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公开(公告)号：US20190144485A1
公开(公告)日：2019-05-16
申请号：US16248273
申请日：2019-01-15
申请人： Daniel DiRocco , Artis Klapars , Edward C. Sherer
发明人： Daniel DiRocco , Artis Klapars , Edward C. Sherer
IPC分类号： C07H19/10 , C07D487/04 , C07H19/06 , C07H19/24
摘要： The present invention is directed to a process for making Chloro-Substituted Nucleoside Phosphoramidate Compounds of formula (I): which are useful for the treatment and prophylaxis of HCV infection. The present invention is also directed to compounds that are useful as synthetic intermediates for making the compounds of formula (I).
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公开(公告)号：US20170226146A1
公开(公告)日：2017-08-10
申请号：US15427674
申请日：2017-02-08
申请人： John Y.L. Chung , Amude Kassim , John Limanto , Michael Shevlin , Peter E. Maligres , Daniel A. DiRocco , James F. Dropinski , Rose Mathew , Yi Ning Ji Chen , Edward C. Sherer , Mikhail Reibarkh , Artis Klapars , Alan Hyde , Susan L. Zultanski , Aaron Moment , Bryon Simmons , Tyler A. Davis , Timothy James Wright , Ralph Calabria , Louis Charles Campeau
发明人： John Y.L. Chung , Amude Kassim , John Limanto , Michael Shevlin , Peter E. Maligres , Daniel A. DiRocco , James F. Dropinski , Rose Mathew , Yi Ning Ji Chen , Edward C. Sherer , Mikhail Reibarkh , Artis Klapars , Alan Hyde , Susan L. Zultanski , Aaron Moment , Bryon Simmons , Tyler A. Davis , Timothy James Wright , Ralph Calabria , Louis Charles Campeau
IPC分类号： C07H19/10 , C07H19/24 , C07D487/04 , C07H19/06
CPC分类号： C07H19/10 , C07D487/04 , C07H19/06 , C07H19/24
摘要： The present invention is directed to a process for making Chloro-Substituted Nucleoside Phosphoramidate Compounds of formula (I): which are useful for the treatment and prophylaxis of HCV infection. The present invention is also directed to compounds that are useful as synthetic intermediates for making the compounds of formula (I).
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公开(公告)号：US20180030036A1
公开(公告)日：2018-02-01
申请号：US15534029
申请日：2015-12-07
申请人： Ting ZHANG , Yi-Heng CHEN , Liangqin GUO , Alan HARUZA , Tianying JIAN , Bing LI , Dongfang MENG , Dann L. PARKER, JR. , Edward C. SHERER , Harold B. WOOD , Isao SAKURADA , MERCK SHARP & DOHME CORP. , MOCHIDA PHARMACEUTICAL CO., LTD
发明人： Ting Zhang , Yi-Heng Chen , Liangqin Guo , Alan Hruza , Tianying Jian , Bing Li , Dongfang Meng , Dann L. Parker , Edward C. Sherer , Harold B. Wood , Isao Sakurada
IPC分类号： C07D403/12 , C07D401/14 , C07D401/12 , C07D471/04
CPC分类号： C07D403/12 , C07D401/12 , C07D401/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
摘要： The present invention provides a compound of Formula I, and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing unstable angina, refractory angina, myocardial infarction, transient ischemic attacks, atrial fibrillation, thrombotic stroke, embolic stroke, deep vein thrombosis, disseminated intravascular coagulation, ocular build up of fibrin, and reocclusion or restenosis of recanalized vessels. The compounds are selective Factor IXa inhibitors.
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公开(公告)号：US20130065845A1
公开(公告)日：2013-03-14
申请号：US13616962
申请日：2012-09-14
IPC分类号： A61K31/7042 , C07H17/08 , A61K31/706 , A61K31/7056 , A61P31/00 , A61P1/00 , A61P35/00 , A61P31/04 , A61P31/10 , A61P33/00 , A61P31/12 , A61P1/10 , C07H17/00 , A61P29/00
摘要： The present invention provides triazole macrocyclic compounds useful as therapeutic agents. More particularly, these compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents.
