公开(公告)号：US09833504B2

公开(公告)日：2017-12-05

申请号：US14117365

申请日：2012-05-01

申请人： Denis Leclerc ,  Pierre Savard

发明人： Denis Leclerc ,  Pierre Savard

IPC分类号： A61K39/12 ,  A61K39/39

CPC分类号： A61K39/12 ,  A61K39/39 ,  C12N2760/10011 ,  C12N2760/16111 ,  C12N2770/26023 ,  C12N2770/26034 ,  C12N2770/26042 ,  Y02A50/403 ,  Y02A50/407 ,  Y02A50/478

摘要： An in vitro process of preparing virus-like particles (VLPs) from recombinant papaya mosaic virus coat protein and ssRNA, which allows for large scale production of VLPs in high yields, is provided. Also provided are VLPs comprising ssRNA prepared by the in vitro process. The VLPs can be used as adjuvants and when fused to an antigen, as vaccines. The use of the VLPs for stimulation of the innate immune response is also provided.

公开(公告)号：US20140255439A1

公开(公告)日：2014-09-11

申请号：US14117365

申请日：2012-05-01

申请人： Denis Leclerc ,  Pierre Savard

发明人： Denis Leclerc ,  Pierre Savard

IPC分类号： A61K39/12

CPC分类号： A61K39/12 ,  A61K39/39 ,  C12N2760/10011 ,  C12N2760/16111 ,  C12N2770/26023 ,  C12N2770/26034 ,  C12N2770/26042 ,  Y02A50/403 ,  Y02A50/407 ,  Y02A50/478

摘要： An in vitro process of preparing virus-like particles (VLPs) from recombinant papaya mosaic virus coat protein and ssRNA, which allows for large scale production of VLPs in high yields, is provided. Also provided are VLPs comprising ssRNA prepared by the in vitro process. The VLPs can be used as adjuvants and when fused to an antigen, as vaccines. The use of the VLPs for stimulation of the innate immune response is also provided.

摘要翻译： 提供了从重组番木瓜花叶病毒外壳蛋白和ssRNA制备病毒样颗粒（VLPs）的体外方法，其允许以高产量大规模生产VLP。 还提供了通过体外方法制备的包含ssRNA的VLP。 作为疫苗，VLP可以用作佐剂，当与抗原融合时。 还提供了VLP用于刺激先天免疫应答的用途。

公开(公告)号：US08862222B2

公开(公告)日：2014-10-14

申请号：US12920242

申请日：2009-03-02

申请人： Pierre Savard ,  Michael Buschmann ,  John Hardin

发明人： Pierre Savard ,  Michael Buschmann ,  John Hardin

IPC分类号： A61B5/05 ,  A61B5/04 ,  A61B5/103 ,  A61B5/117 ,  A61B5/00 ,  A61N1/04

CPC分类号： A61B5/04 ,  A61B5/05 ,  A61B5/4514 ,  A61B5/4528 ,  A61B5/6828 ,  A61B2562/0215 ,  A61N1/0476

摘要： There is described a method for non-invasively measuring electrical activity in a joint of a subject, the method comprising: removably attaching in a non-invasive manner at least two electrodes to a skin surface around an articulation comprising the joint; generating electroarthrographic potentials within the joint by loading the articulation; capturing the electroarthrographic potentials using the at least two electrodes; discriminating between electroarthrographic potentials originating from joint tissue activity and those from other sources; and generating measurement signals representing the electrical activity of joint tissue.

摘要翻译： 描述了用于非侵入性地测量受试者的关节中的电活动的方法，所述方法包括：以非侵入性方式将至少两个电极可移除地附接到围绕包括关节的关节的皮肤表面; 通过加载关节来产生关节内的电势电位; 使用所述至少两个电极捕获电连接电位; 区分源自关节组织活动的电位电位和来自其他来源的电位电位; 并产生表示关节组织的电活动的测量信号。

公开(公告)号：US5779651A

公开(公告)日：1998-07-14

申请号：US796299

申请日：1997-02-07

申请人： Michael D. Buschmann ,  Robert Guardo ,  Martin Garon ,  Pierre Le Guyader ,  Pierre Savard

