公开(公告)号：US07880456B2

公开(公告)日：2011-02-01

申请号：US12724289

申请日：2010-03-15

申请人： Christopher T. Falvey ,  Andrew Wu

发明人： Christopher T. Falvey ,  Andrew Wu

IPC分类号： G05F1/618

CPC分类号： H02M3/158 ,  H02M2001/0009 ,  H02M2001/0045

摘要： A switch-mode DC/DC converter and a linear low drop out (LDO) DC/DC regulator are connected in parallel to drive a single load. Both regulators share a common voltage reference, feedback network, input supply and output such that the regulated voltage is identical during each mode of operation. During heavy loads the switch-mode regulator is in operation and the linear regulator is disabled for the highest efficiency possible. Conversely at light loads the linear regulator is in operation with the switch-mode regulator disabled, also maximizing the efficiency. Each regulator senses load current to automatically transition between the appropriate voltage regulators at fixed load current levels. The presented invention also includes a make before break transition scheme of the voltage regulators to minimize the voltage transients.

摘要翻译： 开关模式DC / DC转换器和线性低压降（LDO）DC / DC调节器并联连接以驱动单个负载。 两个稳压器都有一个共同的参考电压，反馈网络，输入电源和输出，使得每个工作模式下的稳压电压相同。 在重负载期间，开关模式稳压器处于工作状态，线性稳压器被禁用，以实现最高的效率。 相反，轻负载时，线性稳压器工作在禁用开关模式调节器的同时，也使效率最大化。 每个调节器感测负载电流，以在固定负载电流水平下自适应在适当的稳压器之间转换。 本发明还包括电压调节器的断开前转换方案以使电压瞬变最小化。

公开(公告)号：US20100231190A1

公开(公告)日：2010-09-16

申请号：US12724289

申请日：2010-03-15

申请人： Christopher T. Falvey ,  Andrew Wu

发明人： Christopher T. Falvey ,  Andrew Wu

IPC分类号： G05F1/10

CPC分类号： H02M3/158 ,  H02M2001/0009 ,  H02M2001/0045

摘要： A switch-mode DC/DC converter and a linear low drop out (LDO) DC/DC regulator are connected in parallel to drive a single load. Both regulators share a common voltage reference, feedback network, input supply and output such that the regulated voltage is identical during each mode of operation. During heavy loads the switch-mode regulator is in operation and the linear regulator is disabled for the highest efficiency possible. Conversely at light loads the linear regulator is in operation with the switch-mode regulator disabled, also maximizing the efficiency. Each regulator senses load current to automatically transition between the appropriate voltage regulators at fixed load current levels. The presented invention also includes a make before break transition scheme of the voltage regulators to minimize the voltage transients.

摘要翻译： 开关模式DC / DC转换器和线性低压降（LDO）DC / DC调节器并联连接以驱动单个负载。 两个稳压器都有一个共同的参考电压，反馈网络，输入电源和输出，使得每个工作模式下的稳压电压相同。 在重负载期间，开关模式稳压器处于工作状态，线性稳压器被禁用，以实现最高的效率。 相反，轻负载时，线性稳压器工作在禁用开关模式调节器的同时，也使效率最大化。 每个调节器感测负载电流，以在固定负载电流水平下自适应在适当的稳压器之间转换。 本发明还包括电压调节器的断开前转换方案以使电压瞬变最小化。

公开(公告)号：US07679350B2

公开(公告)日：2010-03-16

申请号：US10587785

申请日：2004-02-05

申请人： Christopher T. Falvey ,  Andrew Wu

发明人： Christopher T. Falvey ,  Andrew Wu

IPC分类号： G05F1/618

CPC分类号： H02M3/158 ,  H02M2001/0009 ,  H02M2001/0045

摘要： A switch-mode DC/DC converter (101) and linear low drop out (LIDO) DC/DC regulator (105) are connected in parallel to drive a single load Both regulators share a common voltage reference, feedback network (103), input supply and output such that the regulated voltage is identical during each mode of operation. During heavy loads the switch-mode regulator (107) is in operation and the linear regulator is disabled for the highest efficiency possible. Conversely at light loads the linear regulator is in operation with the switch-mode regulator (107) disabled, also maximizing the efficiency. Each regulator senses load current (131) to automatically transition between the appropriate voltage regulators at fixed load current levels. The presented invention also includes a make before break transition scheme of the voltage regulators (103) to minimize the voltage transients.

