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1.发明申请APPARATUS, SYSTEMS, METHODS AND COMPUTER-ACCESSIBLE MEDIUM FOR SPECTRAL ANALYSIS OF OPTICAL COHERENCE TOMOGRAPHY IMAGES 有权用于光学相干图像图像的光谱分析的装置，系统，方法和计算机可访问介质公开(公告)号：US20110292400A1
公开(公告)日：2011-12-01
申请号：US13115332
申请日：2011-05-25
IPC分类号： G01B9/02
CPC分类号： A61B5/0066 , A61B5/02007 , A61B5/7264 , G01B9/02091 , G01N21/4795 , G01N2021/1787 , G01N2201/129 , G01N2201/1293
摘要： According to an exemplary embodiment of the present disclosure, apparatus and method can be provided for generating information for at least one structure. For example, using at least one first arrangement, it is possible to receive at least one first radiation from the at least one structure and at least one second radiation from a reference, and interfere the first and second radiations to generate at least one third radiation. Further, with at least one second arrangement, it is possible to generate spectroscopic data as a function of the at least one third radiation, and reduce at least one scattering effect in the spectroscopic data to generate the information. In addition or as an alternative, according to a further exemplary embodiment of the present disclosure, it is possible to classify a type of the structure based on the spectroscopic data to generate the information.
摘要翻译： 根据本公开的示例性实施例，可以提供装置和方法来产生用于至少一个结构的信息。 例如，使用至少一个第一布置，可以接收来自至少一个结构的至少一个第一辐射和来自参考的至少一个第二辐射，并且干扰第一和第二辐射以产生至少一个第三辐射 。 此外，利用至少一个第二布置，可以产生作为至少一个第三辐射的函数的光谱数据，并且减少光谱数据中的至少一个散射效应以产生信息。 另外或作为替代，根据本公开的另一示例性实施例，可以基于光谱数据对结构的类型进行分类以生成信息。
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公开(公告)号：US09795301B2
公开(公告)日：2017-10-24
申请号：US13115332
申请日：2011-05-25
CPC分类号： A61B5/0066 , A61B5/02007 , A61B5/7264 , G01B9/02091 , G01N21/4795 , G01N2021/1787 , G01N2201/129 , G01N2201/1293
摘要： According to an exemplary embodiment of the present disclosure, apparatus and method can be provided for generating information for at least one structure. For example, using at least one first arrangement, it is possible to receive at least one first radiation from the at least one structure and at least one second radiation from a reference, and interfere the first and second radiations to generate at least one third radiation. Further, with at least one second arrangement, it is possible to generate spectroscopic data as a function of the at least one third radiation, and reduce at least one scattering effect in the spectroscopic data to generate the information. In addition or as an alternative, according to a further exemplary embodiment of the present disclosure, it is possible to classify a type of the structure based on the spectroscopic data to generate the information.
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3.发明申请SYSTEMS, DEVICES, METHODS, APPARATUS AND COMPUTER-ACCESSIBLE MEDIA FOR PROVIDING OPTICAL IMAGING OF STRUCTURES AND COMPOSITIONS 有权用于提供结构和组成的光学成像的系统，设备，方法，装置和计算机可访问介质公开(公告)号：US20120101374A1
公开(公告)日：2012-04-26
申请号：US13114845
申请日：2011-05-24
申请人： Guillermo J. Tearney , Brett Eugene Bouma , Hongki Yoo , Milen Shishkov , Joseph Gardecki , Roman Shubochkin , Theodore Morse , Farouc Amin Jaffer
发明人： Guillermo J. Tearney , Brett Eugene Bouma , Hongki Yoo , Milen Shishkov , Joseph Gardecki , Roman Shubochkin , Theodore Morse , Farouc Amin Jaffer
IPC分类号： A61B6/00
CPC分类号： A61B5/0084 , A61B5/0066 , A61B5/0071 , A61B5/6852 , G01B9/02029 , G01B9/0205 , G01B9/02091 , G01N21/4795 , G01N21/64 , G01N21/6456 , G01N21/65 , G01N2201/0866
摘要： Exemplary systems, devices, methods, apparatus and computer-accessible media for providing and/or utilizing optical frequency domain imaging (OFDI) and fluorescence of structures and, e.g., multimodality imaging using OFDI techniques and fluorescence imaging techniques are described. For example, an arrangement can provide at least one electro-magnetic radiation to an anatomical structure. Such exemplary arrangement can include at least one optical core and at least one cladding at least partially surrounding the fiber(s). A region between the optical core(s) and the cladding(s) can have an index that is different from indexes of the optical core(s) and the cladding(s). The arrangement can also include at least one apparatus which is configured to transmit the radiation(s) via the optical core(s) and the cladding(s) to the anatomical structure.
