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公开(公告)号：US08288347B2
公开(公告)日：2012-10-16
申请号：US12906777
申请日：2010-10-18
CPC分类号： A61K8/64 , A61K9/0019 , A61K9/06 , A61K31/167 , A61K38/17 , A61K47/42 , A61L27/227 , A61L27/3604 , A61L27/3641 , A61Q19/08 , A61K2300/00
摘要： The present specification provides compositions useful as dermal fillers and methods using such compositions to treat a condition of skin.
摘要翻译： 本说明书提供了可用作真皮填料的组合物和使用这种组合物治疗皮肤病症的方法。
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公开(公告)号：US20120172317A1
公开(公告)日：2012-07-05
申请号：US13420182
申请日：2012-03-14
IPC分类号： A61K38/17 , C09D189/00 , A61P17/00 , C12N5/02 , A61K47/42
CPC分类号： A61F2/12 , A61K8/64 , A61K38/1767 , A61K47/42 , A61K2800/5922 , A61K2800/91 , A61L27/227 , A61L27/26 , A61L27/52 , A61L2430/34 , A61Q19/00 , C08B37/0072 , C08L89/00
摘要： The present specification provides for methods for purifying fibroins, purified fibroins, methods of conjugating biological and synthetic molecules to fibroins, fibroins conjugated to such molecules, methods of making fibroin hydrogels, fibroin hydrogels and fibroin hydrogel formulations useful for a variety of medical uses, including, without limitation uses as bulking agents, tissue space fillers, templates for tissue reconstruction or regeneration, cell culture scaffolds for tissue engineering and for disease models, surface coating to improve medical device function, or drug delivery devices.
摘要翻译： 本说明书提供了用于纯化丝心蛋白，纯化的丝心蛋白，将生物和合成分子与丝心蛋白缀合的方法，与此类分子缀合的丝心蛋白，制备丝心蛋白水凝胶的方法，丝心蛋白水凝胶和用于各种医疗用途的丝心蛋白水凝胶制剂的方法，包括 ，但不限于用作填充剂，组织空间填充剂，用于组织重建或再生的模板，用于组织工程和疾病模型的细胞培养支架，用于改善医疗装置功能的表面涂层或药物递送装置。
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3.发明申请Drug Delivery Platforms Comprising Silk Fibroin Hydrogels and Uses Thereof 审中-公开包含丝素蛋白水凝胶及其用途的药物递送平台公开(公告)号：US20110111031A1
公开(公告)日：2011-05-12
申请号：US12910575
申请日：2010-10-22
申请人： GUANG-LIANG JIANG , ADAM L. COLLETTE , REBECCA L. HORAN , JINGSONG CHEN , GREGORY H. ALTMAN , WHA BIN IM
发明人： GUANG-LIANG JIANG , ADAM L. COLLETTE , REBECCA L. HORAN , JINGSONG CHEN , GREGORY H. ALTMAN , WHA BIN IM
IPC分类号： A61K9/14 , A61K31/381 , A61K31/4025 , A61K31/4015 , A61K31/45 , A61P17/02 , A61K31/215 , A61K31/19 , A61K31/192 , A61K31/41
CPC分类号： A61K9/0024 , A61K9/06 , A61K38/012 , A61K38/17 , A61K47/32 , A61K47/42 , A61L27/26 , A61L27/3604 , A61L27/54 , A61L2300/602 , A61L2430/34 , A61K2300/00 , C08L89/00
摘要： The present specification provides drug delivery platforms useful for the controlled release of a compound over time in an individual.
摘要翻译： 本说明书提供了用于在个体中随时间控制释放化合物的药物递送平台。
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4.发明申请DRUG DELIVERY PLATFORMS COMPRISING SILK FIBROIN HYDROGELS AND USES THEREOF 审中-公开包含丝状纤维素水凝胶的药物递送平台及其用途公开(公告)号：US20110052695A1
公开(公告)日：2011-03-03
申请号：US12873563
申请日：2010-09-01
申请人： Guang-Liang Jiang , Adam L. Collette , Rebecca L. Horan , Jing Song Chen , Gregory H. Altman , Wha Bin Im
发明人： Guang-Liang Jiang , Adam L. Collette , Rebecca L. Horan , Jing Song Chen , Gregory H. Altman , Wha Bin Im
IPC分类号： A61K9/00 , A61K31/381 , A61K31/215 , A61K31/19 , A61K31/192 , A61K31/41 , A61K31/4025 , A61K31/45 , A61P1/00 , A61P17/02 , A61P27/02
CPC分类号： A61K47/46 , A61K9/0014 , A61K9/0024 , A61K9/0051 , A61K9/06 , A61K38/012 , A61K38/17 , A61L15/225 , A61L15/32 , A61L15/40 , A61L27/227 , A61L27/26 , A61L27/3604 , A61L27/52 , A61L27/54 , A61L2300/602 , A61L2430/34 , A61K2300/00 , C08L89/00
摘要： The present specification provides drug delivery platforms useful for the controlled release of a compound over time in an individual.
