公开(公告)号：US08901489B2

公开(公告)日：2014-12-02

申请号：US14126259

申请日：2012-06-15

申请人： Daniel Levin ,  Vlad Sergeyev ,  Volodimir Bondarenko ,  Bohdan Atamanchuk ,  Qunzhou Bian ,  Henryk Zaleski ,  Mark Piniarski ,  Simon Feldberg ,  Ronald Jackson

发明人： Daniel Levin ,  Vlad Sergeyev ,  Volodimir Bondarenko ,  Bohdan Atamanchuk ,  Qunzhou Bian ,  Henryk Zaleski ,  Mark Piniarski ,  Simon Feldberg ,  Ronald Jackson

IPC分类号： H01J49/00 ,  G01N27/62 ,  H01J49/12

CPC分类号： G01N27/622 ,  H01J49/12 ,  H01J49/168

摘要： Looped ionization sources for ion mobility spectrometers are described. The ionization sources can be used to ionize molecules from a sample of interest in order to identify the molecules based on the ions. In an implementation, an electrical ionization source includes a wire that is looped between electrical contacts. The wire is used to form a corona responsive to application of voltage between the wire and the walls of an ionization chamber. The corona can form when a sufficient voltage is applied between the wire and the walls. A difference in electrical potential between the wire and a wall forming an ionization chamber, in which wire is contained, can be used to draw the ions away from the wire. In embodiments, the wire can be heated to reduce the voltage used to strike the corona. The ions, subsequently, may ionize the molecules from the sample of interest. The looped corona source can also be used in mass spectrometers (MS).

摘要翻译： 描述了用于离子迁移率光谱仪的环形电离源。 电离源可以用于从感兴趣的样品中离子化分子，以便基于离子鉴定分子。 在一个实施方案中，电离电离源包括在电触头之间环绕的导线。 导线用于响应于在电线和电离室的壁之间施加电压而形成电晕。 当电线和墙壁之间施加足够的电压时，可以形成电晕。 电线和形成电离室的壁之间的电位差可以用于将离子从电线中吸出。 在实施例中，可以加热导线以降低用于击打电晕的电压。 离子，随后可能离开目标样品的分子。 环形电晕源也可用于质谱仪（MS）。

公开(公告)号：US20140246581A1

公开(公告)日：2014-09-04

申请号：US14126259

申请日：2012-06-15

申请人： Daniel Levin ,  Vlad Sergeyev ,  Volodimir Bondarenko ,  Bohdan Atamanchuk ,  Qunzhou Bian ,  Henryk Zaleski ,  Mark Piniarski ,  Simon Feldberg ,  Ronald Jackson

发明人： Daniel Levin ,  Vlad Sergeyev ,  Volodimir Bondarenko ,  Bohdan Atamanchuk ,  Qunzhou Bian ,  Henryk Zaleski ,  Mark Piniarski ,  Simon Feldberg ,  Ronald Jackson

IPC分类号： G01N27/62 ,  H01J49/12

CPC分类号： G01N27/622 ,  H01J49/12 ,  H01J49/168

摘要： Looped ionization sources for ion mobility spectrometers are described. The ionization sources can be used to ionize molecules from a sample of interest in order to identify the molecules based on the ions. In an implementation, an electrical ionization source includes a wire that is looped between electrical contacts. The wire is used to form a corona responsive to application of voltage between the wire and the walls of an ionization chamber. The corona can form when a sufficient voltage is applied between the wire and the walls. A difference in electrical potential between the wire and a wall forming an ionization chamber, in which wire is contained, can be used to draw the ions away from the wire. In embodiments, the wire can be heated to reduce the voltage used to strike the corona. The ions, subsequently, may ionize the molecules from the sample of interest. The looped corona source can also be used in mass spectrometers (MS).

摘要翻译： 描述了用于离子迁移率光谱仪的环形电离源。 电离源可以用于从感兴趣的样品中离子化分子，以便基于离子鉴定分子。 在一个实施方案中，电离电离源包括在电触头之间环绕的导线。 导线用于响应于在电线和电离室的壁之间施加电压而形成电晕。 当电线和墙壁之间施加足够的电压时，可以形成电晕。 电线和形成电离室的壁之间的电位差可以用于将离子从电线中吸出。 在实施例中，可以加热导线以降低用于击打电晕的电压。 离子，随后可能离开目标样品的分子。 环形电晕源也可用于质谱仪（MS）。

公开(公告)号：US20070148774A1

公开(公告)日：2007-06-28

申请号：US11555519

申请日：2006-11-01

申请人： John McCafferty ,  Anthony Pope ,  Kevin Johnson ,  Hendricus Mattheus Hoogenboom ,  Andrew Griffiths ,  Ronald Jackson ,  Kasper Holliger ,  James Marks ,  Timothy Clackson ,  David Chiswell ,  Gregory Winter ,  Timothy Bonnert

