公开(公告)号：US07787126B2

公开(公告)日：2010-08-31

申请号：US12079352

申请日：2008-03-26

申请人： David D. Nolte ,  Xuefeng Wang

发明人： David D. Nolte ,  Xuefeng Wang

IPC分类号： G01B9/02

CPC分类号： G01N21/45 ,  G01N2021/7776 ,  G01N2021/7779

摘要： A detection system for detecting target material is provided. The system comprises a photonic structure having a reflectance-band and associated side bands; an illumination source for illuminating at a wavelength in at least one of an edge of the reflectance-band and the side bands of the photonic structure and for generating a return beam; a detector system having an intensity-sensitive channel configured to detect an in-line signal from the return beam and a phase-sensitive channel configured to detect a differential phase contrast signal from the return beam; and a processing system for receiving and adding in quadrature the in-line signal and the differential phase contrast signal to generate a joint signal, and for determining one of the presence or the absence of the target material on the photonic structure using the joint signal.

摘要翻译： 提供了一种用于检测目标材料的检测系统。 该系统包括具有反射带和相关联的边带的光子结构; 用于在所述反射带的边缘和所述光子结构的所述边带中的至少一个中的波长处照射并用于产生返回光束的照明源; 具有强度敏感通道的检测器系统，其被配置为检测来自所述返回光束的直线信号;以及相敏通道，被配置为检测来自所述返回光束的差分相位差信号; 以及处理系统，用于接收并相加所述在线信号和所述差分相位对比信号以产生联合信号，并且使用所述联合信号来确定所述光子结构上的所述目标材料的存在或不存在。

公开(公告)号：US20080186477A1

公开(公告)日：2008-08-07

申请号：US12018108

申请日：2008-01-22

申请人： Xuefeng Wang ,  David D. Nolte ,  Manoj Varma ,  Brian Weichel ,  Timothy Norwood ,  Fouad Sayegh ,  Ming Zhao

发明人： Xuefeng Wang ,  David D. Nolte ,  Manoj Varma ,  Brian Weichel ,  Timothy Norwood ,  Fouad Sayegh ,  Ming Zhao

IPC分类号： G01N21/00

CPC分类号： G01N21/6452 ,  G01N21/253

摘要： A multi-modal data acquisition system for detecting target material on a biological reaction surface, the system comprising a radiation source for generating an incoming beam that impinges on the biological reaction surface at an oblique incidence angle and produces a reflected beam, an interferometric detector for detecting an interferometric signal from the illuminated surface, the reflected beam being directed to the interferometric detector, a fluorescence detector for detecting a fluorescence signal from the illuminated surface; the fluorescence detector being positioned to substantially minimize the incidence of the reflected beam; and a processing system for receiving the interferometric and fluorescence signals and determining the presence or absence of target material on the biological reaction surface. A reaction surface conditioned for the simultaneous collection of fluorescence, interferometric and other signals. A multi-modal data acquisition system for collecting and processing additional modes, including multiple interferometric, fluorescence and scattering channels.

摘要翻译： 一种多模式数据采集系统，用于检测生物反应表面上的目标材料，所述系统包括用于产生入射光束的辐射源，该入射光束以倾斜入射角度撞击在生物反应表面上并产生反射光束，干涉检测器 检测来自所述照射表面的干涉信号，所述反射光束被引导到所述干涉检测器;荧光检测器，用于检测来自被照射表面的荧光信号; 荧光检测器被定位成基本上最小化反射光束的入射; 以及用于接收干涉测量和荧光信号并确定生物反应表面上目标材料的存在或不存在的处理系统。 用于同时收集荧光，干涉仪和其他信号的反应表面。 一种多模式数据采集系统，用于收集和处理其他模式，包括多个干涉仪，荧光和散射通道。

