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    Fabricating biopolymer arrays
    4.
    发明授权
    Fabricating biopolymer arrays 失效
    制造生物聚合物阵列

    公开(公告)号：US07282332B2

    公开(公告)日：2007-10-16

    申请号：US10932886

    申请日：2004-09-01

    申请人： Michael P. Caren ,  Carol T. Schembri ,  Peter G. Webb

    发明人： Michael P. Caren ,  Carol T. Schembri ,  Peter G. Webb

    IPC分类号： C12Q1/68 ,  G01N33/543

    CPC分类号： B01J19/0046 ,  B01J2219/00378 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00608 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00619 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00722 ,  B01J2219/00725 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14 ,  Y10T436/2575

    摘要： A method and apparatus for fabricating an array of biopolymers on a substrate using a biopolymer or biomonomer fluid, and using a dispensing head. The head has a reservoir chamber and at least one jet which can dispense droplets onto a substrate. The jet includes a capillary delivery chamber communicating with the reservoir chamber, which delivery chamber has an orifice. The jet further includes an ejector which, when activated, causes a droplet to be ejected from the orifice. The method includes loading the head by positioning the head with the orifice adjacent and facing a biomonomer or biopolymer fluid, and providing a load pressure to the reservoir chamber. The load pressure is sufficiently negative such that the fluid is drawn into the reservoir chamber through the orifice and delivery chamber, while simultaneously being insufficient to result in ambient atmosphere entering the delivery chamber through the orifice once the head has been loaded and no further fluid is facing and adjacent the orifice. The head is positioned with the orifice facing the substrate and multiple droplets are dispensed from the head orifice so as to form an array of droplets on the substrate.

    摘要翻译： 一种使用生物聚合物或生物共聚物流体以及使用分配头在衬底上制造生物聚合物阵列的方法和装置。 头部具有储存室和至少一个可将液滴分配到基底上的射流。 喷射器包括与储存室连通的毛细管输送室，该输送室具有孔口。 射流还包括喷射器，其在被激活时使得液滴从孔口喷出。 该方法包括通过将头部与孔相邻并且面向生物体或生物聚合物流体的位置来装载头部，并向贮存室提供负载压力。 负载压力足够负，使得流体通过孔口和输送室被吸入储存室，同时不足以在头部已经被加载并且没有另外的流体是通过孔口导致环境大气通过孔口进入输送室 面对并邻近孔口。 头部定位成孔口面向衬底，并且从头部孔口分配多个液滴，以便在衬底上形成液滴阵列。

    Pressure variation in array fabrication
    7.
    发明授权
    Pressure variation in array fabrication 失效
    阵列制造中的压力变化

    公开(公告)号：US06656740B1

    公开(公告)日：2003-12-02

    申请号：US09703303

    申请日：2000-10-31

    申请人： Michael P. Caren ,  Peter G. Webb ,  Carol T. Schembri

    发明人： Michael P. Caren ,  Peter G. Webb ,  Carol T. Schembri

    IPC分类号： B01L302

    CPC分类号： B01L3/0268 ,  B01J2219/00378 ,  B01J2219/00529 ,  B01J2219/00608 ,  B01J2219/00662 ,  B01J2219/00689 ,  B01J2219/00722 ,  B01L2200/14 ,  B01L2400/0439 ,  B01L2400/0442 ,  C40B40/06 ,  C40B60/14 ,  Y10T436/2575

    摘要： A method, apparatus and computer program product, for fabricating an array of biopolymers on a substrate. The method uses a biopolymer or biomonomer fluid and a drop dispenser having a chamber into which the fluid is loaded and an orifice communicating with the chamber from which the fluid is dispensed. The method includes, when the chamber is loaded, applying a prime pressure to the fluid which varies over a range sufficient to move fluid within the drop dispenser but insufficient to cause fluid to be dispensed from the orifice. Drops are dispensed from the dispenser to the substrate so as to form the array.

    摘要翻译： 一种用于在衬底上制造生物聚合物阵列的方法，装置和计算机程序产品。 该方法使用生物聚合物或生物共聚物流体和具有腔室的液滴分配器，流体被加载到该腔室中，以及与腔室连通的孔口，流体从该腔室分配。 该方法包括，当腔室被装载时，向在液滴分配器内足以移动流体的范围内变化的流体施加主压力，但不足以使流体从孔口分配。 从分配器将液滴分配到基底以形成阵列。

    Fabricating biopolymer arrays
    8.
    发明授权
    Fabricating biopolymer arrays 失效
    制造生物聚合物阵列

    公开(公告)号：US06323043B1

    公开(公告)日：2001-11-27

    申请号：US09302922

    申请日：1999-04-30

    申请人： Michael P. Caren ,  Carol T. Schembri ,  Peter G. Webb

    发明人： Michael P. Caren ,  Carol T. Schembri ,  Peter G. Webb

    IPC分类号： G01N33543

    CPC分类号： B01J19/0046 ,  B01J2219/00378 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00608 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00619 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00722 ,  B01J2219/00725 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14 ,  Y10T436/2575

