公开(公告)号：US08731686B2

公开(公告)日：2014-05-20

申请号：US12630761

申请日：2009-12-03

申请人： Courtney Lane ,  Jesse Geroy ,  James C. Makous ,  Todd Whitehurst ,  Matthew Flowers ,  John Michael Barker ,  Terry Ferrell ,  John Swoyer ,  Brett Schleicher ,  Jeff Gagnon ,  Andrew DiGiore ,  Ellis Garai ,  Kristen Jaax ,  Rafael Carbunaru

发明人： Courtney Lane ,  Jesse Geroy ,  James C. Makous ,  Todd Whitehurst ,  Matthew Flowers ,  John Michael Barker ,  Terry Ferrell ,  John Swoyer ,  Brett Schleicher ,  Jeff Gagnon ,  Andrew DiGiore ,  Ellis Garai ,  Kristen Jaax ,  Rafael Carbunaru

IPC分类号： A61N1/00

CPC分类号： A61B17/0057 ,  A61B90/10 ,  A61B2090/103 ,  A61N1/0534 ,  A61N1/0539

摘要： A burr hole plug comprises a plug base configured for being mounted around a burr hole. The plug base includes an aperture through which an elongated medical device exiting the burr hole may pass. The burr hole plug further comprises a retainer configured for being mounted within the aperture of the plug base. The retainer further includes first and second slidable clamping mechanisms configured for securing the medical devices therebetween within the aperture of the plug base. A method comprises introducing the medical device through the burr hole, mounting a plug base around the burr hole, such that the medical device extends through the plug base aperture, mounting the retainer within the aperture of the plug base, and sliding the first and second clamping mechanisms secure the medical device therebetween.

摘要翻译： 毛刺孔塞包括构造成围绕钻孔安装的塞子基座。 插头基座包括一个孔，通过该孔可以使离开钻孔的细长医疗装置通过。 毛刺孔塞还包括保持器，其构造成用于安装在插头基座的孔内。 保持器还包括第一和第二可滑动夹紧机构，其被构造用于将医疗装置固定在插头基座的孔内。 一种方法包括：通过毛刺孔引导医疗装置，将插头基座安装在毛刺孔周围，使得医疗装置延伸穿过插头基座孔口，将保持器安装在插头基座的孔内，并将第一和第二 夹紧机构将医疗装置固定在其间。

公开(公告)号：US20100145357A1

公开(公告)日：2010-06-10

申请号：US12630761

申请日：2009-12-03

申请人： Courtney Lane ,  Jesse Geroy ,  James C. Makous ,  Todd Whitehurst ,  Matthew Flowers ,  John Michael Barker ,  Terry Ferrell ,  John Swoyer ,  Brett Schleicher ,  Jeff Gagnon ,  Andrew Digiore ,  Ellis Garai ,  Kristen Jaax ,  Rafael Carbunaru

发明人： Courtney Lane ,  Jesse Geroy ,  James C. Makous ,  Todd Whitehurst ,  Matthew Flowers ,  John Michael Barker ,  Terry Ferrell ,  John Swoyer ,  Brett Schleicher ,  Jeff Gagnon ,  Andrew Digiore ,  Ellis Garai ,  Kristen Jaax ,  Rafael Carbunaru

IPC分类号： A61N1/05 ,  A61B17/00

CPC分类号： A61B17/0057 ,  A61B90/10 ,  A61B2090/103 ,  A61N1/0534 ,  A61N1/0539

摘要： A burr hole plug comprises a plug base configured for being mounted around a burr hole. The plug base includes an aperture through which an elongated medical device exiting the burr hole may pass. The burr hole plug further comprises a retainer configured for being mounted within the aperture of the plug base. The retainer further includes first and second slidable clamping mechanisms configured for securing the medical devices therebetween within the aperture of the plug base. A method comprises introducing the medical device through the burr hole, mounting a plug base around the burr hole, such that the medical device extends through the plug base aperture, mounting the retainer within the aperture of the plug base, and sliding the first and second clamping mechanisms secure the medical device therebetween.