摘要翻译： 本发明提供可用作治疗剂的三唑大环化合物。 更具体地，这些化合物可用作抗感染，抗增殖，抗炎和促动力剂。
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公开(公告)号：US20130131042A1
公开(公告)日：2013-05-23
申请号：US13810946
申请日：2011-08-12
申请人： Joseph L. Duffy , Jianming Bao , Debra L. Ondeyka , Sriram Tyagarajan , Patrick Shao , Feng Ye , Revathi Katipally , Aaron Zwicker , Edward C. Sherer , Michael A. Plotkin , Remond Moningka , Zahid Hussain , Harold B. Wood , Feroze Ujjainwalla , F. Anthony Romero , Paul E. Finke , Yi Zang , Weiguo Liu
发明人： Joseph L. Duffy , Jianming Bao , Debra L. Ondeyka , Sriram Tyagarajan , Patrick Shao , Feng Ye , Revathi Katipally , Aaron Zwicker , Edward C. Sherer , Michael A. Plotkin , Remond Moningka , Zahid Hussain , Harold B. Wood , Feroze Ujjainwalla , F. Anthony Romero , Paul E. Finke , Yi Zang , Weiguo Liu
IPC分类号： C07D498/10 , C07D519/00
CPC分类号： C07D498/10 , C07D519/00
摘要： Substituted spirocyclic amines of structural formula (I) are selective antagonists of the somatostatin subtype receptor 5 (SSTR5) and are useful for the treatment, control or prevention of disorders responsive to antagonism of SSTR5, such as Type 2 diabetes, insulin resistance, lipid disorders, obesity, atherosclerosis, Metabolic Syndrome, depression, and anxiety.
摘要翻译： 结构式（I）的取代的螺环胺是生长抑素亚型受体5（SSTR5）的选择性拮抗剂，可用于治疗，控制或预防对SSTR5的拮抗作用反应的病症，例如2型糖尿病，胰岛素抵抗，脂质障碍 ，肥胖症，动脉粥样硬化，代谢综合征，抑郁症和焦虑症。
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公开(公告)号：US08742110B2
公开(公告)日：2014-06-03
申请号：US13810946
申请日：2011-08-12
申请人： Joseph L. Duffy , Jianming Bao , Debra L. Ondeyka , Sriram Tyagarajan , Patrick Shao , Feng Ye , Revathi Katipally , Aaron Zwicker , Edward C. Sherer , Michael A. Plotkin , Remond Moningka , Zahid Hussain , Harold B. Wood , Feroze Ujjainwalla , F. Anthony Romero , Paul E. Finke , Yi Zang , Weiguo Liu
发明人： Joseph L. Duffy , Jianming Bao , Debra L. Ondeyka , Sriram Tyagarajan , Patrick Shao , Feng Ye , Revathi Katipally , Aaron Zwicker , Edward C. Sherer , Michael A. Plotkin , Remond Moningka , Zahid Hussain , Harold B. Wood , Feroze Ujjainwalla , F. Anthony Romero , Paul E. Finke , Yi Zang , Weiguo Liu
IPC分类号： C07D215/00 , C07D229/00 , A61K31/44 , A61K31/397
CPC分类号： C07D498/10 , C07D519/00
摘要： Substituted spirocyclic amines of structural formula (I) are selective antagonists of the somatostatin subtype receptor 5 (SSTR5) and are useful for the treatment, control or prevention of disorders responsive to antagonism of SSTR5, such as Type 2 diabetes, insulin resistance, lipid disorders, obesity, atherosclerosis, Metabolic Syndrome, depression, and anxiety.
摘要翻译： 结构式（I）的取代的螺环胺是生长抑素亚型受体5（SSTR5）的选择性拮抗剂，可用于治疗，控制或预防对SSTR5的拮抗作用有响应的病症，例如2型糖尿病，胰岛素抵抗，脂质障碍 ，肥胖症，动脉粥样硬化，代谢综合征，抑郁症和焦虑症。
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公开(公告)号：US20100016956A1
公开(公告)日：2010-01-21
申请号：US11990883
申请日：2006-08-24
IPC分类号： A61F2/06 , C07H17/08 , C07H17/00 , A61K31/7048 , A61K31/7052 , A61P31/00
摘要： The present invention provides triazole macrocyclic compounds useful as therapeutic agents. More particularly, these compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. The compounds have the following structure: wherein T is the macrocyclic part.
