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公开(公告)号：US20110230446A1
公开(公告)日：2011-09-22
申请号：US13115462
申请日：2011-05-25
申请人： Christopher I. Bayly , Cameron Black , Serge Leger , Chun Sing Li , Dan McKay , Chirstophe Mellon , Jacques Yves Gauthier , Vouy-Linh Truong , Cheuk Lau , Michel Therien , Michael J. Green , Bernard L. Hirschbein , James William Janc , James T. Palmer , Chitra Baskaran
发明人： Christopher I. Bayly , Cameron Black , Serge Leger , Chun Sing Li , Dan McKay , Chirstophe Mellon , Jacques Yves Gauthier , Vouy-Linh Truong , Cheuk Lau , Michel Therien , Michael J. Green , Bernard L. Hirschbein , James William Janc , James T. Palmer , Chitra Baskaran
IPC分类号： A61K31/277 , A61K31/495 , A61K31/4418 , A61K31/426 , A61K31/4174 , A61K31/663 , A61P19/08 , A61P19/10 , A61P1/02 , A61P19/02 , A61P35/00 , A61P19/00
CPC分类号： C07C237/20 , A61K31/165 , A61K31/18 , A61K31/4174 , A61K31/426 , A61K31/44 , A61K31/4418 , A61K31/495 , C07C255/25 , C07C255/29 , C07C255/46 , C07C255/58 , C07C259/10 , C07C311/37 , C07C317/32 , C07C2601/02 , C07C2601/14 , C07D209/08 , C07D213/38 , C07D213/57 , C07D213/64 , C07D213/70 , C07D213/89 , C07D215/12 , C07D231/12 , C07D233/64 , C07D239/26 , C07D241/12 , C07D261/08 , C07D263/32 , C07D271/06 , C07D277/28 , C07D277/30 , C07D295/135 , C07D295/155 , C07D307/52 , C07D333/20 , C07D401/04 , C07D417/04
摘要： This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.
摘要翻译： 本发明涉及一类新的化合物，它们是半胱氨酸蛋白酶抑制剂，包括但不限于组织蛋白酶K，L，S和B的抑制剂。这些化合物可用于治疗其中指示抑制骨吸收的疾病，例如 骨质疏松症
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公开(公告)号：US20080188529A1
公开(公告)日：2008-08-07
申请号：US12082104
申请日：2008-04-08
申请人： Christopher I. Bayly , Cameron Black , Serge Leger , Chun Sing Li , Dan McKay , Christophe Mellon , Jacques Yves Gauthier , Vouy-Linh Truong , Cheuk Lau , Michel Therien , Michael J. Green , Bernard L. Hirschbein , James William Janc , James T. Palmer , Chitra Baskaran
发明人： Christopher I. Bayly , Cameron Black , Serge Leger , Chun Sing Li , Dan McKay , Christophe Mellon , Jacques Yves Gauthier , Vouy-Linh Truong , Cheuk Lau , Michel Therien , Michael J. Green , Bernard L. Hirschbein , James William Janc , James T. Palmer , Chitra Baskaran
IPC分类号： A61K31/4418 , C07C233/40 , A61K31/165 , C07D213/57
CPC分类号： C07C237/20 , A61K31/165 , A61K31/18 , A61K31/4174 , A61K31/426 , A61K31/44 , A61K31/4418 , A61K31/495 , C07C255/25 , C07C255/29 , C07C255/46 , C07C255/58 , C07C259/10 , C07C311/37 , C07C317/32 , C07C2601/02 , C07C2601/14 , C07D209/08 , C07D213/38 , C07D213/57 , C07D213/64 , C07D213/70 , C07D213/89 , C07D215/12 , C07D231/12 , C07D233/64 , C07D239/26 , C07D241/12 , C07D261/08 , C07D263/32 , C07D271/06 , C07D277/28 , C07D277/30 , C07D295/135 , C07D295/155 , C07D307/52 , C07D333/20 , C07D401/04 , C07D417/04
摘要： This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.
