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18 条记录 (耗时 0.055 秒)

    N-benzyl-3-indoleacetic acids as antiinflammatory drugs
    7.
    发明授权
    N-benzyl-3-indoleacetic acids as antiinflammatory drugs 失效
    N-苄基-3-吲哚乙酸作为抗炎药

    公开(公告)号：US5510368A

    公开(公告)日：1996-04-23

    申请号：US445625

    申请日：1995-05-22

    申请人： Cheuk K. Lau ,  Cameron Black ,  Michel Belley

    发明人： Cheuk K. Lau ,  Cameron Black ,  Michel Belley

    IPC分类号： C07D209/22 ,  A61K31/405

    CPC分类号： C07D209/22

    摘要： The invention encompasses the novel compound of Formula I as well as a method of treating inflammation and, in particular, cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of inflammation and, in particular, cyclooxygenase-2 mediated diseases comprising compounds of Formula I.

    摘要翻译： 本发明包括式I的新型化合物以及治疗炎症，特别是环氧合酶-2介导的疾病的方法，其包括向需要这种治疗无效治疗有效量的式 用于治疗炎症的药物组合物，特别是包含式I化合物的环氧合酶-2介导的疾病。

    Quinoline derivatives as ep4 antagonists
    9.
    发明申请
    Quinoline derivatives as ep4 antagonists 有权
    喹啉衍生物作为ep4拮抗剂

    公开(公告)号：US20090099226A1

    公开(公告)日：2009-04-16

    申请号：US11920275

    申请日：2006-05-15

    申请人： Michel Belley ,  Jason Burch ,  John Colucci ,  Julie Farand ,  Mario Girard ,  Yongxin Han

    发明人： Michel Belley ,  Jason Burch ,  John Colucci ,  Julie Farand ,  Mario Girard ,  Yongxin Han

    IPC分类号： A61K31/437 ,  C07D471/04

    CPC分类号： C07D471/04

    摘要： The invention is directed to quinoline derivatives as prostaglandin E type receptor antagonists useful for the treatment of EP4 mediated diseases or conditions, such as acute and chronic pain, osteoarthritis, rheumatoid arthritis and cancer. The derivatives have the following structure of formula (I): wherein A and B represents either a nitrogen atom or a CH group with the proviso that they cannot both simultaneously be CH, Q can represent a nitrogen or a carbon atom, and Y and Z are either a nitrogen atom, a N(O) group or a C(R5) group. Pharmaceutical compositions comprising the derivatives of formula (I) are also included.

    摘要翻译： 本发明涉及可用于治疗EP4介导的疾病或病症（例如急性和慢性疼痛，骨关节炎，类风湿性关节炎和癌症）的前列腺素E型受体拮抗剂的喹啉衍生物。 衍生物具有式（I）的以下结构：其中A和B表示氮原子或CH基团，条件是它们不能同时为CH，Q可以表示氮或碳原子，Y和Z 是氮原子，N（O）基或C（R5）基团。 还包括包含式（I）的衍生物的药物组合物。