摘要翻译： 毛刺孔塞包括构造成围绕钻孔安装的塞子基座。 插头基座包括一个孔，通过该孔可以使离开钻孔的细长医疗装置通过。 毛刺孔塞还包括保持器，其构造成用于安装在插头基座的孔内。 保持器还包括第一和第二可滑动夹紧机构，其被构造用于将医疗装置固定在插头基座的孔内。 一种方法包括：通过毛刺孔引导医疗装置，将插头基座安装在毛刺孔周围，使得医疗装置延伸穿过插头基座孔口，将保持器安装在插头基座的孔内，并将第一和第二 夹紧机构将医疗装置固定在其间。

公开(公告)号：US20090112327A1

公开(公告)日：2009-04-30

申请号：US12258382

申请日：2008-10-24

申请人： Courtney Lane ,  Jesse Geroy ,  James C. Makous ,  Todd Whitehurst ,  Matthew Flowers ,  John Michael Barker ,  Terry Ferrell ,  John Swoyer ,  Brett Schleicher ,  Jeff Gagnon ,  Andrew Digiore ,  Ellis Garai ,  Kristen Jaax ,  Rafael Carbunaru

发明人： Courtney Lane ,  Jesse Geroy ,  James C. Makous ,  Todd Whitehurst ,  Matthew Flowers ,  John Michael Barker ,  Terry Ferrell ,  John Swoyer ,  Brett Schleicher ,  Jeff Gagnon ,  Andrew Digiore ,  Ellis Garai ,  Kristen Jaax ,  Rafael Carbunaru

IPC分类号： A61F2/02 ,  A61F2/28

CPC分类号： A61B17/0057 ,  A61B90/10 ,  A61B2090/103 ,  A61N1/0534 ,  A61N1/0539

摘要： A burr hole plug comprises a plug base including a flange configured for being mounted around a burr hole, an aperture through which an elongated medical device may pass, and tabs configured for extending within the cranial burr hole to center the plug base relative to the cranial burr hole. The burr hole plug further comprises a retainer configured for being mounted within the aperture of the plug base to secure the medical device. A method may comprise locating the plug base within a burr hole, such that the tabs are disposed within the burr hole to center the plug base relative to the cranial burr hole, introducing the elongated medical device through the cranial burr hole and into the brain tissue of the patient, mounting the retainer within the aperture of the plug base, and actuating the retainer to secure the medical device.

摘要翻译： 一个钻孔塞包括一个插头基座，它包括一个凸缘，该凸缘被配置成安装在一个钻孔周围，一个细长的医疗设备可以通过的孔，以及在头部钻孔内延伸的突出部分，以使插头基座相对于头部 钻孔。 毛刺孔塞还包括保持器，其构造成安装在插头基座的孔内以固定医疗装置。 一种方法可以包括将插头基座定位在钻孔内，使得突出部设置在毛刺孔内，以使塞子基座相对于头颅毛孔中心，将细长的医疗装置通过头颅毛孔引入脑组织 将保持器安装在插头基座的孔内，并致动保持器以固定医疗装置。

公开(公告)号：US20100076535A1

公开(公告)日：2010-03-25

申请号：US12237888

申请日：2008-09-25

申请人： Anne M. Pianca ,  Courtney Lane ,  James C. Makous ,  Andrew DiGiore ,  Ellis Garai

发明人： Anne M. Pianca ,  Courtney Lane ,  James C. Makous ,  Andrew DiGiore ,  Ellis Garai

IPC分类号： A61N1/05

CPC分类号： A61N1/0534 ,  A61N1/0472 ,  A61N1/0529 ,  A61N1/36082

摘要： A lead is configured and arranged for brain stimulation. The lead includes a proximal end and a distal end. The proximal end includes a plurality of terminals disposed at the proximal end. The distal end has a non-circular transverse cross-sectional shape and includes a plurality of electrodes disposed at the distal end. A plurality of conductive wires electrically couple at least one of the plurality of electrodes to at least one of the plurality of terminals.

