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1.发明申请Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions 有权使用脂肪组织来源的细胞治疗心血管疾病的方法公开(公告)号：US20060083720A1
公开(公告)日：2006-04-20
申请号：US11138083
申请日：2005-05-25
申请人： John Fraser , Marc Hedrick , Min Zhu , Brian Strem , Eric Daniels , Isabella Wulur
发明人： John Fraser , Marc Hedrick , Min Zhu , Brian Strem , Eric Daniels , Isabella Wulur
CPC分类号： A61K45/06 , A61K35/28 , C12N5/0653 , A61K2300/00
摘要： Adipose derived regenerative cells are used to treat patients, including patients with cardiovascular conditions, diseases or disorders. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of regenerative cells, e.g., stem and/or progenitor cells, obtained from the adipose tissue to a patient. The methods may be practiced in a closed system so that the stem cells are not exposed to an external environment prior to being administered to a patient. Accordingly, in a preferred method, adipose derived regenerative cells are placed directly into a recipient along with such additives necessary to promote, engender or support a therapeutic cardiovascular benefit.
摘要翻译： 脂肪来源的再生细胞用于治疗患者，包括患有心血管疾病，疾病或病症的患者。 治疗患者的方法包括加工脂肪组织以将从脂肪组织获得的浓缩量的再生细胞例如干细胞和/或祖细胞递送给患者。 所述方法可以在封闭系统中实施，使得干细胞在施用于患者之前不暴露于外部环境。 因此，在优选的方法中，将脂肪来源的再生细胞与促进，产生或支持治疗性心血管益处所必需的这些添加剂一起直接放入受体中。
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公开(公告)号：US20050153442A1
公开(公告)日：2005-07-14
申请号：US10845315
申请日：2004-05-12
申请人： Adam Katz , Ramon Llull , J. Futrell , Marc Hedrick , Prosper Benhaim , Hermann Lorenz , Min Zhu , Patricia Zuk , Peter Ashjian
发明人： Adam Katz , Ramon Llull , J. Futrell , Marc Hedrick , Prosper Benhaim , Hermann Lorenz , Min Zhu , Patricia Zuk , Peter Ashjian
IPC分类号： A61K35/12 , A61K48/00 , A61L27/22 , A61L27/38 , C12N5/00 , C12N5/074 , C12N5/077 , C12N5/0775 , C12N5/0789 , C12N15/85 , C12N5/08
CPC分类号： A61L27/3612 , A61K35/12 , A61K48/00 , A61L27/225 , A61L27/3654 , A61L27/38 , C12N5/0068 , C12N5/0607 , C12N5/0647 , C12N5/0654 , C12N5/0655 , C12N5/0658 , C12N5/0667 , C12N2500/25 , C12N2500/38 , C12N2500/42 , C12N2501/01 , C12N2501/15 , C12N2501/33 , C12N2501/39 , C12N2502/1305 , C12N2510/00 , C12N2533/90
摘要： The present invention provides adipose-derived stem cells (ADSCs), adipose-derived stem cell-enriched fractions (ADSC-EF) and adipose-derived lattices, alone and combined with the ADSCs of the invention. In one aspect, the present invention provides an ADSC substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The ADSCs can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the ADSCs can be expanded and cultured to produce molecules such as hormones, and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect, the present invention provides a adipose-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures.
