公开(公告)号：US4626088A

公开(公告)日：1986-12-02

申请号：US683389

申请日：1984-12-19

申请人： Christian Joncour ,  Alain Pierre ,  Patrice Renan ,  Jean-Louis Roumegoux ,  Francoise Richard, deceased ,  by Jacques M. G. Richard, heir ,  Alexandra A. C. Richard, heir ,  Anne-Lise P. M. Richard, heir

发明人： Christian Joncour ,  Alain Pierre ,  Patrice Renan ,  Jean-Louis Roumegoux ,  Francoise Richard, deceased ,  by Jacques M. G. Richard, heir ,  Alexandra A. C. Richard, heir ,  Anne-Lise P. M. Richard, heir

IPC分类号： A61B3/11 ,  G02C13/00 ,  A61B3/10

CPC分类号： A61B3/111 ,  G02C13/005

摘要： A device for measuring a subject's ocular parameters, in particular the interpupillary distance, comprises a front plate against which the face of the subject is placed, comprising two windows substantially corresponding to the lenses of a pair of eyeglasses. A lens is movable along its optical axis, which is perpendicular to the front plate, from an origin position near the front plate. A viewing eyepiece is disposed at the focus of the lens when in the origin position. A semi-reflecting mirror disposed at 45.degree. renders the eyepiece and a point source coincident, as far as the subject is concerned. Parallel to the semi-reflecting mirror, another mirror reflects an image of a cathode ray tube screen to the eyepiece through another lens. Adjustable calibrated voltage sources are used to produce coincidence of the reflections of the source on the corneas of the eyes of the subject and the luminous traces on the screen of the cathode ray tube, as seen by an operator looking through the eyepiece. These traces constitute graticules, and the voltages which generate them constitute basic measurements of the ocular parameters. The appropriate calculations are implemented by a microprocessor.

摘要翻译： 用于测量被摄体的眼睛参数，特别是瞳孔间距离的装置包括被放置对象的脸部的前板，包括基本对应于一对眼镜的镜片的两个窗口。 透镜可以沿着与其前端板垂直的光轴从前板附近的原点位置移动。 当在原点位置时，观察目镜设置在透镜的焦点处。 设置在45度的半反射镜使目镜和点光源重合，就目标而言。 与半反射镜平行，另一个镜子通过另一透镜将阴极射线管屏幕的图像反射到目镜。 使用可调校准电压源来产生源于受试者眼睛和阴极射线管屏幕上的发光迹线的源的反射的一致性，如通过目镜观察的操作者所见。 这些迹线构成刻度，产生它们的电压构成了眼睛参数的基本测量。 适当的计算由微处理器实现。

公开(公告)号：US4612736A

公开(公告)日：1986-09-23

申请号：US661314

申请日：1984-10-16

申请人： Christian Massard ,  Alain Pierre ,  Jean-Louis Roumegoux

发明人： Christian Massard ,  Alain Pierre ,  Jean-Louis Roumegoux

IPC分类号： B24B9/14 ,  G02C13/00

CPC分类号： B24B9/14

摘要： The peripheral edge of an ophthalmic lens is maintained in contact with a bevelling or grooving wheel while being rotated about an axis of the lens parallel to the axis of the bevelling wheel whereby a bevel or groove is formed in said peripheral edge. The ophthalmic lens is capable of relative axial displacement relative to said bevelling wheel. By way of a force or displacement sensor, the relative axial position of the ophthalmic lens with respect to the bevelling wheel can be made subject to the axial component of reaction forces generated between the lens and the bevelling wheel in their mutual contact zone.