摘要翻译： 本说明书提供了用于在个体中随时间控制释放化合物的药物递送平台。
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公开(公告)号：US08926963B2
公开(公告)日：2015-01-06
申请号：US13398667
申请日：2012-02-16
申请人： Dennis E. Van Epps , Guang-Liang Jiang , Adam L. Collette , Rebecca L. Horan , Jingsong Chen , Gregory H. Altman , Wha Bin Im
发明人： Dennis E. Van Epps , Guang-Liang Jiang , Adam L. Collette , Rebecca L. Horan , Jingsong Chen , Gregory H. Altman , Wha Bin Im
IPC分类号： A01N63/00 , A61K35/32 , A01N35/00 , A61K8/49 , A61K8/98 , A61K31/192 , A61K31/215 , A61K31/4015 , A61K31/4025 , A61K31/421 , A61K38/00 , A61Q19/08 , A61K8/64 , A61K35/12
CPC分类号： A61K8/49 , A61K8/4913 , A61K8/4926 , A61K8/4986 , A61K8/64 , A61K8/981 , A61K31/192 , A61K31/215 , A61K31/4015 , A61K31/4025 , A61K31/421 , A61K35/35 , A61K35/63 , A61K38/00 , A61K38/1767 , A61K2800/91 , A61Q19/08 , A61K2300/00
摘要： The specification discloses compositions and methods for treating a soft tissue defect of an individual.
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公开(公告)号：US08420077B2
公开(公告)日：2013-04-16
申请号：US12764033
申请日：2010-04-20
CPC分类号： A61F2/12 , A61K8/64 , A61K38/1767 , A61K47/42 , A61K2800/5922 , A61K2800/91 , A61L27/227 , A61L27/26 , A61L27/52 , A61L2430/34 , A61Q19/00 , C08B37/0072 , C08L89/00
摘要： The present specification provides for methods for purifying fibroins, purified fibroins, methods of conjugating biological and synthetic molecules to fibroins, fibroins conjugated to such molecules, methods of making fibroin hydrogels, fibroin hydrogels and fibroin hydrogel formulations useful for a variety of medical uses, including, without limitation uses as bulking agents, tissue space fillers, templates for tissue reconstruction or regeneration, cell culture scaffolds for tissue engineering and for disease models, surface coating to improve medical device function, or drug delivery devices.
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公开(公告)号：US20120172985A1
公开(公告)日：2012-07-05
申请号：US13420334
申请日：2012-03-14
CPC分类号： A61F2/12 , A61K8/64 , A61K38/1767 , A61K47/42 , A61K2800/5922 , A61K2800/91 , A61L27/227 , A61L27/26 , A61L27/52 , A61L2430/34 , A61Q19/00 , C08B37/0072 , C08L89/00
摘要： The present specification provides for methods for purifying fibroins, purified fibroins, methods of conjugating biological and synthetic molecules to fibroins, fibroins conjugated to such molecules, methods of making fibroin hydrogels, fibroin hydrogels and fibroin hydrogel formulations useful for a variety of medical uses, including, without limitation uses as bulking agents, tissue space fillers, templates for tissue reconstruction or regeneration, cell culture scaffolds for tissue engineering and for disease models, surface coating to improve medical device function, or drug delivery devices.
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公开(公告)号：US20110129531A1
公开(公告)日：2011-06-02
申请号：US12906777
申请日：2010-10-18
CPC分类号： A61K8/64 , A61K9/0019 , A61K9/06 , A61K31/167 , A61K38/17 , A61K47/42 , A61L27/227 , A61L27/3604 , A61L27/3641 , A61Q19/08 , A61K2300/00
摘要： The present specification provides compositions useful as dermal fillers and methods using such compositions to treat a condition of skin.
摘要翻译： 本说明书提供了可用作真皮填料的组合物和使用这种组合物治疗皮肤病症的方法。
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公开(公告)号：US08741281B2
公开(公告)日：2014-06-03
申请号：US13398661
申请日：2012-02-16
申请人： Dennis E. Van Epps , Guang-Liang Jiang , Adam L. Collette , Rebecca L. Horan , Jingsong Chen , Gregory H. Altman , Wha Bin Im
发明人： Dennis E. Van Epps , Guang-Liang Jiang , Adam L. Collette , Rebecca L. Horan , Jingsong Chen , Gregory H. Altman , Wha Bin Im
CPC分类号： A61K31/381 , A61K8/49 , A61K8/4913 , A61K8/4926 , A61K8/4986 , A61K8/64 , A61K8/981 , A61K31/4015 , A61K31/4025 , A61K31/45 , A61K35/35 , A61K38/1767 , A61K45/06 , A61Q19/00 , A61K2300/00
摘要： The specification discloses compositions and methods for treating a soft tissue defect of an individual.
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公开(公告)号：US20120265297A1
公开(公告)日：2012-10-18
申请号：US13420356
申请日：2012-03-14
CPC分类号： A61F2/12 , A61K8/64 , A61K38/1767 , A61K47/42 , A61K2800/5922 , A61K2800/91 , A61L27/227 , A61L27/26 , A61L27/52 , A61L2430/34 , A61Q19/00 , C08B37/0072 , C08L89/00
摘要： The present specification provides for methods for purifying fibroins, purified fibroins, methods of conjugating biological and synthetic molecules to fibroins, fibroins conjugated to such molecules, methods of making fibroin hydrogels, fibroin hydrogels and fibroin hydrogel formulations useful for a variety of medical uses, including, without limitation uses as bulking agents, tissue space fillers, templates for tissue reconstruction or regeneration, cell culture scaffolds for tissue engineering and for disease models, surface coating to improve medical device function, or drug delivery devices.
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