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29 条记录 (耗时 0.046 秒)

    O-substituted N-hydroxyurea derivatives
    5.
    发明授权
    O-substituted N-hydroxyurea derivatives 失效
    O-取代的N-羟基脲衍生物

    公开(公告)号：US5292900A

    公开(公告)日：1994-03-08

    申请号：US992389

    申请日：1992-12-18

    申请人： Anwer Basha ,  Dee W. Brooks

    发明人： Anwer Basha ,  Dee W. Brooks

    IPC分类号： C07C275/64 ,  C07D309/12 ,  C07D333/58 ,  C07D209/04

    CPC分类号： C07D333/58 ,  C07C275/64 ,  C07D309/12 ,  Y02P20/55

    摘要： The present invention provides compounds useful as intermediates for the preparation of 5-lipoxygenase inhibiting compounds. The intermediates of this invention have the structure ##STR1## wherein R.sup.1 is an O-protecting group selected from the group consisting of ##STR2## In the above, X is oxygen or sulfur.

    摘要翻译： 本发明提供了可用作制备5-脂氧合酶抑制化合物的中间体的化合物。 本发明的中间体具有结构（*化学结构*），其中R1是选自（*化学结构*）（*化学结构*）的O-保护基。在上述中，X是氧或硫。

    Pyrimido-pyrimidine lipoxygenase inhibiting compounds
    7.
    发明授权
    Pyrimido-pyrimidine lipoxygenase inhibiting compounds 失效
    嘧啶 - 嘧啶脂氧合酶抑制化合物

    公开(公告)号：US4963541A

    公开(公告)日：1990-10-16

    申请号：US314008

    申请日：1989-02-22

    申请人： Dee W. Brooks ,  Anwer Basha

    发明人： Dee W. Brooks ,  Anwer Basha

    IPC分类号： C07D487/04

    CPC分类号： C07D487/04

    摘要： Compounds of the formula: ##STR1## wherein A is selected from NR.sub.1 R.sub.2 and N(OR.sub.6)R.sub.2 ; and B and C are chloro when A is N(OR.sub.6)R.sub.2 or are independently selected from NHR.sub.3 and NR.sub.4 R.sub.5 where R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are independently selected from the group consisting of alkyl, cycloalkyl and alkylaryl each of which may be unsubstituted or substituted with one or more substituents selected from the group consisting of hydroxy, OR, NRR, OCOR, OCONRR, NRCOR and NRCONRR where R is selected from the group consisting of hydrogen, alkyl, aryl, alkylaryl, alkoxy and hydroxy or R.sub.1 and R.sub.2 or R.sub.4 and R.sub.5 together can form a heteroaryl group and R.sub.6 is a member selected from the group consisting of hydrogen, alkyl, alkylaryl and trialkylsilyl; and the pharmaceutically acceptable salts thereof.These compounds are useful as inhibitors of lipoxygenase enzymes.

    摘要翻译： 下式的化合物：其中A选自NR1R2和N（OR6）R2; 当A为N（OR 6）R 2时，B和C为氯，或独立地选自NHR 3和NR 4 R 5，其中R 1，R 2，R 3，R 4和R 5独立地选自烷基，环烷基和烷芳基，其各自可以是 未取代或被一个或多个选自羟基，OR，NRR，OCOR，OCONRR，NRCOR和NRCONRR的取代基取代，其中R选自氢，烷基，芳基，烷基芳基，烷氧基和羟基或R 1和 R2或R4和R5一起可以形成杂芳基，R6是选自氢，烷基，烷基芳基和三烷基甲硅烷基的成员; 及其药学上可接受的盐。 这些化合物可用作脂氧合酶的抑制剂。