摘要翻译： 本发明涉及一类新的化合物，它们是半胱氨酸蛋白酶抑制剂，包括但不限于组织蛋白酶K，L，S和B的抑制剂。这些化合物可用于治疗其中指示抑制骨吸收的疾病，例如 骨质疏松症
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公开(公告)号：US08318748B2
公开(公告)日：2012-11-27
申请号：US13115462
申请日：2011-05-25
申请人： Christopher I. Bayly , Cameron Black , Serge Leger , Chun Sing Li , Dan McKay , Christophe Mellon , Jacques Yves Gauthier , Vouy-Linh Truong , Cheuk Lau , Michel Therien , Michael J. Green , Bernard L. Hirschbein , James William Janc , James T. Palmer , Chitra Baskaran
发明人： Christopher I. Bayly , Cameron Black , Serge Leger , Chun Sing Li , Dan McKay , Christophe Mellon , Jacques Yves Gauthier , Vouy-Linh Truong , Cheuk Lau , Michel Therien , Michael J. Green , Bernard L. Hirschbein , James William Janc , James T. Palmer , Chitra Baskaran
IPC分类号： A61K31/4965 , A61K31/66 , A61K31/44 , A61K31/445 , A61K31/425 , A61K31/415
CPC分类号： C07C237/20 , A61K31/165 , A61K31/18 , A61K31/4174 , A61K31/426 , A61K31/44 , A61K31/4418 , A61K31/495 , C07C255/25 , C07C255/29 , C07C255/46 , C07C255/58 , C07C259/10 , C07C311/37 , C07C317/32 , C07C2601/02 , C07C2601/14 , C07D209/08 , C07D213/38 , C07D213/57 , C07D213/64 , C07D213/70 , C07D213/89 , C07D215/12 , C07D231/12 , C07D233/64 , C07D239/26 , C07D241/12 , C07D261/08 , C07D263/32 , C07D271/06 , C07D277/28 , C07D277/30 , C07D295/135 , C07D295/155 , C07D307/52 , C07D333/20 , C07D401/04 , C07D417/04
摘要： This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.
摘要翻译： 本发明涉及一类新的化合物，它们是半胱氨酸蛋白酶抑制剂，包括但不限于组织蛋白酶K，L，S和B的抑制剂。这些化合物可用于治疗其中指示抑制骨吸收的疾病，例如 骨质疏松症
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公开(公告)号：US07973037B2
公开(公告)日：2011-07-05
申请号：US12082104
申请日：2008-04-08
申请人： Christopher I. Bayly , Cameron Black , Serge Leger , Chun Sing Li , Dan McKay , Christophe Mellon , Jacques Yves Gauthier , Vouy-Linh Truong , Cheuk Lau , Michel Therien , Michael J. Green , Bernard L. Hirschbein , James William Janc , James T. Palmer , Chitra Baskaran
发明人： Christopher I. Bayly , Cameron Black , Serge Leger , Chun Sing Li , Dan McKay , Christophe Mellon , Jacques Yves Gauthier , Vouy-Linh Truong , Cheuk Lau , Michel Therien , Michael J. Green , Bernard L. Hirschbein , James William Janc , James T. Palmer , Chitra Baskaran
IPC分类号： A61K31/535 , A61K31/497 , A61K31/435 , A61K31/385 , C07D265/30 , C07D241/04 , C07D211/08 , C07D333/02 , C07D255/03
CPC分类号： C07C237/20 , A61K31/165 , A61K31/18 , A61K31/4174 , A61K31/426 , A61K31/44 , A61K31/4418 , A61K31/495 , C07C255/25 , C07C255/29 , C07C255/46 , C07C255/58 , C07C259/10 , C07C311/37 , C07C317/32 , C07C2601/02 , C07C2601/14 , C07D209/08 , C07D213/38 , C07D213/57 , C07D213/64 , C07D213/70 , C07D213/89 , C07D215/12 , C07D231/12 , C07D233/64 , C07D239/26 , C07D241/12 , C07D261/08 , C07D263/32 , C07D271/06 , C07D277/28 , C07D277/30 , C07D295/135 , C07D295/155 , C07D307/52 , C07D333/20 , C07D401/04 , C07D417/04
摘要： This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.
