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    3 ALPHA-HYDROXY-3 BETA-METHOXYMETHYL-SUBSTITUTED STEROIDS AND THE USE THEREOF
    6.
    发明申请
    3 ALPHA-HYDROXY-3 BETA-METHOXYMETHYL-SUBSTITUTED STEROIDS AND THE USE THEREOF 审中-公开
    3 ALPHA-羟基-3β-甲氧基甲基取代的甾族化合物及其用途

    公开(公告)号：US20050171074A1

    公开(公告)日：2005-08-04

    申请号：US11027682

    申请日：2005-01-03

    申请人： Derk Hogenkamp

    发明人： Derk Hogenkamp

    IPC分类号： A61K31/573 ,  A61K31/58 ,  A61P23/00 ,  A61P25/20 ,  C07J31/00 ,  C07J33/00 ,  C07J43/00

    CPC分类号： C07J43/003

    摘要： This invention relates to compounds having the Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein: R1 is H or methyl; R2 is 5α- or 5β-H; R3 is an optionally substituted N-attached heteroaryl group or a group —X—R4; R4 is an optionally substituted carbon-attached heteroaryl group; and X is O, S or N. The invention also is directed to the use of 3α-hydroxy-3β-methoxymethyl-substituted steroids as sedative/hypnotics and for inducing anesthesia.

    摘要翻译： 本发明涉及具有式I的化合物或其药学上可接受的盐，前药或溶剂化物，其中：R 1是H或甲基; R 2是5α或5β-H; R 3是任选取代的N-连接的杂芳基或基团-X-R 4; R 4是任选取代的含碳杂芳基; 并且X是O，S或N.本发明还涉及3α-羟基-3β-甲氧基甲基取代的类固醇作为镇静/催眠药和诱导麻醉的用途。

    Aryl substituted pyrazoles, imidazoles, oxazoles, thiazoles and pyrroles, and the use thereof
    8.
    发明授权
    Aryl substituted pyrazoles, imidazoles, oxazoles, thiazoles and pyrroles, and the use thereof 有权
    芳基取代的吡唑，咪唑，恶唑，噻唑和吡咯，及其用途

    公开(公告)号：US06737418B2

    公开(公告)日：2004-05-18

    申请号：US10134697

    申请日：2002-04-30

    申请人： Derk Hogenkamp ,  Ravindra Upasani ,  Phong Nguyen

    发明人： Derk Hogenkamp ,  Ravindra Upasani ,  Phong Nguyen

    IPC分类号： A61K3142

    CPC分类号： C07D207/416 ,  C07D231/12 ,  C07D233/54 ,  C07D233/64 ,  C07D235/18 ,  C07D263/34 ,  C07D277/56 ,  C07D403/04

    摘要： This invention relates to compounds having the Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Het and R5-R13 are set in the specification. The invention also is directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.

    摘要翻译： 本发明涉及具有式I化合物或其药学上可接受的盐，前药或溶剂合物，其中Het和R5-R13在本说明书中设定。 本发明还涉及式I化合物用于治疗全身和局部缺血后的神经元损伤，用于治疗或预防神经变性疾病如肌萎缩性侧索硬化（ALS）以及治疗，预防或改善的用途 作为抗惊厥剂，作为抗惊厥剂，作为抗躁狂抑制剂，作为局部麻醉剂，作为抗心律失常药物和用于治疗或预防糖尿病性神经病变。

    Aryl substituted pyrazoles, and pyrroles, and the use thereof
    9.
    发明授权
    Aryl substituted pyrazoles, and pyrroles, and the use thereof 有权
    芳基取代的吡唑和吡咯及其用途

    公开(公告)号：US06414011B1

    公开(公告)日：2002-07-02

    申请号：US09533864

    申请日：2000-03-24

    申请人： Derk Hogenkamp ,  Ravindra Upasani ,  Phong Nguyen

    发明人： Derk Hogenkamp ,  Ravindra Upasani ,  Phong Nguyen

    IPC分类号： A61K31415

    CPC分类号： C07D207/416 ,  C07D231/12 ,  C07D233/54 ,  C07D233/64 ,  C07D235/18 ,  C07D263/34 ,  C07D277/56 ,  C07D403/04

    摘要： This invention relates to compounds having the Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Het and R5-R13 are set in the specification. The invention also is directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.

    摘要翻译： 本发明涉及具有式I化合物或其药学上可接受的盐，前药或溶剂合物，其中Het和R5-R13在本说明书中设定。 本发明还涉及式I化合物用于治疗全身和局部缺血后的神经元损伤，用于治疗或预防神经变性疾病如肌萎缩性侧索硬化（ALS）以及治疗，预防或改善的用途 作为抗惊厥剂，作为抗惊厥剂，作为抗躁狂抑制剂，作为局部麻醉剂，作为抗心律失常药物和用于治疗或预防糖尿病性神经病变。