摘要翻译： 本发明单独提供脂肪来源的干细胞（ADSCs），脂肪来源的干细胞富含级分（ADSC-EF）和脂肪衍生的格子，并与本发明的ADSC组合。 一方面，本发明提供了基本上不含结缔组织干细胞的脂肪细胞和红细胞和克隆群体的ADSC。 ADSC可以单独使用或在生物相容性组合物内使用，以在体内和体外产生分化的组织和结构。 另外，可以扩增和培养ADSC以产生分子如激素，并提供条件培养基以支持其它细胞群的生长和扩增。 另一方面，本发明提供了一种基本上不含细胞的脂肪衍生的晶格，其包括来自脂肪组织的细胞外基质材料。 晶格可以用作底物，以促进细胞的生长和分化，无论是在体内还是在体外，成为成体组织或甚至成熟的组织或结构。
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公开(公告)号：US20050074436A1
公开(公告)日：2005-04-07
申请号：US10614643
申请日：2003-07-07
申请人： John Fraser , Marc Hedrick
发明人： John Fraser , Marc Hedrick
IPC分类号： A61M1/00 , A61K31/436 , A61K35/02 , A61K35/12 , A61K35/28 , A61K35/35 , A61K35/36 , A61K38/00 , A61K38/16 , A61K45/00 , A61L27/00 , A61P1/00 , A61P1/16 , A61P3/00 , A61P3/10 , A61P9/10 , A61P11/00 , A61P13/12 , A61P17/00 , A61P19/00 , A61P19/02 , A61P21/00 , A61P25/00 , A61P27/02 , A61P37/06 , C12M3/06 , C12N5/0775
CPC分类号： A61K35/28 , A61B10/0283 , A61K9/0019 , A61K35/35 , A61M1/0039 , A61M2202/08 , C12M47/04 , C12N5/0667 , C12N5/069 , C12N2506/1384 , G06F19/00
摘要： Cells present in processed lipoaspirate tissue are used to treat patients. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of stem cells obtained from the adipose tissue to a patient. The methods may be practiced in a closed system so that the stem cells are not exposed to an external environment prior to being administered to a patient. Compositions that are administered to a patient include a mixture of adipose tissue and stem cells so that the composition has a higher concentration of stem cells than when the adipose tissue was removed from the patient.
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4.发明申请Methods of using regenerative cells in the treatment of musculoskeletal disorders 有权使用再生细胞治疗肌肉骨骼疾病的方法公开(公告)号：US20050048644A1
公开(公告)日：2005-03-03
申请号：US10884637
申请日：2004-07-01
申请人： Marc Hedrick , John Fraser , Susan Riley , Ronda Schreiber
发明人： Marc Hedrick , John Fraser , Susan Riley , Ronda Schreiber
CPC分类号： A61K35/28 , A61L27/18 , A61L27/3608 , A61L27/365 , A61L27/3654 , A61L27/3691 , A61L27/3834 , A61L27/3847 , A61L27/3852 , A61L27/3895 , A61L27/52 , A61L27/54 , A61L27/56 , A61L2300/40 , A61L2300/412 , A61L2300/64 , A61L2400/06 , A61L2430/02 , A61L2430/06 , A61L2430/40 , C12N5/0667
摘要： Regenerative cells present in adipose tissue are used to treat patients, including patients with musculoskeletal diseases or disorders. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of regenerative cells obtained from the adipose tissue to a patient. The methods may be practiced in a closed system so that the stem cells are not exposed to an external environment prior to being administered to a patient. Accordingly, in a preferred method, regenerative cells present in adipose tissue are placed directly into a recipient along with such additives necessary to promote, engender or support a therapeutic musculoskeletal benefit.
摘要翻译： 存在于脂肪组织中的再生细胞用于治疗患者，包括肌肉骨骼疾病或病症的患者。 治疗患者的方法包括加工脂肪组织以将从脂肪组织获得的浓缩量的再生细胞输送给患者。 所述方法可以在封闭系统中实施，使得干细胞在施用于患者之前不暴露于外部环境。 因此，在优选的方法中，存在于脂肪组织中的再生细胞与用于促进，产生或支持治疗性肌肉骨骼益处所必需的这种添加剂一起直接放置在受体中。
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5.发明申请Methods of using regenerative cells in the treatment of inherited and acquired disorders of the bone, bone marrow, liver, and other tissues 审中-公开使用再生细胞治疗骨，骨髓，肝脏和其他组织的遗传和获得性疾病的方法公开(公告)号：US20050048036A1
公开(公告)日：2005-03-03
申请号：US10885294
申请日：2004-07-01
申请人： Marc Hedrick , John Fraser
发明人： Marc Hedrick , John Fraser
CPC分类号： A61K35/44 , A61K35/28 , A61L27/3834 , A61L27/54 , A61L2300/414 , A61L2300/416 , A61L2430/40 , C12N5/0667
摘要： Stem cells, e.g. HSC and MSC-like stem cells, present in adipose tissue are used to treat diseases and disorders that would benefit from a hematopoietic stem cell transplant. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of stem cells obtained from the adipose tissue to a patient. The methods may be practiced in a closed system so that the stem cells are not exposed to an external environment prior to being administered to a patient. Accordingly, in a preferred method, cells present in adipose tissue are placed directly into a recipient along with such additives necessary to promote, engender or support a therapeutic renal benefit.
