公开(公告)号：US07947227B2

公开(公告)日：2011-05-24

申请号：US12076723

申请日：2008-03-21

申请人： David H. Fine ,  David P. Rounbehler ,  Greg Vasquez

发明人： David H. Fine ,  David P. Rounbehler ,  Greg Vasquez

IPC分类号： A62B7/08 ,  A61M15/00

CPC分类号： A61M16/10 ,  A61M2016/1025 ,  A61M2202/0275 ,  C01B21/24

摘要： A nitric oxide delivery system, which includes a gas bottle having nitrogen dioxide in air, converts nitrogen dioxide to nitric oxide and employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid. A nitric oxide delivery system may be used to generate therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal.

摘要翻译： 包括在空气中具有二氧化氮的气瓶的一氧化氮输送系统将二氧化氮转化为一氧化氮，并使用涂覆有抗氧化剂水溶液如抗坏血酸的表面活性物质如硅胶。 一氧化氮递送系统可用于产生治疗气体，包括用于将治疗气体递送至哺乳动物的一氧化氮。

公开(公告)号：US20110240020A1

公开(公告)日：2011-10-06

申请号：US13113787

申请日：2011-05-23

申请人： David H. Fine ,  David P. Rounbehler ,  Greg Vasquez

发明人： David H. Fine ,  David P. Rounbehler ,  Greg Vasquez

IPC分类号： A61M16/10

CPC分类号： A61M16/10 ,  A61M2016/1025 ,  A61M2202/0275 ,  C01B21/24

摘要： A nitric oxide delivery system, which includes a gas bottle having nitrogen dioxide in air, converts nitrogen dioxide to nitric oxide and employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid. A nitric oxide delivery system may be used to generate therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal.

摘要翻译： 包括在空气中具有二氧化氮的气瓶的一氧化氮输送系统将二氧化氮转化为一氧化氮，并使用涂覆有抗氧化剂水溶液如抗坏血酸的表面活性物质如硅胶。 一氧化氮递送系统可用于产生治疗气体，包括用于将治疗气体递送至哺乳动物的一氧化氮。

公开(公告)号：US20080317874A1

公开(公告)日：2008-12-25

申请号：US12076723

申请日：2008-03-21

申请人： David H. Fine ,  David P. Rounbehler ,  Greg Vasquez

发明人： David H. Fine ,  David P. Rounbehler ,  Greg Vasquez

IPC分类号： A61K33/00 ,  A61P9/12

CPC分类号： A61M16/10 ,  A61M2016/1025 ,  A61M2202/0275 ,  C01B21/24

摘要： A nitric oxide delivery system, which includes a gas bottle having nitrogen dioxide in air, converts nitrogen dioxide to nitric oxide and employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid. A nitric oxide delivery system may be used to generate therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal.

摘要翻译： 包括在空气中具有二氧化氮的气瓶的一氧化氮输送系统将二氧化氮转化为一氧化氮，并使用涂覆有抗氧化剂水溶液如抗坏血酸的表面活性物质如硅胶。 一氧化氮递送系统可用于产生治疗气体，包括用于将治疗气体递送至哺乳动物的一氧化氮。

公开(公告)号：US20120251399A1

公开(公告)日：2012-10-04

申请号：US13436018

申请日：2012-03-30

申请人： David H. Fine ,  David P. Rounbehler ,  Gregory Vasquez ,  Bryan Johnson

发明人： David H. Fine ,  David P. Rounbehler ,  Gregory Vasquez ,  Bryan Johnson

IPC分类号： B01J7/00

CPC分类号： B01J12/007 ,  A61K33/00 ,  A61M16/10 ,  A61M16/122 ,  A61M2016/1025 ,  A61M2202/0007 ,  A61M2202/0078 ,  A61M2202/0275 ,  A61M2205/07 ,  A61M2205/12 ,  A62B7/08 ,  C01B21/24

摘要： A nitric oxide delivery system, which includes a gas bottle having nitrogen dioxide in air, converts nitrogen dioxide to nitric oxide and employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid. A nitric oxide delivery system may be used to generate therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal.