摘要翻译： 眼镜片的周边边缘保持与斜边或切槽轮相接触，同时围绕透镜的轴线平行于斜边轮的轴线旋转，从而在所述周缘形成有斜面或凹槽。 眼镜片相对于所述倾斜轮具有相对的轴向位移。 通过力或位移传感器，眼镜片相对于倾斜轮的相对轴向位置可以在透镜和倾斜轮之间在其相互接触区域中产生的反作用力的轴向分量。

公开(公告)号：US07276512B2

公开(公告)日：2007-10-02

申请号：US10872060

申请日：2004-06-18

申请人： Michel Koch ,  François Tillequin ,  Sylvie Michel ,  John Hickman ,  Alain Pierre ,  Stéphane Leonce ,  Bruno Pfeiffer ,  Pierre Renard

发明人： Michel Koch ,  François Tillequin ,  Sylvie Michel ,  John Hickman ,  Alain Pierre ,  Stéphane Leonce ,  Bruno Pfeiffer ,  Pierre Renard

IPC分类号： A61K31/44

CPC分类号： C07D491/04 ,  C07D491/14

摘要： A compound selected from those of formula (I): wherein: X and Y represent a group selected from hydrogen, halogen, hydroxy, alkoxy, nitro, cyano, alkyl, trihaloalkyl and NRaRb, wherein Ra and Rb are as defined in the description R1 represents hydrogen or alkyl R2 represents a group selected from hydrogen, alkyl, —OR″a, —NR′aR′b, —O-Ta-OR″a, —NR″a-Ta-NR′aR′b, —NR″a—C(O)-TaH, —O—C(O)-TaH, —O-Ta-NR′aR′b, —NR″a-Ta-OR″a, —NR″a-Ta-CO2R″a and —NR″a—C(O)-Ta-NR′aR′b, wherein R′a, R″a, R′b and Ta are as defined in the description R3 and R4 represent hydrogen or alkyl A represents a group of formula —CH(R5)—CH(R6)—, —CH═C(R7)—, —C(R7)═CH—, —C(O)—CH(R8) or —CH(R8)—C(O), wherein R5, R6, R7 and R8 are as defined in the description its isomers, N-oxides, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful in the treatment of cancer.

公开(公告)号：US07056929B2

公开(公告)日：2006-06-06

申请号：US10627463

申请日：2003-07-26

申请人： Michel Koch ,  Francois Tillequin ,  Sylvie Michel ,  Elisabeth Seguin ,  Abdelhakim El Omri ,  John Hickman ,  Alain Pierre ,  Bruno Pfeiffer ,  Pierre Renard

发明人： Michel Koch ,  Francois Tillequin ,  Sylvie Michel ,  Elisabeth Seguin ,  Abdelhakim El Omri ,  John Hickman ,  Alain Pierre ,  Bruno Pfeiffer ,  Pierre Renard

IPC分类号： A61K31/44

CPC分类号： C07D491/04

摘要： A method for treating a living body afflicted with a cancer selected from lung and ovarian carcinoma, comprising the step of administering to the living animal body an amount of a compound selected from those of formula (I): wherein: X and Y represent group selected from hydrogen, halogen, mercapto, cyano, nitro, alkyl, trihaloalkyl, trihaloalkylcarbonylamino, —ORa, —NRaRb, —NRa—C(O)-T1, —O—C(O)-T1, —O-T2-NRaRb, —O-T2-ORa, —NRa-T2-NRaRb, —NRa-T2-ORa and —NRa-T2-CO2Ra wherein Ra, Rb, T1, T2 are as defined in the description, or X and Y together form a methylenedioxy or ethylenedioxy, R1 represents hydrogen or alkyl, R2 represents a group selected from hydrogen, —ORa, —NRaRb, —NRa—C(O)-T1, —O—C(O)-T1, —O-T2-NRaRb, —O-T2-ORa, —NRa-T2-NRaRb, —NRa-T2-ORa and —NRa-T2-CO2Ra wherein Ra, Rb, T1 and T2 are as defined hereinbefore, R3 and R4 represent hydrogen or alkyl, W represents a group of formula —CH(R5)—CH(R6)—, —CH═C(R7)—, —C(R7)═CH— or —C(O)—CH(R8)— wherein R5, R6, R7 and R8 are as defined in the description, their isomers and N-oxides, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same are useful in the treatment of cancer.