摘要翻译： 干细胞，例如 存在于脂肪组织中的HSC和MSC样干细胞用于治疗将受益于造血干细胞移植的疾病和病症。 治疗患者的方法包括加工脂肪组织以将从脂肪组织获得的浓缩量的干细胞输送给患者。 所述方法可以在封闭系统中实施，使得干细胞在施用于患者之前不暴露于外部环境。 因此，在优选的方法中，存在于脂肪组织中的细胞与用于促进，产生或支持治疗性肾功能所必需的这种添加剂一起直接放置在受体中。
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6.发明申请Methods of using regenerative cells in the treatment of renal diseases and disorders 有权使用再生细胞治疗肾脏疾病和病症的方法公开(公告)号：US20050048033A1
公开(公告)日：2005-03-03
申请号：US10884639
申请日：2004-07-01
申请人： John Fraser , Marc Hedrick , Eric Daniels
发明人： John Fraser , Marc Hedrick , Eric Daniels
CPC分类号： A61K35/28 , A61K35/22 , A61K35/35 , A61K35/44 , A61L27/3834 , A61L27/3886 , A61L27/54 , A61L2300/414 , A61L2300/416 , A61L2430/26 , A61M1/3692 , A61M1/3693 , A61M1/3696 , A61M2202/0437 , A61M2202/08 , C12N5/0667
摘要： Cells present in processed lipoaspirate tissue are used to treat patients, including patients with renal conditions, diseases or disorders. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of stem cells obtained from the adipose tissue to a patient. The methods may be practiced in a closed system so that the stem cells are not exposed to an external environment prior to being administered to a patient. Accordingly, in a preferred method, cells present in processed lipoaspirate are placed directly into a recipient along with such additives necessary to promote, engender or support a therapeutic renal benefit.
摘要翻译： 存在于加工的脂肪抽吸组织中的细胞用于治疗患者，包括患有肾脏疾病或疾病的患者。 治疗患者的方法包括加工脂肪组织以将从脂肪组织获得的浓缩量的干细胞输送给患者。 所述方法可以在封闭系统中实施，使得干细胞在施用于患者之前不暴露于外部环境。 因此，在优选的方法中，存在于加工的lipoaspirate中的细胞与用于促进，产生或支持治疗性肾功能所必需的这些添加剂一起直接放置在受体中。
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7.发明申请Systems and methods for isolating and using clinically safe adipose derived regenerative cells 有权用于分离和使用临床安全的脂肪来源的再生细胞的系统和方法公开(公告)号：US20050260175A1
公开(公告)日：2005-11-24
申请号：US10884638
申请日：2004-07-02
申请人： Marc Hedrick , John Fraser , Michael Schulzki , Bobby Byrnes , Grace Carlson , Ronda Schreiber , Isabella Wulur
发明人： Marc Hedrick , John Fraser , Michael Schulzki , Bobby Byrnes , Grace Carlson , Ronda Schreiber , Isabella Wulur
摘要： Systems and methods are described that are used to separate cells from a wide variety of tissues. In particular, automated systems and methods are described that separate regenerative cells, e.g., stem and/or progenitor cells, from adipose tissue. The systems and methods described herein provide rapid and reliable methods of separating and concentrating regenerative cells suitable for re-infusion into a subject.
摘要翻译： 描述了用于从多种组织分离细胞的系统和方法。 特别地，描述了从脂肪组织分离再生细胞例如干细胞和/或祖细胞的自动化系统和方法。 本文所述的系统和方法提供了快速且可靠的分离和浓缩适于再次输注到受试者中的再生细胞的方法。
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公开(公告)号：US20050282275A1
公开(公告)日：2005-12-22
申请号：US11211114
申请日：2005-08-24
申请人： Adam Katz , Ramon Llull , J. Futrell , Marc Hedrick , Prosper Benhaim , Hermann Lorenz , Min Zhu
发明人： Adam Katz , Ramon Llull , J. Futrell , Marc Hedrick , Prosper Benhaim , Hermann Lorenz , Min Zhu
IPC分类号： C12N5/071 , A61K35/12 , A61K48/00 , C12N5/00 , C12N5/077 , C12N5/0775 , C12N5/0789 , C12N5/10 , C12N15/63 , C12N5/08
CPC分类号： C12N5/0658 , A61K35/12 , A61K48/00 , C12N5/0068 , C12N5/0647 , C12N5/0652 , C12N5/0653 , C12N5/0654 , C12N5/0655 , C12N5/0667 , C12N2500/25 , C12N2500/38 , C12N2500/42 , C12N2501/01 , C12N2501/33 , C12N2501/39 , C12N2502/1305 , C12N2506/1384 , C12N2510/00 , C12N2533/90
摘要： The present invention provides adipose-derived stem cells and lattices. In one aspect, the present invention provides a lipo-derived stem cell substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The invention also provides a method of isolating stem cells from adipose tissues. The cells can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the cells can be expanded and cultured to produce hormones and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect, the present invention provides a lipo-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures.
