以使用角膜的监视位置来校正视力长度测量量在该时间段内的眼睛移动量，以便 获得眼睛长度的准确度量。 在一些实施例中，单个OCT设备可以起到监视眼睛位置的双重作用，同时进行眼睛长度测量

公开(公告)号：US20060164653A1

公开(公告)日：2006-07-27

申请号：US11331567

申请日：2006-01-13

申请人： Matthew Everett ,  Keith O'Hara

发明人： Matthew Everett ,  Keith O'Hara

IPC分类号： G01B9/02

CPC分类号： A61B3/102 ,  A61B3/0025 ,  A61B3/113 ,  A61B3/1233 ,  A61B5/0059 ,  A61B5/0066 ,  G01B9/02048 ,  G01B9/02077 ,  G01B9/02087 ,  G01B9/02091 ,  G01N21/4795 ,  G01N2021/1787

摘要： An image data set acquired by an optical coherence tomography (OCT) system is corrected for effects due to motion of the sample. A first set of A-scans is acquired within a time short enough to avoid any significant motion of the sample. A second more extensive set of A-scans is acquired over an overlapping region on the sample. Significant sample motion may occur during acquisition of the second set. A-scans from the first set are matched with A-scans from the second set, based on similarity between the longitudinal optical scattering profiles they contain. Such matched pairs of A-scans are likely to correspond to the same region in the sample. Comparison of the OCT scanner coordinates that produced each A-scan in a matching pair, in conjunction with any shift in the longitudinal scattering profiles between the pair of A-scans, reveals the displacement of the sample between acquisition of the first and second A-scans in the pair. Estimates of the sample displacement are used to correct the transverse and longitudinal coordinates of the A-scans in the second set, to form a motion-corrected OCT data set.

公开(公告)号：US20070030483A1

公开(公告)日：2007-02-08

申请号：US11196043

申请日：2005-08-03

申请人： Matthew Everett ,  Yan Zhou ,  Jochen Horn ,  Keith O'Hara ,  James Foley

发明人： Matthew Everett ,  Yan Zhou ,  Jochen Horn ,  Keith O'Hara ,  James Foley

IPC分类号： G01J3/28

CPC分类号： G01N21/4795 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0208 ,  G01J3/0216 ,  G01J3/0224 ,  G01J3/0256 ,  G01J3/0286 ,  G01J3/18 ,  G01J3/22 ,  G02B5/1814 ,  G02B27/4244

摘要： A compact conical diffraction Littrow spectrometer is disclosed. The distortion of the conically diffracted spectral component beams is compensated and as a result, the diffracted spectral beams can still be focused into a substantially straight line to shine onto a detector array. A spectral domain optical coherence tomography (SD-OCT) system incorporating a Littrow spectrometer or a spectrometer having one or more shared focusing element(s) and an SD-OCT system incorporating a spectrometer that is substantially polarization independent are also disclosed.

摘要翻译： 公开了一种紧凑的圆锥衍射Littrow光谱仪。 对锥形衍射光谱分量光束的失真进行补偿，结果衍射的光束束仍可被聚焦成基本上直线以照射到检测器阵列上。 还公开了包含Littrow光谱仪或具有一个或多个共享聚焦元件的光谱仪的光谱相干光学相干断层扫描（SD-OCT）系统和包含基本上偏振无关的光谱仪的SD-OCT系统。

公开(公告)号：US20060228011A1

公开(公告)日：2006-10-12

申请号：US11389351

申请日：2006-03-24

申请人： Matthew Everett ,  Claus Flachenecker ,  Martin Hacker ,  Scott Meyer ,  Keith O'Hara ,  Rick Williams

发明人： Matthew Everett ,  Claus Flachenecker ,  Martin Hacker ,  Scott Meyer ,  Keith O'Hara ,  Rick Williams

IPC分类号： G09G5/00 ,  G06K9/00

CPC分类号： A61B3/102 ,  A61B3/113

摘要： A line scan imager is used to determine the motion of a subject. Each line of image data from the line scan imager is compared with a reference image. The location of a matching line in the reference image reveals the displacement of the subject. The current subject displacement can be determined based on each line of image data. The resulting displacement information can be used to correctly place other optical beams on the subject. The method can be applied to tracking the human eye to facilitate measurement, imaging, or treatment with a beam of optical radiation.

