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公开(公告)号:US08900571B2
公开(公告)日:2014-12-02
申请号:US13398674
申请日:2012-02-16
申请人: Dennis E. Van Epps , Guang-Liang Jiang , Adam L. Collette , Rebecca L. Horan , Jingsong Chen , Gregory H. Altman , Wha Bin Im
发明人: Dennis E. Van Epps , Guang-Liang Jiang , Adam L. Collette , Rebecca L. Horan , Jingsong Chen , Gregory H. Altman , Wha Bin Im
IPC分类号: A01N63/00 , A61F2/20 , A61K8/49 , A61K8/64 , A61K31/5377 , A61K31/519 , A61K31/4025 , A61K8/98 , A61Q19/00 , A61K38/17 , A61K35/12
CPC分类号: A61K31/4025 , A61K8/49 , A61K8/4913 , A61K8/4926 , A61K8/4986 , A61K8/64 , A61K8/981 , A61K31/519 , A61K31/5377 , A61K35/35 , A61K38/1767 , A61Q19/00 , A61K2300/00
摘要: The invention relates to compositions comprising a silk fibroin material, adipose tissue and a compound of the structure where X1 and X5 are independently CH or N; X7 is NH, O or S; X8 and X9 are independently CH or N; R13 is an optionally substituted aryl or optionally substituted heteroaryl and R14 is C1-6 alkyl, optionally substituted aryl or optionally substituted heteroaryl. The composition is administered to a site of a soft tissue condition including those of breast tissue. The silk fibroin material can be in the form of a silk hydrogel, a silk film, a silk scaffold, a silk sheet, a silk porous material or a silk fiber. The silk fibroin material can be substantially sericin free.
摘要翻译: 本发明涉及包含丝素蛋白材料,脂肪组织和其中X1和X5独立地为CH或N的结构的化合物的组合物; X7是NH,O或S; X8和X9独立地为CH或N; R13是任选取代的芳基或任选取代的杂芳基,R 14是C 1-6烷基,任选取代的芳基或任选取代的杂芳基。 将组合物施用于包括乳房组织的组织状况的部位。 丝素蛋白材料可以是丝素水凝胶,丝膜,丝绸支架,丝绸片,丝多孔材料或丝纤维的形式。 丝素蛋白材料可以基本上不含丝胶蛋白。
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公开(公告)号:US20120269777A1
公开(公告)日:2012-10-25
申请号:US13398667
申请日:2012-02-16
申请人: Dennis E. Van Epps , Guang-Liang Jiang , Adam L. Collette , Rebecca L. Horan , Jingsong Chen , Gregory H. Altman , Wha Bin Im
发明人: Dennis E. Van Epps , Guang-Liang Jiang , Adam L. Collette , Rebecca L. Horan , Jingsong Chen , Gregory H. Altman , Wha Bin Im
CPC分类号: A61K8/49 , A61K8/4913 , A61K8/4926 , A61K8/4986 , A61K8/64 , A61K8/981 , A61K31/192 , A61K31/215 , A61K31/4015 , A61K31/4025 , A61K31/421 , A61K35/35 , A61K35/63 , A61K38/00 , A61K38/1767 , A61K2800/91 , A61Q19/08 , A61K2300/00
摘要: The specification discloses compositions and methods for treating a soft tissue defect of an individual.
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公开(公告)号:US20120213853A1
公开(公告)日:2012-08-23
申请号:US13398674
申请日:2012-02-16
申请人: Dennis E. Van Epps , Guang-Liang Jiang , Adam L. Collette , Rebecca L. Horan , Jingsong Chen , Gregory H. Altman , Wha Bin Im
发明人: Dennis E. Van Epps , Guang-Liang Jiang , Adam L. Collette , Rebecca L. Horan , Jingsong Chen , Gregory H. Altman , Wha Bin Im
IPC分类号: A61K9/00 , A61P1/00 , A61P13/00 , A61K35/12 , A61K8/49 , A61Q19/00 , A61P15/00 , A61P17/00 , A61P1/02
CPC分类号: A61K31/4025 , A61K8/49 , A61K8/4913 , A61K8/4926 , A61K8/4986 , A61K8/64 , A61K8/981 , A61K31/519 , A61K31/5377 , A61K35/35 , A61K38/1767 , A61Q19/00 , A61K2300/00
摘要: The specification discloses compositions and methods for treating a soft tissue defect of an individual.