发明人： Michael D. Buschmann ,  Robert Guardo ,  Martin Garon ,  Pierre Le Guyader ,  Pierre Savard

IPC分类号： A61B5/05 ,  A61B5/0408 ,  A61B5/0478 ,  A61B5/0492 ,  A61B5/103

CPC分类号： A61B5/4514 ,  A61B5/0408 ,  A61B5/103 ,  A61B2562/0209 ,  A61B2562/043 ,  A61B5/4528

摘要： The present invention relates to a medical apparatus for the early detection and the diagnosis of cartilage degeneration and a method for using such apparatus. The apparatus comprises at least two point electrodes, a signal processor located in proximity of the electrodes, a defined abutment in recess of the electrodes for allowing compression of the cartilage against the electrodes until the cartilage abuts against the abutment surface and a computer program for analyzing and interpreting the data received from the electrodes. The medical apparatus may be used in research to identify effects of new compounds or drugs on the cartilage or may be used in clinics to monitor the degradation of cartilage of a patient over an extended period of time.

摘要翻译： 本发明涉及用于软骨退化的早期检测和诊断的医疗装置以及使用该装置的方法。 该装置包括至少两个点电极，位于电极附近的信号处理器，在电极的凹槽中的限定的邻接部分，用于允许软骨压靠电极直到软骨抵靠抵靠表面，并且计算机程序用于分析 并解释从电极接收的数据。 医学仪器可用于研究以鉴定新化合物或药物对软骨的作用，或者可用于临床中以监测患者在较长时间内的软骨退化。

公开(公告)号：US5311873A

公开(公告)日：1994-05-17

申请号：US937487

申请日：1992-08-28

申请人： Pierre Savard ,  Reginald Nadeau ,  Marc Dubuc

发明人： Pierre Savard ,  Reginald Nadeau ,  Marc Dubuc

IPC分类号： A61N1/08 ,  A61N1/36 ,  A61N1/372 ,  A61N1/00

CPC分类号： A61N1/36014 ,  A61N1/08 ,  A61N1/372 ,  A61B2034/2053

摘要： Body surface potential map (BSPM) pace-mapping is a system and method that can be used in medicine to localize with precision the site of origin of abnormal cardiac electrical activity and to guide the positioning of a catheter over this site of origin, such as the site of ventricular preexcitation in patients with the Wolff-Parkinson-White syndrome or the focus of ectopic activity in patients with tachycardia. Body surface potential distributions are measured with a large number of electrodes, e.g. 24 to 128, distributed over the entire torso surface. The electrical signals are first amplified, converted into digital data and treated to remove electrical or muscle artifacts. Data recorded during abnormal activation (reference beat) are aligned with data recorded during cardiac pacing (paced beat) so as to maximize the average value of the correlation coefficient between the reference and the paced potential distributions during a preset time interval following the beginning of the QRS complex. Reference and paced maps showing color-coded isopotential contour lines are displayed side by side for the same time instant. Visual analysis of these maps according to previously published criteria determines the relative position of the pacing catheter with respect to the focus of abnormal activation, and gives information so as to guide the catheter toward the focus.

摘要翻译： 身体表面电位图（BSPM）速度绘图是一种可用于医学中的系统和方法，用于精确定位异常心脏电活动的原点，并引导导管在该原点位置的定位，例如 患有Wolff-Parkinson-White综合征患者心室预激的部位或心动过速患者异位活动的重点。 用大量的电极测量体表面电位分布，例如， 24到128，分布在整个躯干表面。 电信号首先被放大，转换成数字数据并被处理以去除电或肌肉伪像。 在异常激活期间记录的数据（参考拍子）与在心脏起搏（起搏节拍）期间记录的数据对准，以便在开始之后的预设时间间隔期间使参考和起搏电位分布之间的相关系数的平均值最大化 QRS综合 显示彩色等电位轮廓线的参考和节奏地图在同一时刻并排显示。 根据先前发布的标准的这些图的视觉分析确定起搏导管相对于异常激活的焦点的相对位置，并且给出信息以引导导管朝向焦点。

公开(公告)号：US5255678A

公开(公告)日：1993-10-26

申请号：US719006

申请日：1991-06-21

申请人： Antoine Deslauriers ,  Pierre Savard ,  Pierre Page ,  Rene Cardinal ,  Josee Rousseau