    摘要： A method and apparatus for fabricating an array of biopolymers on a substrate using a biopolymer or biomonomer fluid, and using a dispensing head. The head has a reservoir chamber and at least one jet which can dispense droplets onto a substrate. The jet includes a capillary delivery chamber communicating with the reservoir chamber, which delivery chamber has an orifice. The jet further includes an ejector which, when activated, causes a droplet to be ejected from the orifice. The method includes loading the head by positioning the head with the orifice adjacent and facing a biomonomer or biopolymer fluid, and providing a load pressure to the reservoir chamber. The load pressure is sufficiently negative such that the fluid is drawn into the reservoir chamber through the orifice and delivery chamber, while simultaneously being insufficient to result in ambient atmosphere entering the delivery chamber through the orifice once the head has been loaded and no further fluid is facing and adjacent the orifice. The head is positioned with the orifice facing the substrate and multiple droplets are dispensed from the head orifice so as to form an array of droplets on the substrate.

    摘要翻译： 一种使用生物聚合物或生物共聚物流体以及使用分配头在衬底上制造生物聚合物阵列的方法和装置。 头部具有储存室和至少一个可将液滴分配到基底上的射流。 喷射器包括与储存室连通的毛细管输送室，该输送室具有孔口。 射流还包括喷射器，其在被激活时使得液滴从孔口喷出。 该方法包括通过将头部与孔相邻并且面向生物体或生物聚合物流体的位置来装载头部，并向贮存室提供负载压力。 负载压力足够负，使得流体通过孔口和输送室被吸入储存室，同时不足以在头部已经被加载并且没有另外的流体是通过孔口导致环境大气通过孔口进入输送室 面对并邻近孔口。 头部定位成孔口面向衬底，并且从头部孔口分配多个液滴，以便在衬底上形成液滴阵列。

    Apparatus for deposition and inspection of chemical and biological fluids
    9.
    发明授权
    Apparatus for deposition and inspection of chemical and biological fluids 失效
    用于沉积和检查化学和生物流体的装置

    公开(公告)号：US06689319B1

    公开(公告)日：2004-02-10

    申请号：US09429895

    申请日：1999-10-29

    申请人： William D. Fisher ,  Henrique A. S. Martins ,  Peter G. Webb

    发明人： William D. Fisher ,  Henrique A. S. Martins ,  Peter G. Webb

    IPC分类号： G01N3510

    CPC分类号： B41J29/393 ,  B01J19/0046 ,  B01J2219/00351 ,  B01J2219/00378 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00659 ,  B01J2219/00693 ,  B01J2219/00722 ,  B01J2219/00725 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14 ,  G01N21/95607

    摘要： An apparatus and method are provided for producing and inspecting a plurality of deposited features in a pattern on a portion of a substrate surface, as in an oligonucleotide array. The apparatus comprises a printhead for depositing a fluid to form the array of features on the substrate surface and a camera for imaging the deposited features. The apparatus also comprises a printhead controller for positioning and activating the inkjet printhead to deposit the array features. The camera, e.g., a digital line scan camera, is controlled by a camera controller such that the camera acquires images corresponding to substantially only the portion of the surface on which features should have been deposited. The camera and printhead are preferably situated such that an induced movement of the printhead relative to the substrate results in a substantially identical corresponding movement of the camera. Optionally, the apparatus further comprises means for comparing an image acquired by the camera with a predetermined standard to produce a signal.

    摘要翻译： 提供了一种用于在衬底表面的一部分上以图案形式生产和检查多个沉积特征的装置和方法，如寡核苷酸阵列中那样。 该装置包括用于沉积流体以形成衬底表面上的特征阵列的打印头和用于对沉积的特征进行成像的照相机。 该装置还包括用于定位和启动喷墨打印头以沉积阵列特征的打印头控制器。 照相机，例如数字线扫描照相机，由照相机控制器控制，使得照相机获取对应于基本上只有特征应该已经被沉积的表面部分的图像。 相机和打印头优选地被定位成使得打印头相对于基板的感应运动导致相机的基本上相同的相应运动。 可选地，该装置还包括用于将由照相机获取的图像与预定标准进行比较以产生信号的装置。

    Array fabrication
    10.
    发明授权
    Array fabrication 失效
    阵列制作

    公开(公告)号：US06599693B1

    公开(公告)日：2003-07-29

    申请号：US09628963

    申请日：2000-07-31

    申请人： Peter G. Webb

    发明人： Peter G. Webb

    IPC分类号： C12Q100

    CPC分类号： B01J19/0046 ,  Y10T436/143333

    摘要： A method of fabricating an array with multiple sets of neighboring features. In the method, for each of multiple sets of neighboring features, at least one set of drops is deposited from a corresponding same pulse jet dispenser onto a substrate so as to form the array with the sets formed from drops deposited by respective different dispensers. Apparatus and computer program products which can execute a method of the invention, are also provided.

    摘要翻译： 一种制造具有多组相邻特征的阵列的方法。 在该方法中，对于多组相邻特征中的每一组，至少一组液滴从相应的相同的脉冲喷射分配器沉积到基底上，以便形成阵列，其中由通过相应的不同分配器沉积的液滴形成。 还提供了可以执行本发明的方法的装置和计算机程序产品。