公开(公告)号：US20130164828A1

公开(公告)日：2013-06-27

申请号：US13643279

申请日：2011-06-10

Applicant: Kishan Dholakia ,  Na Ma ,  Praveen Cheriyan Ashok ,  David Stevenson ,  Francis James Gunn-Moore

Inventor： Kishan Dholakia ,  Na Ma ,  Praveen Cheriyan Ashok ,  David Stevenson ,  Francis James Gunn-Moore

IPC: C12N15/85

CPC classification number: C12M35/02 ,  C12N15/87 ,  G02B21/32

Abstract: An integrated fibre based device for transfecting material into a cell comprising an optical fiber that has a lens formed at its end for directing light to a surface of the cell, and a channel for delivery of the material for transfection into the cell.

Abstract translation: 一种用于将材料转染到细胞中的集成的基于纤维的装置，包括具有在其端部形成的用于将光引导到细胞表面的透镜的光纤，以及用于将所述材料输送到细胞中的通道。

公开(公告)号：US20090150244A1

公开(公告)日：2009-06-11

申请号：US12342385

申请日：2008-12-23

Applicant: David Ciancio ,  David Stevenson

Inventor： David Ciancio ,  David Stevenson

IPC: G06Q30/00

CPC classification number: G06Q20/363 ,  G06Q20/20 ,  G06Q20/202 ,  G06Q30/0224 ,  G06Q30/0238 ,  G07F7/0866

Abstract: A combined in-store and fuel center point-of-sale system having a first point-of-sale system, having a checkout manager and one or more checkout terminals, and a second point-of-sale system, having a fuel center and one or more fuel pumps, in communication with each other and with one or more primary databases containing marketing data, consumer data, customer data, master sales data, discount data, and merchandise product data, for generating a fuel discount at the second point-of-sale system based on first purchasing activity at the first point-of-sale system and/or second purchasing activity at said second point-of-sale system. The fuel discount is maintained for each customer in one of said primary databases and is based on a total purchase of products, a total purchase of product units, a total purchase amount of a product type, time period for total purchase of products, or a tiered spending amount.

Abstract translation: 具有第一销售点系统的组合的店内和燃料中心销售点系统，具有结帐管理器和一个或多个结账终端，以及具有燃料中心和第二销售点系统的第二销售点系统， 一个或多个燃料泵，彼此通信，以及一个或多个主要数据库，其包含营销数据，消费者数据，客户数据，主销售数据，折扣数据和商品产品数据，用于在第二点处产生燃料折扣， 所述销售系统基于所述第一销售点系统的第一购买活动和/或所述第二销售点系统的第二购买活动。 其中一个主要数据库中的每个客户维持燃料折扣，并且基于产品的总购买，产品单元的总购买量，产品类型的总购买量，总购买产品的时间段 分层支出金额。

公开(公告)号：US20070067317A1

公开(公告)日：2007-03-22

申请号：US10554031

申请日：2004-04-23

Applicant: David Stevenson

Inventor： David Stevenson

IPC: G06F7/00

CPC classification number: G06F16/954

Abstract: An interactive/electronic guide for allowing navigation around a group of electronic documents, such as on internet or in an intranet site or such like, the guide being operable automatically to present a plurality of topic identifiers together with an indication of the importance of the topics identified within a site. Each topic is user selectable. Selection of a given topic provides access to information on that topic. Preferably, the guide also provides information about multiple sites that are potentially related by content as well as an indication of a degree of similarity in content between such multiple sites.

Abstract translation: 一种互动/电子指南，用于允许在诸如互联网或内部网站点等的一组电子文档之间导航，该指南可自动地操作以呈现多个主题标识符以及主题的重要性的指示 在网站内识别。 每个主题都是用户可选择的。 选择给定的主题可以访问有关该主题的信息。 优选地，该指南还提供关于可能与内容有关的多个站点的信息，以及这些多个站点之间的内容的相似程度的指示。

公开(公告)号：US4623716A

公开(公告)日：1986-11-18

申请号：US667025

申请日：1984-11-01

Applicant: David Stevenson ,  Mohammad A. Islam

Inventor： David Stevenson ,  Mohammad A. Islam

IPC: C07K1/00 ,  A61K38/00 ,  C07K1/02 ,  C07K1/06 ,  C07K1/113 ,  C07K7/16 ,  C07K14/575 ,  C07K14/585 ,  C07K14/655

CPC classification number: C07K1/02 ,  C07K1/067 ,  C07K14/585 ,  A61K38/00 ,  Y10S930/15 ,  Y10S930/16

Abstract: Peptides, such as calcitonin, having two cysteine residues connected by a disulfide bond are prepared by a process which includes the step of cyclizing the cysteines at a pH of 8.5 to 9.0, and a concentration of 0.4 to 1.8 mg of peptide per ml of solution. These novel conditions produce rapid cyclization with an unforeseen improvement in yield.