发明人： Antoine Deslauriers ,  Pierre Savard ,  Pierre Page ,  Rene Cardinal ,  Josee Rousseau

IPC分类号： A61B5/042 ,  A61B5/04

CPC分类号： A61B5/6853 ,  A61B5/042 ,  A61B5/0422 ,  A61B2562/0209 ,  A61B2562/046 ,  A61M2025/1086

摘要： An electrode balloon for use in anatomical cavities, such as cardiac chambers, to pick up bioelectrical signals from the walls thereof simultaneously in a multitude of sites for the mapping of the activation potentials thereof comprises an inflated tight rubber balloon having an opening at a proximal end thereof communicating with a filling tube which defines apertures for dispensing fluid in the rubber balloon. An extensible knitting which covers the rubber balloon is provided with a plurality of electrode heads distributed thereon to contact the walls of the cavity when the rubber balloon is inflated by a fluid conveyed therein through the tube. Insulated electrical conductors connect the electrodes to a signal recording and processing device. A tutor extending longitudinally through the rubber balloon and further extending therefrom to form a handle includes two separate longitudinal compartments which constitute the filling tube and a compartment for receiving an intubation guide which serves to guide the knitting covered rubber balloon into the cavity. The electrodes are hollow balls sewn to the knitting and joined to the conducting wires with weldless joints. The knitting is patterned in order to confer to the inflated rubber balloon the shape of the cavity being studied. The electrode balloon is adapted, for instance, to study the left and right ventricles by way of its the insertion through an incision in their respective auricles and through the mitral and tricuspid valves thereof, respectively.

摘要翻译： 用于解剖腔体（例如心脏腔室）的电极球囊，用于在多个位置同时从其壁拾取生物电信号以用于映射其活化电位，其包括充气的紧密橡胶球囊，其在近端具有开口 其与填充管连通，该填充管限定用于分配橡胶气囊中的流体的孔。 覆盖橡胶球囊的可伸展针织物设置有多个分布在其上的电极头，当橡胶球囊被其中通过管输送的流体膨胀时，其与腔体的壁接触。 绝缘电导体将电极连接到信号记录和处理装置。 纵向延伸穿过橡胶球并形成手柄的导师包括构成灌装管的两个独立的纵向隔室和用于接纳用于将针织被覆盖的橡胶气球引导到空腔中的插管引导件的隔间。 电极是缝制到针织上的中空球，并且用无焊缝接合到导线上。 对编织进行图案化以赋予膨胀的橡胶球囊所研究的空腔的形状。 例如，电极球适合于通过其通过其各自耳廓中的切口插入并分别穿过其二尖瓣和三尖瓣来研究左心室和右心室。

公开(公告)号：US20110034797A1

公开(公告)日：2011-02-10

申请号：US12920242

申请日：2009-03-02

申请人： Pierre Savard ,  Michael Buschmann ,  John Hardin

发明人： Pierre Savard ,  Michael Buschmann ,  John Hardin

IPC分类号： A61B5/05

CPC分类号： A61B5/04 ,  A61B5/05 ,  A61B5/4514 ,  A61B5/4528 ,  A61B5/6828 ,  A61B2562/0215 ,  A61N1/0476

摘要： There is described a method for non-invasively measuring electrical activity in a joint of a subject, the method comprising: removably attaching in a non-invasive manner at least two electrodes to a skin surface around an articulation comprising the joint; generating electroarthrographic potentials within the joint by loading the articulation; capturing the electroarthrographic potentials using the at least two electrodes; discriminating between electroarthrographic potentials originating from joint tissue activity and those from other sources; and generating measurement signals representing the electrical activity of joint tissue.

摘要翻译： 描述了用于非侵入性地测量受试者的关节中的电活动的方法，所述方法包括：以非侵入性方式将至少两个电极可移除地附接到围绕包括关节的关节的皮肤表面; 通过加载关节来产生关节内的电势电位; 使用所述至少两个电极捕获电连接电位; 区分源自关节组织活动的电位电位和来自其他来源的电位电位; 并产生表示关节组织的电活动的测量信号。