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1.发明授权Systems and methods for separating and concentrating adipose derived stem cells from tissue 有权从组织中分离和浓缩脂肪来源的干细胞的系统和方法公开(公告)号：US07514075B2
公开(公告)日：2009-04-07
申请号：US10877822
申请日：2004-06-25
申请人： Marc H. Hedrick , John K. Fraser , Michael J. Schulzki , Bobby Byrnes , Grace Carlson , Robert K. Shanahan
发明人： Marc H. Hedrick , John K. Fraser , Michael J. Schulzki , Bobby Byrnes , Grace Carlson , Robert K. Shanahan
IPC分类号： A01N63/00
CPC分类号： A61K35/28
摘要： Systems and methods are described that are used to separate cells from a wide variety of tissues. In particular, automated systems and methods are described that separate regenerative cells, e.g., stem and/or progenitor cells, from adipose tissue. The systems and methods described herein provide rapid and reliable methods of separating and concentrating regenerative cells suitable for re-infusion into a subject.
摘要翻译： 描述了用于从多种组织分离细胞的系统和方法。 特别地，描述了从脂肪组织分离再生细胞例如干细胞和/或祖细胞的自动化系统和方法。 本文所述的系统和方法提供了快速且可靠的分离和浓缩适于再次输注到受试者中的再生细胞的方法。
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2.发明授权Automated methods for isolating and using clinically safe adipose derived regenerative cells 有权用于分离和使用临床安全的脂肪来源的再生细胞的自动化方法公开(公告)号：US07585670B2
公开(公告)日：2009-09-08
申请号：US10884638
申请日：2004-07-02
申请人： Marc H. Hedrick , John K. Fraser , Michael J. Schulzki , Bobby Byrnes , Grace Carlson , Ronda Elizabeth Schreiber , Isabella Wulur
发明人： Marc H. Hedrick , John K. Fraser , Michael J. Schulzki , Bobby Byrnes , Grace Carlson , Ronda Elizabeth Schreiber , Isabella Wulur
IPC分类号： C12N5/00
摘要： Systems and methods are described that are used to separate cells from a wide variety of tissues. In particular, automated systems and methods are described that separate regenerative cells, e.g., stem and/or progenitor cells, from adipose tissue. The systems and methods described herein provide rapid and reliable methods of separating and concentrating regenerative cells suitable for re-infusion into a subject.
摘要翻译： 描述了用于从多种组织分离细胞的系统和方法。 特别地，描述了从脂肪组织分离再生细胞例如干细胞和/或祖细胞的自动化系统和方法。 本文所述的系统和方法提供了快速且可靠的分离和浓缩适于再次输注到受试者中的再生细胞的方法。
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3.发明申请SYSTEMS AND METHODS FOR ISOLATING AND USING CLINICALLY SAFE ADIPOSE DERIVED REGENERATIVE CELLS 有权用于分离和使用临床安全性ADIPOSE衍生的再生细胞的系统和方法公开(公告)号：US20120264200A1
公开(公告)日：2012-10-18
申请号：US13452349
申请日：2012-04-20
申请人： Marc H. Hedrick , John K. Fraser , Michael J. Schulzki , Bobby Byrnes , Grace Carlson , Rhonda Elizabeth Schreiber , Isabella Wulur
发明人： Marc H. Hedrick , John K. Fraser , Michael J. Schulzki , Bobby Byrnes , Grace Carlson , Rhonda Elizabeth Schreiber , Isabella Wulur
IPC分类号： C12M1/12
摘要： Systems and methods are described that are used to separate cells from a wide variety of tissues. In particular, automated systems and methods are described that separate regenerative cells, e.g., stem and/or progenitor cells, from adipose tissue. The systems and methods described herein provide rapid and reliable methods of separating and concentrating regenerative cells suitable for re-infusion into a subject.
摘要翻译： 描述了用于从多种组织分离细胞的系统和方法。 特别地，描述了从脂肪组织分离再生细胞例如干细胞和/或祖细胞的自动化系统和方法。 本文所述的系统和方法提供了快速且可靠的分离和浓缩适于再次输注到受试者中的再生细胞的方法。
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4.发明授权Systems and methods for isolating and using clinically safe adipose derived regenerative cells 有权用于分离和使用临床安全的脂肪来源的再生细胞的系统和方法公开(公告)号：US08163276B2
公开(公告)日：2012-04-24
申请号：US12554755
申请日：2009-09-04
申请人： Marc H. Hedrick , John K. Fraser , Michael J. Schulzki , Bobby Byrnes , Grace Carlson , Ronda Schreiber , Isabella Wulur
发明人： Marc H. Hedrick , John K. Fraser , Michael J. Schulzki , Bobby Byrnes , Grace Carlson , Ronda Schreiber , Isabella Wulur
IPC分类号： C12N5/00
摘要： Systems and methods are described that are used to separate cells from a wide variety of tissues. In particular, automated systems and methods are described that separate regenerative cells, e.g., stem and/or progenitor cells, from adipose tissue. The systems and methods described herein provide rapid and reliable methods of separating and concentrating regenerative cells suitable for re-infusion into a subject.