公开(公告)号：US07001906B2

公开(公告)日：2006-02-21

申请号：US10481991

申请日：2002-06-28

申请人： Michelle Prudhomme ,  Christelle Marminon ,  Sylvain Routier ,  Gérard Coudert ,  Jean-Yves Merour ,  John Hickman ,  Alain Pierre ,  Pierre Renard ,  Bruno Pfeiffer

发明人： Michelle Prudhomme ,  Christelle Marminon ,  Sylvain Routier ,  Gérard Coudert ,  Jean-Yves Merour ,  John Hickman ,  Alain Pierre ,  Pierre Renard ,  Bruno Pfeiffer

IPC分类号： A61K31/4985 ,  A61K31/437 ,  C07D491/22 ,  C07D405/14

CPC分类号： C07H15/252

摘要： Compounds of formula (I): wherein: W1 and W2, together with the carbon atoms to which they are bonded, represent a phenyl group or a pyridyl group, and at least one of the groups W1 or W2 represents a pyridyl group, R1 and R2 each represent a group of formula U-V as defined in the description, X and X1 each represent a hydrogen atom or a hydroxy, alkoxy, mercapto or alkylthio group, Y and Y1 each represent a hydrogen atom, or X and Y, X1 and Y1, together with the carbon atom carrying them, represent a carbonyl or thiocarbonyl group, R4 and R5 are as defined in the description, Q1, Q2 represent a hydrogen atom, or Q1 and Q2, together with the carbon atoms carrying them, form an aromatic bond. Medicaments.

摘要翻译： 式（I）化合物：化学式id =“CHEM-US-00001”num =“000

公开(公告)号：US20060004428A1

公开(公告)日：2006-01-05

申请号：US10531620

申请日：2003-10-14

申请人： Michelle Prudhomme ,  Bernadette Hugon ,  Fabrice Anizon ,  John Hickman ,  Alain Pierre ,  Roy Golsteyn ,  Pierre Renard ,  Bruno Pfeiffer

发明人： Michelle Prudhomme ,  Bernadette Hugon ,  Fabrice Anizon ,  John Hickman ,  Alain Pierre ,  Roy Golsteyn ,  Pierre Renard ,  Bruno Pfeiffer

IPC分类号： A61N1/00

CPC分类号： C07D487/14

摘要： A compound selected from those of formula (I): wherein: Z represents a group of the formula U-V as defined in the description, W1 represents together with carbon to which it is bonded, phenyl, pyridyl, W2 is as defined in the description, X1, X2 each represents hydrogen, hydroxy, alkoxy, mercapto or alkylthio, Y1, Y2 each represents hydrogen, or X1 and Y1, X2 and Y2 with carbon carrying them, together form carbonyl or thiocarbonyl, R1 is as defined in the description, Q represents oxygen, a group NR2 as defined in the description, its isomers, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful in the treatment of cancer.

摘要翻译： 选自式（I）的化合物：其中：Z表示如说明书中所定义的式UV基团，W 1代表与其键合的碳，苯基，吡啶基， W 2 2如说明书中所定义，X 1，X 2各自表示氢，羟基，烷氧基，巯基或烷硫基，Y _{1，Y 2各自表示氢，或X 1和Y 1，X 2， 和Y 2带有带有它们的碳，一起形成羰基或硫代羰基，R 1如说明书中所定义，Q表示氧，NR 2基团， SUB>，其异构体及其与药学上可接受的酸或碱的加成盐，以及含有该物质的药物可用于治疗癌症。}

公开(公告)号：US20060003997A1

公开(公告)日：2006-01-05

申请号：US10531648

申请日：2003-10-17

申请人： Gerard Coudert ,  Franck Lepifre ,  Daniel-Henri Caignard ,  Pierre Renard ,  John Hickman ,  Alain Pierre ,  Laurence Kraus-Berthier

发明人： Gerard Coudert ,  Franck Lepifre ,  Daniel-Henri Caignard ,  Pierre Renard ,  John Hickman ,  Alain Pierre ,  Laurence Kraus-Berthier