公开(公告)号：US07659968B2

公开(公告)日：2010-02-09

申请号：US12018108

申请日：2008-01-22

申请人： Xuefeng Wang ,  David D. Nolte ,  Manoj Varma ,  Brian Weichel ,  Timothy Norwood ,  Fouad Sayegh ,  Ming Zhao

发明人： Xuefeng Wang ,  David D. Nolte ,  Manoj Varma ,  Brian Weichel ,  Timothy Norwood ,  Fouad Sayegh ,  Ming Zhao

IPC分类号： G01N21/00 ,  G01N21/64

CPC分类号： G01N21/6452 ,  G01N21/253

摘要： A multi-modal data acquisition system for detecting target material on a biological reaction surface, the system comprising a radiation source for generating an incoming beam that impinges on the biological reaction surface at an oblique incidence angle and produces a reflected beam, an interferometric detector for detecting an interferometric signal from the illuminated surface, the reflected beam being directed to the interferometric detector, a fluorescence detector for detecting a fluorescence signal from the illuminated surface; the fluorescence detector being positioned to substantially minimize the incidence of the reflected beam; and a processing system for receiving the interferometric and fluorescence signals and determining the presence or absence of target material on the biological reaction surface. A reaction surface conditioned for the simultaneous collection of fluorescence, interferometric and other signals. A multi-modal data acquisition system for collecting and processing additional modes, including multiple interferometric, fluorescence and scattering channels.

摘要翻译： 一种多模式数据采集系统，用于检测生物反应表面上的目标材料，所述系统包括用于产生入射光束的辐射源，该入射光束以倾斜入射角度撞击在生物反应表面上并产生反射光束，干涉检测器 检测来自所述照射表面的干涉信号，所述反射光束被引导到所述干涉检测器;荧光检测器，用于检测来自被照射表面的荧光信号; 荧光检测器被定位成基本上最小化反射光束的入射; 以及用于接收干涉测量和荧光信号并确定生物反应表面上目标材料的存在或不存在的处理系统。 用于同时收集荧光，干涉仪和其他信号的反应表面。 一种多模式数据采集系统，用于收集和处理其他模式，包括多个干涉仪，荧光和散射通道。

公开(公告)号：US20080304073A1

公开(公告)日：2008-12-11

申请号：US12079352

申请日：2008-03-26

申请人： David D. Nolte ,  Xuefeng Wang

发明人： David D. Nolte ,  Xuefeng Wang

IPC分类号： G01B9/02

CPC分类号： G01N21/45 ,  G01N2021/7776 ,  G01N2021/7779

摘要： A detection system for detecting target material is provided. The system comprises a photonic structure having a reflectance-band and associated side bands; an illumination source for illuminating at a wavelength in at least one of an edge of the reflectance-band and the side bands of the photonic structure and for generating a return beam; a detector system having an intensity-sensitive channel configured to detect an in-line signal from the return beam and a phase-sensitive channel configured to detect a differential phase contrast signal from the return beam; and a processing system for receiving and adding in quadrature the in-line signal and the differential phase contrast signal to generate a joint signal, and for determining one of the presence or the absence of the target material on the photonic structure using the joint signal.

摘要翻译： 提供了一种用于检测目标材料的检测系统。 该系统包括具有反射带和相关联的边带的光子结构; 用于在所述反射带的边缘和所述光子结构的所述边带中的至少一个中的波长处照射并用于产生返回光束的照明源; 具有强度敏感通道的检测器系统，其被配置为检测来自所述返回光束的直线信号;以及相敏通道，被配置为检测来自所述返回光束的差分相位差信号; 以及处理系统，用于接收并相加所述在线信号和所述差分相位对比信号以产生联合信号，并且使用所述联合信号来确定所述光子结构上的所述目标材料的存在或不存在。

公开(公告)号：US08072585B2

公开(公告)日：2011-12-06

申请号：US12650692

申请日：2009-12-31

申请人： Xuefeng Wang ,  David D. Nolte ,  Manoj Varma ,  Brian Weichel ,  Timothy Norwood ,  Fouad Sayegh ,  Ming Zhao