摘要翻译： 本发明提供脂肪来源的干细胞和晶格。 一方面，本发明提供了一种基本上不含脂肪细胞和结缔组织干细胞的红细胞和克隆群的脂衍生的干细胞。 本发明还提供了从脂肪组织分离干细胞的方法。 细胞可以单独使用或在生物相容性组合物内使用，以在体内和体外产生分化的组织和结构。 此外，细胞可以扩增和培养以产生激素，并提供条件培养基以支持其他细胞群体的生长和扩增。 另一方面，本发明提供了一种基本上不含细胞的脂衍生晶格，其包括来自脂肪组织的细胞外基质材料。 晶格可以用作底物，以促进细胞的生长和分化，无论是在体内还是在体外，成为成体组织或甚至成熟的组织或结构。
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9.发明申请Systems and methods for separating and concentrating regenerative cells from tissue 有权将再生细胞从组织中分离和集中的系统和方法公开(公告)号：US20050084961A1
公开(公告)日：2005-04-21
申请号：US10877822
申请日：2004-06-25
申请人： Marc Hedrick , John Fraser , Michael Schulzki , Bobby Byrnes , Grace Carlson
发明人： Marc Hedrick , John Fraser , Michael Schulzki , Bobby Byrnes , Grace Carlson
CPC分类号： A61K35/28
摘要： Systems and methods are described that are used to separate cells from a wide variety of tissues. In particular, automated systems and methods are described that separate regenerative cells, e.g., stem and/or progenitor cells, from adipose tissue. The systems and methods described herein provide rapid and reliable methods of separating and concentrating regenerative cells suitable for re-infusion into a subject.
摘要翻译： 描述了用于从多种组织分离细胞的系统和方法。 特别地，描述了从脂肪组织分离再生细胞例如干细胞和/或祖细胞的自动化系统和方法。 本文所述的系统和方法提供了快速且可靠的分离和浓缩适于再次输注到受试者中的再生细胞的方法。
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10.发明申请Cell carrier and cell carrier containment devices containing regenerative cells 有权含有再生细胞的细胞载体和细胞载体包封装置公开(公告)号：US20050058632A1
公开(公告)日：2005-03-17
申请号：US10885293
申请日：2004-07-01
申请人： Marc Hedrick , John Fraser , Susan Riley , Joseph Tai
发明人： Marc Hedrick , John Fraser , Susan Riley , Joseph Tai
CPC分类号： A61K35/32 , A61F2/442 , A61F2/4455 , A61F2/4465 , A61F2/447 , A61F2002/30062 , A61F2002/30075 , A61F2002/30133 , A61F2002/30448 , A61F2002/30604 , A61F2002/30841 , A61F2002/30879 , A61F2002/4445 , A61F2002/445 , A61F2002/4475 , A61F2210/0004 , A61F2210/0061 , A61F2220/005 , A61F2230/0015 , A61K9/0019 , A61K35/28 , B33Y80/00 , C12N5/0667 , C12N5/069 , C12N2506/1384
摘要： The present invention relates to a device comprising a cell carrier portion containing regenerative cells, e.g., stem and progenitor cells, and a cell carrier containment portion. The device is useful for the treatment of bone related disorders, including spinal fusion related disorders and long bone or flat bone related defects. The device may be used in conjunction with disclosed automated systems and methods for separating and concentrating regenerative cells.
摘要翻译： 本发明涉及包含含有再生细胞例如干细胞和祖细胞的细胞载体部分和细胞载体封闭部分的装置。 该装置可用于治疗骨相关疾病，包括脊柱融合相关疾病和长骨或平骨相关缺陷。 该装置可以与公开的用于分离和集中再生细胞的自动化系统和方法结合使用。
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