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    Hydrophilic lubricity coating for medical devices comprising a hybrid top coat
    1.
    发明授权
    Hydrophilic lubricity coating for medical devices comprising a hybrid top coat 有权
    用于医疗装置的亲水性润滑性涂层，包括混合面漆

    公开(公告)号：US06610035B2

    公开(公告)日：2003-08-26

    申请号：US09822973

    申请日：2001-03-30

    申请人： Dachuan Yang ,  Lixiao Wang ,  Joel Stanslaski ,  Liguang Tang

    发明人： Dachuan Yang ,  Lixiao Wang ,  Joel Stanslaski ,  Liguang Tang

    IPC分类号： A61M2500

    CPC分类号： A61L29/145 ,  A61L29/085 ,  A61L29/12 ,  C08L83/04

    摘要： The present invention relates to a medical device for insertion into the body wherein the device has at least one surface which periodically comes into contact with a second surface. The first surface comprises an improved lubricious coating having a first hydrogel layer and a second hydrophobic top coating which prevents the hydrogel coating from prematurely absorbing too much moisture. The hydrophobic top coating comprises at least one hydrophilic surfactant which acts as a carrier to facilitate removal of the hydrophobic top coating upon entry into an aqueous environment.

    摘要翻译： 本发明涉及用于插入体内的医疗装置，其中装置具有周期性地与第二表面接触的至少一个表面。 第一表面包括改进的润滑涂层，其具有第一水凝胶层和第二疏水性顶涂层，其防止水凝胶涂层过早吸收太多的水分。 疏水性顶涂层包含至少一种作为载体的亲水性表面活性剂，以便在进入水性环境时有助于除去疏水性顶涂层。

    Hydrophilic lubricity coating for medical devices comprising a hydrophobic top coat
    2.
    发明授权
    Hydrophilic lubricity coating for medical devices comprising a hydrophobic top coat 有权
    用于医疗装置的亲水性润滑性涂层包括疏水性面漆

    公开(公告)号：US06589215B2

    公开(公告)日：2003-07-08

    申请号：US09728589

    申请日：2000-12-01

    申请人： Dachuan Yang ,  Lixiao Wang ,  Joel Stanslaski ,  Liguang Tang

    发明人： Dachuan Yang ,  Lixiao Wang ,  Joel Stanslaski ,  Liguang Tang

    IPC分类号： A61M2500

    CPC分类号： A61L29/145 ,  A61L29/085 ,  A61L29/12 ,  C08L83/04 ,  C08L71/02 ,  A61L29/049

    摘要： The present invention relates to a medical device for insertion into the body wherein the device has at least one surface which periodically comes into contact with a second surface. The first surface comprises an improved lubricious coating having a first hydrogel layer and a second hydrophobic top coating which prevents the hydrogel coating from prematurely absorbing too much moisture. The hydrophobic top coating comprises at least one hydrophilic surfactant which acts as a carrier to facilitate removal of the hydrophobic top coating upon entry into an aqueous environment.

    摘要翻译： 本发明涉及用于插入体内的医疗装置，其中装置具有周期性地与第二表面接触的至少一个表面。 第一表面包括改进的润滑涂层，其具有第一水凝胶层和第二疏水性顶涂层，其防止水凝胶涂层过早吸收太多的水分。 疏水性顶涂层包含至少一种作为载体的亲水性表面活性剂，以便在进入水性环境时有助于除去疏水性顶涂层。

    Hydrophilic lubricity coating for medical devices comprising a hydrophobic top coat
    3.
    发明授权
    Hydrophilic lubricity coating for medical devices comprising a hydrophobic top coat 有权
    用于医疗装置的亲水性润滑性涂层包括疏水性面漆

    公开(公告)号：US06176849B1

    公开(公告)日：2001-01-23

    申请号：US09316502

    申请日：1999-05-21

    申请人： Dachuan Yang ,  Lixiao Wang ,  Joel Stanslaski ,  Liguang Tang

    发明人： Dachuan Yang ,  Lixiao Wang ,  Joel Stanslaski ,  Liguang Tang

    IPC分类号： A61M532

    CPC分类号： A61L29/145 ,  A61L29/085 ,  A61L29/12 ,  C08L83/04 ,  C08L71/02 ,  A61L29/049

    摘要： The present invention relates to a medical device for insertion into the body wherein the device has at least one surface which periodically comes into contact with a second surface. The first surface comprises an improved lubricious coating having a first hydrogel layer and a second hydrophobic top coating which prevents the hydrogel coating from prematurely absorbing too much moisture. The hydrophobic top coating comprises at least one hydrophilic surfactant which acts as a carrier to facilitate removal of the hydrophobic top coating upon entry into an aqueous environment.