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公开(公告)号:US08926963B2
公开(公告)日:2015-01-06
申请号:US13398667
申请日:2012-02-16
申请人: Dennis E. Van Epps , Guang-Liang Jiang , Adam L. Collette , Rebecca L. Horan , Jingsong Chen , Gregory H. Altman , Wha Bin Im
发明人: Dennis E. Van Epps , Guang-Liang Jiang , Adam L. Collette , Rebecca L. Horan , Jingsong Chen , Gregory H. Altman , Wha Bin Im
IPC分类号: A01N63/00 , A61K35/32 , A01N35/00 , A61K8/49 , A61K8/98 , A61K31/192 , A61K31/215 , A61K31/4015 , A61K31/4025 , A61K31/421 , A61K38/00 , A61Q19/08 , A61K8/64 , A61K35/12
CPC分类号: A61K8/49 , A61K8/4913 , A61K8/4926 , A61K8/4986 , A61K8/64 , A61K8/981 , A61K31/192 , A61K31/215 , A61K31/4015 , A61K31/4025 , A61K31/421 , A61K35/35 , A61K35/63 , A61K38/00 , A61K38/1767 , A61K2800/91 , A61Q19/08 , A61K2300/00
摘要: The specification discloses compositions and methods for treating a soft tissue defect of an individual.
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公开(公告)号:US08894992B2
公开(公告)日:2014-11-25
申请号:US13398680
申请日:2012-02-16
申请人: Dennis E. Van Epps , Guang-Liang Jiang , Adam L. Collette , Rebecca L. Horan , Jingsong Chen , Gregory H. Altman , Wha Bin Im
发明人: Dennis E. Van Epps , Guang-Liang Jiang , Adam L. Collette , Rebecca L. Horan , Jingsong Chen , Gregory H. Altman , Wha Bin Im
IPC分类号: A61F2/20 , A01N63/00 , A61K8/44 , A61K8/64 , A61K35/12 , A61Q19/00 , A61K31/195 , A61K8/98 , A61K31/4025 , A61L27/40 , A61K35/64
CPC分类号: A61K31/4025 , A61K8/44 , A61K8/64 , A61K8/981 , A61K31/195 , A61K35/35 , A61K35/63 , A61K38/1767 , A61L27/40 , A61Q19/00 , A61K2300/00
摘要: The invention relates to compositions comprising adipose tissue, a silk fibroin material and a compound of the structure The composition is administered to a site of a soft tissue condition including those of breast tissue. The silk fibroin material can be in the form of a silk hydrogel, a silk film, a silk scaffold, a silk sheet, a silk porous material, a silk fiber or a combination of those materials. The silk material may be substantially sericin free.
摘要翻译: 本发明涉及包含脂肪组织,丝素蛋白材料和结构化合物的组合物。将组合物施用于包括乳腺组织的软组织病症的部位。 丝素蛋白材料可以是丝素水凝胶,丝膜,丝绸支架,丝
绸,丝绸多孔材料,丝纤维或这些材料的组合的形式。 丝质材料可以基本上不含丝氨酸。-
公开(公告)号:US20120213852A1
公开(公告)日:2012-08-23
申请号:US13398661
申请日:2012-02-16
申请人: Dennis E. Van Epps , Guang-Liang Jiang , Adam L. Collette , Rebecca L. Horan , Jingsong Chen , Gregory H. Altman , Wha Bin Im
发明人: Dennis E. Van Epps , Guang-Liang Jiang , Adam L. Collette , Rebecca L. Horan , Jingsong Chen , Gregory H. Altman , Wha Bin Im
CPC分类号: A61K31/381 , A61K8/49 , A61K8/4913 , A61K8/4926 , A61K8/4986 , A61K8/64 , A61K8/981 , A61K31/4015 , A61K31/4025 , A61K31/45 , A61K35/35 , A61K38/1767 , A61K45/06 , A61Q19/00 , A61K2300/00
摘要: The specification discloses compositions and methods for treating a soft tissue defect of an individual.