公开(公告)号：US5472882A

公开(公告)日：1995-12-05

申请号：US320407

申请日：1994-10-03

申请人： David P. Rounbehler ,  Eugene K. Achter ,  David H. Fine ,  Freeman W. Fraim ,  Stephen J. MacDonald ,  Helmut W. Klotzsch

发明人： David P. Rounbehler ,  Eugene K. Achter ,  David H. Fine ,  Freeman W. Fraim ,  Stephen J. MacDonald ,  Helmut W. Klotzsch

IPC分类号： G01N21/76 ,  G01N21/90 ,  G01N33/00 ,  G01N35/00 ,  G01N35/04 ,  G01N35/10 ,  G01N35/02

CPC分类号： G01N21/9018 ,  G01N21/76 ,  G01N21/766 ,  G01N35/00 ,  G01N2033/0081 ,  G01N2035/0484 ,  G01N35/10 ,  Y10T436/113332 ,  Y10T436/17 ,  Y10T436/173845

摘要： Disclosed is an improved method and system for injecting liquid into containers and for inspecting containers for the presence of certain substances such as potential contaminants such as ammonium salts or amine salts in glass or plastic bottles. A high speed system and method are provided for detecting these contaminants in these bottles. Ammonia and amines can be detected by chemiluminescence of samples of volatiles emitted from the bottles during the high speed inspection process. A solution of Na.sub.2 CO.sub.3 is injected into the bottles in order to enhance the conversion of ammonium or amine salts to free ammonia or amines which are then released as vapors. This enhances the likelihood that a gas-phase detection system such as one using chemiluminescence detection techniques will detect the presence of contaminants containing ammonium salts or amine salts.

摘要翻译： 公开了一种改进的方法和系统，用于将液体注入容器中并用于检查容器中是否存在某些物质，例如玻璃或塑料瓶中的诸如铵盐或胺盐的潜在污染物。 提供了一种用于检测这些瓶子中这些污染物的高速系统和方法。 氨和胺可以通过在高速检查过程中从瓶子发出的挥发物样品的化学发光来检测。 将Na 2 CO 3溶液注入瓶中以增强铵盐或胺盐向游离氨或胺的转化，然后将其释放为蒸气。 这增强了诸如使用化学发光检测技术的气相检测系统将检测到含有铵盐或胺盐的污染物的存在的可能性。

公开(公告)号：US5470754A

公开(公告)日：1995-11-28

申请号：US20804

申请日：1993-02-22

申请人： David P. Rounbehler ,  David H. Fine ,  Eugene K. Achter ,  Stephen J. MacDonald ,  Daniel B. Dennison

发明人： David P. Rounbehler ,  David H. Fine ,  Eugene K. Achter ,  Stephen J. MacDonald ,  Daniel B. Dennison

IPC分类号： B07C5/34 ,  B08B9/46 ,  B29B17/00 ,  B29B17/02 ,  G01N1/00 ,  G01N1/22 ,  G01N1/24 ,  G01N21/64 ,  G01N21/76 ,  G01N21/90 ,  G01N33/00 ,  G01N33/44

CPC分类号： B07C5/34 ,  B07C5/3408 ,  B08B9/46 ,  B29B17/00 ,  B29B17/02 ,  G01N1/2226 ,  G01N21/64 ,  G01N21/766 ,  G01N21/9018 ,  B08B2203/005 ,  B29B2017/0275 ,  G01N1/2202 ,  G01N1/24 ,  G01N2001/2223 ,  G01N2001/2229 ,  G01N2033/0081 ,  G01N21/76 ,  Y02W30/62 ,  Y02W30/622 ,  Y10T436/113332 ,  Y10T436/17 ,  Y10T436/206664 ,  Y10T436/21

摘要： A system and method are provided for minimizing the effects of background signals in masking signals indicating the presence of substances to be detected such as contaminants in materials moving rapidly along a conveyor. The contaminants detected may include nitrogen containing compounds and hydrocarbons. The system and method of the present invention minimize during detection of the presence or absence of such substances, the number of falsely positive indications of the presence of such substances due to background signals and changes in background signals. The substances detected are divided into first and second sample portions and the respective portions are heated. The first heated portion is mixed with ozone to cause a chemical reaction therewith in order to generate radiation by chemiluminescence having characteristic wavelengths related to substances in the first portion. The second portion heated is also mixed with ozone to cause a chemical reaction therewith in order to generate radiation by chemiluminescence having characteristic wavelengths related to substances in the second portion. The radiation of the respective first and second portions is selectively detected. The heating and detecting steps are performed in a manner so as to yield a higher level of detected radiation from one of the portions of the sample then the other for at least some of the selected compounds being detected. Electrical signals from the respective first and second portions are generated and compared in order to determine the presence or absence of selected compounds in the sample. Appropriate reject signals for a bottle sorting system are generated accordingly.