发明人： John McCafferty ,  Anthony Pope ,  Kevin Johnson ,  Hendricus Mattheus Hoogenboom ,  Andrew Griffiths ,  Ronald Jackson ,  Kasper Holliger ,  James Marks ,  Timothy Clackson ,  David Chiswell ,  Gregory Winter ,  Timothy Bonnert

IPC分类号： C12N15/86 ,  C12N15/74

CPC分类号： C07K16/005 ,  B01J2219/00718 ,  C07K16/00 ,  C07K16/18 ,  C07K16/26 ,  C07K16/34 ,  C07K16/40 ,  C07K16/44 ,  C07K16/462 ,  C07K16/468 ,  C07K19/00 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/62 ,  C07K2317/622 ,  C07K2317/92 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/41 ,  C07K2319/735 ,  C12N15/1037 ,  C12N15/62 ,  C12N15/73 ,  C40B40/02 ,  G01N33/53 ,  G01N33/6857 ,  Y10S530/867

摘要： A member of a specific binding pair (sbp) is identified by expressing DNA encoding a genetically diverse population of such sbp members in recombinant host cells in which the sbp members are displayed in functional form at the surface of a secreted recombinant genetic display package (rgdp) containing DNA encoding the sbp member or a polypeptide component thereof, by virtue of the sbp member or a polypeptide component thereof being expressed as a fusion with a capsid component of the rgdp. The displayed sbps may be selected by affinity with a complementary sbp member, and the DNA recovered from selected rgdps for expression of the selected sbp members. Antibody sbp members may be thus obtained, with the different chains thereof expressed, one fused to the capsid component and the other in free form for association with the fusion partner polypeptide. A phagemid may be used as an expression vector, with said capsid fusion helping to package the phagemid DNA. Using this method libraries of DNA encoding respective chains of such multimeric sbp members may be combined, thereby obtaining a much greater genetic diversity in the sbp members than could easily be obtained by conventional methods.

摘要翻译： 特异性结合对（sbp）的成员通过在重组宿主细胞中表达编码这种sbp成员的遗传多样性群体的DNA来鉴定，其中sbp成员以分泌重组遗传显示包（rgdp）的表面以功能形式显示 ），其含有编码sbp成员或其多肽组分的DNA，其中sbp成员或其多肽组分被表达为与rgdp的衣壳组分的融合物。 显示的sbps可以通过与补充sbp成员的亲和力来选择，并且从所选的rgdps中恢复的DNA用于表达所选择的sbp成员。 因此可以获得抗体sbp成员，其中不同的链表达，一个与衣壳组分融合，另一个与游离形式融合，用于与融合伴侣多肽结合。 噬菌粒可以用作表达载体，所述衣壳融合有助于包装噬菌粒DNA。 使用这种方法，可以组合编码这种多聚体sbp成员的各个链的DNA文库，从而获得在sbp成员中比通过常规方法容易地获得的更大的遗传多样性。

公开(公告)号：US20060180333A1

公开(公告)日：2006-08-17

申请号：US11402739

申请日：2006-04-12

申请人： Julio Rodrigues ,  Ronald Jackson ,  Ed Jacobs

发明人： Julio Rodrigues ,  Ronald Jackson ,  Ed Jacobs

IPC分类号： H02G3/14

CPC分类号： H01R4/70 ,  H02G15/10

摘要： An insulated cover for electrical connectors which includes a transparent housing having a top section and a bottom section, a pair of opposing end walls and a plurality of flexible fingers extending inwardly from the periphery of an aperture in each end wall. The fingers have a plurality of transverse grooves which increase the flexibility of the fingers. The depth of the grooves increases towards their terminus to increase their flexibility.

公开(公告)号：US20070290043A1

公开(公告)日：2007-12-20

申请号：US11805837

申请日：2007-05-24

申请人： Garrett Russell ,  Mark Schmidt ,  Ronald Jackson ,  Sung Byun ,  Timothy Good

发明人： Garrett Russell ,  Mark Schmidt ,  Ronald Jackson ,  Sung Byun ,  Timothy Good

IPC分类号： G06K7/10

CPC分类号： G07G3/00 ,  A47F9/04 ,  G06K7/10574 ,  G06K7/10584 ,  G07G1/0036 ,  G07G1/0045 ,  G07G3/006

摘要： Novel POS-based bar code symbol reading systems are disclosed having an integrated customer-kiosk terminal. Also disclosed are novel POS-Based Bar Code Reading Cash Register Systems having Integrated Internet-Enabled Customer-Kiosk Terminals.