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公开(公告)号:US08741281B2
公开(公告)日:2014-06-03
申请号:US13398661
申请日:2012-02-16
申请人: Dennis E. Van Epps , Guang-Liang Jiang , Adam L. Collette , Rebecca L. Horan , Jingsong Chen , Gregory H. Altman , Wha Bin Im
发明人: Dennis E. Van Epps , Guang-Liang Jiang , Adam L. Collette , Rebecca L. Horan , Jingsong Chen , Gregory H. Altman , Wha Bin Im
CPC分类号: A61K31/381 , A61K8/49 , A61K8/4913 , A61K8/4926 , A61K8/4986 , A61K8/64 , A61K8/981 , A61K31/4015 , A61K31/4025 , A61K31/45 , A61K35/35 , A61K38/1767 , A61K45/06 , A61Q19/00 , A61K2300/00
摘要: The specification discloses compositions and methods for treating a soft tissue defect of an individual.
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公开(公告)号:US20120219627A1
公开(公告)日:2012-08-30
申请号:US13398680
申请日:2012-02-16
申请人: Dennis E. Van Epps , Guang-Liang Jiang , Adam L. Collette , Rebecca L. Horan , Jingsong Chen , Gregory H. Altman , Wha Bin Im
发明人: Dennis E. Van Epps , Guang-Liang Jiang , Adam L. Collette , Rebecca L. Horan , Jingsong Chen , Gregory H. Altman , Wha Bin Im
CPC分类号: A61K31/4025 , A61K8/44 , A61K8/64 , A61K8/981 , A61K31/195 , A61K35/35 , A61K35/63 , A61K38/1767 , A61L27/40 , A61Q19/00 , A61K2300/00
摘要: The specification discloses compositions and methods for treating a soft tissue defect of an individual.
摘要翻译: 本说明书公开了用于治疗个体的软组织缺陷的组合物和方法。
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9.DRUG DELIVERY PLATFORMS COMPRISING SILK FIBROIN HYDROGELS AND USES THEREOF 审中-公开
标题翻译: 包含丝状纤维素水凝胶的药物递送平台及其用途公开(公告)号:US20110052695A1
公开(公告)日:2011-03-03
申请号:US12873563
申请日:2010-09-01
申请人: Guang-Liang Jiang , Adam L. Collette , Rebecca L. Horan , Jing Song Chen , Gregory H. Altman , Wha Bin Im
发明人: Guang-Liang Jiang , Adam L. Collette , Rebecca L. Horan , Jing Song Chen , Gregory H. Altman , Wha Bin Im
IPC分类号: A61K9/00 , A61K31/381 , A61K31/215 , A61K31/19 , A61K31/192 , A61K31/41 , A61K31/4025 , A61K31/45 , A61P1/00 , A61P17/02 , A61P27/02
CPC分类号: A61K47/46 , A61K9/0014 , A61K9/0024 , A61K9/0051 , A61K9/06 , A61K38/012 , A61K38/17 , A61L15/225 , A61L15/32 , A61L15/40 , A61L27/227 , A61L27/26 , A61L27/3604 , A61L27/52 , A61L27/54 , A61L2300/602 , A61L2430/34 , A61K2300/00 , C08L89/00
摘要: The present specification provides drug delivery platforms useful for the controlled release of a compound over time in an individual.
摘要翻译: 本说明书提供了用于在个体中随时间控制释放化合物的药物递送平台。
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10.
公开(公告)号:US08288347B2
公开(公告)日:2012-10-16
申请号:US12906777
申请日:2010-10-18
CPC分类号: A61K8/64 , A61K9/0019 , A61K9/06 , A61K31/167 , A61K38/17 , A61K47/42 , A61L27/227 , A61L27/3604 , A61L27/3641 , A61Q19/08 , A61K2300/00
摘要: The present specification provides compositions useful as dermal fillers and methods using such compositions to treat a condition of skin.
摘要翻译: 本说明书提供了可用作真皮填料的组合物和使用这种组合物治疗皮肤病症的方法。
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