摘要翻译： 提供了一种系统和方法，用于最小化背景信号在屏蔽指示待检测物质的存在的信号中的影响，例如沿着传送器快速移动的材料中的污染物。 检测到的污染物可能包括含氮化合物和碳氢化合物。 本发明的系统和方法在检测到这种物质的存在或不存在期间最小化了由于背景信号和背景信号的变化而导致的这种物质的存在的错误的阳性迹象的数量。 所检测的物质被分成第一和第二样品部分，并且各个部分被加热。 将第一加热部分与臭氧混合以引起与其的化学反应，以通过具有与第一部分中的物质相关的特征波长的化学发光来产生辐射。 加热的第二部分也与臭氧混合以引起与其的化学反应，以通过具有与第二部分中的物质相关的特征波长的化学发光产生辐射。 选择性地检测相应的第一和第二部分的辐射。 加热和检测步骤以这样的方式进行，以便从样品的一个部分产生更高水平的检测到的辐射，然后对于检测到的至少一些所选化合物产生另一个。 产生并比较来自相应的第一和第二部分的电信号，以确定样品中选定化合物的存在或不存在。 相应地生成用于瓶分选系统的适当拒绝信号。

公开(公告)号：US5092219A

公开(公告)日：1992-03-03

申请号：US81967

申请日：1987-07-08

申请人： David P. Rounbehler ,  David H. Fine

发明人： David P. Rounbehler ,  David H. Fine

IPC分类号： G01N1/00 ,  G01N1/02 ,  G01N1/22 ,  G01N1/28 ,  G01N1/40 ,  G01N21/76 ,  G01N27/417 ,  G01N30/02 ,  G01N30/06 ,  G01N30/08 ,  G01N30/12 ,  G01N30/14 ,  G01N30/16 ,  G01N30/30 ,  G01N30/40 ,  G01N30/46 ,  G01N30/62 ,  G01N30/64 ,  G01N30/72 ,  G01N30/84 ,  G01N31/12 ,  G01N33/00 ,  G01N33/22 ,  G01V9/00

CPC分类号： G01N30/461 ,  G01N1/02 ,  G01N30/08 ,  G01N30/12 ,  G01N30/84 ,  G01N33/0057 ,  G01V9/007 ,  G01N1/2214 ,  G01N1/2226 ,  G01N1/28 ,  G01N1/40 ,  G01N2001/022 ,  G01N2001/028 ,  G01N2030/025 ,  G01N2030/065 ,  G01N2030/085 ,  G01N2030/121 ,  G01N2030/122 ,  G01N2030/123 ,  G01N2030/125 ,  G01N2030/126 ,  G01N2030/143 ,  G01N2030/167 ,  G01N2030/3007 ,  G01N2030/3046 ,  G01N2030/3053 ,  G01N2030/3061 ,  G01N2030/3069 ,  G01N2030/3076 ,  G01N2030/3084 ,  G01N2030/626 ,  G01N2030/642 ,  G01N2030/8405 ,  G01N21/76 ,  G01N30/14 ,  G01N30/40 ,  G01N30/62 ,  G01N30/72

摘要： A highly selective, sensitive, fast detection system and method are disclosed for detecting vapors of specific compounds in air. Vapors emanating from compounds such as explosives, or stripped from surfaces using heat and suction from a hand-held sample gun, are collected on surfaces coated with gas chromatograph (GC) material which trap explosives vapors but repel nitric oxide, then are desorbed and concentrated in one or more cold spot concentrators. A high speed gas chromatograph (GC) separates the vapors, after which specific vapors are decomposed in two pyrolyzers arranged in parallel and the resulting nitric oxide is detected. A low temperature pyrolyzer with silver produces NO from nitramines or nitrite esters; a high temperature pyrolyzer decomposes all explosives vapors to permit detetion of the remaining explosives. Also disclosed is a series arrangement of pyrolyzers and gas chromatographs and an NO detector to time-shift detection of certain vapors and facilitate very fast GC analyses. The use of hydrogen as a carrier gas, plus unique collectors and concentrators, high speed heaters, NO detectors, and very fast, temperature-programmable GC's enhance selectivity, sensitivity and speed of detection.

