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    SYNTHETIC IMMUNOGEN USEFUL FOR GENERATING LONG LASTING IMMUNITY AND PROTECTION AGAINST PATHOGENS
    1.
    发明申请
    SYNTHETIC IMMUNOGEN USEFUL FOR GENERATING LONG LASTING IMMUNITY AND PROTECTION AGAINST PATHOGENS 有权
    合成免疫用于生成长期放射免疫和防治病原体

    公开(公告)号：US20130183377A1

    公开(公告)日：2013-07-18

    申请号：US13822881

    申请日：2011-09-14

    申请人： Javed Naim Agrewala ,  Uthaman Gowthaman ,  David Jackson ,  Weiguang Zeng

    发明人： Javed Naim Agrewala ,  Uthaman Gowthaman ,  David Jackson ,  Weiguang Zeng

    IPC分类号： C07K19/00

    CPC分类号： C07K19/00 ,  A61K39/04 ,  A61K2039/55516 ,  A61K2039/6018 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/484

    摘要： The present invention relates to a synthetic immunogen represented by the general formula 1, useful for generating long lasting protective immunity against various intracellular pathogens which are the causative agents of tuberculosis, leishmaniasis, AIDS, trypanosomiasis, malaria and also allergy, cancer and a process for the preparation thereof. The developed immunogen is able to circumvent HLA restriction in humans and livestock. The invention further relates to a vaccine comprising the said immunogen for generating enduring protective immunity against various diseases. The said vaccine is targeted against intracellular pathogens, more particularly the pathogen M. tuberculosis in this case. In the present invention, promiscuous peptides of M. tuberculosis are conjugated to TLR ligands especially; Pam2Cys to target them mainly to dendritic cells and therefore elicit long-lasting protective immunity. (The formula (I) should be inserted here) General formula (I) wherein, X1=a promiscuous CD4 T helper epitope selected from SEQ ID No. 1 to 98 OR nil; X2=a promiscuous CD8 T cytotoxic epitope selected from SEQ ID No. 99 to 103 OR nil; when X1=nil; X2=SEQ ID No. 99 to 103 and when X2=nil; X1=SEQ ID No. 1 to 98; Y=Lysine; and S=Serine.

    摘要翻译： 本发明涉及由通式1表示的合成免疫原，其可用于产生针对结核病，利什曼原虫病，艾滋病，艾滋病，锥虫病，疟疾和过敏，癌症的致病因子的各种细胞内病原体的长期保护性免疫，以及用于 其制备。 发达的免疫原能够规避人类和家畜的HLA限制。 本发明还涉及包含所述免疫原的疫苗，用于产生针对各种疾病的持久的保护性免疫。 在这种情况下，所述疫苗针对细胞内病原体，特别是病原体结核分枝杆菌。 在本发明中，结核分枝杆菌杂交肽特别与TLR配体结合; Pam2Cys将其主要靶向树突细胞，从而引发持久的保护性免疫。 （式（I）应在此插入）通式（I）其中X1 =选自SEQ ID No.1至98的杂交CD4T辅助表位或无; X2 =选自SEQ ID NO：99至103的混杂CD8 T细胞毒性表位或无; 当X1 = nil; X2 = SEQ ID No.99至103，当X2 = nil时; X1 = SEQ ID No.1至98; Y =赖氨酸; 和S =丝氨酸。

    Immunogenic lipopeptides comprising T-helper and B-cell epitopes
    3.
    发明授权
    Immunogenic lipopeptides comprising T-helper and B-cell epitopes 失效

    公开(公告)号：US08367067B2

    公开(公告)日：2013-02-05

    申请号：US12488485

    申请日：2009-06-19

    申请人： David Jackson ,  Weiguang Zeng

    发明人： David Jackson ,  Weiguang Zeng

    IPC分类号： A61K39/00

    CPC分类号： C07K14/775 ,  A61K38/00 ,  A61K39/0006 ,  A61K2039/543 ,  A61K2039/6018 ,  A61K2039/6068 ,  C07K19/00

    摘要： The present invention provides synthetic immunogenic lipopeptide molecules comprising co-linear T-helper and B cell epitopes, and methods for their production and use in the generation of primary and secondary immune responses, and for the vaccination of animal subjects against particular antigens. More particularly, the present invention provides highly soluble lipopeptides wherein the lipid moiety is attached to the terminal side-chain group of an internal lysine or lysine analog, preferably to the terminal side-chain group of an internal diamino acid residue. Preferably the internal lysine or lysine analog is positioned between the T-helper epitope and the B cell epitope or within the T-helper epitope.