摘要翻译： 描述了用于提供和/或利用光学频域成像（OFDI）和结构荧光以及例如使用OFDI技术和荧光成像技术的多模态成像的示例性系统，装置，方法，装置和计算机可访问介质。 例如，一种布置可以向解剖结构提供至少一个电磁辐射。 这种示例性布置可以包括至少一个光学芯和至少部分围绕光纤的至少一个包层。 光纤芯和包层之间的区域可以具有与光纤芯和包层的折射率不同的折射率。 该装置还可以包括至少一个被配置成经由光学核和包层传播辐射到解剖结构的装置。
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4.发明授权Apparatus, systems and methods for measuring blood pressure within at least one vessel 有权用于测量至少一个血管内的血压的装置，系统和方法公开(公告)号：US09510758B2
公开(公告)日：2016-12-06
申请号：US13283143
申请日：2011-10-27
申请人： William C. Warger, II , Simon C. Schlachter , Joseph Gardecki , Brett Eugene Bouma , Guillermo J. Tearney
发明人： William C. Warger, II , Simon C. Schlachter , Joseph Gardecki , Brett Eugene Bouma , Guillermo J. Tearney
IPC分类号： A61B6/00 , A61B5/021 , A61B5/00 , A61B5/1455 , A61B5/0205 , A61B3/14 , A61B5/02 , A61B5/12 , A61B5/20
CPC分类号： A61B5/021 , A61B3/14 , A61B5/0066 , A61B5/02007 , A61B5/02055 , A61B5/12 , A61B5/14558 , A61B5/202 , A61B5/4064 , A61B5/407 , A61B5/42 , A61B2576/00
摘要： Exemplary apparatus and method for obtaining information for at least one structure can be provided. For example, it is possible to forward at least one first electro-magnetic radiation to the at least one structure which is external from the apparatus. At least one second electro magnetic radiation provided from the at least one structure (which is based on the first electro-magnetic radiation(s)) can be detected. It is also possible to determine at least one characteristic of the structure(s) based on the second electro-magnetic radiation(s), and obtain data relating to a pressure of at least one portion of the structure(s) based on the characteristic(s).
摘要翻译： 可以提供用于获得至少一个结构的信息的示例性装置和方法。 例如，可以将至少一个第一电磁辐射转发到从装置外部的至少一个结构。 可以检测从至少一个结构（其基于第一电磁辐射）提供的至少一个第二电磁辐射。 也可以基于第二电磁辐射来确定结构的至少一个特性，并且基于特性获得与结构的至少一部分的压力有关的数据 （s）。
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5.发明申请APPARATUS, SYSTEMS AND METHODS FOR MEASURING BLOOD PRESSURE WITHIN AT LEAST ONE VESSEL 有权装置，系统和方法，用于在最小的一条船上测量血压公开(公告)号：US20120108956A1
公开(公告)日：2012-05-03
申请号：US13283143
申请日：2011-10-27
申请人： William C. Warger, II , Simon C. Schlachter , Joseph Gardecki , Brett Eugene Bouma , Guillermo J. Tearney
发明人： William C. Warger, II , Simon C. Schlachter , Joseph Gardecki , Brett Eugene Bouma , Guillermo J. Tearney
IPC分类号： A61B6/00
CPC分类号： A61B5/021 , A61B3/14 , A61B5/0066 , A61B5/02007 , A61B5/02055 , A61B5/12 , A61B5/14558 , A61B5/202 , A61B5/4064 , A61B5/407 , A61B5/42 , A61B2576/00
摘要： Exemplary apparatus and method for obtaining information for at least one structure can be provided. For example, it is possible to forward at least one first electro-magnetic radiation to the at least one structure which is external from the apparatus. At least one second electro magnetic radiation provided from the at least one structure (which is based on the first electro-magnetic radiation(s)) can be detected. It is also possible to determine at least one characteristic of the structure(s) based on the second electro-magnetic radiation(s), and obtain data relating to a pressure of at least one portion of the structure(s) based on the characteristic(s).
