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公开(公告)号：US20060122623A1
公开(公告)日：2006-06-08
申请号：US11165652
申请日：2005-06-24
申请人： Csaba Truckai , John Shadduck , Robert Luzzi , Grace Carlson , C. Rappleye
发明人： Csaba Truckai , John Shadduck , Robert Luzzi , Grace Carlson , C. Rappleye
IPC分类号： A61F2/34
CPC分类号： A61B17/8836 , A61B17/864 , A61B2017/00022 , A61B2017/00026 , A61B2017/00084 , A61F2/44
摘要： The present invention relates in certain embodiments to medical devices for treating osteoplasty procedures such as vertebral compression fractures. More particularly, embodiments of the invention relate to instruments and methods for controllably restoring vertebral body height by controlling the geometry of fill material introduced into cancellous bone. An exemplary system utilizes Rf energy in combination a conductive bone fill material for polymerizing the surface of the inflow plume to control the geometry of the fill material and the application of force caused by inflows of fill material. In another embodiment, method of treating bone includes injecting a volume of fill material into a bone and selectively modifying a viscosity of a selected portion of the bone filler to control the direction of flow of the fill material within the bone. A system for treating bone using this method includes an introducer for delivering fill material into the bone and an energy source selectively coupleable to the fill material to alter the viscosity of the fill material as it flows out of the introducer.
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公开(公告)号：US20060122624A1
公开(公告)日：2006-06-08
申请号：US11196045
申请日：2005-08-02
申请人： Csaba Truckai , John Shadduck , Robert Luzzi , Grace Carlson
发明人： Csaba Truckai , John Shadduck , Robert Luzzi , Grace Carlson
IPC分类号： A61F2/34
CPC分类号： A61B17/7095 , A61B17/7098 , A61B17/864 , A61B17/8811 , A61B17/8836 , A61B2017/00022 , A61B2017/00026 , A61B2017/00084 , A61F2/44
摘要： The present invention relates in certain embodiments to medical devices for treating osteoplasty procedures such as vertebral compression fractures. More particularly, embodiments of the invention relate to instruments and methods for controllably restoring vertebral body height by controlling the geometry of fill material introduced into cancellous bone. An exemplary system utilizes Rf energy in combination a conductive bone fill material for polymerizing the surface of the inflow plume to control the geometry of the fill material and the application of force caused by inflows of fill material. In another embodiment, method of treating bone includes injecting a volume of fill material into a bone and selectively modifying a viscosity of a selected portion of the bone filler to control the direction of flow of the fill material within the bone. A system for treating bone using this method includes an introducer for delivering fill material into the bone and an energy source selectively coupleable to the fill material to alter the viscosity of the fill material as it flows out of the introducer.
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公开(公告)号：US20060122622A1
公开(公告)日：2006-06-08
申请号：US11165651
申请日：2005-06-24
申请人： Csaba Truckai , John Shadduck , Robert Luzzi , Grace Carlson , C. Rappleye
发明人： Csaba Truckai , John Shadduck , Robert Luzzi , Grace Carlson , C. Rappleye
IPC分类号： A61F2/34
CPC分类号： A61B17/8836 , A61B17/7095 , A61B17/7098 , A61B17/864 , A61B17/8811 , A61B2017/00022 , A61B2017/00026 , A61B2017/00084 , A61F2/44
摘要： The present invention relates in certain embodiments to medical devices for treating osteoplasty procedures such as vertebral compression fractures. More particularly, embodiments of the invention relate to instruments and methods for controllably restoring vertebral body height by controlling the geometry of fill material introduced into cancellous bone. An exemplary system utilizes Rf energy in combination a conductive bone fill material for polymerizing the surface of the inflow plume to control the geometry of the fill material and the application of force caused by inflows of fill material. In another embodiment, method of treating bone includes injecting a volume of fill material into a bone and selectively modifying a viscosity of a selected portion of the bone filler to control the direction of flow of the fill material within the bone. A system for treating bone using this method includes an introducer for delivering fill material into the bone and an energy source selectively coupleable to the fill material to alter the viscosity of the fill material as it flows out of the introducer.
