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公开(公告)号：US20140182579A1
公开(公告)日：2014-07-03
申请号：US14029932
申请日：2013-09-18
申请人： David George Allen
发明人： David George Allen
IPC分类号： F24J2/05
摘要： A solar energy collection conduit (10) comprising an optical concentrator (40) incorporated into an outer tube (30) having a sunlight-transmitting ceiling (32). The concentrator (40) focuses, guides, directs, and/or otherwise concentrates sunlight towards a pipe (50). Fluid (60) conveyed by the pipe (50) can be heated to very high temperatures (e.g., up to and above about 100° C., about 200° C., and/or about 300° C.).
摘要翻译： 一种太阳能收集管道（10），其包括结合到具有阳光透射天花板（32）的外管（30）中的聚光器（40）。 集中器（40）聚焦，引导，引导和/或以其他方式将太阳光集中到管道（50）。 由管道（50）输送的流体（60）可被加热到非常高的温度（例如，高达和高于约100℃，约200℃和/或约300℃）。
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公开(公告)号：US06495528B1
公开(公告)日：2002-12-17
申请号：US09720390
申请日：2001-02-20
申请人： David George Allen , Chuen Chan , Richard Peter Charles Cousins , Brian Cox , Joanna Victoria Geden , Heather Hobbs , Suzanne Elaine Keeling , Alison Judith Redgrave , Thomas Davis Roper, IV , Shiping Xie
发明人： David George Allen , Chuen Chan , Richard Peter Charles Cousins , Brian Cox , Joanna Victoria Geden , Heather Hobbs , Suzanne Elaine Keeling , Alison Judith Redgrave , Thomas Davis Roper, IV , Shiping Xie
IPC分类号： A61L3170
CPC分类号： C07H19/16 , A61K31/7076 , C07H7/06 , Y10S514/885
摘要： A series of 2-(Purin-9-yl)-tetrahydrofuran-3,4-diol derivatives with broad anti-inflammatory properties which inhibit leukocyte recruitment and activation and which are agonists of the adenosine 2a receptor are described.
摘要翻译： 描述了一系列具有抑制白细胞募集和活化并且是腺苷2a受体激动剂的广泛抗炎性质的2-（嘌呤-9-基） - 四氢呋喃-3,4-二醇衍生物。
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公开(公告)号：US06426337B1
公开(公告)日：2002-07-30
申请号：US09331526
申请日：1999-08-20
申请人： Brian Cox , Suzanne Elaine Keeling , David George Allen , Alison Judith Redgrave , Michael David Barker , Heather Hobbs , Thomas Davis Roper, IV , Joanna Victoria Geden
发明人： Brian Cox , Suzanne Elaine Keeling , David George Allen , Alison Judith Redgrave , Michael David Barker , Heather Hobbs , Thomas Davis Roper, IV , Joanna Victoria Geden
IPC分类号： A61K3170
CPC分类号： C07D473/00 , C07H19/16 , Y10S514/826 , Y10S514/851 , Y10S514/885 , Y10S514/921 , Y10S514/925
摘要： There are provided according to the invention novel compounds of formula (I) wherein R1, R2, and R3 are as described in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.
摘要翻译： 根据本发明提供新的式（I）化合物，其中R 1，R 2和R 3如说明书中所述，其制备方法，含有它们的制剂及其在治疗炎性疾病中的用途。
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公开(公告)号：US07985740B2
公开(公告)日：2011-07-26
申请号：US11995921
申请日：2006-07-17
CPC分类号： C07H19/16
摘要： The invention provides novel compounds which are agonists of the adenosine 2A receptor along with pharmaceutical compositions thereof, and methods of administering such compounds.
摘要翻译： 本发明提供了作为腺苷2A受体的激动剂及其药物组合物的新化合物，以及施用这些化合物的方法。
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公开(公告)号：US06528494B2
公开(公告)日：2003-03-04
申请号：US10025678
申请日：2001-12-19
申请人： Brian Cox , Suzanne Elaine Keeling , David George Allen , Alison Judith Redgrave , Michael David Barker , Heather Hobbs , Thomas Davis Roper, IV , Joanna Victoria Geden
发明人： Brian Cox , Suzanne Elaine Keeling , David George Allen , Alison Judith Redgrave , Michael David Barker , Heather Hobbs , Thomas Davis Roper, IV , Joanna Victoria Geden
IPC分类号： A01N4304
CPC分类号： C07D473/00 , C07H19/16 , Y10S514/826 , Y10S514/851 , Y10S514/885 , Y10S514/921 , Y10S514/925
摘要： There are provided according to the invention novel compounds of formula I wherein R1, R2 and R3 are as described in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.