摘要翻译： 开关模式DC / DC转换器（101）和线性低压降（LIDO）DC / DC稳压器（105）并联连接以驱动单个负载。两个稳压器共享公共参考电压，反馈网络（103），输入 供应和输出，使得在每个操作模式期间调节电压相同。 在重负载期间，开关模式稳压器（107）处于工作状态，线性稳压器被禁用，以实现最高的效率。 相反，轻负载时，线性稳压器在开关模式稳压器（107）禁用的情况下运行，同时也使效率最大化。 每个调节器感测负载电流（131），以在固定负载电流水平下自适应在适当的电压调节器之间转换。 本发明还包括电压调节器（103）的断开前转换方案以最小化电压瞬变。

公开(公告)号：US10342623B2

公开(公告)日：2019-07-09

申请号：US14917896

申请日：2015-03-12

申请人： Justin Huelman ,  Andrew Wu ,  Michael Jung ,  Marc Child ,  Vidit Sharma ,  Addason Mccaslin ,  PROXIMED, LLC

发明人： Justin Huelman ,  Andrew Wu ,  Michael Jung ,  Marc Child ,  Vidit Sharma ,  Addason Mccaslin

IPC分类号： A61B34/20 ,  A61B17/00 ,  A61B17/42 ,  A61B90/00

摘要： Surgical systems and methods for avoiding injury to an anatomical structure are disclosed. According to some aspects, an implantable device configured to emit a detectable field may be attached to the anatomical structure. A proximity sensor may be attached to a distal end of a surgical instrument and may be configured to detect the detectable field. A control unit in communication with the proximity sensor may be configured to use the proximity sensor to determine if the distal end of the surgical instrument is within a predetermined distance of the implantable device. If so, a notification such as a vibration or alarm may be provided to a user of the surgical instrument so that the user can maneuver the surgical instrument to limit or prevent contact with the anatomical structure.

公开(公告)号：US20170202617A1

公开(公告)日：2017-07-20

申请号：US15478113

申请日：2017-04-03

申请人： Denise Zarins ,  Andrew Wu ,  Hanson Gifford, III ,  Mark Deem ,  Mark Gelfand ,  Howard R. Levin

发明人： Denise Zarins ,  Andrew Wu ,  Hanson Gifford, III ,  Mark Deem ,  Mark Gelfand ,  Howard R. Levin

IPC分类号： A61B18/14 ,  A61M5/172 ,  A61N1/40 ,  A61N7/02 ,  A61F7/12 ,  A61N1/36

CPC分类号： A61B18/1492 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00505 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61F7/123 ,  A61F2007/126 ,  A61M5/14276 ,  A61M5/1723 ,  A61M2210/1082 ,  A61N1/28 ,  A61N1/32 ,  A61N1/326 ,  A61N1/36007 ,  A61N1/36017 ,  A61N1/36114 ,  A61N1/36117 ,  A61N1/3627 ,  A61N1/403 ,  A61N5/045 ,  A61N7/02 ,  A61N2007/003

摘要： Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues. In some embodiments, thermally-induced renal neuromodulation is achieved via delivery of a pulsed thermal therapy.

公开(公告)号：US20160220314A1

公开(公告)日：2016-08-04

申请号：US14917896

申请日：2015-03-12

申请人： Justin HUELMAN ,  Andrew WU ,  Michael JUNG ,  Marc CHILD ,  Vidit SHARMA ,  Addason MCCASLIN ,  PROXIMED, LLC

发明人： Justin Huelman ,  Andrew Wu ,  Michael Jung ,  Marc Child ,  Vidit Sharma ,  Addason Mccaslin

IPC分类号： A61B34/20

CPC分类号： A61B34/20 ,  A61B2017/00022 ,  A61B2017/00119 ,  A61B2017/00876 ,  A61B2017/4216 ,  A61B2034/2051 ,  A61B2034/2072 ,  A61B2090/3954 ,  A61B2562/0223 ,  A61B2562/0257

摘要： Surgical systems and methods for avoiding injury to an anatomical structure are disclosed. According to some aspects, an implantable device configured to emit a detectable field may be attached to the anatomical structure. A proximity sensor may be attached to a distal end of a surgical instrument and may be configured to detect the detectable field. A control unit in communication with the proximity sensor may be configured to use the proximity sensor to determine if the distal end of the surgical instrument is within a predetermined distance of the implantable device. If so, a notification such as a vibration or alarm may be provided to a user of the surgical instrument so that the user can maneuver the surgical instrument to limit or prevent contact with the anatomical structure.