IPC分类号： A61K31/5383 ,  C07D491/14

CPC分类号： C07D497/04 ,  C07D497/14

摘要： A compound selected from those of formula (I): wherein: W1, with the carbon atoms to which it is bonded, represents phenyl or pyridyl, Z represents a group selected from hydrogen, halogen, linear or branched (C1-C6)alkyl, aryl, aryl-(C1-C6)alkyl, aryloxy, aryl-(C1-C6)alkoxy, hydroxy and linear or branched (C1-C6)alkoxy, R1 is as defined in the description, R2 represents hydrogen or —CH2CH2O—R8, R3 and R4 each represents hydrogen, linear or branched (C1-C6)alkyl, aryl or aryl-(C1-C6)alkyl, n represents an integer of from 1 to 6 inclusive, its isomers, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful in the treatment of cancer.

摘要翻译： 选自式（I）的化合物的化合物：其中：W 1与其键合的碳原子代表苯基或吡啶基，Z表示选自氢，卤素，直链或 支链（C 1 -C 6 -C 6）烷基，芳基，芳基 - （C 1 -C 6 -C 6）烷基 ，芳氧基，芳基 - （C 1 -C 6 -C 6）烷氧基，羟基和直链或支链（C 1 -C 6 - R 1和R 2如在说明书中所定义，R 2表示氢或-CH 2 CH 2， R 3，R 3和R 4各自表示直链或支链（C 1 -C 4）烷基的氢， C 6 -C 6烷基，芳基或芳基 - （C 1 -C 6）烷基，n表示1〜6的整数， 其异构体及其与药学上可接受的酸或碱的加成盐，以及含有该物质的药物，可用于治疗癌症。

公开(公告)号：US06548515B1

公开(公告)日：2003-04-15

申请号：US09718917

申请日：2000-11-22

申请人： Henri-Philippe Husson ,  Sylviane Giorgi-Renault ,  Christophe Tratrat ,  Ghanem Atassi ,  Alain Pierre ,  Pierre Renard ,  Bruno Pfeiffer

发明人： Henri-Philippe Husson ,  Sylviane Giorgi-Renault ,  Christophe Tratrat ,  Ghanem Atassi ,  Alain Pierre ,  Pierre Renard ,  Bruno Pfeiffer

IPC分类号： A61K314741

CPC分类号： C07D491/04 ,  C07D219/06 ,  C07D221/16 ,  C07D221/18 ,  C07D491/14 ,  C07D495/04

摘要： The invention relates to compound of formula (I): wherein: represents a single or double bond, R0 represents hydrogen or hydroxy or alkoxy, R1 and R2, which are identical or different, each represents hydrogen or halogen or alkyl, alkoxy, hydroxy, polyhaloalkyl, nitro or optionally substituted amino or  wherein m represents an integer such that 1≦m≦4, or form together with the carbon atoms carrying them an aromatic or non-aromatic, mono- or bi-cyclic group having from 5 to 12 ring members and optionally containing 1 or 2 hetero atoms selected from O, S and N, R3 represents hydrogen or aryl, heteroaryl, cycloalkyl, optionally substituted alkyl or a group of formula COR7 wherein R7 represents aryl, optionally substituted alkyl, optionally substituted amino or OR10 wherein R10 represents aryl or optionally substituted alkyl, X represents oxygen or sulphur or —CH2— or —CH2—CH2—, Ar represents aryl, heteroaryl or arylalkyl, its optical isomers, its hydrates, solvates, and also its addition salts with a pharmaceutically acceptable acid. Medicinal products containing the same are useful in the treatment of cancer.