摘要翻译： 本发明涉及一类新的化合物，它们是半胱氨酸蛋白酶抑制剂，包括但不限于组织蛋白酶K，L，S和B的抑制剂。这些化合物可用于治疗其中指示抑制骨吸收的疾病，例如 骨质疏松症
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公开(公告)号：US07375134B2
公开(公告)日：2008-05-20
申请号：US10505796
申请日：2003-02-28
申请人： Christopher I. Bayly , Cameron Black , Serge Leger , Chun Sing Li , Dan McKay , Christophe Mellon , Jacques Yves Gauthier , Vouy-Linh Truong , Cheuk Lau , Michel Therien
发明人： Christopher I. Bayly , Cameron Black , Serge Leger , Chun Sing Li , Dan McKay , Christophe Mellon , Jacques Yves Gauthier , Vouy-Linh Truong , Cheuk Lau , Michel Therien
IPC分类号： A01N37/34
CPC分类号： C07C237/20 , A61K31/165 , A61K31/18 , A61K31/4174 , A61K31/426 , A61K31/44 , A61K31/4418 , A61K31/495 , C07C255/25 , C07C255/29 , C07C255/46 , C07C255/58 , C07C259/10 , C07C311/37 , C07C317/32 , C07C2601/02 , C07C2601/14 , C07D209/08 , C07D213/38 , C07D213/57 , C07D213/64 , C07D213/70 , C07D213/89 , C07D215/12 , C07D231/12 , C07D233/64 , C07D239/26 , C07D241/12 , C07D261/08 , C07D263/32 , C07D271/06 , C07D277/28 , C07D277/30 , C07D295/135 , C07D295/155 , C07D307/52 , C07D333/20 , C07D401/04 , C07D417/04
摘要： This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.
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6.发明授权公开(公告)号：US06211210B1
公开(公告)日：2001-04-03
申请号：US09561565
申请日：2000-04-28
IPC分类号： C07D28506
CPC分类号： C07D285/06
摘要： The invention encompasses compounds of Formula I as well as a method of treating COX-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. The invention also encompasses certain pharmaceutical compositions for treatment of COX-2 mediated diseases comprising compounds of Formula I.
摘要翻译： 本发明包括式I化合物以及治疗COX-2介导的疾病的方法，其包括给予需要这种治疗无毒治疗有效量的式I化合物的患者。本发明还包括某些药物 用于治疗包含式I化合物的COX-2介导的疾病的组合物。
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7.发明授权
公开(公告)号：US6020343A
公开(公告)日：2000-02-01
申请号：US97543
申请日：1998-06-15
申请人： Michel Belley , Jacques Yves Gauthier , Erich Grimm , Yves LeBlanc , Chun-Sing Li , Michel Therien , Cameron Black , Petpiboon Prasit , Cheuk-Kun Lau , Patrick Roy
发明人： Michel Belley , Jacques Yves Gauthier , Erich Grimm , Yves LeBlanc , Chun-Sing Li , Michel Therien , Cameron Black , Petpiboon Prasit , Cheuk-Kun Lau , Patrick Roy
IPC分类号： C07C317/24 , C07D307/58 , C07D307/60 , C07D307/62 , C07D307/64 , C07D307/66 , C07D307/68 , C07D307/83 , C07D307/94 , C07D405/12 , C07D409/12 , C07D417/12 , C07D471/04 , C07D491/04 , C07D495/04 , C07D498/04 , C07D513/04 , A61K31/665
CPC分类号： C07D405/12 , C07C317/24 , C07D307/58 , C07D307/60 , C07D307/62 , C07D307/64 , C07D307/66 , C07D307/68 , C07D307/83 , C07D307/94 , C07D409/12 , C07D417/12 , C07D471/04 , C07D491/04 , C07D495/04 , C07D513/04 , C07C2101/08
摘要： The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.