摘要翻译： 根据本发明提供新的式I化合物，其中R 1，R 2和R 3如说明书中所述，其制备方法，含有它们的制剂及其在治疗炎性疾病中的应用。
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6.发明授权
公开(公告)号：US5861414A
公开(公告)日：1999-01-19
申请号：US836981
申请日：1997-05-29
IPC分类号： C07D401/04 , A61K20060101 , A61K31/415 , A61K31/4427 , A61K31/445 , A61P7/02 , C07D20060101 , C07D401/14
CPC分类号： C07D401/14
摘要： The invention provides the compounds of formula (I) ##STR1## and pharmaceutically acceptable derivatives thereof, in which: X represents either CH.sub.2 --CH.sub.2 or CH.dbd.CH, andY represents a hydrogen atom or a phenylmethyl group, wherein the phenyl group is optionally substituted by one or more halogen atoms.Compounds of formula (I) inhibit blood platelet aggregation.
摘要翻译： PCT No.PCT / EP95 / 05043 Sec。 371日期1997年5月29日 102（e）日期1997年5月29日PCT 1995年12月21日PCT PCT。 公开号WO96 / 20192 日期：1996年7月4日本发明提供式（I）化合物及其药学上可接受的衍生物，其中：X表示CH 2 -CH 2或CH = CH，Y表示氢原子或苯甲基 基团，其中苯基任选被一个或多个卤素原子取代。 式（I）化合物抑制血小板聚集。
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![PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS, AND THEIR USE AS PDE4 INHIBITORS](/abs-image/US/2009/12/24/US20090318494A1/abs.jpg.150x150.jpg)
7.发明申请PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS, AND THEIR USE AS PDE4 INHIBITORS 审中-公开吡咯并[3,4-B]吡啶化合物及其用作PDE4抑制剂公开(公告)号：US20090318494A1
公开(公告)日：2009-12-24
申请号：US12375695
申请日：2007-08-01
IPC分类号： A61K31/437 , C07D471/04 , A61P29/00 , A61P11/00
CPC分类号： C07D471/04
摘要： The invention provides a compound of formula (I) or a salt thereof: wherein Ar has the sub-formula (w), (y), (z1) or (z2): wherein the several groups are defined herein below, and the use of these compounds as inhibitors of phosphodiesterase type IV (PDE4).
摘要翻译： 本发明提供式（I）化合物或其盐：其中Ar具有下式（w），（y），（z1）或（z2）：其中数个基团如下文所定义， 的这些化合物作为磷酸二酯酶IV（PDE4）的抑制剂。
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![Pyrazolo[3,4-B]pyridine compounds, and their use as phosphodiesterase inhibitors](/abs-image/US/2009/05/05/US07528148B2/abs.jpg.150x150.jpg)
8.发明授权Pyrazolo[3,4-B]pyridine compounds, and their use as phosphodiesterase inhibitors 失效吡唑并[3,4-B]吡啶化合物及其作为磷酸二酯酶抑制剂的用途公开(公告)号：US07528148B2
公开(公告)日：2009-05-05
申请号：US10540371
申请日：2003-12-19
申请人： David George Allen , Diane Mary Coe , Caroline Mary Cook , Anthony William James Cooper , Michael Dennis Dowle , Christopher David Edlin , Julie Nicole Hamblin , Martin Redpath Johnson , Paul Spencer Jones , Mika Kristian Lindvall , Charlotte Jane Mitchell , Alison Judith Redgrave
发明人： David George Allen , Diane Mary Coe , Caroline Mary Cook , Anthony William James Cooper , Michael Dennis Dowle , Christopher David Edlin , Julie Nicole Hamblin , Martin Redpath Johnson , Paul Spencer Jones , Mika Kristian Lindvall , Charlotte Jane Mitchell , Alison Judith Redgrave
IPC分类号： C07D471/02 , C07D491/02 , C07D498/02 , C07D513/02 , C07D515/02 , A01N43/42 , A61K31/44
CPC分类号： C07D471/04
摘要： The invention relates to a compound of formula (I) or a salt thereof: wherein: R1 is C1-4alkyl, C1-3fluoroalkyl or —(CH2)2OH; R2 is a hydrogen atom (H), methyl or C1fluoroalkyl; R3a is a hydrogen atom (H) or C1-3alkyl; R3 is optionally substituted branched C3-6alkyl, optionally substituted C3-8cycloalkyl, optionally substituted mono-unsaturated-C5-7cycloalkenyl, optionally substituted phenyl, or an optionally substituted heterocyclic group of sub-formula (aa), (bb) or (cc): in which n1 and n2 independently are 1 or 2; and Y is O, S, SO2, or NR4; and wherein Het is of sub-formula (i), (ii), (iii), (iv) or (v): The compounds are phosphodiesterase (PDE) inhibitors, in particular PDE4 inhibitors. Also provided is the use of a compound of formula (I), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the treatment and/or prophylaxis of an inflammatory and/or allergic disease in a mammal such as a human, for example chronic obstructive pulmonary disease (COPD), asthma, or allergic rhinitis.