摘要翻译： 可以提供用于获得至少一个结构的信息的示例性装置和方法。 例如，可以将至少一个第一电磁辐射转发到从装置外部的至少一个结构。 可以检测从至少一个结构（其基于第一电磁辐射）提供的至少一个第二电磁辐射。 也可以基于第二电磁辐射来确定结构的至少一个特性，并且基于特性获得与结构的至少一部分的压力有关的数据 （s）。
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6.发明授权Systems, devices, methods, apparatus and computer-accessible media for providing optical imaging of structures and compositions 有权用于提供结构和组合物的光学成像的系统，装置，方法，装置和计算机可访问介质公开(公告)号：US09557154B2
公开(公告)日：2017-01-31
申请号：US13114845
申请日：2011-05-24
申请人： Guillermo J. Tearney , Brett Eugene Bouma , Hongki Yoo , Milen Shishkov , Joseph Gardecki , Roman Shubochkin , Theodore Morse , Farouc Amin Jaffer
发明人： Guillermo J. Tearney , Brett Eugene Bouma , Hongki Yoo , Milen Shishkov , Joseph Gardecki , Roman Shubochkin , Theodore Morse , Farouc Amin Jaffer
CPC分类号： A61B5/0084 , A61B5/0066 , A61B5/0071 , A61B5/6852 , G01B9/02029 , G01B9/0205 , G01B9/02091 , G01N21/4795 , G01N21/64 , G01N21/6456 , G01N21/65 , G01N2201/0866
摘要： Exemplary systems, devices, methods, apparatus and computer-accessible media for providing and/or utilizing optical frequency domain imaging (OFDI) and fluorescence of structures and, e.g., multimodality imaging using OFDI techniques and fluorescence imaging techniques are described. For example, an arrangement can provide at least one electro-magnetic radiation to an anatomical structure. Such exemplary arrangement can include at least one optical core and at least one cladding at least partially surrounding the fiber(s). A region between the optical core(s) and the cladding(s) can have an index that is different from indexes of the optical core(s) and the cladding(s). The arrangement can also include at least one apparatus which is configured to transmit the radiation(s) via the optical core(s) and the cladding(s) to the anatomical structure.
摘要翻译： 描述了用于提供和/或利用光学频域成像（OFDI）和结构荧光以及例如使用OFDI技术和荧光成像技术的多模态成像的示例性系统，装置，方法，装置和计算机可访问介质。 例如，一种布置可以向解剖结构提供至少一个电磁辐射。 这种示例性布置可以包括至少一个光学芯和至少部分围绕光纤的至少一个包层。 光纤芯和包层之间的区域可以具有与光纤芯和包层的折射率不同的折射率。 该装置还可以包括至少一个被配置为经由光学核和包层传播辐射到解剖结构的装置。
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公开(公告)号：US20070167836A1
公开(公告)日：2007-07-19
申请号：US11492301
申请日：2006-07-25
申请人： Obrad Scepanovic , Joseph Gardecki , Michael Feld
发明人： Obrad Scepanovic , Joseph Gardecki , Michael Feld
IPC分类号： A61B6/00
CPC分类号： A61B5/0091 , A61B5/0068 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/42 , A61B5/4312 , G01N21/64 , G01N2021/656
摘要： The present invention relates to multimodal spectroscopy (MMS) as a clinical tool for the in vivo diagnosis of disease in humans. The MMS technology combines Raman and fluorescence spectroscopy. A preferred embodiment involves diagnosis cancer of the breast and of vulnerable atherosclerotic plaque, esophageal, colon, cervical and bladder cancer. MMS is used to provide a more comprehensive picture of the metabolic, biochemical and morphological state of a tissue than afforded by either Raman or fluorescence and reflectance spectroscopies alone.
摘要翻译： 本发明涉及多峰光谱（MMS）作为人体内疾病体内诊断的临床工具。 MMS技术结合了拉曼和荧光光谱。 优选的实施方案涉及诊断乳腺癌和易受损的动脉粥样硬化斑块，食管癌，结肠癌，子宫颈癌和膀胱癌的诊断。 MMS用于提供组织的代谢，生物化学和形态状态的更全面的图像，而不是由单独的拉曼或荧光和反射光谱提供。
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