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公开(公告)号：US20060122614A1
公开(公告)日：2006-06-08
申请号：US11196089
申请日：2005-08-02
申请人： Csaba Truckai , John Shadduck , Robert Luzzi , Grace Carlson
发明人： Csaba Truckai , John Shadduck , Robert Luzzi , Grace Carlson
IPC分类号： A61B17/58
CPC分类号： A61B17/7095 , A61B17/7098 , A61B17/864 , A61B17/8811 , A61B17/8836 , A61B2017/00022 , A61B2017/00026 , A61B2017/00084 , A61F2/44
摘要： The present invention relates in certain embodiments to medical devices for treating osteoplasty procedures such as vertebral compression fractures. More particularly, embodiments of the invention relate to instruments and methods for controllably restoring vertebral body height by controlling the geometry of fill material introduced into cancellous bone. An exemplary system utilizes Rf energy in combination a conductive bone fill material for polymerizing the surface of the inflow plume to control the geometry of the fill material and the application of force caused by inflows of fill material. In another embodiment, method of treating bone includes injecting a volume of fill material into a bone and selectively modifying a viscosity of a selected portion of the bone filler to control the direction of flow of the fill material within the bone. A system for treating bone using this method includes an introducer for delivering fill material into the bone and an energy source selectively coupleable to the fill material to alter the viscosity of the fill material as it flows out of the introducer.
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5.发明申请SYSTEMS AND METHODS FOR ISOLATING AND USING CLINICALLY SAFE ADIPOSE DERIVED REGENERATIVE CELLS 有权用于分离和使用临床安全性ADIPOSE衍生的再生细胞的系统和方法公开(公告)号：US20100136668A1
公开(公告)日：2010-06-03
申请号：US12554755
申请日：2009-09-04
申请人： Marc H. Hedrick , John K. Fraser , Michael J. Schulzki , Bobby Byrnes , Grace Carlson , Ronda Elizabeth Schreiber , Isabella Wulur
发明人： Marc H. Hedrick , John K. Fraser , Michael J. Schulzki , Bobby Byrnes , Grace Carlson , Ronda Elizabeth Schreiber , Isabella Wulur
IPC分类号： C12M1/00
摘要： Systems and methods are described that are used to separate cells from a wide variety of tissues. In particular, automated systems and methods are described that separate regenerative cells, e.g., stem and/or progenitor cells, from adipose tissue. The systems and methods described herein provide rapid and reliable methods of separating and concentrating regenerative cells suitable for re-infusion into a subject.
摘要翻译： 描述了用于从多种组织分离细胞的系统和方法。 特别地，描述了从脂肪组织分离再生细胞例如干细胞和/或祖细胞的自动化系统和方法。 本文所述的系统和方法提供了快速且可靠的分离和浓缩适于再次输注到受试者中的再生细胞的方法。
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6.发明授权Systems and methods for separating and concentrating adipose derived stem cells from tissue 有权从组织中分离和浓缩脂肪来源的干细胞的系统和方法公开(公告)号：US07514075B2
公开(公告)日：2009-04-07
申请号：US10877822
申请日：2004-06-25
申请人： Marc H. Hedrick , John K. Fraser , Michael J. Schulzki , Bobby Byrnes , Grace Carlson , Robert K. Shanahan
发明人： Marc H. Hedrick , John K. Fraser , Michael J. Schulzki , Bobby Byrnes , Grace Carlson , Robert K. Shanahan
IPC分类号： A01N63/00
CPC分类号： A61K35/28
摘要： Systems and methods are described that are used to separate cells from a wide variety of tissues. In particular, automated systems and methods are described that separate regenerative cells, e.g., stem and/or progenitor cells, from adipose tissue. The systems and methods described herein provide rapid and reliable methods of separating and concentrating regenerative cells suitable for re-infusion into a subject.
摘要翻译： 描述了用于从多种组织分离细胞的系统和方法。 特别地，描述了从脂肪组织分离再生细胞例如干细胞和/或祖细胞的自动化系统和方法。 本文所述的系统和方法提供了快速且可靠的分离和浓缩适于再次输注到受试者中的再生细胞的方法。
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公开(公告)号：US06849044B1
公开(公告)日：2005-02-01
申请号：US10051720
申请日：2002-01-15
申请人： Larry Voss , Steven Peng , David Hancock , Grace Carlson
发明人： Larry Voss , Steven Peng , David Hancock , Grace Carlson
CPC分类号： A61B17/02 , A61B2017/0243 , A61B2017/2829 , Y10T403/32311
摘要： An organ-stabilizing element is covered with a layer of textile material such as cloth to enhance slip-free engagement with an organ such as a beating heart during surgery thereon. The organ-stabilizing element is supported on a stacked structure of successive ball elements and rings that can be selectively flexible or rigid in response to tensioning of a flexible cable within a central bore of the structure.