摘要翻译： 公开了一种高选择性，灵敏，快速的检测系统和方法，用于检测空气中特定化合物的蒸气。 从化合物如爆炸物或从手持式样品枪吸取热量从表面剥离的蒸气被收集在涂有气相色谱（GC）材料的表面上，该气相色谱（GC）材料捕获爆炸物蒸气但排斥一氧化氮，然后被解吸和浓缩 在一个或多个冷点浓缩器中。 高速气相色谱仪（GC）分离蒸汽，之后特定的蒸汽在平行排列的两个热解器中分解，并检测到所产生的一氧化氮。 含有银的低温热解器由硝胺或亚硝酸酯产生NO; 高温热解器分解所有爆炸物蒸汽，以允许其他爆炸物的爆破。 还公开了热解器和气相色谱仪的串联布置和用于某些蒸气的时移检测的NO检测器，并且促进非常快速的GC分析。 使用氢气作为载气，加上独特的收集器和浓缩器，高速加热器，NO检测器和非常快速的温度可编程GC增强了选择性，灵敏度和检测速度。

公开(公告)号：US20100104667A1

公开(公告)日：2010-04-29

申请号：US12563662

申请日：2009-09-21

申请人： David H. Fine ,  David P. Rounbehler ,  Gregory Vasquez

发明人： David H. Fine ,  David P. Rounbehler ,  Gregory Vasquez

IPC分类号： A61K33/00 ,  A61M16/12

CPC分类号： B01J12/007 ,  A61K33/00 ,  A61M16/10 ,  A61M16/122 ,  A61M2016/1025 ,  A61M2202/0007 ,  A61M2202/0078 ,  A61M2202/0275 ,  A61M2205/07 ,  A61M2205/12 ,  A62B7/08 ,  C01B21/24

摘要： A nitric oxide delivery system, which includes a gas bottle having nitrogen dioxide in air, converts nitrogen dioxide to nitric oxide and employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid. A nitric oxide delivery system may be used to generate therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal.

公开(公告)号：US5551278A

公开(公告)日：1996-09-03

申请号：US81953

申请日：1987-07-08

申请人： David P. Rounbehler ,  Eugene K. Achter ,  David P. Lieb ,  David H. Fine ,  Eugenie Hainsworth ,  Alf L. Carroll ,  Gregory J. Wendell

发明人： David P. Rounbehler ,  Eugene K. Achter ,  David P. Lieb ,  David H. Fine ,  Eugenie Hainsworth ,  Alf L. Carroll ,  Gregory J. Wendell

IPC分类号： G01N1/00 ,  G01N1/02 ,  G01N1/22 ,  G01N1/28 ,  G01N1/40 ,  G01N21/76 ,  G01N27/417 ,  G01N30/02 ,  G01N30/06 ,  G01N30/08 ,  G01N30/12 ,  G01N30/14 ,  G01N30/16 ,  G01N30/30 ,  G01N30/40 ,  G01N30/46 ,  G01N30/62 ,  G01N30/64 ,  G01N30/72 ,  G01N30/84 ,  G01N31/12 ,  G01N33/00 ,  G01N33/22 ,  G01V9/00 ,  G01K19/00 ,  B01D15/08

CPC分类号： G01N30/461 ,  G01N1/02 ,  G01N30/08 ,  G01N30/12 ,  G01N30/84 ,  G01N33/0057 ,  G01V9/007 ,  G01N1/2214 ,  G01N1/2226 ,  G01N1/28 ,  G01N1/40 ,  G01N2001/022 ,  G01N2001/028 ,  G01N2030/025 ,  G01N2030/065 ,  G01N2030/085 ,  G01N2030/121 ,  G01N2030/122 ,  G01N2030/123 ,  G01N2030/125 ,  G01N2030/126 ,  G01N2030/143 ,  G01N2030/167 ,  G01N2030/3007 ,  G01N2030/3046 ,  G01N2030/3053 ,  G01N2030/3061 ,  G01N2030/3069 ,  G01N2030/3076 ,  G01N2030/3084 ,  G01N2030/626 ,  G01N2030/642 ,  G01N2030/8405 ,  G01N21/76 ,  G01N30/14 ,  G01N30/40 ,  G01N30/62 ,  G01N30/72

