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公开(公告)号：US11027250B2
公开(公告)日：2021-06-08
申请号：US16328129
申请日：2017-09-04
Applicant: Cytiva BioProcess R&D AB
Inventor： Jimmy Hedin Dahlstrom , Jonas Bengtsson , Per Erik Emilsson , Maranda Fordham , Eva Holmgren , Ronnie Palmgren , Fernando Polanco
Abstract: A system and method for producing fine droplets of polysaccharide from a premixed water-in-oil emulsion uses a packed bed (5) comprising hydrophilic beads (7).
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公开(公告)号：US20220315647A1
公开(公告)日：2022-10-06
申请号：US17604964
申请日：2020-04-29
Applicant: Cytiva Bioprocess R&D AB
Inventor： Gustav Rodrigo , Mats Ander , Tomas Bjorkman , Ronnie Palmgren , Charlotte Brink
Abstract: The invention discloses a method for separation of antibodies or antibody fragments, comprising the steps of: a) providing a feed comprising antibodies or antibody fragments having a VH3 region and being devoid of an Fc region capable of binding to Protein A; b) contacting the feed with a separation resin having covalently coupled ligands, wherein the ligands comprise a polypeptide as defined by SEQ ID NO 1 and wherein the antibodies or antibody fragments bind to the separation resin; c) optionally washing the separation resin with a washing liquid; d) eluting the antibodies or antibody fragments from the separation resin with an elution liquid and recovering the antibodies or antibody fragments.
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公开(公告)号：US20210163529A1
公开(公告)日：2021-06-03
申请号：US16955119
申请日：2018-12-13
Applicant: Cytiva Bioprocess R&D AB
Inventor： Gustav Rodrigo , Mats Ander , Ronnie Palmgren , Tomas Bjorkman
Abstract: A method for preparation of a separation matrix, comprising the steps of: a) providing a solid support and an alkali-stable ligand derived from an immunoglobulin-binding bacterial protein; b) reacting said alkali-stable ligand with said solid support to form a separation matrix having covalently coupled alkali-stable ligands; and c) washing said separation matrix having covalently coupled alkali-stable ligands with a wash solution comprising at least 10 mM of an alkali metal hydroxide.
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公开(公告)号：US12005424B2
公开(公告)日：2024-06-11
申请号：US17045779
申请日：2019-04-24
Applicant: Cytiva BioProcess R&D AB
Inventor： Jonas Bengtsson , Linn Carlsson , Andreas Axen , Ronnie Palmgren
IPC: B01D15/08 , B01J20/24 , B01J20/26 , B01J20/28 , B01J20/285 , B01J20/291 , B01J20/30
CPC classification number: B01J20/267 , B01D15/08 , B01J20/24 , B01J20/28023 , B01J20/28047 , B01J20/285 , B01J20/291 , B01J20/3042 , B01J2220/445 , B01J2220/54
Abstract: The invention discloses a separation matrix comprising polysaccharide gel beads, wherein said polysaccharide gel beads comprise embedded fibers. The invention further discloses a method of preparing the separation matrix and use of the matrix for separation purposes.
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Patent Agency Ranking
公开(公告)号：US20210060525A1
公开(公告)日：2021-03-04
申请号：US17045779
申请日：2019-04-24
Applicant: Cytiva BioProcess R&D AB
Inventor： Jonas Bengtsson , Linn Carlsson , Andreas Axen , Ronnie Palmgren
IPC: B01J20/24 , B01J20/28 , B01J20/291 , B01J20/30 , B01J20/281 , B01D15/08
Abstract: The invention discloses a separation matrix comprising polysaccharide gel beads, wherein said polysaccharide gel beads comprise embedded fibers. The invention further discloses a method of preparing the separation matrix and use of the matrix for separation purposes.
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公开(公告)号：US20240076650A1
公开(公告)日：2024-03-07
申请号：US18260560
申请日：2022-01-26
Applicant: CYTIVA BIOPROCESS R&D AB
Inventor： Peter Lundback , Ronnie Palmgren , Ola Lind , Nils Norrman , Helen Cheek , Susana Brito Dos Santos , Per Denker
IPC: C12N15/10 , B01D15/38 , B01J20/26 , B01J20/28 , B01J20/289
CPC classification number: C12N15/101 , B01D15/3819 , B01J20/265 , B01J20/28035 , B01J20/28038 , B01J20/289 , B01J2220/52
Abstract: The invention relates to processes for purification of poly-tagged products, such as mRNA, from synthetic or biological compositions. The process involves contacting the composition with a oligo d (T)-functionalized chromatography medium comprising a convection-based chromatography material.
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公开(公告)号：US11680081B2
公开(公告)日：2023-06-20
申请号：US16955119
申请日：2018-12-13
Applicant: Cytiva Bioprocess R&D AB
Inventor： Gustav Rodrigo , Mats Ander , Ronnie Palmgren , Tomas Bjorkman
CPC classification number: C07K1/22 , B01D15/3809 , B01J20/24 , B01J20/288 , B01J20/28016 , B01J20/3071 , B01J20/3212 , B01J20/3217 , B01J20/3274 , B01J20/3295 , C07K16/00 , B01J2220/54
Abstract: Methods that include providing and reacting a solid support and an alkali-stable ligand derived from an immunoglobulin-binding bacterial protein to form a separation matrix having covalently coupled alkali-stable ligands; and washing with a wash solution comprising at least 10 mM of an alkali metal hydroxide.
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公开(公告)号：US20220362744A1
公开(公告)日：2022-11-17
申请号：US17853514
申请日：2022-06-29
Applicant: Cytiva BioProcess R&D AB
Inventor： Ronnie Palmgren , Jean-Luc Maloisel , Gustav Rodrigo , Tomas Bjorkman
Abstract: A separation matrix comprising porous particles to which antibody-binding protein ligands have been covalently immobilized, wherein the density of said ligands is above 5 mg/ml, the volume-weighted median diameter of said porous particles is at least 10 and below 30 μm and the said porous particles have a gel phase distribution coefficient, expressed as KD for dextran of molecular weight 110 kDa, of 0.5-0.9.
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公开(公告)号：US11053283B2
公开(公告)日：2021-07-06
申请号：US16386628
申请日：2019-04-17
Applicant: Cytiva BioProcess R&D AB
Inventor： Jean-Luc Maloisel , Ola Lind , Bjorn Noren , Ronnie Palmgren
Abstract: The present invention relates to a method for removal of large contaminants, such as virus, in a chromatographic process for purification of a target molecule, preferably monoclonal antibodies, mAbs, by using a specifically designed chromatographic bead having a thin outer layer and a core functionalized with a ligand adsorbing the mAbs or parts thereof.
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