摘要翻译： 铅的配置和排列用于脑刺激。 引线包括近端和远端。 近端包括设置在近端的多个端子。 前端具有非圆形横截面形状，并且包括设置在远端的多个电极。 多个导线将多个电极中的至少一个电连接到多个端子中的至少一个。

公开(公告)号：US09855421B2

公开(公告)日：2018-01-02

申请号：US13219874

申请日：2011-08-29

申请人： Ellis Garai ,  Aravind Swaminathan

发明人： Ellis Garai ,  Aravind Swaminathan

IPC分类号： A61B19/00 ,  A61N1/05

CPC分类号： A61N1/057 ,  A61N1/0558 ,  A61N1/0573

摘要： A device for positioning an electrode in tissue includes: a lead body having a distal portion; an electrode array coupled to the lead distal portion; an anchoring element having an anchor tip and being operable in a first configuration in which the anchor tip is retracted within the lead and in a second configuration in which the anchor tip is extended outside the lead and configured to fixate within the tissue; and a displacement mechanism that is actuated to bias the electrode array or the anchoring element toward the tissue. A method for positioning an electrode in tissue includes: navigating, to the tissue, a lead with an electrode array, an anchoring element with a distal anchor tip, and a displacement mechanism; biasing the electrode array and anchoring element towards the tissue with the displacement mechanism; and deploying the anchoring element, and verifying fixation of the anchor tip within the tissue.

公开(公告)号：US20140316255A1

公开(公告)日：2014-10-23

申请号：US14241790

申请日：2012-08-23

申请人： Ellis Garai ,  Cristina Zavaleta ,  Michael Mandella ,  Jonathan Liu ,  Sanjiv Sam Gambhir ,  Christopher H. Contag

发明人： Ellis Garai ,  Cristina Zavaleta ,  Michael Mandella ,  Jonathan Liu ,  Sanjiv Sam Gambhir ,  Christopher H. Contag

IPC分类号： A61B5/00 ,  A61B1/07 ,  A61B10/02 ,  A61K49/00 ,  A61B19/00

CPC分类号： A61B5/0075 ,  A61B1/07 ,  A61B5/0079 ,  A61B5/0084 ,  A61B10/02 ,  A61B34/20 ,  A61B2034/2057 ,  A61K49/0095 ,  B82Y15/00 ,  G01J1/0433 ,  G01J3/0213 ,  G01J3/0218 ,  G01J3/18 ,  G01J3/2803 ,  G01J3/44 ,  G01N21/658

摘要： In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, embodiments of the present disclosure, in one aspect, relate to Raman imaging devices (e.g., Raman endoscope probes) or systems, methods of using Raman agents, Raman imaging devices, and/or systems to image or detect a signal, and the like.

摘要翻译： 根据本公开的目的，如本文所体现和广泛描述的，本公开的实施例在一个方面涉及拉曼成像装置（例如，拉曼内窥镜探针）或系统，使用拉曼剂的方法 ，拉曼成像装置和/或用于对信号进行成像或检测的系统等。

公开(公告)号：US20120323253A1

公开(公告)日：2012-12-20

申请号：US13219874

申请日：2011-08-29

申请人： Ellis Garai ,  Aravind Swaminathan

发明人： Ellis Garai ,  Aravind Swaminathan

IPC分类号： A61N1/05

CPC分类号： A61N1/057 ,  A61N1/0558 ,  A61N1/0573

摘要： A device for positioning an electrode in tissue includes: a lead body having a distal portion; an electrode array coupled to the lead distal portion; an anchoring element having an anchor tip and being operable in a first configuration in which the anchor tip is retracted within the lead and in a second configuration in which the anchor tip is extended outside the lead and configured to fixate within the tissue; and a displacement mechanism that is actuated to bias the electrode array or the anchoring element toward the tissue. A method for positioning an electrode in tissue includes: navigating, to the tissue, a lead with an electrode array, an anchoring element with a distal anchor tip, and a displacement mechanism; biasing the electrode array and anchoring element towards the tissue with the displacement mechanism; and deploying the anchoring element, and verifying fixation of the anchor tip within the tissue.

摘要翻译： 用于将电极定位在组织中的装置包括：具有远端部分的引线主体; 耦合到所述引线远端部分的电极阵列; 锚固元件具有锚定尖端并且可以在第一构造中操作，其中锚定尖端在引线内缩回，并且在第二构造中，锚固尖端延伸到引线外部并且被配置为固定在组织内; 以及被致动以将电极阵列或锚定元件偏向组织的位移机构。 用于将电极定位在组织中的方法包括：向组织导航具有电极阵列的引线，具有远侧锚固尖端的锚固元件和位移机构; 用移位机构将电极阵列和锚固元件偏压到组织; 并且展开该锚定元件，以及验证锚固头在组织内的固定。