发明人： Xuefeng Wang ,  David D. Nolte ,  Manoj Varma ,  Brian Weichel ,  Timothy Norwood ,  Fouad Sayegh ,  Ming Zhao

IPC分类号： G01N21/00 ,  G01N21/64

CPC分类号： G01N21/6452 ,  G01N21/253

摘要： A multi-modal data acquisition system for detecting target material on a biological reaction surface, the system comprising a radiation source for generating an incoming beam that impinges on the biological reaction surface at an oblique incidence angle and produces a reflected beam, an interferometric detector for detecting an interferometric signal from the illuminated surface, the reflected beam being directed to the interferometric detector, a fluorescence detector for detecting a fluorescence signal from the illuminated surface; the fluorescence detector being positioned to substantially minimize the incidence of the reflected beam; and a processing system for receiving the interferometric and fluorescence signals and determining the presence or absence of target material on the biological reaction surface. A reaction surface conditioned for the simultaneous collection of fluorescence, interferometric and other signals. A multi-modal data acquisition system for collecting and processing additional modes, including multiple interferometric, fluorescence and scattering channels.

摘要翻译： 一种多模式数据采集系统，用于检测生物反应表面上的目标材料，所述系统包括用于产生入射光束的辐射源，该入射光束以倾斜入射角度撞击在生物反应表面上并产生反射光束，干涉检测器 检测来自所述照射表面的干涉信号，所述反射光束被引导到所述干涉检测器;荧光检测器，用于检测来自被照射表面的荧光信号; 荧光检测器被定位成基本上最小化反射光束的入射; 以及用于接收干涉测量和荧光信号并确定生物反应表面上目标材料的存在或不存在的处理系统。 用于同时收集荧光，干涉仪和其他信号的反应表面。 一种多模式数据采集系统，用于收集和处理其他模式，包括多个干涉仪，荧光和散射通道。

公开(公告)号：US20100145627A1

公开(公告)日：2010-06-10

申请号：US12650692

申请日：2009-12-31

申请人： Xuefeng Wang ,  David D. Nolte ,  Manoj Varma ,  Brian Weichel ,  Timothy Norwood ,  Fouad Sayegh ,  Ming Zhao

发明人： Xuefeng Wang ,  David D. Nolte ,  Manoj Varma ,  Brian Weichel ,  Timothy Norwood ,  Fouad Sayegh ,  Ming Zhao

IPC分类号： G01N33/48 ,  G01N21/00 ,  G06F19/00

CPC分类号： G01N21/6452 ,  G01N21/253

摘要： A multi-modal data acquisition system for detecting target material on a biological reaction surface, the system comprising a radiation source for generating an incoming beam that impinges on the biological reaction surface at an oblique incidence angle and produces a reflected beam, an interferometric detector for detecting an interferometric signal from the illuminated surface, the reflected beam being directed to the interferometric detector, a fluorescence detector for detecting a fluorescence signal from the illuminated surface; the fluorescence detector being positioned to substantially minimize the incidence of the reflected beam; and a processing system for receiving the interferometric and fluorescence signals and determining the presence or absence of target material on the biological reaction surface. A reaction surface conditioned for the simultaneous collection of fluorescence, interferometric and other signals. A multi-modal data acquisition system for collecting and processing additional modes, including multiple interferometric, fluorescence and scattering channels.