摘要： A highly selective, sensitive, fast detection system and method are disclosed for detecting vapors of specific compounds in air. Vapors emanating from compounds such as explosives, or stripped from surfaces using heat and suction from a hand-held sample gun, are collected on surfaces coated with gas chromatograph (GC) material which trap explosives vapors but repel nitric oxide, then are desorbed and concentrated in one or more cold spot concentrators, A high speed gas chromatograph (GC) separates the vapors, after which specific vapors are decomposed in two pyrolyzers arranged in parallel and the resulting nitric oxide is detected, A low temperature pyrolyzer with silver produces NO from nitramines or nitrite esters; a high temperature pyrolyzer decomposes all explosives vapors to permit detection of the remaining explosives, Also disclosed is a series arrangement of pyrolyzers and gas chromatographs and an NO detector to time-shift detection of certain vapors and facilitate very fast GC analyses, The use of hydrogen as a carrier gas, plus unique collectors and concentrators, high speed heaters, NO detectors, and very fast, temperature-programmable GC's enhance selectivity, sensitivity and speed of detection,

摘要翻译： 公开了一种高选择性，灵敏，快速的检测系统和方法，用于检测空气中特定化合物的蒸气。 从化合物如爆炸物或从手持式样品枪吸取热量从表面剥离的蒸气被收集在涂有气相色谱（GC）材料的表面上，该气相色谱（GC）材料捕获爆炸物蒸气但排斥一氧化氮，然后被解吸和浓缩 在一个或多个冷点浓缩器中，高速气相色谱仪（GC）分离蒸气，之后特定的蒸气在平行排列的两个热解器中分解，并检测到所产生的一氧化氮。具有银的低温热解器由硝酸盐产生NO 或亚硝酸酯; 高温热解器分解所有爆炸物蒸气以允许检测剩余的炸药。还公开了热解器和气相色谱仪的串联布置以及NO检测器对某些蒸气进行时移检测，并促进非常快速的GC分析。使用氢 作为载气，加上独特的收集器和浓缩器，高速加热器，NO检测器和非常快速的温度可编程GC增强了选择性，灵敏度和检测速度，

公开(公告)号：US20120238031A1

公开(公告)日：2012-09-20

申请号：US13480376

申请日：2012-05-24

申请人： David H. Fine ,  Gregory Vasquez ,  David P. Rounbehler

发明人： David H. Fine ,  Gregory Vasquez ,  David P. Rounbehler

IPC分类号： G01N27/26

CPC分类号： C01B21/32 ,  A61D7/04 ,  A61K33/00 ,  A61M16/0051 ,  A61M16/0057 ,  A61M16/009 ,  A61M16/104 ,  A61M16/1055 ,  A61M16/107 ,  A61M16/1075 ,  A61M16/12 ,  A61M16/16 ,  A61M2016/102 ,  A61M2202/0275 ,  C01B21/24 ,  G01N27/416 ,  Y10T436/179228

摘要： Various systems, devices, NO2 absorbents, NO2 scavengers and NO2 recuperator for generating nitric oxide are disclosed herein. According to one embodiment, an apparatus for converting nitrogen dioxide to nitric oxide can include a receptacle including an inlet, an outlet, a surface-active material coated with an aqueous solution of ascorbic acid and an absorbent wherein the inlet is configured to receive a gas flow and fluidly communicate the gas flow to the outlet through the surface-active material and the absorbent such that nitrogen dioxide in the gas flow is converted to nitric oxide.

摘要翻译： 本文公开了各种系统，装置，NO 2吸收剂，NO 2清除剂和用于产生一氧化氮的NO 2还原剂。 根据一个实施方案，用于将二氧化氮转化成一氧化氮的装置可以包括容器，其包括入口，出口，涂覆有抗坏血酸水溶液的表面活性材料和吸收剂，其中所述入口构造成接收气体 通过表面活性材料和吸收剂流动并流动地将气流传递到出口，使得气流中的二氧化氮转化为一氧化氮。