    NOVEL IMMUNOGENIC LIPOPEPTIDES COMPRISING T-HELPER AND B-CELL EPITOPES
    5.
    发明申请
    NOVEL IMMUNOGENIC LIPOPEPTIDES COMPRISING T-HELPER AND B-CELL EPITOPES 失效
    包含T-HELPER和B细胞外膜的新型免疫缺陷型脂蛋白

    公开(公告)号：US20100092500A1

    公开(公告)日：2010-04-15

    申请号：US12488485

    申请日：2009-06-19

    申请人： David Jackson ,  Weiguang Zeng

    发明人： David Jackson ,  Weiguang Zeng

    IPC分类号： A61K39/00 ,  A61K38/08 ,  A61K38/10 ,  A61K38/16 ,  A61K38/07 ,  C07K7/06 ,  C07K7/08 ,  C07K14/00 ,  C07K5/10

    CPC分类号： C07K14/775 ,  A61K38/00 ,  A61K39/0006 ,  A61K2039/543 ,  A61K2039/6018 ,  A61K2039/6068 ,  C07K19/00

    摘要： The present invention provides synthetic immunogenic lipopeptide molecules comprising co-linear T-helper and B cell epitopes, and methods for their production and use in the generation of primary and secondary immune responses, and for the vaccination of animal subjects against particular antigens. More particularly, the present invention provides highly soluble lipopeptides wherein the lipid moiety is attached to the terminal side-chain group of an internal lysine or lysine analog, preferably to the terminal side-chain group of an internal diamino acid residue. Preferably the internal lysine or lysine analog is positioned between the T-helper epitope and the B cell epitope or within the T-helper epitope.

    摘要翻译： 本发明提供了包含共线T-辅助细胞和B细胞表位的合成的免疫原性脂肽分子，以及其生产和用于产生初级和次级免疫应答的方法，以及针对特定抗原的动物受试者的疫苗接种。 更具体地，本发明提供高可溶性脂肽，其中脂质部分连接到内部赖氨酸或赖氨酸类似物的末端侧链基团，优选连接到内部二氨基酸残基的末端侧链基团。 优选地，内部赖氨酸或赖氨酸类似物位于T辅助表位和B细胞表位之间或T辅助表位内。

    Immunogenic lipopeptides comprising T-helper and B-cell epitopes
    6.
    发明授权
    Immunogenic lipopeptides comprising T-helper and B-cell epitopes 失效
    包含T辅助细胞和B细胞表位的免疫原性脂肽

    公开(公告)号：US07569225B2

    公开(公告)日：2009-08-04

    申请号：US10525301

    申请日：2003-08-12

    申请人： David Jackson ,  Weiguang Zeng

    发明人： David Jackson ,  Weiguang Zeng

    IPC分类号： A61K39/00

    CPC分类号： C07K14/775 ,  A61K38/00 ,  A61K39/0006 ,  A61K2039/543 ,  A61K2039/6018 ,  A61K2039/6068 ,  C07K19/00

    摘要： The present invention provides synthetic immunogenic lipopeptide molecules comprising co-linear T-helper and B cell epitopes, and methods for their production and use in the generation of primary and secondary immune responses, and for the vaccination of animal subjects against particular antigens. More particularly, the present invention provides highly soluble lipopeptides wherein the lipid moiety is attached to the terminal side-chain group of an internal lysine or lysine analog, preferably to the terminal side-chain group of an internal diamino acid residue. Preferably the internal lysine or lysine analog is positioned between the T-helper epitope and the B cell epitope or within the T-helper epitope.

    摘要翻译： 本发明提供了包含共线T-辅助细胞和B细胞表位的合成的免疫原性脂肽分子，以及其生产和用于产生初级和次级免疫应答的方法，以及针对特定抗原的动物受试者的疫苗接种。 更具体地，本发明提供高可溶性脂肽，其中脂质部分连接到内部赖氨酸或赖氨酸类似物的末端侧链基团，优选连接到内部二氨基酸残基的末端侧链基团。 优选地，内部赖氨酸或赖氨酸类似物位于T辅助表位和B细胞表位之间或T辅助表位内。

    Synthetic immunogen useful for generating long lasting immunity and protection against pathogens
    8.
    发明授权
    Synthetic immunogen useful for generating long lasting immunity and protection against pathogens 有权
    用于产生持久免疫力和防止病原体的合成免疫原

