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22 条记录 (耗时 0.036 秒)

    Novel dicationic imidazo[1,2-a]pyridines and 5,6,7,8,-tetrahydro-imidazo[1,2,-a]pyridines as antiprotozoal agents
    5.
    发明申请
    Novel dicationic imidazo[1,2-a]pyridines and 5,6,7,8,-tetrahydro-imidazo[1,2,-a]pyridines as antiprotozoal agents 有权
    新型二环咪唑并[1,2-a]吡啶和5,6,7,8-四氢 - 咪唑并[1,2-a]吡啶作为抗原虫剂

    公开(公告)号：US20050282853A1

    公开(公告)日：2005-12-22

    申请号：US11074565

    申请日：2005-03-08

    申请人： David Boykin ,  Richard Tidwell ,  W. Wilson ,  Mohamed Ismail

    发明人： David Boykin ,  Richard Tidwell ,  W. Wilson ,  Mohamed Ismail

    IPC分类号： A61K31/4745 ,  C07D471/02 ,  C07D471/04

    CPC分类号： C07D471/04

    摘要： A method for treating a microbial infection, including an infection from a protozoan pathogen, such as Trypanosoma brucei rhodesiense and Plasmodium falciparum, in a subject in need thereof by administering to the subject an effective amount of a dicationic imidazopyridine compound or a dicationic tetrahydro-imidazopyridine compound. Processes for synthesizing dicationic imidazopyridines and dicationic tetrahydro-imidazopyridines and the novel dicationic imidazopyridine and dicationic tetrahydro-imidazopyridine compounds themselves.

    摘要翻译： 一种用于治疗微生物感染的方法，包括通过向受试者施用有效量的双阳离子咪唑并吡啶化合物或双阳离子四氢 - 咪唑并吡啶化合物，在有需要的受试者中治疗来自原生动物病原体（例如，罗氏黑曲霉和恶性疟原虫）的感染 复合。 双阳离子咪唑并吡啶和双阳离子四氢 - 咪唑并吡啶的合成方法以及新型的双阳离子咪唑并吡啶和双阳离子四氢 - 咪唑并吡啶化合物本身。

    Channel estimation in a CDMA receiver
    7.
    发明申请
    Channel estimation in a CDMA receiver 审中-公开
    CDMA接收机中的信道估计

    公开(公告)号：US20050213529A1

    公开(公告)日：2005-09-29

    申请号：US11033752

    申请日：2005-01-13

    申请人： Yuk Chow ,  Michael Fitton ,  Khurram Rizvi ,  Mohamed Ismail ,  Yan Bian

    发明人： Yuk Chow ,  Michael Fitton ,  Khurram Rizvi ,  Mohamed Ismail ,  Yan Bian

    IPC分类号： H04B1/707 ,  H04B7/216

    CPC分类号： H04B1/711 ,  H04B2201/70701

    摘要： A receiver for receiving a CDMA signal comprises a common channel interference cancellation facility operable to cancel common channel interference by applying a common channel interference estimate to the received signal through a weighted hybrid of parallel and serial interference cancellation, and a physical channel self-interference cancellation facility operable to cancel physical channel self-interference by applying an interference estimate to the received signal through a weighted hybrid of parallel and serial interference cancellation.

    摘要翻译： 用于接收CDMA信号的接收机包括公共信道干扰消除设备，其可操作以通过并行和串行干扰消除的加权混合以及物理信道自干扰消除对接收到的信号应用公共信道干扰估计来消除共同信道干扰 该设施可操作以通过并行和串行干扰消除的加权混合来对接收的信号应用干扰估计来消除物理信道自身干扰。

    Synthons for the synthesis and deprotection of peptide nucleic acids under mild conditions
    8.
    发明授权
    Synthons for the synthesis and deprotection of peptide nucleic acids under mild conditions 失效
    用于在温和条件下合成和去保护肽核酸的合成子

    公开(公告)号：US06172226B2

    公开(公告)日：2001-01-09

    申请号：US09116793

    申请日：1998-07-16

    申请人： James M. Coull ,  Michael Egholm ,  Richard P. Hodge ,  Mohamed Ismail ,  S. B. Rajur

    发明人： James M. Coull ,  Michael Egholm ,  Richard P. Hodge ,  Mohamed Ismail ,  S. B. Rajur

    IPC分类号： C07D23910

    CPC分类号： C07D239/47 ,  C07D473/18 ,  C07D473/34 ,  C07D473/40 ,  C07K14/003 ,  Y02P20/55

    摘要： A method is disclosed for preparing novel PNA synthons having protecting groups capable of removal under mild conditions. The PNA synthons are prepared by coupling novel N-substituted nucleobase intermediates having carbamate protection of the exocyclic amino group of the heterocycle to an amino protected backbone or an amino protected backbone ester of the amino acid N-(2-aminoethyl)-glycine. By the method of this invention, the resultant PNA synthons can have orthogonal protection of the carbamate protected nucleobase and the amino protected backbone. The PNA synthons are useful in the synthesis of peptide nucleic acids (PNAs) and other oligomers such as PNA-DNA chimeras, and may be used in automated synthesizers. Novel compositions of matter are also disclosed. In addition, a guanine PNA synthon having selective carbamate protection of the exocyclic 2-amino group with the C6 carbonyl group unprotected is disclosed.

    摘要翻译： 公开了一种制备具有能够在温和条件下去除的保护基的新型PNA合成子的方法。 通过将具有杂环的外环氨基的氨基甲酸酯保护的新的N-取代的核碱基中间体与氨基酸N-（2-氨基乙基） - 甘氨酸的氨基保护的主链或氨基保护的主链酯偶联来制备PNA合成子。 通过本发明的方法，所得的PNA合成子可以具有氨基甲酸酯保护的核碱基和氨基保护的主链的正交保护。 PNA合成子可用于合成肽核酸（PNA）和其他寡聚体如PNA-DNA嵌合体，并可用于自动合成仪中。 还公开了新的组合物。 此外，公开了具有不受保护的C6羰基的环外2-氨基的选择性氨基甲酸酯保护的鸟嘌呤PNA合成子。