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公开(公告)号：US10005739B2
公开(公告)日：2018-06-26
申请号：US15030804
申请日：2014-10-23
发明人： Takeshi Murata , Sousuke Hara , Satoshi Niizuma , Kihito Hada , Hatsuo Kawada , Masahiro Sakaitani , Hideaki Shimada , Yoshito Nakanishi
IPC分类号： C07D217/24 , C07D239/90 , C07D239/91 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D409/12 , C07D413/06 , C07D471/04 , C07D487/04 , C07D239/92 , C07D239/94 , C07D491/056
CPC分类号： C07D239/92 , C07D217/24 , C07D239/90 , C07D239/91 , C07D239/94 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D409/12 , C07D413/06 , C07D471/04 , C07D487/04 , C07D491/056
摘要： The present invention relates to quinazolinone and isoquinolinone derivatives represented by formula (I) or pharmaceutically acceptable salts thereof.
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公开(公告)号：US09567304B2
公开(公告)日：2017-02-14
申请号：US14396498
申请日：2013-04-24
发明人： Takeshi Murata , Hatsuo Kawada , Satoshi Niizuma , Sousuke Hara , Kihito Hada , Hideaki Shimada , Hiroshi Tanaka , Toshiyuki Mio
IPC分类号： C07D239/96 , C07D401/06 , C07D403/06 , C07D405/04 , C07D405/12 , C07D487/04 , C07D401/14
CPC分类号： C07D239/96 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/04 , C07D405/12 , C07D487/04
摘要： The present invention relates to quinazolinedione derivatives represented by formula (I) or pharmaceutically acceptable salts thereof.
摘要翻译： 本发明涉及由式（I）表示的喹唑啉酮衍生物或其药学上可接受的盐。
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公开(公告)号：US20150141400A1
公开(公告)日：2015-05-21
申请号：US14396498
申请日：2013-04-24
发明人： Takeshi Murata , Hatsuo Kawada , Satoshi Niizuma , Sousuke Hara , Kihito Hada , Hideaki Shimada , Hiroshi Tanaka , Toshiyuki Mio
IPC分类号： C07D239/96 , C07D403/06 , C07D401/14 , C07D401/06 , C07D487/04 , C07D405/04 , C07D405/12
CPC分类号： C07D239/96 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/04 , C07D405/12 , C07D487/04
摘要： The present invention relates to quinazolinedione derivatives represented by formula (I) or pharmaceutically acceptable salts thereof.
摘要翻译： 本发明涉及由式（I）表示的喹唑啉酮衍生物或其药学上可接受的盐。
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公开(公告)号：US20150152047A1
公开(公告)日：2015-06-04
申请号：US14396678
申请日：2013-04-24
发明人： Takeshi Murata , Satoshi Niizuma , Sousuke Hara , Hatsuo Kawada , Kihito Hada , Hideaki Shimada , Hiroshi Tanaka , Yoshito Nakanishi
IPC分类号： C07C321/28 , C07D487/08 , C07D309/14 , C07C317/14 , C07D213/82
CPC分类号： C07C321/28 , C07C317/14 , C07C317/34 , C07C317/40 , C07C323/42 , C07C323/48 , C07C2601/02 , C07D205/04 , C07D207/09 , C07D207/12 , C07D207/14 , C07D211/26 , C07D211/56 , C07D211/68 , C07D213/62 , C07D213/82 , C07D241/04 , C07D263/34 , C07D295/14 , C07D295/16 , C07D309/14 , C07D401/12 , C07D403/04 , C07D487/08
摘要： The present invention relates to benzamide derivatives represented by formula (I) or pharmaceutically acceptable salts thereof.
摘要翻译： 本发明涉及由式（I）表示的苯甲酰胺衍生物或其药学上可接受的盐。
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公开(公告)号：US11312767B2
公开(公告)日：2022-04-26
申请号：US17466509
申请日：2021-09-03
摘要： The objective of the invention is to provide cross-species anti-latent TGF-beta 1 antibodies which inhibit a protease mediated activation of latent TGF-beta 1 without inhibiting integrin mediated activation of latent TGF-beta 1. To obtain the anti-latent TGF-beta 1 antibodies of the invention, anti-latent-latent TGF-beta 1 antibodies which inhibit a protease mediated activation of latent TGF-beta 1 without inhibiting integrin mediated activation of latent TGF-beta 1 were screened, and then humanized, and further optimized. The invention also provides combination therapies comprising an anti-latent TGF-beta 1 antibody and one or more immune checkpoint inhibitors, preferably a PD-1 axis binding antagonists.
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公开(公告)号：US09695118B2
公开(公告)日：2017-07-04
申请号：US14396678
申请日：2013-04-24
发明人： Takeshi Murata , Satoshi Niizuma , Sousuke Hara , Hatsuo Kawada , Kihito Hada , Hideaki Shimada , Hiroshi Tanaka , Yoshito Nakanishi
IPC分类号： C07D213/82 , C07D487/08 , C07C321/28 , C07D309/14 , C07C317/14 , C07D401/12 , C07D403/04 , C07C317/34 , C07D241/04 , C07C323/42 , C07D263/34 , C07D205/04 , C07D207/09 , C07D207/12 , C07D207/14 , C07D211/26 , C07D211/56 , C07D295/14 , C07D211/68 , C07D295/16 , C07D213/62 , C07C317/40 , C07C323/48
CPC分类号： C07C321/28 , C07C317/14 , C07C317/34 , C07C317/40 , C07C323/42 , C07C323/48 , C07C2601/02 , C07D205/04 , C07D207/09 , C07D207/12 , C07D207/14 , C07D211/26 , C07D211/56 , C07D211/68 , C07D213/62 , C07D213/82 , C07D241/04 , C07D263/34 , C07D295/14 , C07D295/16 , C07D309/14 , C07D401/12 , C07D403/04 , C07D487/08
摘要： The present invention relates to benzamide derivatives represented by formula (I) or pharmaceutically acceptable salts thereof.
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