公开(公告)号：US20120281212A1

公开(公告)日：2012-11-08

申请号：US13384954

申请日：2010-01-29

Applicant: David Fattal ,  Zhiyong Li

Inventor： David Fattal ,  Zhiyong Li

IPC: G01N21/01 ,  G01N21/65

CPC classification number: G01N21/658 ,  B82Y20/00 ,  G01N21/554 ,  G01N21/7743

Abstract: A self-collecting substrate (10) for surface enhanced Raman spectroscopy having a first surface (10a) and a second surface (10b) opposed thereto, comprising: a waveguiding layer (10′) supported on a support layer (10″), with the waveguiding layer associated with the first surface and the support layer associated with the second surface; and a plurality of metal nano-antennae (14) established on the first surface and operatively associated with the plurality of openings such that exposure of analyte (18) to the light causes preferential aggregation of the analystes in the vicinity of the nano-antennae. A system (50) for at least one of attracting the analytes 18) to the metal nano-antennae (14) and performing surface enhanced Raman spectroscopy using the substrate (10) and a method for increasing a signal for surface enhanced Raman spectroscopy are provided.

Abstract translation: 一种用于表面增强拉曼光谱的自动采集衬底（10），具有与其相对的第一表面（10a）和第二表面（10b），包括：支撑在支撑层（10“）上的波导层（10'）， 与第一表面相关联的波导层和与第二表面相关联的支撑层; 以及多个金属纳米天线（14），其建立在所述第一表面上并且与所述多个开口可操作地相关联，使得分析物（18）暴露于所述光引起所述分析物在所述纳米天线附近的优先聚集。 提供了用于使金属纳米天线（14）吸引分析物18）和使用基板（10）进行表面增强拉曼光谱的系统（50）和用于增加表面增强拉曼光谱信号的方法的系统（50） 。

公开(公告)号：US20100020327A1

公开(公告)日：2010-01-28

申请号：US12262151

申请日：2008-10-30

Applicant: David Fattal ,  Zhiyong Li

Inventor： David Fattal ,  Zhiyong Li

IPC: G01N21/55

CPC classification number: G01N21/658

Abstract: A plasmonic conveyor, system and method of plasmonic conveyance employ a surface plasmon that is controllably moved on a surface of a plasmonic element. The conveyor includes a first plasmonic element and a second plasmonic element that individually supports a respective surface plasmon. The conveyor further includes a controller that provides controlled movement of a location of the respective surface plasmon on a surface of the plasmonic element. The controlled movement facilitates translocation of an analyte particle around a periphery of the respective plasmonic element using a high field region of the respective surface plasmon. The system includes the conveyor and an excitation signal source that provides an excitation signal having one or both of a polarization and a frequency that are controllably variable. The method includes exciting a surface plasmon with the excitation signal and moving a location of the excited surface plasmon.

Abstract translation: 等离子体激元输送机，等离子体激元传输的系统和方法采用可等离子体激元在等离子体元素表面上移动的表面等离子体激元。 输送机包括单独支撑相应的表面等离子体激元的第一等离子体元素和第二等离子体元素。 输送机还包括一个控制器，该控制器提供相应表面等离子体的位置的受控运动在等离子体元素的表面上。 受控运动有助于使用相应表面等离子体激元的高场区域使分析物质绕相应等离子体元素周围的位移。 该系统包括输送机和激励信号源，其提供具有可控地变化的偏振和频率中的一个或两个的激励信号。 该方法包括用激发信号激发表面等离子体激元并移动受激表面等离子体的位置。

公开(公告)号：US07876444B2

公开(公告)日：2011-01-25

申请号：US12262151

申请日：2008-10-30

Applicant: David Fattal ,  Zhiyong Li

Inventor： David Fattal ,  Zhiyong Li

IPC: G01N21/55

CPC classification number: G01N21/658

Abstract: A plasmonic conveyor, system and method of plasmonic conveyance employ a surface plasmon that is controllably moved on a surface of a plasmonic element. The conveyor includes a first plasmonic element and a second plasmonic element that individually supports a respective surface plasmon. The conveyor further includes a controller that provides controlled movement of a location of the respective surface plasmon on a surface of the plasmonic element. The controlled movement facilitates translocation of an analyte particle around a periphery of the respective plasmonic element using a high field region of the respective surface plasmon. The system includes the conveyor and an excitation signal source that provides an excitation signal having one or both of a polarization and a frequency that are controllably variable. The method includes exciting a surface plasmon with the excitation signal and moving a location of the excited surface plasmon.

