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17 条记录 (耗时 0.024 秒)

    Derivatized polystyrene and other polymer supports for spectroscopic studies
    4.
    发明授权
    Derivatized polystyrene and other polymer supports for spectroscopic studies 失效
    衍生聚苯乙烯和其他聚合物载体进行光谱研究

    公开(公告)号：US06528292B1

    公开(公告)日：2003-03-04

    申请号：US08467260

    申请日：1995-06-06

    申请人： Brian R. Clark

    发明人： Brian R. Clark

    IPC分类号： C12N1108

    CPC分类号： C08J7/12 ,  C08J2325/02

    摘要： Molded articles formed of polystyrene or other polymers containing an aromatic moiety can be derivatized on the surface of the article by subjecting the molded article to a chemical reaction wherein the reaction media utilizes tetramethylsulfone as the reactant solvent and a suitable substituent group which is substituted on to the aromatic moiety of the polystyrene or other polymer by electrophilic substitution. By choosing the substituent group to further include a leaving group, further substitution of the primary substituent can be effected normally by nucleophilic substitution reaction. In this way, biologically important molecules can be attached to a polystyrene or other aromatic containing polymer without effecting certain properties of the molded article such as its optical or spectroscopic clarity.

    摘要翻译： 由聚苯乙烯或含有芳族部分的其它聚合物形成的模制品可以通过使成型制品进行化学反应，其中反应介质利用四甲基砜作为反应物溶剂和适当的取代基 聚苯乙烯或其他聚合物的芳族部分通过亲电取代。 通过选择取代基进一步包括离去基团，可以通过亲核取代反应进一步取代一级取代基。 以这种方式，生物重要的分子可以连接到聚苯乙烯或其它含芳族聚合物，而不影响模制品的某些性质，例如其光学或光谱透明度。

    Method of preparing derivatized polystyrene for spectroscopic studies
    7.
    发明授权
    Method of preparing derivatized polystyrene for spectroscopic studies 失效
    制备用于光谱研究的衍生聚苯乙烯的方法

    公开(公告)号：US4978724A

    公开(公告)日：1990-12-18

    申请号：US948418

    申请日：1986-12-30

    申请人： Brian R. Clark

    发明人： Brian R. Clark

    IPC分类号： C08J7/02 ,  C08J7/12 ,  G01N33/545

    CPC分类号： C08J7/02 ,  C08J7/12 ,  G01N33/545 ,  C08J2325/06

    摘要： Molded articles formed of polystyrene or other polymers containing an aromatic moiety can be derivatized on the surface of the article by subjecting the molded article to a chemical reaction wherein the reaction media utilizes tetramethylsulfone as the reactant solvent and a suitable substituent group which is substituted on to the aromatic moiety of the polystyrene or other polymer by electrophilic substitution. By choosing the substituent group to further include a leaving group, further substitution of the primary substituent can be effected normally by nucleophilic substitution reaction. In this way, biologically important molecules can be attached to a polystyrene or other aromatic containing polymer without effecting certain properties of the molded article such as its optical or spectroscopic clarity.

    摘要翻译： 由聚苯乙烯或含有芳族部分的其它聚合物形成的模制品可以通过使成型制品进行化学反应，其中反应介质利用四甲基砜作为反应物溶剂和适当的取代基 聚苯乙烯或其他聚合物的芳族部分通过亲电取代。 通过选择取代基进一步包括离去基团，可以通过亲核取代反应进一步取代一级取代基。 以这种方式，生物重要的分子可以连接到聚苯乙烯或其它含芳族聚合物，而不影响模制品的某些性质，例如其光学或光谱透明度。

    Method for detection and prevention of human cytomegalovirus infection
    8.
    发明授权
    Method for detection and prevention of human cytomegalovirus infection 失效
    检测和预防人巨细胞病毒感染的方法

    公开(公告)号：US6133433A

    公开(公告)日：2000-10-17

    申请号：US469920

    申请日：1995-06-06

    申请人： Hema Pande ,  Arthur D. Riggs ,  John A. Zaia ,  Brian R. Clark

    发明人： Hema Pande ,  Arthur D. Riggs ,  John A. Zaia ,  Brian R. Clark

    IPC分类号： A61K39/00 ,  C07K14/045 ,  C12Q1/68 ,  C12Q1/70 ,  C07H19/00 ,  C07H21/04 ,  C07K1/00

    CPC分类号： C07K14/005 ,  C12Q1/705 ,  A61K2039/53 ,  A61K39/00 ,  C12N2710/16122 ,  C12Q1/6841

    摘要： A DNA probe has been isolated which is capable of hybridizing to an oligonucleotide sequence coding for a polypeptide from a major 64 Kilodalton protein of human cytomegalovirus (HCMVgp64). The probe has a sequence of at least seventeen (17) to as many as seven hundred twenty-one (721) nucleotides. The DNA fragments coding for the major late protein of human cytomegalovirus (HCMVgp64) may be hybridized to DNA fragments of HCMV DNA from an individual having human cytomegalovirus infection. The major late protein of human cytomegalovirus (HCMVgp64) also reacts with T-lymphocytes of an individual after natural infection of that individual with human cytomegalovirus. Thus, the HCMVgp64 protein may be used as a vaccine to prevent HCMV infection.

    摘要翻译： 已经分离出能够与人巨细胞病毒（HCMVgp64）的主要64千道尔顿蛋白质编码多肽的寡核苷酸序列杂交的DNA探针。 探针具有至少十七（17）至多二百七十一（721）个核苷酸的序列。 编码人巨细胞病毒（HCMVgp64）的主要晚期蛋白的DNA片段可能与来自具有人巨细胞病毒感染的个体的HCMV DNA的DNA片段杂交。 人巨细胞病毒（HCMVgp64）的主要晚期蛋白质也与人巨细胞病毒自然感染后个体的T淋巴细胞反应。 因此，HCMVgp64蛋白可以用作预防HCMV感染的疫苗。