Abstract translation: 具有通过二硫键连接的两个半胱氨酸残基的肽例如降钙素通过包括以下步骤的方法制备，所述方法包括在8.5至9.0的pH下使半胱氨酸环化，并且每ml溶液的浓度为0.4至1.8mg肽 。 这些新颖的条件产生快速环化，产量不可预见的提高。

公开(公告)号：US20080043050A1

公开(公告)日：2008-02-21

申请号：US11923134

申请日：2007-10-24

Applicant: Lucas Barkley ,  David Stevenson

Inventor： Lucas Barkley ,  David Stevenson

IPC: B41J29/38

CPC classification number: B41J2/04541 ,  B41J2/04586 ,  B41J2/04588 ,  B41J2/04598

Abstract: A method and device for providing a plurality of fire pulses in an ink jet printer, which includes a production of a plurality of fire signals. Each fire signal of the plurality of fire signals are asserted at a different timing than the other of the plurality of fire signals. The plurality of fire signals are combined to form a composite fire signal that maintains the different timing.

公开(公告)号：US20070152038A1

公开(公告)日：2007-07-05

申请号：US11263080

申请日：2005-10-31

Applicant: David Ciancio ,  David Stevenson

Inventor： David Ciancio ,  David Stevenson

IPC: G06F7/08 ,  G06K15/00 ,  G07B15/02

CPC classification number: G06Q20/363 ,  G06Q20/20 ,  G06Q20/202 ,  G06Q30/0224 ,  G06Q30/0238 ,  G07F7/0866

Abstract: A combined in-store and fuel center point-of-sale system having a first point-of-sale system, having a checkout manager and one or more checkout terminals, and a second point-of-sale system, having a fuel center and one or more fuel pumps, in communication with each other and with one or more primary databases containing marketing data, consumer data, customer data, master sales data, discount data, and merchandise product data, for generating a fuel discount at the second point-of-sale system based on first purchasing activity at the first point-of-sale system and/or second purchasing activity at said second point-of-sale system. The fuel discount is maintained for each customer in one of said primary databases and is based on a total purchase of products, a total purchase of product units, a total purchase amount of a product type, time period for total purchase of products, or a tiered spending amount.

Abstract translation: 具有第一销售点系统的组合的店内和燃料中心销售点系统，具有结帐管理器和一个或多个结账终端，以及具有燃料中心和第二销售点系统的第二销售点系统， 一个或多个燃料泵，彼此通信，以及一个或多个主要数据库，其包含营销数据，消费者数据，客户数据，主销售数据，折扣数据和商品产品数据，用于在第二点处产生燃料折扣， 所述销售系统基于所述第一销售点系统的第一购买活动和/或所述第二销售点系统的第二购买活动。 其中一个主要数据库中的每个客户维持燃料折扣，并且基于产品的总购买，产品单元的总购买量，产品类型的总购买量，总购买产品的时间段 分层支出金额。

公开(公告)号：US20050128233A1

公开(公告)日：2005-06-16

申请号：US10736183

申请日：2003-12-15

Applicant: Lucas Barkley ,  David Stevenson

Inventor： Lucas Barkley ,  David Stevenson

IPC: B41J2/045 ,  B41J29/38

CPC classification number: B41J2/04541 ,  B41J2/04586 ,  B41J2/04588 ,  B41J2/04598

Abstract: A method and device for providing a plurality of fire pulses in an ink jet printer, which includes a production of a plurality of fire signals. Each fire signal of the plurality of fire signals are asserted at a different timing than the other of the plurality of fire signals. The plurality of fire signals are combined to form a composite fire signal that maintains the different timing.

Abstract translation: 一种用于在喷墨打印机中提供多个起火脉冲的方法和装置，其包括产生多个火情信号。 多个火情信号的每个发射信号在与多个火情信号中另一个不同的定时被断言。 多个火焰信号被组合以形成维持不同定时的复合火情信号。

公开(公告)号：US5749610A

公开(公告)日：1998-05-12

申请号：US618132

申请日：1996-03-19

Applicant: Terrence N. Brammall ,  Randel Mills ,  Rodney Ridenour ,  David Stevenson

Inventor： Terrence N. Brammall ,  Randel Mills ,  Rodney Ridenour ,  David Stevenson

IPC: G09F3/03 ,  E05B39/02

CPC classification number: G09F3/0317 ,  Y10T292/495 ,  Y10T292/496 ,  Y10T292/51

Abstract: A steel bolt has weakening grooves at one end to which a head is swaged, the head having two frusto-conical portions at opposite ends. One end has a frusto-conical step for receiving a pair of jaws of a bolt breaking tool. A resilient spacer is attached to the bolt next to the head for limiting the depth of entry of the bolt head into a hasp hole, to provide access clearance for the tool and to permit the bolt to tilt to assist in breaking the bolt. The spacer is received in one hasp hole smaller in diameter than a second hasp hole to limit the depth of insertion of the spacer and the bolt head tapered end portion into the hasp. A seal with a conventional locking mechanism has a frusto-conical end region which partially engages the other hasp hole. The bolt and seal cooperate to lock the seal axially at different positions so the seal is engaged with one hasp hole and the bolt head engaged with the other hasp hole. A tool is disclosed which mates with the bolt head for breaking the bolt at the head when used with J-shaped hasps with limited tool receiving space.