摘要翻译： 器官稳定元件被一层纺织材料如布覆盖，以在其手术过程中增强与诸如搏动心脏的器官的滑动接合。 器官稳定元件被支撑在连续的球形元件和环的堆叠结构上，响应于柔性电缆在结构的中心孔内的张紧而可以选择性地弹性或刚性。
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8.发明申请SYSTEMS AND METHODS FOR ISOLATING AND USING CLINICALLY SAFE ADIPOSE DERIVED REGENERATIVE CELLS 有权用于分离和使用临床安全性ADIPOSE衍生的再生细胞的系统和方法公开(公告)号：US20120264200A1
公开(公告)日：2012-10-18
申请号：US13452349
申请日：2012-04-20
申请人： Marc H. Hedrick , John K. Fraser , Michael J. Schulzki , Bobby Byrnes , Grace Carlson , Rhonda Elizabeth Schreiber , Isabella Wulur
发明人： Marc H. Hedrick , John K. Fraser , Michael J. Schulzki , Bobby Byrnes , Grace Carlson , Rhonda Elizabeth Schreiber , Isabella Wulur
IPC分类号： C12M1/12
摘要： Systems and methods are described that are used to separate cells from a wide variety of tissues. In particular, automated systems and methods are described that separate regenerative cells, e.g., stem and/or progenitor cells, from adipose tissue. The systems and methods described herein provide rapid and reliable methods of separating and concentrating regenerative cells suitable for re-infusion into a subject.
摘要翻译： 描述了用于从多种组织分离细胞的系统和方法。 特别地，描述了从脂肪组织分离再生细胞例如干细胞和/或祖细胞的自动化系统和方法。 本文所述的系统和方法提供了快速且可靠的分离和浓缩适于再次输注到受试者中的再生细胞的方法。
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9.发明授权Systems and methods for isolating and using clinically safe adipose derived regenerative cells 有权用于分离和使用临床安全的脂肪来源的再生细胞的系统和方法公开(公告)号：US08163276B2
公开(公告)日：2012-04-24
申请号：US12554755
申请日：2009-09-04
申请人： Marc H. Hedrick , John K. Fraser , Michael J. Schulzki , Bobby Byrnes , Grace Carlson , Ronda Schreiber , Isabella Wulur
发明人： Marc H. Hedrick , John K. Fraser , Michael J. Schulzki , Bobby Byrnes , Grace Carlson , Ronda Schreiber , Isabella Wulur
IPC分类号： C12N5/00
摘要： Systems and methods are described that are used to separate cells from a wide variety of tissues. In particular, automated systems and methods are described that separate regenerative cells, e.g., stem and/or progenitor cells, from adipose tissue. The systems and methods described herein provide rapid and reliable methods of separating and concentrating regenerative cells suitable for re-infusion into a subject.
摘要翻译： 描述了用于从多种组织分离细胞的系统和方法。 特别地，描述了从脂肪组织分离再生细胞例如干细胞和/或祖细胞的自动化系统和方法。 本文所述的系统和方法提供了快速且可靠的分离和浓缩适于再次输注到受试者中的再生细胞的方法。
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10.发明申请Systems and methods for isolating and using clinically safe adipose derived regenerative cells 有权用于分离和使用临床安全的脂肪来源的再生细胞的系统和方法公开(公告)号：US20050260175A1
公开(公告)日：2005-11-24
申请号：US10884638
申请日：2004-07-02
申请人： Marc Hedrick , John Fraser , Michael Schulzki , Bobby Byrnes , Grace Carlson , Ronda Schreiber , Isabella Wulur
发明人： Marc Hedrick , John Fraser , Michael Schulzki , Bobby Byrnes , Grace Carlson , Ronda Schreiber , Isabella Wulur
摘要： Systems and methods are described that are used to separate cells from a wide variety of tissues. In particular, automated systems and methods are described that separate regenerative cells, e.g., stem and/or progenitor cells, from adipose tissue. The systems and methods described herein provide rapid and reliable methods of separating and concentrating regenerative cells suitable for re-infusion into a subject.
摘要翻译： 描述了用于从多种组织分离细胞的系统和方法。 特别地，描述了从脂肪组织分离再生细胞例如干细胞和/或祖细胞的自动化系统和方法。 本文所述的系统和方法提供了快速且可靠的分离和浓缩适于再次输注到受试者中的再生细胞的方法。
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