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12 条记录 (耗时 0.02 秒)

    Process for the purification of phosphonium salts
    1.
    发明授权
    Process for the purification of phosphonium salts 失效

    公开(公告)号：US06630605B2

    公开(公告)日：2003-10-07

    申请号：US10161682

    申请日：2002-06-05

    申请人： Christoph Wegner ,  Daniela Klein

    发明人： Christoph Wegner ,  Daniela Klein

    IPC分类号： C07F954

    CPC分类号： C07F9/5428 ,  C07F9/025 ,  C07F9/5435

    摘要： The invention relates to a process for the purification of phosphonium salts in which a solution of the crude phosphonium salt is passed over a bed of a cation exchange resin in salt form or of an adsorber resin, the resin is washed with a polar protic solvent in the case of the cation exchange resin and with an electrolyte solution and a nonpolar solvent in the case of the adsorber resin, and the phosphonium salt is eluted from the cation exchange resin with an electrolyte solution or from the adsorber resin with a polar solvent.

    Method for the production of chiral imidazolidin-2-ones
    2.
    发明授权
    Method for the production of chiral imidazolidin-2-ones 失效
    制备手性咪唑烷-2-酮的方法

    公开(公告)号：US07365210B2

    公开(公告)日：2008-04-29

    申请号：US10510439

    申请日：2003-04-08

    申请人： Hansgeorg Ernst ,  Jürgen Koppenhöfer ,  Daniela Klein

    发明人： Hansgeorg Ernst ,  Jürgen Koppenhöfer ,  Daniela Klein

    IPC分类号： C07D233/04

    CPC分类号： C07D233/00

    摘要： The invention relates to a process for preparing chiral imidazolidin-2-ones of the formula I in which R1 is C1-C8-alkyl, cyclohexyl, phenyl, a C1-C6-alkyl-, halo-, nitro-, C1-C6-alkoxy-, C1-C6-alkylmercapto- or CF3-substituted phenyl radical, naphthyl or a C1-C6-alkyl-, halo-, nitro-, C1-C6-alkoxy- or CF3-substituted naphthyl radical, R2 is C1-C8-alkyl, C2-C8-alkenyl, cyclohexyl, phenyl or a phenyl-C1-C6-alkyl radical which may be substituted by a nitro, C1-C6-alkoxy, methylenedioxy or CF3 radical, and R3 is C1-C12-alkyl, C2-C8-alkenyl, cyclohexyl, phenyl or a C1-C6-alkyl-, halo-, nitro-, C1-C6-alkoxy-, methylenedioxy-, dialkylamino- or CF3-substituted phenyl radical, by reacting a compound of the formula II or the salt thereof in which R1, R2 and R3 have the abovementioned meaning, with urea in the presence of an involatile ammonium salt, wherein the reaction is carried out in the presence of an aprotic polar organic solvent.

    摘要翻译： 本发明涉及一种制备其中R 1是C 1 -C 8 - 的式I的手性咪唑烷-2-酮的方法， 烷基，环己基，苯基，C 1 -C 6 - 烷基 - ，卤代 - ，硝基 - ，C 1 -C 3 - C 6 - 烷氧基 - ，C 1 -C 6 - 烷基巯基或CF 3 - 取代的苯基，萘基或C C 1 -C 6 - 烷基 - ，卤代 - ，硝基 - ，C 1 -C 6 - 烷氧基 - 或CF 3 - 取代的萘基，R 2是C 1 -C 8 - 烷基，C 和R 3具有上述含义，在非挥发性铵盐存在下用脲进行反应，其中反应在非质子极性有机溶剂的存在下进行。

    Method for the production of chiral imidazolidin-2-ones
    5.
    发明申请
    Method for the production of chiral imidazolidin-2-ones 失效
    制备手性咪唑烷-2-酮的方法

    公开(公告)号：US20050165078A1

    公开(公告)日：2005-07-28

    申请号：US10510439

    申请日：2003-04-08

    申请人： Hansgeorg Ernst ,  Jurgen Koppenhofer ,  Daniela Klein

    发明人： Hansgeorg Ernst ,  Jurgen Koppenhofer ,  Daniela Klein

    IPC分类号： C07D233/34 ,  C07B53/00 ,  C07B61/00 ,  C07D233/00 ,  A61K31/4178 ,  A61K31/4168 ,  C07D233/04 ,  C07D47/02

    CPC分类号： C07D233/00

    摘要： The invention relates to a process for preparing chiral imidazolidin-2-ones of the formula I in which R1 is C1-C8-alkyl, cyclohexyl, phenyl, a C1-C6-alkyl-, halo-, nitro-, C1-C6-alkoxy-, C1-C6-alkylmercapto- or CF3-substituted phenyl radical, naphthyl or a C1-C6-alkyl-, halo-, nitro-, C1-C6-alkoxy- or CF3-substituted naphthyl radical, R2 is C1-C8-alkyl, C2-C8-alkenyl, cyclohexyl, phenyl or a phenyl-C1-C6-alkyl radical which may be substituted by a nitro, C1-C6-alkoxy, methylenedioxy or CF3 radical, and R3 is C1-C12-alkyl, C2-C8-alkenyl, cyclohexyl, phenyl or a C1-C6-alkyl-, halo-, nitro-, C1-C6-alkoxy-, methylenedioxy-, dialkylamino- or CF3-substituted phenyl radical, by reacting a compound of the formula II or the salt thereof in which R1, R2 and R3 have the abovementioned meaning, with urea in the presence of an involatile ammonium salt, wherein the reaction is carried out in the presence of an aprotic polar organic solvent.