    公开(公告)号：US09340622B2

    公开(公告)日：2016-05-17

    申请号：US13822881

    申请日：2011-09-14

    申请人： Javed N. Agrewala ,  Uthaman Gowthaman ,  David Jackson ,  Weiguang Zeng

    发明人： Javed N. Agrewala ,  Uthaman Gowthaman ,  David Jackson ,  Weiguang Zeng

    IPC分类号： A61K39/04 ,  A61K39/02 ,  A61K39/00 ,  C07K19/00

    CPC分类号： C07K19/00 ,  A61K39/04 ,  A61K2039/55516 ,  A61K2039/6018 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/484

    摘要： The present invention relates to a synthetic immunogen represented by the general formula 1, useful for generating long lasting protective immunity against various intracellular pathogens which are the causative agents of tuberculosis, leishmaniasis, AIDS, trypanosomiasis, malaria and also allergy, cancer and a process for the preparation thereof. The developed immunogen is able to circumvent HLA restriction in humans and livestock. The invention further relates to a vaccine comprising the said immunogen for generating enduring protective immunity against various diseases. The said vaccine is targeted against intracellular pathogens, more particularly the pathogen M. tuberculosis in this case. In the present invention, promiscuous peptides of M. tuberculosis are conjugated to TLR ligands especially; Pam2Cys to target them mainly to dendritic cells and therefore elicit long-lasting protective immunity. wherein, X1=a promiscuous CD4 T helper epitope selected from SEQ ID No. 1 to 98 OR nil; X2=a promiscuous CD8 T cytotoxic epitope selected from SEQ ID No. 99 to 103 OR nil; when X1=nil; X2=SEQ ID No. 99 to 103 and when X2=nil; X1=SEQ ID No. 1 to 98; Y=Lysine; and S=Serine.

    摘要翻译： 本发明涉及由通式1表示的合成免疫原，其可用于产生针对结核病，利什曼原虫病，艾滋病，艾滋病，锥虫病，疟疾和过敏，癌症的致病因子的各种细胞内病原体的长期保护性免疫，以及用于 其制备。 发达的免疫原能够规避人类和家畜的HLA限制。 本发明还涉及包含所述免疫原的疫苗，用于产生针对各种疾病的持久的保护性免疫。 在这种情况下，所述疫苗针对细胞内病原体，特别是病原体结核分枝杆菌。 在本发明中，结核分枝杆菌杂交肽特别与TLR配体结合; Pam2Cys将其主要靶向树突细胞，从而引发持久的保护性免疫。 其中X1 =选自SEQ ID No.1至98的杂交CD4T辅助表位或无; X2 =选自SEQ ID NO：99至103的混杂CD8 T细胞毒性表位或无; 当X1 = nil; X2 = SEQ ID No.99至103，当X2 = nil时; X1 = SEQ ID No.1至98; Y =赖氨酸; 和S =丝氨酸。

    Novel immunogenic lipopeptides comprising t-helper and b-cell epitopes
    10.
    发明申请
    Novel immunogenic lipopeptides comprising t-helper and b-cell epitopes 失效
    新型免疫原性脂肽，其包含t辅助细胞和b细胞表位

    公开(公告)号：US20070066534A1

    公开(公告)日：2007-03-22

    申请号：US10525301

    申请日：2003-08-12

    申请人： David Jackson ,  Weiguang Zeng

    发明人： David Jackson ,  Weiguang Zeng

    IPC分类号： A61K38/10 ,  C07K7/08 ,  C07K14/775

    CPC分类号： C07K14/775 ,  A61K38/00 ,  A61K39/0006 ,  A61K2039/543 ,  A61K2039/6018 ,  A61K2039/6068 ,  C07K19/00

    摘要： The present invention provides synthetic immunogenic lipopeptide molecules comprising co-linear T-helper and B cell epitopes, and methods for their production and use in the generation of primary and secondary immune responses, and for the vaccination of animal subjects against particular antigens. More particularly, the present invention provides highly soluble lipopeptides wherein the lipid moiety is attached to the terminal side-chain group of an internal lysine or lysine analog, preferably to the terminal side-chain group of an internal diamino acid residue. Preferably the internal lysine or lysine analog is positioned between the T-helper epitope and the B cell epitope or within the T-helper epitope.

    摘要翻译： 本发明提供了包含共线T-辅助细胞和B细胞表位的合成的免疫原性脂肽分子，以及其生产和用于产生初级和次级免疫应答的方法，以及针对特定抗原的动物受试者的疫苗接种。 更具体地，本发明提供高可溶性脂肽，其中脂质部分连接到内部赖氨酸或赖氨酸类似物的末端侧链基团，优选连接到内部二氨基酸残基的末端侧链基团。 优选地，内部赖氨酸或赖氨酸类似物位于T辅助表位和B细胞表位之间或T辅助表位内。