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公开(公告)号：US20100168851A1
公开(公告)日：2010-07-01
申请号：US12641412
申请日：2009-12-18
CPC分类号： G02B1/043 , A61F2/1613 , C08L63/00 , C08L85/04 , C08L33/068
摘要： Disclosed are surface modified biomedical devices having a coating on a surface thereof, the coating comprising an inner layer comprising a polymer comprising monomeric units derived from an ethylenically unsaturated monomer containing a boronic acid moiety, and an outer layer comprising a hydrophilic hydrolyzed reactive polymer comprising monomeric units derived from an ethylenically unsaturated containing monomer having hydrolyzable reactive functionalities.
摘要翻译： 公开了在其表面上具有涂层的表面改性的生物医学装置，该涂层包含内层，该内层包含衍生自含有硼酸部分的烯属不饱和单体的单体单元的聚合物，以及包含亲水性水解反应性聚合物的外层，其包含单体 衍生自具有可水解反应性官能团的含烯属不饱和单体的单元。
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公开(公告)号：US08534031B2
公开(公告)日：2013-09-17
申请号：US12641483
申请日：2009-12-18
IPC分类号： B65B55/18
CPC分类号： A61L12/086 , A61L12/00 , G02B1/043 , C08L85/04 , C08L51/085 , C08L83/10
摘要： Packaging systems for storing ophthalmic devices such as contact lenses and to methods for packaging such ophthalmic devices with solutions to improve the comfort of the lenses during wear are disclosed.
摘要翻译： 公开了用于存储诸如隐形眼镜的眼科装置的包装系统，以及用于包装这些眼科装置的方法以提供穿戴期间镜片的舒适度的解决方案。
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公开(公告)号：US20100168356A1
公开(公告)日：2010-07-01
申请号：US12641464
申请日：2009-12-18
IPC分类号： C08F230/06
CPC分类号： A61L27/16 , A61L2430/16 , C08L101/02
摘要： Biomedical devices are provided herein which are formed from a polymerization product of a monomeric mixture comprising (a) a polymerizable monomer containing a boronic acid moiety and an electron withdrawing moiety; and (b) a biomedical device-forming comonomer.
摘要翻译： 本文提供由包含（a）含有硼酸部分和吸电子部分的可聚合单体的单体混合物的聚合产物形成的生物医学装置; 和（b）生物医学装置形成共聚单体。
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公开(公告)号：US20100162663A1
公开(公告)日：2010-07-01
申请号：US12641483
申请日：2009-12-18
IPC分类号： B65B63/08
CPC分类号： A61L12/086 , A61L12/00 , G02B1/043 , C08L85/04 , C08L51/085 , C08L83/10
摘要： Packaging systems for storing ophthalmic devices such as contact lenses and to methods for packaging such ophthalmic devices with solutions to improve the comfort of the lenses during wear are disclosed.
摘要翻译： 公开了用于存储诸如隐形眼镜的眼科装置的包装系统，以及用于包装这些眼科装置的方法以提供穿戴期间镜片的舒适度的解决方案。
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公开(公告)号：US20100168855A1
公开(公告)日：2010-07-01
申请号：US12641422
申请日：2009-12-18
CPC分类号： G02B1/043 , A61L27/34 , A61L29/085 , A61L31/10 , A61L2400/18 , A61L2430/16
摘要： Disclosed are biomedical devices having a hydrophilic coating on a portion of a surface thereof, the biomedical device comprising: (a) a biomedical device obtained from a polymerization product of a monomeric mixture comprising (i) a polymerizable monomer containing a boronic acid moiety and an electron withdrawing moiety; and (ii) a biomedical device-forming comonomer; and (b) a hydrophilic reactive polymer having complementary reactive functionalities along the polymer chain, wherein the complementary reactive functionalities along the polymer chain of the hydrophilic reactive polymer of (b) bind with the boronic acid moieties of the biomedical device of (a), thereby producing a biocompatible coating which can be removed and re-applied to restore the surface properties of the biomedical device to substantially as-new condition. Methods for treating the biomedical device are also disclosed.