    摘要翻译： 本发明涉及一种制备其中R 1是C 1 -C 8 - 的式I的手性咪唑烷-2-酮的方法， 烷基，环己基，苯基，C 1 -C 6 - 烷基 - ，卤代 - ，硝基 - ，C 1 -C 3 - C 6 - 烷氧基 - ，C 1 -C 6 - 烷基巯基或CF 3 - 取代的苯基，萘基或C C 1 -C 6 - 烷基 - ，卤代 - ，硝基 - ，C 1 -C 6 - 烷氧基 - 或CF 3 - 取代的萘基，R 2是C 1 -C 8 - 烷基，C 和R 3具有上述含义，在非挥发性铵盐存在下用脲进行反应，其中反应在非质子极性有机溶剂的存在下进行。

    Method for the production of methionine
    7.
    发明申请
    Method for the production of methionine 有权
    生产甲硫氨酸的方法

    公开(公告)号：US20070122888A1

    公开(公告)日：2007-05-31

    申请号：US10583304

    申请日：2004-12-17

    申请人： Matthias Boy ,  Daniela Klein ,  Hartwig Schroder

    发明人： Matthias Boy ,  Daniela Klein ,  Hartwig Schroder

    IPC分类号： C12P13/12 ,  C07C323/35

    CPC分类号： C07C319/28 ,  C12P13/12 ,  C07C323/58

    摘要： The present invention relates to a process for producing methionine by fermentation, a process for isolating the methionine formed, the methionine-containing biomass produced in isolation, use thereof for producing a feedstuff or feed supplement, and also to the use of the isolated methionine for producing foodstuffs or feedstuffs or food supplements or feed supplements.

    摘要翻译： 本发明涉及通过发酵生产甲硫氨酸的方法，分离形成的甲硫氨酸的方法，分离产生的含有甲硫氨酸的生物质，用于生产饲料或饲料添加剂的用途，以及将分离的甲硫氨酸用于 生产食品或饲料或食品补充剂或饲料添加剂。

    Method for producing carotenoids or their precursors using genetically modified organisms of the blakeslea genus, carotenoids or their precursors produced by said method and use thereof
    8.
    发明申请
    Method for producing carotenoids or their precursors using genetically modified organisms of the blakeslea genus, carotenoids or their precursors produced by said method and use thereof 审中-公开
    使用所述方法生产的布鲁氏菌属，类胡萝卜素或其前体的遗传修饰生物来生产类胡萝卜素或其前体的方法及其用途

    公开(公告)号：US20060234333A1

    公开(公告)日：2006-10-19

    申请号：US10541750

    申请日：2004-01-09

    申请人： Markus Matuschek ,  Daniela Klein ,  Thorsten Heinekamp ,  Andre Schmidt

    发明人： Markus Matuschek ,  Daniela Klein ,  Thorsten Heinekamp ,  Andre Schmidt

    IPC分类号： C12P23/00 ,  C12N15/74 ,  C12N1/14

    CPC分类号： C12N15/80 ,  A23K20/179 ,  A23L5/00 ,  A23L5/44 ,  A23L31/00 ,  A23L33/105 ,  C12P23/00

    摘要： The invention relates to a method for producing carotenoids or their precursors using genetically modified organisms of the Blakeslea genus. Said method comprises the following steps (i) transformation of at least one of the cells, (ii) optional homokaryotic conversion of the cells obtained in step (i) to produce cells, in which one or more genetic characteristics of the nuclei are all modified in an identical manner and said modification manifests itself in the cells, (iii) selection and reproduction of the genetically modified cell or cells, (iv) cultivation of the genetically modified cells, (v) preparation of the carotenoids produced by the genetically modified cells or the carotenoid precursor produced by said genetically modified cells. The invention also relates to carotenoids or their precursors produced according to said method and to the use thereof.

    摘要翻译： 本发明涉及使用布鲁氏菌属的转基因生物来生产类胡萝卜素或其前体的方法。 所述方法包括以下步骤：（i）至少一个细胞的转化，（ii）步骤（i）中获得的细胞的任选的同源转化以产生其中一个或多个核的遗传特征都被修饰的细胞 以相同的方式，并且所述修饰本身在细胞中，（iii）遗传修饰的细胞或细胞的选择和繁殖，（iv）遗传修饰的细胞的培养，（v）由遗传修饰的细胞产生的类胡萝卜素的制备 或由所述遗传修饰的细胞产生的类胡萝卜素前体。 本发明还涉及根据所述方法生产的类胡萝卜素或其前体及其用途。

    Method for the production of methionine
    9.
    发明授权
    Method for the production of methionine 有权
    生产甲硫氨酸的方法

    公开(公告)号：US07785846B2

    公开(公告)日：2010-08-31

    申请号：US10583304

    申请日：2004-12-17

    申请人： Matthias Boy ,  Daniela Klein ,  Hartwig Schröder

    发明人： Matthias Boy ,  Daniela Klein ,  Hartwig Schröder

    IPC分类号： C12P13/12

    CPC分类号： C07C319/28 ,  C12P13/12 ,  C07C323/58

    摘要： The present invention relates to a process for producing methionine by fermentation, a process for isolating the methionine formed, the methionine-containing biomass produced in isolation, use thereof for producing a feedstuff or feed supplement, and also to the use of the isolated methionine for producing foodstuffs or feedstuffs or food supplements or feed supplements.

    摘要翻译： 本发明涉及通过发酵生产甲硫氨酸的方法，分离形成的甲硫氨酸的方法，分离产生的含有甲硫氨酸的生物质，用于生产饲料或饲料添加剂的用途，以及将分离的甲硫氨酸用于 生产食品或饲料或食品补充剂或饲料添加剂。