摘要翻译： 公开了用于避免对解剖结构的损伤的手术系统和方法。 根据一些方面，构造成发射可检测区域的可植入装置可以附接到解剖结构。 接近传感器可以附接到手术器械的远端，并且可以被配置为检测可检测的场。 与接近传感器通信的控制单元可以被配置为使用接近传感器来确定外科器械的远端是否在可植入装置的预定距离内。 如果是这样，可以向外科器械的使用者提供诸如振动或警报的通知，使得用户能够操纵外科器械来限制或阻止与解剖结构的接触。

公开(公告)号：US09345900B2

公开(公告)日：2016-05-24

申请号：US12147191

申请日：2008-06-26

申请人： Andrew Wu ,  Benjamin J. Clark ,  Erik Thai ,  Nicolas Zadno ,  Denise Zarins

发明人： Andrew Wu ,  Benjamin J. Clark ,  Erik Thai ,  Nicolas Zadno ,  Denise Zarins

IPC分类号： A61F7/00 ,  A61F7/12 ,  A61F2/00 ,  A61N1/40 ,  A61B18/14 ,  A61N1/05 ,  A61N1/36 ,  A61N1/06 ,  A61B18/00 ,  A61B18/12 ,  A61B18/18 ,  A61B19/00 ,  A61B17/00 ,  A61B17/22 ,  A61F7/10 ,  A61N5/06 ,  A61N7/02 ,  A61N7/00

CPC分类号： A61B18/1233 ,  A61B18/12 ,  A61B18/1206 ,  A61B18/14 ,  A61B18/1492 ,  A61B18/1815 ,  A61B90/39 ,  A61B2017/00084 ,  A61B2017/22054 ,  A61B2017/22068 ,  A61B2018/00023 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00261 ,  A61B2018/00279 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00505 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/00636 ,  A61B2018/00666 ,  A61B2018/00702 ,  A61B2018/00714 ,  A61B2018/00755 ,  A61B2018/00779 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/00994 ,  A61B2018/143 ,  A61B2018/1432 ,  A61B2018/144 ,  A61B2018/1475 ,  A61F7/007 ,  A61F7/10 ,  A61F7/12 ,  A61F2007/0056 ,  A61F2007/0075 ,  A61F2007/126 ,  A61N1/0558 ,  A61N1/057 ,  A61N1/06 ,  A61N1/36007 ,  A61N1/36017 ,  A61N1/403 ,  A61N5/0601 ,  A61N5/0622 ,  A61N7/02 ,  A61N7/022 ,  A61N2005/0612 ,  A61N2007/0026 ,  A61N2007/003

摘要： Methods and system are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues. In some embodiments, thermally-induced renal neuromodulation is achieved via delivery of a pulsed thermal therapy.

摘要翻译： 提供热诱导肾神经调节的方法和系统。 热诱导的肾神经调节可以通过直接和/或通过间接施加热能来加热或冷却有助于肾功能的神经纤维或者供给或灌注神经纤维的血管结构来实现。 在一些实施例中，神经纤维，非目标组织或热能递送元件的参数可以经由一个或多个传感器来监测，以控制热诱导的神经调节。 在一些实施方案中，可以提供保护元件以减少在非靶组织中诱导的热损伤程度。 在一些实施方案中，热诱导的肾神经调节通过脉冲热疗法的递送来实现。

公开(公告)号：US08956352B2

公开(公告)日：2015-02-17

申请号：US13281395

申请日：2011-10-25

申请人： Kevin Mauch ,  Mario Alvarado ,  Robert Beetel ,  William Chang ,  Justin Goshgarian ,  Leonila Rivera ,  Sukyoung Shin ,  Michele Silver ,  Sina Som ,  Andrew Wu ,  Denise Zarins ,  Juanita Sanchez-Cole ,  Maria G. Aboytes

发明人： Kevin Mauch ,  Mario Alvarado ,  Robert Beetel ,  William Chang ,  Justin Goshgarian ,  Leonila Rivera ,  Sukyoung Shin ,  Michele Silver ,  Sina Som ,  Andrew Wu ,  Denise Zarins ,  Juanita Sanchez-Cole ,  Maria G. Aboytes

IPC分类号： A61B18/14 ,  A61B18/04 ,  A61B18/18 ,  A61B18/00 ,  A61M25/00 ,  A61M25/01

CPC分类号： A61B18/1492 ,  A61B2018/00023 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00505 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/1435 ,  A61B2018/1467 ,  A61M25/0041 ,  A61M25/0074 ,  A61M25/0133 ,  A61M25/0138 ,  A61M25/0147