摘要翻译： 一种多模式数据采集系统，用于检测生物反应表面上的目标材料，所述系统包括用于产生入射光束的辐射源，该入射光束以倾斜入射角度撞击在生物反应表面上并产生反射光束，干涉检测器 检测来自所述照射表面的干涉信号，所述反射光束被引导到所述干涉检测器;荧光检测器，用于检测来自被照射表面的荧光信号; 荧光检测器被定位成基本上最小化反射光束的入射; 以及用于接收干涉测量和荧光信号并确定生物反应表面上目标材料的存在或不存在的处理系统。 用于同时收集荧光，干涉仪和其他信号的反应表面。 一种多模式数据采集系统，用于收集和处理其他模式，包括多个干涉仪，荧光和散射通道。

公开(公告)号：US08751939B2

公开(公告)日：2014-06-10

申请号：US13094684

申请日：2011-04-26

申请人： Margaret Law ,  Rashmi Channarayapattna ,  Jason Ellis ,  Anshu Agarwal ,  Xuefeng Wang

发明人： Margaret Law ,  Rashmi Channarayapattna ,  Jason Ellis ,  Anshu Agarwal ,  Xuefeng Wang

IPC分类号： G06F3/00 ,  G06F3/048

CPC分类号： G06F3/0483 ,  G06F3/0482 ,  G06F3/0486 ,  G06F17/30522

摘要： Systems and methods for displaying tab elements representing viewable page elements. A set of one or more main tabs are displayed on a first portion of a display, each main tab defining a link to a database object stored in a database. A user selection of a first one of the main tabs is received (e.g., to determine which tab provides default display), and two or more side tabs are displayed in a first, default order on a second portion of the display, each said side tab defining a link to an element or portion of a first object. In certain aspects, a user selection of a new order for the two or more side tabs is received, and thereafter the two or more side tabs are displayed in the new order, and the new order is stored to the database, wherein upon later access of the first object by the user, the two or more side tabs are automatically displayed in the new order.

摘要翻译： 用于显示表示可视页面元素的选项卡元素的系统和方法。 一组一个或多个主标签显示在显示器的第一部分上，每个主标签定义到存储在数据库中的数据库对象的链接。 接收对主标签中的第一个标签的用户选择（例如，以确定哪个标签提供默认显示），并且两个或更多个侧标签以显示器的第二部分上的第一默认顺序显示，每个所述侧 选项卡定义到第一个对象的元素或部分的链接。 在某些方面，接收用户对两个或更多个侧面选项卡的新订单的选择，然后以新的顺序显示两个或更多个侧面选项卡，并且将新的订单存储到数据库，其中在稍后访问 由用户提供的第一个对象，两个或更多个侧面选项卡将以新的顺序自动显示。

公开(公告)号：US08685749B2

公开(公告)日：2014-04-01

申请号：US12629088

申请日：2009-12-02

申请人： Philip Alexander Shoemaker ,  Weston Blaine Griffin ,  Erin Jean Finehout ,  Xuefeng Wang ,  Kashan Ali Shaikh ,  Greg Darryl Goddard

发明人： Philip Alexander Shoemaker ,  Weston Blaine Griffin ,  Erin Jean Finehout ,  Xuefeng Wang ,  Kashan Ali Shaikh ,  Greg Darryl Goddard

IPC分类号： G01N15/08 ,  C12Q1/02 ,  C12M1/34

CPC分类号： G01N1/4055 ,  B01L3/5025 ,  B01L3/50255 ,  B01L2200/025 ,  B01L2200/0689 ,  B01L2300/0627 ,  B01L2300/0829 ,  B01L2300/0832 ,  G01N1/34 ,  G01N1/405 ,  G01N1/4077 ,  G01N30/7233 ,  G01N35/00029 ,  G01N35/1095 ,  G01N2001/4061 ,  G01N2001/4088 ,  G01N2030/009 ,  G01N2030/062 ,  G01N2035/00128 ,  Y10T436/24 ,  Y10T436/25 ,  Y10T436/25375 ,  Y10T436/255

摘要： Methods and systems for processing samples fixed to a porous substrate generally comprising, a compressor defining one or more fluid isolation areas, a support, for the porous substrate, having an opening corresponding to one or more of the fluid isolation areas of the compressor, an actuator that causes at least a portion of the compressor to press against the porous substrate, a fluid inlet having access to the fluid isolation area at least when the compressor is pressed against the porous substrate, and a fluid outlet to receive fluid, through the opening in the support corresponding to the fluid isolation area of the compressor, at least when the compressor is pressed against the porous substrate.