摘要翻译： 公开了一种新型的基于POS的条形码符号读取系统，其具有集成的顾客信息亭终端。 还公开了具有综合互联网的客户端站的基于POS的条形码读取收款机系统。

公开(公告)号：US07753269B2

公开(公告)日：2010-07-13

申请号：US11805837

申请日：2007-05-24

申请人： Garrett Russell ,  Mark Schmidt ,  Ronald Jackson ,  Sung Byun ,  Timothy A. Good

发明人： Garrett Russell ,  Mark Schmidt ,  Ronald Jackson ,  Sung Byun ,  Timothy A. Good

IPC分类号： G06K15/00

CPC分类号： G07G3/00 ,  A47F9/04 ,  G06K7/10574 ,  G06K7/10584 ,  G07G1/0036 ,  G07G1/0045 ,  G07G3/006

摘要： Novel POS-based bar code symbol reading systems are disclosed having an integrated customer-kiosk terminal. Also disclosed are novel POS-Based Bar Code Reading Cash Register Systems having Integrated Internet-Enabled Customer-Kiosk Terminals.

摘要翻译： 公开了一种新型的基于POS的条形码符号读取系统，其具有集成的顾客信息亭终端。 还公开了具有综合互联网的客户端站的基于POS的条形码读取收款机系统。

公开(公告)号：US20060038009A1

公开(公告)日：2006-02-23

申请号：US11203669

申请日：2005-08-12

申请人： Garrett Russell ,  Mark Schmidt ,  Ronald Jackson ,  Sung Byun ,  Timothy Good

发明人： Garrett Russell ,  Mark Schmidt ,  Ronald Jackson ,  Sung Byun ,  Timothy Good

IPC分类号： G06K15/00 ,  G06K7/10

CPC分类号： G07G3/00 ,  A47F9/04 ,  G06K7/10574 ,  G06K7/10584 ,  G07G1/0036 ,  G07G1/0045 ,  G07G3/006

摘要： Novel POS-based bar code symbol reading systems are disclosed having an integrated customer-kiosk terminal. Also disclosed are novel POS-Based Bar Code Reading Cash Register Systems having Integrated Internet-Enabled Customer-Kiosk Terminals.

摘要翻译： 公开了一种新型的基于POS的条形码符号读取系统，其具有集成的顾客信息亭终端。 还公开了具有综合互联网的客户端站的基于POS的条形码读取收款机系统。

公开(公告)号：US20060011372A1

公开(公告)日：2006-01-19

申请号：US11159495

申请日：2005-06-23

申请人： Julio Rodrigues ,  Ronald Jackson ,  Ed Jacobs

发明人： Julio Rodrigues ,  Ronald Jackson ,  Ed Jacobs

IPC分类号： H02G3/06

CPC分类号： H01R4/70 ,  H02G15/10

摘要： An insulated cover for electrical connectors which includes a transparent housing having a top section and a bottom section, a pair of opposing end walls and a plurality of flexible fingers extending inwardly from the periphery of an aperture in each end wall. The fingers have a plurality of transverse grooves which increase the flexibility of the fingers. The depth of the grooves increases towards their terminus to increase their flexibility.

摘要翻译： 一种用于电连接器的绝缘盖，其包括具有顶部和底部的透明壳体，一对相对的端壁和从每个端壁中的孔的周边向内延伸的多个柔性指状物。 手指具有多个横向凹槽，这增加了手指的柔韧性。 凹槽的深度朝着它们的末端增加以增加其柔性。

公开(公告)号：US20050049403A1

公开(公告)日：2005-03-03

申请号：US10625307

申请日：2003-07-23

申请人： Julia Thompson ,  Tristan Vaughan ,  Andrew Williams ,  Jonathan Green ,  Ronald Jackson ,  Louise Bacon ,  Kevin Johnson ,  Alison Wilton ,  Philip Tempest ,  Anthony Pope

发明人： Julia Thompson ,  Tristan Vaughan ,  Andrew Williams ,  Jonathan Green ,  Ronald Jackson ,  Louise Bacon ,  Kevin Johnson ,  Alison Wilton ,  Philip Tempest ,  Anthony Pope

IPC分类号： A61K38/00 ,  C07K16/22

CPC分类号： C07K16/22 ,  A61K38/00 ,  C07K2317/21 ,  C07K2317/622

摘要： Specific binding members comprising human antibody antigen binding domains specific for human transforming growth factor beta (TGFβ) bind specifically isoforms TGFβ2 and TGFβ1 or both, preferentially compared with TGFβ3. Specific binding members may be isolated and utilized in the treatment of disease, particularly fibrotic disease and also immune/inflammatory diseases. Therapeutic utility is demonstrated using in vitro and in vivo models. Full sequence and binding information is provided, including epitope sequence information for particularly advantageous specific binding member which binds the active form of TGFβ2, neutralizing its activity, but does not bind the latent member.

摘要翻译： 包含对人转化生长因子β（TGFbeta）特异性的人抗体结合结构域的特异性结合成员特异性结合TGFβ2和TGFbeta1或两者，优先与TGFbeta3相比较。 特异性结合成员可以被分离并用于治疗疾病，特别是纤维化疾病以及免疫/炎性疾病。 使用体外和体内模型证明治疗效用。 提供了完整的序列和结合信息，包括用于结合TGFβ2活性形式的特别有利的特异性结合成员的表位序列信息，中和其活性但不结合潜伏成员。