摘要翻译： 本发明涉及式（I）的化合物：其中：表示单键或双键，R 0表示氢或羟基或烷氧基，R 1和R 2相同或不同，各自表示氢或卤素或烷基，烷氧基，羟基，多卤代烷基，硝基或任选取代的氨基或 其中m表示1≤= m = 4的整数，或与带有带有5至12个环成员的芳族或非芳族单环或双环基团的碳原子一起形成，并且任选地含有1或 2个选自O，S和N的杂原子，R 3表示氢或芳基，杂芳基，环烷基，任选取代的烷基或式COR7基团，其中R7表示芳基，任选取代的烷基，任选取代的氨基或OR 10，其中R 10表示芳基或任选地 取代的烷基，X表示氧或硫或-CH 2 - 或-CH 2-CH 2 - ，Ar表示芳基，杂芳基或芳基烷基，其光学异构体，其水合物，溶剂合物，以及其与药学上可接受的酸的加成盐。含有它们的医药产品可用于治疗癌症。

公开(公告)号：US6071945A

公开(公告)日：2000-06-06

申请号：US361064

申请日：1999-07-26

申请人： Sylvain Rault ,  Cecile Enguehard ,  Jean-Charles Lancelot ,  Max Robba ,  Ghanem Atassi ,  Alain Pierre ,  Daniel-Henri Caignard ,  Pierre Renard

发明人： Sylvain Rault ,  Cecile Enguehard ,  Jean-Charles Lancelot ,  Max Robba ,  Ghanem Atassi ,  Alain Pierre ,  Daniel-Henri Caignard ,  Pierre Renard

IPC分类号： A61K31/00 ,  A61K31/40 ,  A61K31/407 ,  A61P35/00 ,  C07D495/14

CPC分类号： C07D495/14 ,  Y02P20/55

摘要： A compound selected from those of formula (I): ##STR1## wherein: R.sub.1 represents hydrogen, halogen, alkyl, nitro, hydroxy, alkoxy, trihaloalkyl, trihaloalkoxy or optionally substituted amino,R.sub.2 represents optionally substituted aryl or heteroaryl,R.sub.3 represents hydrogen, halogen, alkyl, nitro, hydroxy, alkoxy, trihaloalkyl, trihaloalkoxy or optionally substituted amino,their isomers and addition pharmaceutically-acceptable acid or base salts thereof and medicinal products containing the same are useful in the treatment of cancer.

摘要翻译： 选自式（I）的化合物：其中：R 1表示氢，卤素，烷基，硝基，羟基，烷氧基，三卤代烷基，三卤代烷氧基或任选取代的氨基，R 2表示任选取代的芳基或杂芳基，R 3表示氢， 硝基，羟基，烷氧基，三卤代烷基，三卤代烷氧基或任选取代的氨基，它们的异构体及其加成药学上可接受的酸或碱盐和含有它们的药物可用于治疗癌症。

公开(公告)号：US5595976A

公开(公告)日：1997-01-21

申请号：US521189

申请日：1995-08-30

申请人： David Billington ,  Gilbert Dorey ,  Pascale Leon ,  Ghanem Atassi ,  Alain Pierre ,  Michael Burbridge ,  Nicolas Guilbaud

发明人： David Billington ,  Gilbert Dorey ,  Pascale Leon ,  Ghanem Atassi ,  Alain Pierre ,  Michael Burbridge ,  Nicolas Guilbaud

IPC分类号： C07H9/02 ,  A61K31/70 ,  A61K31/7028 ,  A61P9/00 ,  A61P29/00 ,  A61P35/00 ,  C07H9/04 ,  C07H15/04 ,  C07H15/10 ,  C07H15/18 ,  C07H15/26 ,  A61K37/00 ,  C07H3/00

CPC分类号： C07H9/04 ,  C07H15/04 ,  C07H15/10 ,  C07H15/26

摘要： A compound selected from those of formula (I): ##STR1## in which: A either represents --OR.sub.6, and B represents --CH.sub.2 --X,or, together with B and the carbon atom carrying them, forms an oxygen-containing heterocycle selected from oxirane, 2,2-dimethyl[1,3]dioxolane and [1,3]dioxolan-2-one,and R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6 and X are as defined in the description.

摘要翻译： 选自式（I）的化合物：其中：A表示-OR6，B表示-CH2-X，或者与B和携带它们的碳原子一起形成氧 - 含有杂环的环氧乙烷，2,2-二甲基[1,3]二氧戊环和[1,3]二氧戊环-2-酮，R1，R2，R3，R4，R5，R6和X如说明书中所定义。