Abstract translation: 等离子体激元输送机，等离子体激元传输的系统和方法采用可等离子体激元在等离子体元素表面上移动的表面等离子体激元。 输送机包括单独支撑相应的表面等离子体激元的第一等离子体元素和第二等离子体元素。 输送机还包括一个控制器，该控制器提供相应表面等离子体的位置的受控运动在等离子体元素的表面上。 受控运动有助于使用相应表面等离子体激元的高场区域使分析物质绕相应等离子体元素周围的位移。 该系统包括输送机和激励信号源，其提供具有可控地变化的偏振和频率中的一个或两个的激励信号。 该方法包括用激发信号激发表面等离子体激元并移动受激表面等离子体的位置。

公开(公告)号：US10520440B2

公开(公告)日：2019-12-31

申请号：US14377524

申请日：2012-02-08

Applicant: Devin Alexander Mourey ,  James William Stasiak ,  James Elmer Abbott, Jr. ,  Zhiyong Li

Inventor： Devin Alexander Mourey ,  James William Stasiak ,  James Elmer Abbott, Jr. ,  Zhiyong Li

IPC: G01J3/44 ,  G01N21/65

Abstract: Molecule sensing apparatus. The apparatus has first and second chambers, an input port extending into the first chamber, a fluid channel extending from the first chamber to the second chamber, and a surface-enhanced substrate in the second chamber.

公开(公告)号：US09709538B2

公开(公告)日：2017-07-18

申请号：US14239330

申请日：2011-09-30

Applicant: Wei Wu ,  Zhiyong Li ,  Ansoon Kim ,  Min Hu ,  Michael Josef Stuke

Inventor： Wei Wu ,  Zhiyong Li ,  Ansoon Kim ,  Min Hu ,  Michael Josef Stuke

IPC: G01N31/22 ,  G01N21/64 ,  G01N21/65 ,  B01L3/00 ,  B82Y15/00

CPC classification number: G01N31/22 ,  B01L3/5085 ,  B01L3/50853 ,  B01L2200/141 ,  B01L2300/0636 ,  B01L2300/069 ,  B01L2300/0819 ,  B82Y15/00 ,  G01N21/648 ,  G01N21/658 ,  G01N2201/0227 ,  G01N2201/023 ,  Y10T436/25

Abstract: Devices to detect a substance and methods of producing such a device are disclosed. An example device to detect a substance includes a housing defining an externally accessible chamber and a seal to enclose at least a portion of the chamber. The example device also includes a substrate includes nanoparticles positioned within the chamber. The nanoparticles to react to the substance when exposed thereto. The example device also includes a non-analytic solution within the chamber to protect the nanoparticles from premature exposure.

公开(公告)号：US09678013B2

公开(公告)日：2017-06-13

申请号：US14394295

申请日：2012-04-20

Applicant: Alexandre M. Bratkovski ,  Zhiyong Li ,  Wei Wu ,  Min Hu ,  R. Stanley Williams ,  Ansoon Kim

Inventor： Alexandre M. Bratkovski ,  Zhiyong Li ,  Wei Wu ,  Min Hu ,  R. Stanley Williams ,  Ansoon Kim

IPC: G01N21/01 ,  G01N21/65 ,  G01N35/00 ,  B01L3/00 ,  G01N21/64

CPC classification number: G01N21/658 ,  B01L3/5088 ,  B01L2300/0627 ,  B01L2300/0819 ,  B01L2300/161 ,  G01N21/648 ,  G01N35/00009 ,  G01N2035/00019

Abstract: Examples of integrated sensors are disclosed herein. An example of an integrated sensor includes a substrate and a sensing member formed on a surface of the substrate. The sensing member includes collapsible signal amplifying structures and an area surrounding the collapsible signal amplifying structures that enables self-positioning of droplets exposed thereto toward the collapsible signal amplifying structures.

公开(公告)号：US09592001B2

公开(公告)日：2017-03-14

申请号：US14406601

申请日：2012-07-29

Applicant: Steven Barcelo ,  Zhiyong Li ,  Ansoon Kim ,  Gary Gibson

Inventor： Steven Barcelo ,  Zhiyong Li ,  Ansoon Kim ,  Gary Gibson

IPC: G01J3/44 ,  A61B5/1459 ,  G01N21/65 ,  A61B5/00

CPC classification number: A61B5/1459 ,  A61B5/0075 ,  A61B5/6862 ,  G01N21/658

Abstract: An implantable nanosensor includes a stent to be implanted inside a fluid conduit. The stent has a well in a surface of the stent. The implantable nanosensor further includes a nanoscale-patterned sensing substrate disposed in the well. The nanoscale-patterned sensing substrate is to produce an optical scattering response signal indicative of a presence of an analyte in a fluid carried by the fluid conduit when interrogated by an optical stimulus signal.