公开(公告)号：US20070216909A1

公开(公告)日：2007-09-20

申请号：US11717263

申请日：2007-03-13

申请人： Matthew Everett ,  Paul Stetson ,  Scott Meyer ,  Shahram Dastmalchi ,  Jochen Straub

发明人： Matthew Everett ,  Paul Stetson ,  Scott Meyer ,  Shahram Dastmalchi ,  Jochen Straub

IPC分类号： G01B9/02 ,  G01B11/02

CPC分类号： A61B3/10 ,  A61B3/00 ,  A61B3/102 ,  A61B5/0059 ,  A61B5/0066 ,  G01B9/02048 ,  G01B9/02089 ,  G01B9/02091 ,  G01N21/4795 ,  G06F19/00

摘要： Various methods are disclosed for mapping optical coherence tomography (OCT) data to facilitate review and diagnosis. In one aspect, high resolution 2D line scans are obtained along with lower density 3D cube scans and displayed in a manner to provide context to the clinician. In another aspect, OCT data is analyzed to provide information about non-uniformities of the tissue. Binary image maps of maps useful for determining tautness of membranes are also disclosed.

摘要翻译： 公开了各种用于映射光学相干断层扫描（OCT）数据的方法以便于检查和诊断。 在一个方面，获得高分辨率2D线扫描以及较低密度的3D立方体扫描，并以向临床医生提供上下文的方式显示。 在另一方面，分析OCT数据以提供关于组织的非均匀性的信息。 还公开了可用于确定膜紧张度的地图的二进制图像映射。

公开(公告)号：US06175669B1

公开(公告)日：2001-01-16

申请号：US09050571

申请日：1998-03-30

申请人： Billy W. Colston ,  Matthew Everett ,  Luiz B. Da Silva ,  Dennis Matthews

发明人： Billy W. Colston ,  Matthew Everett ,  Luiz B. Da Silva ,  Dennis Matthews

IPC分类号： G02B600

CPC分类号： A61B5/6852 ,  A61B1/00177 ,  A61B1/00181 ,  A61B5/0066 ,  A61B5/0084

摘要： A guidewire with optical sensing capabilities is based on a multiplexed optical coherence domain reflectometer (OCDR), which allows it to sense location, thickness, and structure of the arterial walls or other intra-cavity regions as it travels through the body during minimally invasive medical procedures. This information will be used both to direct the guidewire through the body by detecting vascular junctions and to evaluate the nearby tissue. The guidewire contains multiple optical fibers which couple light from the proximal to distal end. Light from the fibers at the distal end of the guidewire is directed onto interior cavity walls via small diameter optics such as gradient index lenses and mirrored corner cubes. Both forward viewing and side viewing fibers can be included. The light reflected or scattered from the cavity walls is then collected by the fibers, which are multiplexed at the proximal end to the sample arm of an optical low coherence reflectometer. The guidewire can also be used in nonmedical applications.

摘要翻译： 具有光学感测能力的导丝基于多路复用光学相干域反射计（OCDR），其允许其在微创医疗中穿过身体时感测动脉壁或其他腔内区域的位置，厚度和结构 程序。 该信息将用于通过检测血管结点引导导线穿过身体并评估附近的组织。 导丝包含多个光纤，其将光从近端耦合到远端。 来自导线远端的纤维的光通过诸如梯度折射率透镜和镜像角立方体的小直径光学器件引导到内腔壁上。 可以包括前视和侧视纤维。 然后从空腔壁反射或散射的光被纤维收集，纤维在近端被多路复用到光学低相干反射计的样品臂。 导丝也可用于非医疗应用。

公开(公告)号：US20060259310A1

公开(公告)日：2006-11-16

申请号：US11128640

申请日：2005-05-13

申请人： Matthew Everett ,  Supriya Mandava

发明人： Matthew Everett ,  Supriya Mandava

IPC分类号： G06Q99/00 ,  G07G1/00 ,  H04M3/51 ,  G06F17/30

CPC分类号： G06Q30/02 ,  G06Q30/0206 ,  G06Q30/0283

摘要： Systems and techniques for management and analysis of cost and savings information. Products sold by an enterprise, and the components used in the creation of those products are identified. Transaction data relating to purchases of components by the enterprise is gathered from various sources and used to generate cost information for the components. The cost information is compared to baseline cost information to compute savings information for the components. Specifications of components used in products, information relating to the number of products created and sold and information categorizing components and products is used to generate cost and savings information for components, products and categories of products.

摘要翻译： 用于管理和分析成本和储蓄信息的系统和技术。 确定企业销售的产品，以及用于创建这些产品的组件。 与企业采购组件相关的交易数据从各种来源收集，用于生成组件的成本信息。 将成本信息与基准成本信息进行比较，以计算组件的储蓄信息。 产品中使用的部件规格，与创建和销售的产品数量相关的信息以及组件和产品分类信息用于生成组件，产品和产品类别的成本和储蓄信息。

公开(公告)号：US06905885B2

公开(公告)日：2005-06-14

申请号：US09880515

申请日：2001-06-12

申请人： Billy W. Colston ,  Matthew Everett ,  Fred P. Milanovich ,  Steve B. Brown ,  Kodumudi Vendateswaran ,  Jonathan N. Simon

发明人： Billy W. Colston ,  Matthew Everett ,  Fred P. Milanovich ,  Steve B. Brown ,  Kodumudi Vendateswaran ,  Jonathan N. Simon

IPC分类号： G01N33/543 ,  G01N33/53

CPC分类号： G01N33/54313

摘要： A portable pathogen detection system that accomplishes on-site multiplex detection of targets in biological samples. The system includes: microbead specific reagents, incubation/mixing chambers, a disposable microbead capture substrate, and an optical measurement and decoding arrangement. The basis of this system is a highly flexible Liquid Array that utilizes optically encoded microbeads as the templates for biological assays. Target biological samples are optically labeled and captured on the microbeads, which are in turn captured on an ordered array or disordered array disposable capture substrate and then optically read.

