摘要:
The present invention is directed to tricyclic compounds of formula (I) which are inhibitors of one or more mutant IDH enzymes: (I). The present invention is also directed to uses of the tricyclic compounds described herein in the potential treatment or prevention of cancers in which one or more mutant IDH enzymes are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such cancers.
摘要:
Disclosed are the ERK inhibitors of formula (1): and the pharmaceutically acceptable salts thereof. Also disclosed are methods of treating cancer using the compounds of formula (1).
摘要:
A method for improving the effectiveness of a building air circulation system having motorized blower and a contamination filter. The method including predicting a cost of operation of the system over an operational duration based on at least electricity consumption of the motor (115), and an operational cost to operate the filter (148), predicting a cost of maintenance of the system over the operational duration based on at least one of, a condition of the filter (148), a cost of a filter (148), a cost of labor to clean or replace the filter (148), and an effectiveness of the filter (148) over the operational duration, and balancing the cost of operation of the circulation system versus the cost of maintenance of the circulation system over the duration to recommend at least one of a filter use/bypass schedule, a filter maintenance schedule, and a fresh air input schedule satisfying an operation objective and an operational constraint.
摘要:
Provided in the present invention is an adjustment and design method of an illumination system matched with multiple objective lenses in an extreme ultraviolet lithography machine; the illumination system to which the method is applied comprises a light source, a collection lens, a field compound eye, a pupil compound eye and a relay lens group; the method specifically comprises the steps: before a projection objective lens of an extreme ultraviolet lithography machine is replaced, calculating aperture angles of emergent ray of a relay lens A on a meridian plane and a sagittal plane by means of ray tracing; after the projection objective lens of the extreme ultraviolet lithography machine is replaced, taking out a central point of a exit pupil plane as an object point for ray tracing; adjusting inclination angles and positions of the relay lens A and a relay lens B, and adjusting inclination angles of central compound eye units of the pupil compound eye and the field compound eye, till an image plane of a current illumination system approximates to an arc-shaped image plane corresponding to the projection objective lens. By adjusting the illumination system on the basis of the adjustment method of the present invention, an illumination system matched with the projection objective lens system can be obtained, which dramatically reduces the cost of designing a projection lithography machine.
摘要:
Systems and methods are provided for scoring non-native, spontaneous speech. A spontaneous speech sample is received, where the sample is of spontaneous speech spoken by a non-native speaker. Automatic speech recognition is performed on the sample using an automatic speech recognition system to generate a transcript of the sample, where a speech recognizer metric is determined by the automatic speech recognition system. A word accuracy rate estimate is determined for the transcript of the sample generated by the automatic speech recognition system based on the speech recognizer metric. The spontaneous speech sample is scored using a preferred scoring model when the word accuracy rate estimate satisfies a threshold, and the spontaneous speech sample is scored using an alternate scoring model when the word accuracy rate estimate fails to satisfy the threshold.
摘要:
A mobile electronic device and a sound playback method thereof are provided. The mobile electronic device includes a sensor, a speaker, and a controller coupled to the sensor and the speaker. The sensor detects whether the speaker is blocked or not. When the speaker is blocked, the controller multiplies a sound signal by a transfer function and then outputs the multiplied sound signal. The speaker plays the sound signal outputted by the controller. The transfer function changes the direction in which the speaker plays the sound signal.
摘要:
A network interface module can include a housing including a first cavity configured to receive a first network plug having a first dimension. The housing also includes a second cavity within the first cavity, and configured to receive a second network plug having a second dimension that is less than the first dimension. The network interface module can also include a network detection circuit coupled to a first terminal within the housing.
摘要:
Provided herein is a method for detecting landing quality of an aircraft. Method steps include using an aircraft data system to determine whether a vertical speed rate is greater than a first preset value when the aircraft lands; determine whether a vertical acceleration is greater than a second preset value if the vertical speed rate is not greater than the first preset value when the aircraft lands; collect landing data; generate a landing message based on the collected landing data; store or transmit the landing message; and determine the landing quality based on the landing data in the landing message.
摘要:
Computer-implemented methods and systems may perform one or more operations including, but not limited to: receiving input data from a source; applying an interleaving protocol to the input data to generate at least one component codeword; decoding the at least one component codeword; determining a first convergence value of at least one decoded component codeword; computing extrinsic data associated with the at least one component codeword according to the bit error count and the first convergence of at least one component codeword; determining a second convergence value associated with the at least one component codeword according to the extrinsic data associated with the at least one component codeword.