摘要翻译： 本发明涉及式（I）化合物或其盐：其中：R 1为C 1-4烷基，C 1-3氟烷基或 - （CH 2）2 OH; R2是氢原子（H），甲基或C1-4烷基; R3a是氢原子（H）或C1-3烷基; R 3是任选取代的支链C 3-6烷基，任选取代的C 3-8环烷基，任选取代的单不饱和C 5-7环烯基，任选取代的苯基或任选取代的亚式（aa），（bb）或（cc） 其中n1和n2独立地为1或2; Y是O，S，SO 2或NR 4; 并且其中Het为亚式（i），（ii），（iii），（iv）或（v）：所述化合物是磷酸二酯酶（PDE）抑制剂，特别是PDE4抑制剂。 还提供了式（I）化合物或其药学上可接受的盐在制备用于治疗和/或预防哺乳动物例如人的炎性和/或过敏性疾病的药物中的用途， 例如慢性阻塞性肺疾病（COPD），哮喘或过敏性鼻炎。
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公开(公告)号：US06534486B1
公开(公告)日：2003-03-18
申请号：US09720193
申请日：2001-02-28
申请人： David George Allen , Chuen Chan , Caroline Mary Cook , Richard Peter Charles Cousins , Brian Cox , Hazel Joan Dyke , Frank Ellis , Joanna Victoria Geden , Heather Hobbs , Suzanne Elaine Keeling , Alison Judith Redgrave , Stephen Swanson , Caroline Whitworth , David Bays
发明人： David George Allen , Chuen Chan , Caroline Mary Cook , Richard Peter Charles Cousins , Brian Cox , Hazel Joan Dyke , Frank Ellis , Joanna Victoria Geden , Heather Hobbs , Suzanne Elaine Keeling , Alison Judith Redgrave , Stephen Swanson , Caroline Whitworth , David Bays
IPC分类号： A01N4304
CPC分类号： C07H19/16 , Y10S514/826 , Y10S514/851 , Y10S514/921 , Y10S514/925
摘要： A series of 2-(Purin-9-yl)-tetrahydrofuran-3,4-diol derivatives with broad anti-inflammatory properties which inhibit leukocyte recruitment and activation and which are agonists of the adenosine 2a receptor are described.
摘要翻译： 描述了一系列具有抑制白细胞募集和活化并且是腺苷2a受体激动剂的广泛抗炎性质的2-（嘌呤-9-基） - 四氢呋喃-3,4-二醇衍生物。
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公开(公告)号：US20120053150A1
公开(公告)日：2012-03-01
申请号：US13265037
申请日：2010-04-22
申请人： David George Allen , Diane Mary Coe , Anthony William James Cooper , Paul Martin Gore , David House , Stefan Senger , Steven Leslie Sollis , Sadie Vile , Caroline Wilson
发明人： David George Allen , Diane Mary Coe , Anthony William James Cooper , Paul Martin Gore , David House , Stefan Senger , Steven Leslie Sollis , Sadie Vile , Caroline Wilson
IPC分类号： A61K31/675 , C07D401/12 , C07D403/10 , C07D413/10 , C07D413/12 , C07D403/12 , C07F9/6503 , A61K31/415 , A61K31/4439 , A61K31/4245 , A61K31/422 , A61K31/513 , A61P11/06 , A61P29/00 , C07D231/40
CPC分类号： C07D231/40
摘要： The present invention relates to amide compounds, processes for their preparation, pharmaceutical compositions containing these compounds and to their use in the treatment of disorders, conditions or disorders such as allergic disorders, inflammatory disorders and disorders of the immune system.
摘要翻译： 本发明涉及酰胺化合物，其制备方法，含有这些化合物的药物组合物及其用于治疗疾病，病症或病症如过敏性疾病，炎症性疾病和免疫系统疾病的用途。
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