Abstract translation: 可植入纳米传感器包括待植入流体导管内的支架。 支架在支架表面有一个井。 可植入纳米传感器还包括设置在井中的纳米级图案感测基片。 纳米级图案化感测衬底将产生光学散射响应信号，该信号指示由光学刺激信号询问时由流体导管携带的流体中分析物的存在。

公开(公告)号：US09310306B2

公开(公告)日：2016-04-12

申请号：US14006436

申请日：2011-03-24

Applicant: Zhiyong Li ,  Ivan Naumov ,  Farzad Parvaresh

Inventor： Zhiyong Li ,  Ivan Naumov ,  Farzad Parvaresh

IPC: G01J3/44 ,  G01N21/65 ,  B05D3/00

CPC classification number: G01N21/65 ,  B05D3/007 ,  G01N21/658

Abstract: An apparatus for use in sensing applications includes a substrate and a plurality of clusters arranged in an aperiodic configuration on the substrate, wherein each of the plurality of clusters is formed of a plurality of Raman-active material nano-particles, and wherein each of the Raman-active material nano-particles is positioned in a substantially ordered configuration with respect to each other in each of the respective plurality of clusters.

Abstract translation: 用于感测应用的装置包括基板和在基板上以非周期配置布置的多个簇，其中多个簇中的每一个由多个拉曼活性材料纳米颗粒形成，并且其中 拉曼活性材料纳米颗粒在相应的多个簇中的每一个中相对于彼此定位成基本排列的构型。

公开(公告)号：US20150241355A1

公开(公告)日：2015-08-27

申请号：US14406653

申请日：2012-07-31

Applicant: Shih-Yuan Wang ,  Gary Gibson ,  Zhiyong Li ,  Alexandre M. Bratkovski ,  Steven Barcelo ,  Ansoon Kim ,  Mineo Yamakawa ,  Zhang-Lin Zhou ,  Huei Pei Kuo

Inventor： Shih-Yuan Wang ,  Gary Gibson ,  Zhiyong Li ,  Alexandre M. Bratkovski ,  Steven Barcelo ,  Ansoon Kim ,  Mineo Yamakawa ,  Zhang-Lin Zhou ,  Huei Pei Kuo

IPC: G01N21/65 ,  A61F2/02 ,  A61F2/82 ,  G02B5/10

CPC classification number: G01N21/658 ,  A61F2/02 ,  A61F2/82 ,  G01N2201/068 ,  G02B5/10 ,  Y10T29/49826

Abstract: According to an example, an apparatus for performing spectroscopy includes a parabolic reflector and a plurality of surface-enhanced Raman spectroscopy (SERS) elements spaced from the parabolic reflector and positioned substantially at a focal point of the parabolic reflector. The parabolic reflector is to reflect Raman scattered light emitted from molecules in a near field generated by the plurality of SERS elements to substantially increase the flux of the Raman scattered light emitted out of the apparatus.

Abstract translation: 根据一个实例，用于执行光谱学的装置包括抛物面反射器和与抛物面反射器间隔开并且基本上位于抛物面反射器的焦点的多个表面增强拉曼光谱（SERS）元件。 抛物面反射器是反射由多个SERS元件产生的近场中的分子发射的拉曼散射光，以大大增加从该装置发出的拉曼散射光的通量。

公开(公告)号：US09001324B2

公开(公告)日：2015-04-07

申请号：US13810982

申请日：2010-07-30

Applicant: Zhiyong Li ,  Min Hu ,  Wei Wu

Inventor： Zhiyong Li ,  Min Hu ,  Wei Wu

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01N21/658

Abstract: A surface enhanced Raman spectroscopy (SERS) probe apparatus and a method of SERS probing employ Raman-active surfaces of a plurality of nanoscale field concentrator (NFC) structures at a terminal end of an optical fiber. The SERS probe apparatus includes an optical fiber having an optical path and a terminal end that terminates the optical path. The SERS probe apparatus further includes a plurality of NFC structures and nanoparticles on surfaces of the plurality of NFC structures. First ends of the NFC structures are adjacent to the terminal end of optical fiber. The nanoparticles are Raman active to an analyte.

Abstract translation: 表面增强拉曼光谱（SERS）探针装置和SERS探测的方法在光纤的末端使用多个纳米尺度场集中器（NFC）结构的拉曼活性表面。 SERS探针装置包括具有光路的光纤和终止光路的终端。 SERS探针装置还包括在多个NFC结构的表面上的多个NFC结构和纳米颗粒。 NFC结构的第一端与光纤的终端相邻。 纳米颗粒是对分析物有活性的拉曼。