摘要： Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present technology, for example, is directed to a treatment device having a multi-electrode array configured to be delivered to a renal blood vessel. The array is selectively transformable between a delivery or low-profile state (e.g., a generally straight shape) and a deployed state (e.g., a radially expanded, generally helical shape). The multi-electrode array is sized and shaped so that the electrodes or energy delivery elements contact an interior wall of the renal blood vessel when the array is in the deployed (e.g., helical) state. The electrodes or energy delivery elements are configured for direct and/or indirect application of thermal and/or electrical energy to heat or otherwise electrically modulate neural fibers that contribute to renal function or of vascular structures that feed or perfuse the neural fibers.

摘要翻译： 本文公开了通过血管内通路实现肾脏神经调节的导管装置，系统和方法。 例如，本技术的一个方面涉及具有被配置为输送到肾血管的多电极阵列的治疗装置。 阵列可以在传送或低轮廓状态（例如，大致直线形状）和展开状态（例如，径向膨胀，大致螺旋形状）之间选择性地变换。 多电极阵列的尺寸和形状使得当阵列处于部署（例如螺旋状态）时，电极或能量递送元件接触肾血管的内壁。 电极或能量输送元件构造成用于直接和/或间接施加热和/或电能以加热或以其他方式电调节有助于肾功能的神经纤维或者供给或灌注神经纤维的血管结构。

公开(公告)号：US20130296767A1

公开(公告)日：2013-11-07

申请号：US13868426

申请日：2013-04-23

申请人： Denise Zarins ,  Hanson Gifford, III ,  Mark Deem ,  Nicolas Zadno ,  Benjamin J. Clark ,  Andrew Wu ,  Kenneth J. Michlisch

发明人： Denise Zarins ,  Hanson Gifford, III ,  Mark Deem ,  Nicolas Zadno ,  Benjamin J. Clark ,  Andrew Wu ,  Kenneth J. Michlisch

IPC分类号： A61B18/14 ,  A61B18/12

CPC分类号： A61B18/1492 ,  A61B18/1206 ,  A61B18/18 ,  A61B2018/00023 ,  A61B2018/00077 ,  A61B2018/0016 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00648 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/124 ,  A61B2018/1435 ,  A61B2018/1465 ,  A61N1/0551 ,  A61N1/32 ,  A61N1/327 ,  A61N1/36007 ,  A61N7/022

摘要： Methods and apparatus are provided for non-continuous circumferential treatment of a body lumen. Apparatus may be positioned within a body lumen of a patient and may deliver energy at a first lengthwise and angular position to create a less-than-full circumferential treatment zone at the first position. The apparatus also may deliver energy at one or more additional lengthwise and angular positions within the body lumen to create less-than-full circumferential treatment zone(s) at the one or more additional positions that are offset lengthwise and angularly from the first treatment zone. Superimposition of the first treatment zone and the one or more additional treatment zones defines a non-continuous circumferential treatment zone without formation of a continuous circumferential lesion. Various embodiments of methods and apparatus for achieving such non-continuous circumferential treatment are provided.

摘要翻译： 提供了用于不间断地周围处理体腔的方法和装置。 装置可以定位在患者的体腔内，并且可以在第一纵向和角位置处递送能量，以在第一位置处产生小于整个圆周的处理区域。 该装置还可以在体腔内的一个或多个附加的纵向和角度位置处递送能量，以在一个或多个附加位置处创建小于整个圆周处理区域，该一个或多个附加位置从第一处理区域纵向和角度偏移 。 第一处理区和一个或多个另外的处理区的叠置限定非连续的圆周处理区，而不形成连续的周向损伤。 提供了用于实现这种非连续圆周处理的方法和装置的各种实施例。

公开(公告)号：US20100220421A1

公开(公告)日：2010-09-02

申请号：US12776668

申请日：2010-05-10

申请人： Andrew Wu

发明人： Andrew Wu

IPC分类号： H02H9/02

CPC分类号： H02M3/1588 ,  H02M1/32 ,  H02M2001/0009 ,  Y02B70/1466

摘要： A regulator with a high side pass device and a low side pass device coupled in series to the high side pass device is disclosed. The apparatus further includes a control module coupled to the high side pass device and the low side pass device. The control module is coupled to the high side pass device and the low side pass device to control the high side pass device and the low side pass device. The control module is operable to lock out the high side pass device under certain conditions.