Abstract translation: 钢螺栓在一端被削弱的槽具有削弱的槽，头部在相对的端部具有两个截头圆锥形部分。 一端具有用于接收螺栓破坏工具的一对夹爪的截头圆锥形台阶。 弹性间隔件附接到靠近头部的螺栓上，用于限制螺栓头进入散热孔的深度，以提供工具的进入间隙，并允许螺栓倾斜以帮助破坏螺栓。 间隔件被容纳在直径小于第二凹槽孔的一个孔口中，以将间隔件的插入深度和螺栓头锥形端部部分限制到搭扣中。 具有常规锁定机构的密封件具有部分地接合另一个钩孔的截头圆锥形端部区域。 螺栓和密封件配合以将密封件轴向地锁定在不同的位置，使得密封件与一个扣件孔接合，并且螺栓头与另一个孔孔接合。 公开了一种工具，其与用于具有有限工具接收空间的J形散热器一起用于将头部螺栓打破的螺栓头配合。

公开(公告)号：US4427827A

公开(公告)日：1984-01-24

申请号：US435581

申请日：1982-10-20

Applicant: David Stevenson

Inventor： David Stevenson

IPC: A61K38/00 ,  C07K1/04 ,  C07K14/585 ,  C07C103/52 ,  C08L89/00

CPC classification number: C07K1/04 ,  C07K14/585 ,  A61K38/00

Abstract: The yield of peptide synthesis processes of the type in which a protected intermediate resin peptide of the formula Resin--CH.sub.2 --O--Phe--X, Resin--CH.sub.2 --O--Gly--X, Resin--CH.sub.2 --O--Ala--X, or Resin--CH.sub.2 --O--Leu--X is deprotected, and successively protected amino acids are coupled to the resin peptide and deprotected, is increased significantly by deprotecting the first residue with trifluoroacetic acid and deprotecting the other residues with hydrogen chloride.

Abstract translation: 肽类合成方法的产率，其中通式为Resin-CH2-O-Phe-X，Resin-CH2-O-Gly-X，Resin-CH2-O-Ala-X的保护的中间体树脂肽或 将树脂-CH 2 -O-Leu-X脱保护，连续保护的氨基酸与树脂肽偶联并去保护，通过用三氟乙酸脱保护第一残余物并用氯化氢脱保护其它残余物而显着增加。

公开(公告)号：US4385050A

公开(公告)日：1983-05-24

申请号：US277497

申请日：1981-06-26

Applicant: Karl Lederis ,  David Stevenson ,  Donald B. Olsen ,  Charles D. Bossinger ,  Everett Flanigan

Inventor： Karl Lederis ,  David Stevenson ,  Donald B. Olsen ,  Charles D. Bossinger ,  Everett Flanigan

IPC: A61K38/00 ,  C07K14/575 ,  A61K37/00 ,  C07C103/52

CPC classification number: C07K14/57509 ,  A61K38/00 ,  Y10S530/80

Abstract: Peptides of the structureR.sub.1 --Ala--Arg--Ile--Glu--Asn--Glu--Glu--Glu--Gln--Ala--Gly--Leu--Asn--Arg--Lys--Tyr--Leu--Val--R.sub.2whereinR.sub.1 is hydrogen, a peptide residue containing from 1 to 18 amino acid residues, or N-acyl, andR.sub.2 is hydrogen, an alcohol moiety of an ester, an amide, or a peptide residue containing from 1 to 10 amino acid residues,whereinthe acyl group is lower alkanoyl having from 1 to 8 carbon atoms, aroyl, or heterocarbonyl, and the alcohol moiety of the ester is an alkyl group having from 1 to 8 carbon atoms have antihypertensive activity.

Abstract translation: 结构R1-Ala-Arg-Ile-Glu-Asn-Glu-Glu-Glu-Gln-Ala-Gly-Leu-Asn-Arg-Lys-Tyr-Leu -Val-R2的肽，其中R1是氢，肽 含有1至18个氨基酸残基的残基或N-酰基，R2是氢，含有1至10个氨基酸残基的酯，酰胺或肽残基的醇部分，其中酰基是低级烷酰基 具有1至8个碳原子，芳酰基或杂羰基，并且酯的醇部分是具有1至8个碳原子的烷基具有抗高血压活性。