摘要翻译： 描述了用于从多种组织分离细胞的系统和方法。 特别地，描述了从脂肪组织分离再生细胞例如干细胞和/或祖细胞的自动化系统和方法。 本文所述的系统和方法提供了快速且可靠的分离和浓缩适于再次输注到受试者中的再生细胞的方法。
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5.发明申请SYSTEMS AND METHODS FOR ISOLATING AND USING CLINICALLY SAFE ADIPOSE DERIVED REGENERATIVE CELLS 有权用于分离和使用临床安全性ADIPOSE衍生的再生细胞的系统和方法公开(公告)号：US20100136668A1
公开(公告)日：2010-06-03
申请号：US12554755
申请日：2009-09-04
申请人： Marc H. Hedrick , John K. Fraser , Michael J. Schulzki , Bobby Byrnes , Grace Carlson , Ronda Elizabeth Schreiber , Isabella Wulur
发明人： Marc H. Hedrick , John K. Fraser , Michael J. Schulzki , Bobby Byrnes , Grace Carlson , Ronda Elizabeth Schreiber , Isabella Wulur
IPC分类号： C12M1/00
摘要： Systems and methods are described that are used to separate cells from a wide variety of tissues. In particular, automated systems and methods are described that separate regenerative cells, e.g., stem and/or progenitor cells, from adipose tissue. The systems and methods described herein provide rapid and reliable methods of separating and concentrating regenerative cells suitable for re-infusion into a subject.
摘要翻译： 描述了用于从多种组织分离细胞的系统和方法。 特别地，描述了从脂肪组织分离再生细胞例如干细胞和/或祖细胞的自动化系统和方法。 本文所述的系统和方法提供了快速且可靠的分离和浓缩适于再次输注到受试者中的再生细胞的方法。
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6.发明授权Systems and methods for isolating and using clinically safe adipose derived regenerative cells 有权用于分离和使用临床安全的脂肪来源的再生细胞的系统和方法公开(公告)号：US08883499B2
公开(公告)日：2014-11-11
申请号：US13452349
申请日：2012-04-20
申请人： Marc H. Hedrick , John K. Fraser , Michael J. Schulzki , Bobby Byrnes , Grace Carlson , Ronda Elizabeth Schreiber , Isabella Wulur
发明人： Marc H. Hedrick , John K. Fraser , Michael J. Schulzki , Bobby Byrnes , Grace Carlson , Ronda Elizabeth Schreiber , Isabella Wulur
摘要： Systems and methods are described that are used to separate cells from a wide variety of tissues. In particular, automated systems and methods are described that separate regenerative cells, e.g., stem and/or progenitor cells, from adipose tissue. The systems and methods described herein provide rapid and reliable methods of separating and concentrating regenerative cells suitable for re-infusion into a subject.
摘要翻译： 描述了用于从多种组织分离细胞的系统和方法。 特别地，描述了从脂肪组织分离再生细胞例如干细胞和/或祖细胞的自动化系统和方法。 本文所述的系统和方法提供了快速且可靠的分离和浓缩适于再次输注到受试者中的再生细胞的方法。
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7.发明授权Methods of using adipose derived regenerative cells to promote restoration of intevertebral disc 有权使用脂肪来源的再生细胞促进椎间盘恢复的方法公开(公告)号：US09504716B2
公开(公告)日：2016-11-29
申请号：US12853110
申请日：2010-08-09
IPC分类号： C12N5/00 , A61K35/28 , A61L27/38 , A61L27/52 , A61L27/56 , C12N5/0775 , A61L27/18 , A61L27/36 , A61L27/54
CPC分类号： A61K35/28 , A61L27/18 , A61L27/3608 , A61L27/365 , A61L27/3654 , A61L27/3691 , A61L27/3834 , A61L27/3847 , A61L27/3852 , A61L27/3895 , A61L27/52 , A61L27/54 , A61L27/56 , A61L2300/40 , A61L2300/412 , A61L2300/64 , A61L2400/06 , A61L2430/02 , A61L2430/06 , A61L2430/40 , C12N5/0667
摘要： Regenerative cells present in adipose tissue are used to treat patients, including patients with musculoskeletal diseases or disorders. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of regenerative cells obtained from the adipose tissue to a patient. The methods may be practiced in a closed system so that the stem cells are not exposed to an external environment prior to being administered to a patient. Accordingly, in a preferred method, regenerative cells present in adipose tissue are placed directly into a recipient along with such additives necessary to promote, engender or support a therapeutic musculoskeletal benefit.