摘要翻译： 用于处理固定到多孔基材的样品的方法和系统通常包括限定一个或多个流体隔离区域的压缩机，用于多孔基材的支撑体，其具有对应于压缩机的一个或多个流体隔离区域的开口， 致动器，其使至少一部分压缩机压靠多孔基底，至少当压缩机被压靠在多孔基底上时，流体入口至少进入流体隔离区域，以及流体出口以接收流体，通过开口 在对应于压缩机的流体隔离区域的支撑件中，至少当压缩机被压靠在多孔基底上时。

公开(公告)号：US20130168548A1

公开(公告)日：2013-07-04

申请号：US13340401

申请日：2011-12-29

申请人： Xuefeng Wang ,  Bo Li ,  Cheng-Po Chen ,  Rui Chen

发明人： Xuefeng Wang ,  Bo Li ,  Cheng-Po Chen ,  Rui Chen

IPC分类号： H01J49/10 ,  H01J49/36 ,  H01J49/28

CPC分类号： A61B5/082 ,  G01N27/622 ,  G01N27/624 ,  G01N33/497

摘要： Disclosed embodiments include systems for analyzing the breath of a patient for the presence of one or more analytes of interest. The systems may include an ion detection system capable of receiving a gas mixture having an analyte of interest expired by a patient, flowing the gas mixture, and ionizing molecules within the gas mixture. The molecules include at least the analyte of interest. The ion detection system is also capable of detecting the ionized analyte of interest.

摘要翻译： 公开的实施方案包括用于分析患者的呼吸以了解感兴趣的一种或多种分析物的存在的系统。 该系统可以包括离子检测系统，其能够接收具有患者期望的分析物的气体混合物，使气体混合物流动，以及离子化气体混合物内的分子。 分子至少包括目标分析物。 离子检测系统还能够检测感兴趣的电离分析物。

公开(公告)号：US08232408B2

公开(公告)日：2012-07-31

申请号：US12920320

申请日：2009-03-10

申请人： Jiamei Chen ,  Tongbu Lu ,  Song Chen ,  Jinghui Cai ,  Zhaolin Fu ,  Zhe He ,  Xuefeng Wang ,  Chaozhi Wang ,  Yonge Liu ,  Lijian Tao ,  Gaoyun Hu

发明人： Jiamei Chen ,  Tongbu Lu ,  Song Chen ,  Jinghui Cai ,  Zhaolin Fu ,  Zhe He ,  Xuefeng Wang ,  Chaozhi Wang ,  Yonge Liu ,  Lijian Tao ,  Gaoyun Hu

IPC分类号： C07D211/72 ,  A61K31/44

CPC分类号： C07D213/64

摘要： Crystalline pyridone compound, which is the white needle crystal containing no water and other crystallization solvents. Its unit cell belongs to monoclinic system and has space group of P21/n, wherein a=3.8512(2), b=20.2535(12), c=12.1628(6) Å, β=92.850(5)° and crystal cell volume V=947.53(9) Å3. Pyridone compound crystal of this form has the needed properties for preparing or making treatment compositions in large scale. It can be used for treating organs fibrosis of liver, kidney, lung and etc. and reducing skin scars.

摘要翻译： 结晶吡啶酮化合物，其是不含水和其他结晶溶剂的白色针状结晶。 其单元属于单斜晶系，具有P21 / n的空间群，其中a = 3.8512（2），b = 20.2535（12），c = 12.1628（6），bgr = 92.850（5） 体积V = 947.53（9）Å3。 这种形式的吡啶酮化合物晶体具有大规模制备或制备治疗组合物所需的性质。 可用于治疗肝，肾，肺等器官纤维化，减少皮肤瘢痕。