摘要翻译： 公开了在其表面的一部分上具有亲水涂层的生物医学装置，所述生物医学装置包括：（a）由单体混合物的聚合产物获得的生物医学装置，其包含（i）含有硼酸部分的可聚合单体和 吸电子部分; 和（ii）生物医学装置形成共聚单体; 和（b）沿着聚合物链具有互补的反应性官能团的亲水性反应性聚合物，其中沿着（b）的亲水性反应性聚合物的聚合物链的互补反应性官能团与（a）的生物医学装置的硼酸部分结合， 从而产生生物相容性涂层，其可以被去除并重新施加以将生物医学装置的表面性质恢复到基本上新的状态。 还公开了用于治疗生物医学装置的方法。
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公开(公告)号：US08377126B2
公开(公告)日：2013-02-19
申请号：US12641422
申请日：2009-12-18
IPC分类号： A61F2/16
CPC分类号： G02B1/043 , A61L27/34 , A61L29/085 , A61L31/10 , A61L2400/18 , A61L2430/16
摘要： Disclosed are biomedical devices having a hydrophilic coating on a portion of a surface thereof, the biomedical device comprising: (a) a biomedical device obtained from a polymerization product of a monomeric mixture comprising (i) a polymerizable monomer containing a boronic acid moiety and an electron withdrawing moiety; and (ii) a biomedical device-forming comonomer; and (b) a hydrophilic reactive polymer having complementary reactive functionalities along the polymer chain, wherein the complementary reactive functionalities along the polymer chain of the hydrophilic reactive polymer of (b) bind with the boronic acid moieties of the biomedical device of (a), thereby producing a biocompatible coating which can be removed and re-applied to restore the surface properties of the biomedical device to substantially as-new condition. Methods for treating the biomedical device are also disclosed.
摘要翻译： 公开了在其表面的一部分上具有亲水涂层的生物医学装置，所述生物医学装置包括：（a）由单体混合物的聚合产物获得的生物医学装置，其包含（i）含有硼酸部分的可聚合单体和 吸电子部分; 和（ii）生物医学装置形成共聚单体; 和（b）沿着聚合物链具有互补的反应性官能团的亲水性反应性聚合物，其中沿着（b）的亲水性反应性聚合物的聚合物链的互补反应性官能团与（a）的生物医学装置的硼酸部分结合， 从而产生生物相容性涂层，其可以被去除并重新施加以将生物医学装置的表面性质恢复到基本上新的状态。 还公开了用于治疗生物医学装置的方法。
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公开(公告)号：US06759496B2
公开(公告)日：2004-07-06
申请号：US10008441
申请日：2001-12-06
IPC分类号： C08F12600
摘要： Biomedical devices are formed from the polymerization product of a monomeric mixture including a poly(2-oxazoline) endcapped with an ethylenically unsaturated radical, such as poly(2-oxazoline) macromonomers and telechelics. Preferred devices are ophthalmic lenses, especially contact lenses and intraocular lenses.
摘要翻译： 生物医学装置由包含与烯键式不饱和基团（例如聚（2-恶唑啉））大分子单体和电视电解质封端的聚（2-恶唑啉）的单体混合物的聚合产物形成。 优选的装置是眼科镜片，特别是隐形眼镜和人工晶状体。
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8.发明授权公开(公告)号：US06599559B1
公开(公告)日：2003-07-29
申请号：US09541588
申请日：2000-04-03
IPC分类号： C08J704
CPC分类号： G02B1/043 , A61L27/34 , C08J7/047 , Y10T428/31511 , Y10T428/31663 , C08L83/00 , C08L43/04
摘要： The present invention is directed toward the renewable surface treatment of medical devices such as contact lenses and medical implants. In particular, the present invention is directed to a method of modifying the surface of a medical device to increase its biocompatibility or hydrophilicity by coating the device with a removable hydrophilic polymer by means of reaction between reactive functionalities on the hydrophilic polymer which functionalities are complementary to reactive functionalities on or near the surface of the medical device. The present invention is also directed to a contact lens or other medical device having such a surface coating.
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公开(公告)号：US06440571B1
公开(公告)日：2002-08-27
申请号：US09315620
申请日：1999-05-20
IPC分类号： B32B2708
CPC分类号： C08J7/047 , A61L27/34 , C08J2383/04 , G02B1/043 , Y10T428/31663 , C08L83/10
摘要： The present invention is directed toward the surface treatment of silicone medical devices such as contact lenses and medical implants. In particular, the present invention is directed to a method of modifying the surface of a medical device to increase its biocompatibility or hydrophilicity by coating the device with a hydrophilic polymer by means of reaction between reactive functionalities on the hydrophilic polymer which functionalities are complementary to reactive functionalities on or near the surface of the medical device. The present invention is also directed to a contact lens or other medical device having such a surface coating.
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公开(公告)号：US5981675A
公开(公告)日：1999-11-09
申请号：US206470
申请日：1998-12-07
IPC分类号： C08F290/04 , C08F290/12 , G02B1/04 , C08F30/08
CPC分类号： C08F290/12 , C08F290/04 , G02B1/043
摘要： Low water siloxane macromonomer are disclosed. This macromonomer can be copolymerized with unsaturated silicone containing monomers to prepare polymeric materials useful as biomedical devices. These macromonomers are particularly suited for soft contact lens applications.
摘要翻译： 公开了低水硅氧烷大分子单体。 这种大分子单体可以与含有不饱和硅氧烷的单体共聚以制备用作生物医学装置的聚合材料。 这些大分子单体特别适用于软性隐形眼镜应用。
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