摘要翻译： 本发明包括可用于治疗环氧合酶-2介导的疾病的新颖的式I化合物。 本发明还包括用于治疗包含式I化合物的环氧合酶-2介导的疾病的某些药物组合物。
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8.发明授权公开(公告)号：US06169188A
公开(公告)日：2001-01-02
申请号：US09422151
申请日：1999-10-21
申请人： Michel Belley , Jacques Yves Gauthier , Erich Grimm , Yves LeBlanc , Chun-Sing Li , Michel Therien , Cameron Black , Petpiboon Prasit , Cheuk-Kun Lau , Patrick Roy
发明人： Michel Belley , Jacques Yves Gauthier , Erich Grimm , Yves LeBlanc , Chun-Sing Li , Michel Therien , Cameron Black , Petpiboon Prasit , Cheuk-Kun Lau , Patrick Roy
IPC分类号： C07D31744
CPC分类号： C07D405/12 , C07C317/24 , C07C2601/08 , C07D307/58 , C07D307/60 , C07D307/62 , C07D307/64 , C07D307/66 , C07D307/68 , C07D307/83 , C07D307/94 , C07D409/12 , C07D417/12 , C07D471/04 , C07D491/04 , C07D495/04 , C07D513/04
摘要： The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.
摘要翻译： 本发明包括可用于治疗环加氧酶-2介导的疾病的新颖的式I化合物。本发明还包括用于治疗包含式I化合物的环氧合酶-2介导的疾病的某些药物组合物。
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9.发明授权
公开(公告)号：US5981576A
公开(公告)日：1999-11-09
申请号：US97537
申请日：1998-06-15
申请人： Michel Belley , Jacques Yves Gauthier , Erich Grimm , Yves LeBlanc , Chun-Sing Li , Michel Therien , Cameron Black , Petpiboon Prasit , Cheuk-Kun Lau , Patrick Roy
发明人： Michel Belley , Jacques Yves Gauthier , Erich Grimm , Yves LeBlanc , Chun-Sing Li , Michel Therien , Cameron Black , Petpiboon Prasit , Cheuk-Kun Lau , Patrick Roy
IPC分类号： C07C317/24 , C07D307/58 , C07D307/60 , C07D307/62 , C07D307/64 , C07D307/66 , C07D307/68 , C07D307/83 , C07D307/94 , C07D405/12 , C07D409/12 , C07D417/12 , C07D471/04 , C07D491/04 , C07D495/04 , C07D498/04 , C07D513/04 , C07D307/02 , A61K31/34
CPC分类号： C07C317/24 , C07D307/58 , C07D307/60 , C07D307/62 , C07D307/64 , C07D307/66 , C07D307/68 , C07D307/83 , C07D307/94 , C07D405/12 , C07D409/12 , C07D417/12 , C07D471/04 , C07D491/04 , C07D495/04 , C07D513/04 , C07C2101/08
摘要： The invention encompasses the novel compound of Formula A that is useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula A.
摘要翻译： 本发明包括可用于治疗环氧合酶-2介导的疾病的新颖的式A化合物。 本发明还包括用于治疗包含式A化合物的环氧合酶-2介导的疾病的某些药物组合物。
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10.发明授权Phosphonic acid biaryl derivatives as inhibitors of protein tyrosine phosphatase 1B (PTP-1B) 失效作为蛋白酪氨酸磷酸酶1B（PTP-1B）的抑制剂的膦酸联芳衍生物公开(公告)号：US06486141B2
公开(公告)日：2002-11-26
申请号：US09745199
申请日：2000-12-21
申请人： Cheuk Kun Lau , Christopher Bayly , Jacques Yves Gauthier , Yves Leblanc , Chun Sing Li , Patrick Roy , Michel Therien , Zhaoyin Wang
发明人： Cheuk Kun Lau , Christopher Bayly , Jacques Yves Gauthier , Yves Leblanc , Chun Sing Li , Patrick Roy , Michel Therien , Zhaoyin Wang
IPC分类号： A61K31663
CPC分类号： C07F9/65583 , C07F9/65188
摘要： The invention encompasses the novel class of compounds represented by formula I which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases, including diabetes, obesity, and diabetes-related conditions.
摘要翻译： 本发明包括作为PTP-1B酶抑制剂的由式I表示的新一类化合物。本发明还包括治疗或预防PTP-1B介导的疾病的药物组合物和方法，包括糖尿病，肥胖症和糖尿病相关病症 。
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