    摘要翻译： 本发明涉及用于插入体内的医疗装置，其中装置具有周期性地与第二表面接触的至少一个表面。 第一表面包括改进的润滑涂层，其具有第一水凝胶层和第二疏水性顶涂层，其防止水凝胶涂层过早吸收太多的水分。 疏水性顶涂层包含至少一种作为载体的亲水性表面活性剂，以便在进入水性环境时有助于除去疏水性顶涂层。

    Dual surface protection coating for drug delivery balloon catheters and stents
    4.
    发明授权
    Dual surface protection coating for drug delivery balloon catheters and stents 失效
    用于药物输送气囊导管和支架的双表面保护涂层

    公开(公告)号：US06656156B2

    公开(公告)日：2003-12-02

    申请号：US10154186

    申请日：2002-05-22

    申请人： Dachuan Yang ,  Joel Stanslaski ,  Lixiao Wang

    发明人： Dachuan Yang ,  Joel Stanslaski ,  Lixiao Wang

    IPC分类号： A61M2900

    CPC分类号： A61L31/16 ,  A61F2/0077 ,  A61F2/91 ,  A61F2/915 ,  A61F2/958 ,  A61F2002/91541 ,  A61F2002/91558 ,  A61F2250/0067 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/416 ,  A61L2300/608 ,  A61L2420/08

    摘要： The invention relates to a medical device, such as a stent or a balloon catheter that includes an expandable body portion which has an exterior surface that contacts a vessel wall during treatment. The medical device includes a first coating disposed over at least a portion of the exterior surface. The first coating includes a therapeutic substance that is intended for controlled release from the exterior surface. The medical device further includes a second coating overlaying at least a substantial portion of the first coating. The second coating includes a material that is generally impervious to elution of the therapeutic substance therethrough when the body portion is inserted into the vessel lumen. The material of the second coating is relatively inelastic so that the second coating fractures during expansion of the body portion to allow elution of the therapeutic substance through fissures formed in the second coating.

    摘要翻译： 本发明涉及医疗装置，例如支架或气囊导管，其包括在治疗期间具有与血管壁接触的外表面的可扩张体部分。 医疗装置包括设置在外表面的至少一部分上的第一涂层。 第一涂层包括旨在从外表面控制释放的治疗物质。 医疗装置还包括覆盖第一涂层的至少大部分的第二涂层。 第二涂层包括当主体部分插入血管内腔时通常不能透过治疗物质洗脱的材料。 第二涂层的材料相对无弹性，使得第二涂层在体部膨胀期间断裂，以允许通过在第二涂层中形成的裂缝洗脱治疗物质。

    Surface protection method for stents and balloon catheters for drug delivery
    5.
    发明授权
    Surface protection method for stents and balloon catheters for drug delivery 有权
    用于药物输送的支架和球囊导管的表面保护方法

    公开(公告)号：US06419692B1

    公开(公告)日：2002-07-16

    申请号：US09243580

    申请日：1999-02-03

    申请人： Duchuan Yang ,  Joel Stanslaski ,  Lixiao Wang

    发明人： Duchuan Yang ,  Joel Stanslaski ,  Lixiao Wang

    IPC分类号： A61F206

    CPC分类号： A61L31/16 ,  A61F2/0077 ,  A61F2/91 ,  A61F2/915 ,  A61F2/958 ,  A61F2002/91541 ,  A61F2002/91558 ,  A61F2250/0067 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/416 ,  A61L2300/608 ,  A61L2420/08

    摘要： A medical device, such as a stent or balloon of a balloon catheter which includes a body portion which has an exterior surface which contacts, at least in part, a vessel wall during treatment. The body portion is expandable from a first position, wherein the body portion is sized for insertion into the vessel lumen, to a second position, wherein at least a portion of the exterior surface is in contact with the lumen wall. The medical device includes a first coating disposed over at least a portion of the exterior surface of the body portion with the first coating including a drug or therapeutic substance which is intended for controlled release from the surface. The medical device further includes a second coating overlying at least a substantial portion of the first coating. The second coating includes a material that is generally impervious to elution of the drug or therapeutic substance therethrough when the body portion is in a first position when inserted into the vessel lumen. The material of the second coating is relatively inelastic so that the second coating fractures during expansion of the body portion to the second position to allow elution of therapeutic substance through a multiplicity of fissures formed through the second coating.

    摘要翻译： 一种医疗装置，例如球囊导管的支架或球囊，其包括主体部分，该主体部分具有在治疗期间至少部分地与血管壁接触的外表面。 主体部分从第一位置可膨胀，其中主体部分的尺寸适于插入血管腔，到达第二位置，其中外表面的至少一部分与内腔壁接触。 医疗装置包括设置在主体部分的外表面的至少一部分上的第一涂层，第一涂层包括用于从表面受控释放的药物或治疗物质。 医疗装置还包括覆盖第一涂层的至少大部分的第二涂层。 第二涂层包括当插入血管内腔时主体部分处于第一位置时通常不透过药物或治疗物质的洗脱的材料。 第二涂层的材料相对无弹性，使得第二涂层在主体部分膨胀到第二位置期间断裂，以允许通过穿过第二涂层形成的多个裂缝洗脱治疗物质。