摘要翻译： 存在于脂肪组织中的再生细胞用于治疗患者，包括肌肉骨骼疾病或病症的患者。 治疗患者的方法包括加工脂肪组织以将从脂肪组织获得的浓缩量的再生细胞输送给患者。 所述方法可以在封闭系统中实施，使得干细胞在施用于患者之前不暴露于外部环境。 因此，在优选的方法中，存在于脂肪组织中的再生细胞与用于促进，产生或支持治疗性肌肉骨骼益处所必需的这种添加剂一起直接放置在受体中。
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8.发明申请CELL CARRIER AND CELL CARRIER CONTAINMENT DEVICES CONTAINING REGENERATIVE CELLS 审中-公开包含再生细胞的细胞载体和细胞载体包含装置公开(公告)号：US20130060338A1
公开(公告)日：2013-03-07
申请号：US13598203
申请日：2012-08-29
IPC分类号： A61F2/44
CPC分类号： A61K35/32 , A61F2/442 , A61F2/4455 , A61F2/4465 , A61F2/447 , A61F2002/30062 , A61F2002/30075 , A61F2002/30133 , A61F2002/30448 , A61F2002/30604 , A61F2002/30841 , A61F2002/30879 , A61F2002/4445 , A61F2002/445 , A61F2002/4475 , A61F2210/0004 , A61F2210/0061 , A61F2220/005 , A61F2230/0015 , A61K9/0019 , A61K35/28 , B33Y80/00 , C12N5/0667 , C12N5/069 , C12N2506/1384
摘要： The present invention relates to a device comprising a cell carrier portion containing regenerative cells, e.g., stem and progenitor cells, and a cell carrier containment portion. The device is useful for the treatment of bone related disorders, including spinal fusion related disorders and long bone or flat bone related defects. The device may be used in conjunction with disclosed automated systems and methods for separating and concentrating regenerative cells.
摘要翻译： 本发明涉及包含含有再生细胞例如干细胞和祖细胞的细胞载体部分和细胞载体封闭部分的装置。 该装置可用于治疗骨相关疾病，包括脊柱融合相关疾病和长骨或平骨相关缺陷。 该装置可以与公开的用于分离和集中再生细胞的自动化系统和方法结合使用。
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9.发明授权Methods of using adipose tissue-derived cells in augmenting autologous fat transfer 有权使用脂肪组织来源的细胞增强自体脂肪转移的方法公开(公告)号：US08246947B2
公开(公告)日：2012-08-21
申请号：US12694103
申请日：2010-01-26
申请人： Marc H. Hedrick , John K. Fraser
发明人： Marc H. Hedrick , John K. Fraser
IPC分类号： C12N5/00
CPC分类号： A61K35/44 , A61K35/28 , A61L27/3604 , A61L27/3834 , A61L27/3886 , A61L27/54 , A61L2300/414 , A61L2300/416 , A61L2300/426 , A61L2430/34 , C12N5/0667 , C12N5/069 , C12N2506/1384
摘要： Methods of treating patients for conditions such as breast augmentation, soft tissue defects, and urinary incontinence, are described. The methods include removing adipose tissue from a patient, processing a portion of the adipose tissue to obtain a substantially isolated population of cells comprising disaggregated adipose-derived stem cells, mixing the concentrated population of adipose-derived cells comprising disaggregated adipose-derived cells with a portion of unprocessed, intact, non-disaggregated adipose tissue to form a composition, and administering the composition to the patient from which the adipose tissue was removed.
摘要翻译： 描述了治疗患者的症状如隆胸，软组织缺损和尿失禁的方法。 所述方法包括从患者中去除脂肪组织，加工脂肪组织的一部分以获得包含解聚的脂肪来源的干细胞的基本上分离的细胞群，将包含解聚的脂肪来源的细胞的浓缩的脂肪来源的细胞与 未处理的，未分解的脂肪组织的部分以形成组合物，并将组合物施用于除去脂肪组织的患者。
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10.发明授权Methods of using regenerative cells in the treatment of musculoskeletal disorders 有权使用再生细胞治疗肌肉骨骼疾病的方法公开(公告)号：US07771716B2
公开(公告)日：2010-08-10
申请号：US10884637
申请日：2004-07-01
IPC分类号： A01N63/00
CPC分类号： A61K35/28 , A61L27/18 , A61L27/3608 , A61L27/365 , A61L27/3654 , A61L27/3691 , A61L27/3834 , A61L27/3847 , A61L27/3852 , A61L27/3895 , A61L27/52 , A61L27/54 , A61L27/56 , A61L2300/40 , A61L2300/412 , A61L2300/64 , A61L2400/06 , A61L2430/02 , A61L2430/06 , A61L2430/40 , C12N5/0667
摘要： Regenerative cells present in adipose tissue are used to treat patients, including patients with musculoskeletal diseases or disorders. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of regenerative cells obtained from the adipose tissue to a patient. The methods may be practiced in a closed system so that the stem cells are not exposed to an external environment prior to being administered to a patient. Accordingly, in a preferred method, regenerative cells present in adipose tissue are placed directly into a recipient along with such additives necessary to promote, engender or support a therapeutic musculoskeletal benefit.
摘要翻译： 存在于脂肪组织中的再生细胞用于治疗患者，包括肌肉骨骼疾病或病症的患者。 治疗患者的方法包括加工脂肪组织以将从脂肪组织获得的浓缩量的再生细胞输送给患者。 所述方法可以在封闭系统中实施，使得干细胞在施用于患者之前不暴露于外部环境。 因此，在优选的方法中，存在于脂肪组织中的再生细胞与用于促进，产生或支持治疗性肌肉骨骼益处所必需的这种添加剂一起直接放置在受体中。
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