摘要翻译： 本发明提供可用作治疗剂的三唑大环化合物。 更具体地，这些化合物可用作抗感染，抗增殖，抗炎和促动力剂。 该化合物具有以下结构：其中T是大环部分。
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公开(公告)号：US08841263B2
公开(公告)日：2014-09-23
申请号：US13525900
申请日：2012-06-18
申请人： Jay J. Farmer , Ashoke Bhattacharjee , Yi Chen , Joel A. Goldberg , Joseph A. Ippolito , Zoltan F. Kanyo , Rongliang Lou , Adegboyega K. Oyelere , Edward C. Sherer , Joyce A. Sutcliffe , Deping Wang , Yusheng Wu , Yanming Du
发明人： Jay J. Farmer , Ashoke Bhattacharjee , Yi Chen , Joel A. Goldberg , Joseph A. Ippolito , Zoltan F. Kanyo , Rongliang Lou , Adegboyega K. Oyelere , Edward C. Sherer , Joyce A. Sutcliffe , Deping Wang , Yusheng Wu , Yanming Du
摘要： The present invention provides macrocyclic compounds useful as therapeutic agents of the formula: or a pharmaceutically acceptable salt, ester, N-oxide, or prodrug thereof, wherein T, R1, R2, R3, D, E, F, and G are as defined herein. More particularly, these compounds are useful as anti-infective, antiproliferative, anti-inflammatory and prokinetic agents.
摘要翻译： 本发明提供可用作下式的治疗剂的大环化合物：或其药学上可接受的盐，酯，N-氧化物或前药，其中T，R 1，R 2，R 3，D，E，F和G如上所定义 这里。 更具体地，这些化合物可用作抗感染，抗增殖，抗炎和促动力剂。
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公开(公告)号：US20120252747A1
公开(公告)日：2012-10-04
申请号：US13525900
申请日：2012-06-18
申请人： Jay J. Farmer , Ashoke Bhattacharjee , Yi Chen , Joel A. Goldberg , Joseph A. Ippolito , Zoltan F. Kanyo , Rongliang Lou , Adegboyega K. Oyelere , Edward C. Sherer , Joyce A. Sutcliffe , Deping Wang , Yusheng Wu , Yanming Du
发明人： Jay J. Farmer , Ashoke Bhattacharjee , Yi Chen , Joel A. Goldberg , Joseph A. Ippolito , Zoltan F. Kanyo , Rongliang Lou , Adegboyega K. Oyelere , Edward C. Sherer , Joyce A. Sutcliffe , Deping Wang , Yusheng Wu , Yanming Du
IPC分类号： A61K31/7056 , C07H17/08 , A61P1/14 , A61P31/00 , A61P29/00 , A61P35/00 , C07H17/00 , A61K31/706
摘要： The present invention provides macrocyclic compounds useful as therapeutic agents of the formula: or a pharmaceutically acceptable salt, ester, N-oxide, or prodrug thereof, wherein T, R1, R2, R3, D, E, F, and G are as defined herein. More particularly, these compounds are useful as anti-infective, antiproliferative, anti-inflammatory and prokinetic agents.
摘要翻译： 本发明提供可用作下式的治疗剂的大环化合物：或其药学上可接受的盐，酯，N-氧化物或前药，其中T，R 1，R 2，R 3，D，E，F和G如上所定义 这里。 更具体地，这些化合物可用作抗感染，抗增殖，抗炎和促动力剂。
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公开(公告)号：US08278281B2
公开(公告)日：2012-10-02
申请号：US11990883
申请日：2006-08-24
摘要： The present invention provides triazole macrocyclic compounds useful as therapeutic agents. More particularly, these compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. The compounds have the following structure: wherein T is the macrocyclic part.
摘要翻译： 本发明提供可用作治疗剂的三唑大环化合物。 更具体地，这些化合物可用作抗感染，抗增殖，抗炎和促动力剂。 该化合物具有以下结构：其中T是大环部分。
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