摘要翻译： 便携式病原体检测系统，实现了生物样品中靶标的现场多重检测。 该系统包括：微珠特异性试剂，孵育/混合室，一次性微珠捕获底物和光学测量和解码装置。 该系统的基础是高度灵活的液体阵列，其利用光学编码的微珠作为生物测定的模板。 目标生物样品被光学标记并捕获在微珠上，微珠又依次在有序阵列或无序阵列一次性捕获基底上捕获，然后光学读取。

公开(公告)号：US20070002327A1

公开(公告)日：2007-01-04

申请号：US11174158

申请日：2005-07-01

申请人： Yan Zhou ,  Matthew Everett

发明人： Yan Zhou ,  Matthew Everett

IPC分类号： G01J3/45 ,  G01B11/02 ,  G01B9/02

CPC分类号： G01J3/10 ,  A61B3/1005 ,  A61B3/102 ,  A61B5/0066 ,  A61B5/0073 ,  G01B9/02004 ,  G01B9/02069 ,  G01B9/02091 ,  G01B2290/45 ,  G01J3/0259 ,  G01J3/4532 ,  G01J2003/1239 ,  G01N21/4795

摘要： The present invention is an alternative Fourier domain optical coherence system (FD-OCT) and its associated method. The system comprises a swept multi-wavelength laser, an optical interferometer and a multi-channel receiver. By employing a multi-wavelength laser, the sweeping range for each lasing wavelength is substantially reduced as compared to a pure swept single wavelength laser that needs to cover the same overall spectral range. The overall spectral interferogram is divided over the individual channels of the multi-channel receiver and can be re-constructed through processing of the data from each channel detector. In addition to a substantial increase in the speed of each axial scan, the cost of invented FD-OCT system can also be substantially less than that of a pure swept source OCT or a pure spectral domain OCT system.

摘要翻译： 本发明是替代的傅里叶域光学相干系统（FD-OCT）及其相关方法。 该系统包括扫频多波长激光器，光学干涉仪和多通道接收器。 通过采用多波长激光器，与需要覆盖相同总光谱范围的纯扫频单波长激光器相比，每个激光波长的扫描范围显着降低。 整个光谱干涉图在多通道接收机的各个通道上分配，并且可以通过处理来自每个通道检测器的数据来重新构建。 除了每个轴向扫描的速度的显着增加之外，发明的FD-OCT系统的成本也可以显着小于纯扫频源OCT或纯谱域OCT系统的成本。

公开(公告)号：US20060072424A1

公开(公告)日：2006-04-06

申请号：US10933795

申请日：2004-09-03

申请人： Matthew Everett ,  Scott Meyer ,  Yan Zhou

发明人： Matthew Everett ,  Scott Meyer ,  Yan Zhou

IPC分类号： G11B7/135

CPC分类号： A61B3/102 ,  A61B3/1005 ,  G01B9/02012 ,  G01B9/02044 ,  G01B9/02049 ,  G01B9/02069 ,  G01B9/02091 ,  G01B2290/35

摘要： A low cost patterned spinning disk is disclosed for achieving relatively rapid discrete optical phase shifts for an optical beam. The invention is particularly useful in a spectral domain optical coherence tomography system. The disk contains stepped patterns of different heights and/or refractive index distribution such that as it spins, an optical beam passing through or being reflected by the disk will experience different discrete optical phase delays. The disk can be operated as a phase shifter or it can be operated in synchronization with an intensity modulating chopper disk or a direct intensity modulation of the light source. The disk can also contain intensity modulating patterns such that both phase shifting and intensity modulation can be achieved at the same time. Various possible methods are also disclosed for the fabrication of the disk.

摘要翻译： 公开了一种低成本图案旋转盘，用于实现光束的相对快速的离散光学相移。 本发明在频域光学相干断层摄影系统中特别有用。 盘包含不同高度和/或折射率分布的阶梯图案，使得当其旋转时，通过或被盘反射的光束将经历不同的离散光学相位延迟。 磁盘可以作为移相器来操作，或者可以与强度调制斩波盘同步操作，也可以与光源进行直接强度调制。 磁盘还可以包含强度调制模式，使得可以同时实现相移和强度调制。 还公开了用于制造盘的各种可能的方法。