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公开(公告)号：US20130164828A1
公开(公告)日：2013-06-27
申请号：US13643279
申请日：2011-06-10
IPC分类号： C12N15/85
摘要： An integrated fibre based device for transfecting material into a cell comprising an optical fiber that has a lens formed at its end for directing light to a surface of the cell, and a channel for delivery of the material for transfection into the cell.
摘要翻译： 一种用于将材料转染到细胞中的集成的基于纤维的装置，包括具有在其端部形成的用于将光引导到细胞表面的透镜的光纤，以及用于将所述材料输送到细胞中的通道。
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公开(公告)号：US20120075627A1
公开(公告)日：2012-03-29
申请号：US12892640
申请日：2010-09-28
IPC分类号： G01J3/44
CPC分类号： G01N21/65 , G01N21/05 , G01N2021/0346 , G01N2201/08
摘要： A microfluidic device comprising at least one microfluidic channel with an input and an output for allowing fluid flow; and at least one Raman fiber based probe having an excitation fiber probe and/or a collection fiber probe positioned so that one end of the probe is in the microfluidic channel.
摘要翻译： 一种微流体装置，包括至少一个具有输入的微流体通道和用于允许流体流动的输出; 以及至少一个具有激发纤维探针和/或收集纤维探针的拉曼光纤探针，其定位使得探针的一端在微流体通道中。
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公开(公告)号：US20130222799A1
公开(公告)日：2013-08-29
申请号：US13818501
申请日：2011-09-28
IPC分类号： G01J3/02
CPC分类号： G01N33/146 , B01L3/502715 , B01L3/502784 , B01L2200/027 , B01L2200/0673 , B01L2300/0627 , B01L2300/0654 , B01L2300/0816 , B01L2300/0883 , B01L2300/16 , G01J3/0218 , G01N21/05 , G01N21/64 , G01N21/645 , G01N21/65 , G01N2021/651 , G01N2201/0846
摘要： A Raman spectroscopic detection device comprising at least one microfluidic sample channel; at least one excitation waveguide for exciting a Raman signal and at least one collection waveguide for collecting a Raman signal. The output of the excitation waveguide and the input of the collection waveguide are positioned directly in the microfluidic sample channel.
摘要翻译： 一种拉曼光谱检测装置，包括至少一个微流体样品通道; 用于激发拉曼信号的至少一个激励波导和用于收集拉曼信号的至少一个收集波导。 激发波导的输出和收集波导的输入直接位于微流体样品通道中。
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公开(公告)号：US10222362B2
公开(公告)日：2019-03-05
申请号：US14861570
申请日：2015-09-22
摘要： A Raman spectroscopic detection device comprising at least one microfluidic sample channel; at least one excitation waveguide for exciting a Raman signal and at least one collection waveguide for collecting a Raman signal. The output of the excitation waveguide and the input of the collection waveguide are positioned directly in the microfluidic sample channel.
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公开(公告)号：US20160084766A1
公开(公告)日：2016-03-24
申请号：US14861570
申请日：2015-09-22
CPC分类号： G01N33/146 , B01L3/502715 , B01L3/502784 , B01L2200/027 , B01L2200/0673 , B01L2300/0627 , B01L2300/0654 , B01L2300/0816 , B01L2300/0883 , B01L2300/16 , G01J3/0218 , G01N21/05 , G01N21/64 , G01N21/645 , G01N21/65 , G01N2021/651 , G01N2201/0846
摘要： A Raman spectroscopic detection device comprising at least one microfluidic sample channel; at least one excitation waveguide for exciting a Raman signal and at least one collection waveguide for collecting a Raman signal. The output of the excitation waveguide and the input of the collection waveguide are positioned directly in the microfluidic sample channel.
摘要翻译： 一种拉曼光谱检测装置，包括至少一个微流体样品通道; 用于激发拉曼信号的至少一个激励波导和用于收集拉曼信号的至少一个收集波导。 激发波导的输出和收集波导的输入直接位于微流体样品通道中。
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公开(公告)号：US08638431B2
公开(公告)日：2014-01-28
申请号：US12892640
申请日：2010-09-28
IPC分类号： G01J3/44
CPC分类号： G01N21/65 , G01N21/05 , G01N2021/0346 , G01N2201/08
摘要： A microfluidic device comprising at least one microfluidic channel with an input and an output for allowing fluid flow; and at least one Raman fiber based probe having an excitation fiber probe and/or a collection fiber probe positioned so that one end of the probe is in the microfluidic channel.
摘要翻译： 一种微流体装置，包括至少一个具有输入的微流体通道和用于允许流体流动的输出; 以及至少一个具有激发纤维探针和/或收集纤维探针的拉曼光纤探针，其定位使得探针的一端在微流体通道中。
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公开(公告)号：US09683209B2
公开(公告)日：2017-06-20
申请号：US14110384
申请日：2012-06-20
CPC分类号： C12M35/02 , B01L3/502715 , B01L3/502761 , C12N13/00 , G01N21/05 , G01N2021/0346
摘要： A cell permeabilizing microfluidic system for permeabilizing one or more cells in a fluid flow. The system has a microfluidic channel for channeling at least one cell in a fluid flow and an optical source for generating a beam of light for permeabilizing the at least one cell, wherein the channel and the source are arranged so that the light beam and fluid flow are collinear in a permeabilization part of the channel and cells are permeabilized within the permeabilization part.
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公开(公告)号：US08922767B2
公开(公告)日：2014-12-30
申请号：US12303526
申请日：2007-06-08
CPC分类号： G01J3/0297 , B01L3/5027 , G01J3/28 , G01J3/433 , G01J3/44 , G01J3/4412 , G01N21/65 , G01N2021/651 , G01N2021/656
摘要： A micro-fluidic system comprising means for optically trapping a particle and a Raman excitation source for causing Raman scatter from the particle while it is in the optical trap.
摘要翻译： 一种微流体系统，包括用于光学捕获颗粒和拉曼激发源的装置，用于在所述光阱中引起来自所述颗粒的拉曼散射。
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公开(公告)号：US09957476B2
公开(公告)日：2018-05-01
申请号：US13639296
申请日：2011-04-11
CPC分类号： C12N5/0006 , C12M35/02 , C12N15/87
摘要： A method for porating one or more cells comprising positioning a particle near each cell; and causing laser-induced breakdown of the particle to create one or more cavitations, wherein the cavitation(s) causes poration of the cell.
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公开(公告)号：US09815058B2
公开(公告)日：2017-11-14
申请号：US10554937
申请日：2004-05-07
CPC分类号： B01L3/502753 , B01L3/502761 , B01L2200/0647 , B01L2300/0864 , B01L2400/0454 , G01N15/1434 , G01N15/1459 , G01N2015/145 , G01N2015/149 , G01N30/02 , B01D2015/3895
摘要： A fractionation system comprising means for forming a three dimensional optical lattice that is operable to separate particles that have different physical characteristics. Preferably, the wells of the optical lattice are interlinked. For example, the wells may be linked in such a manner as to provide deflection greater than or equal to 15 degrees.
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