公开(公告)号：US4391821A

公开(公告)日：1983-07-05

申请号：US284573

申请日：1981-07-17

申请人： Dezso Korbonits ,  Mihaly Nogradi ,  Borbala Vermes nee Szluha ,  Janos Strelisky ,  Andras Wolfner ,  Gergely Heja ,  Gabor Kovacz ,  Jozsef Szegi ,  Sandor Virag

发明人： Dezso Korbonits ,  Mihaly Nogradi ,  Borbala Vermes nee Szluha ,  Janos Strelisky ,  Andras Wolfner ,  Gergely Heja ,  Gabor Kovacz ,  Jozsef Szegi ,  Sandor Virag

IPC分类号： A61K31/35 ,  A61K31/352 ,  A61P9/00 ,  C07D311/22 ,  C07D311/58 ,  C07D311/60 ,  C07D407/12

CPC分类号： C07D407/12 ,  C07D311/22 ,  C07D311/58 ,  C07D311/60 ,  Y10S514/821

摘要： The present invention relates to novel 7-substituted benzopyranes of formula (I), whereinR.sub.1 and R.sub.2 are hydrogen, alkyl of from 1 to 6 carbon atoms, hydroxyalkyl, alkenyl, cycloalkyl, phenylalkyl, dimethoxy-phenylalkyl, or R.sub.1 and R.sub.2 together with the joining nitrogen atom may represent a 5-7-membered heterocyclic ring,R.sub.3 is hydrogen, alkyl of from 1 to 4 carbon atoms or phenyl,R.sub.4 is hydrogen,R.sub.5 is hydrogen or phenyl, orR.sub.4 and R.sub.5 together may represent a bonding electron pair between the second and the third carbon atoms of the benzopyrane ring,R.sub.6 and R.sub.7 are hydrogen or they may represent an oxygen atom together,n is 1 or 2,with the proviso, that the pyrane ring may bear only one alkyl or phenyl substituent, and preparation process thereof.The novel compounds have valuable therapeutical effects, mainly in cardiotherapy.

摘要翻译： 本发明涉及式（I）的新型7-取代苯并吡喃，其中R1和R2是氢，1-6个碳原子的烷基，羟基烷基，烯基，环烷基，苯基烷基，二甲氧基 - 苯基烷基或R1和R2连同 连接的氮原子可以表示5-7元杂环，R3是氢，1-4个碳原子的烷基或苯基，R4是氢，R5是氢或苯基，或R4和R5一起可以代表键合电子 苯并吡喃环的第二个和第三个碳原子之间的对，R6和R7是氢，或者它们可以一起代表氧原子，n是1或2，条件是吡喃环可以仅带有一个烷基或苯基取代基 ，及其制备方法。 新化合物具有重要的治疗作用，主要用于心脏治疗。

公开(公告)号：US4166862A

公开(公告)日：1979-09-04

申请号：US470444

申请日：1974-05-16

申请人： Laszlo Feuer ,  Mihaly Nogradi ,  Agnes Gettsegen ,  Borbala Vermes ,  Janos Strelisky ,  Andras Wolfner ,  Lorant Farkas ,  Sandor Antus ,  Maria K. Toth

发明人： Laszlo Feuer ,  Mihaly Nogradi ,  Agnes Gettsegen ,  Borbala Vermes ,  Janos Strelisky ,  Andras Wolfner ,  Lorant Farkas ,  Sandor Antus ,  Maria K. Toth

IPC分类号： A23K1/16 ,  C07D311/36 ,  A61K31/35

CPC分类号： C07D311/36 ,  A23K20/121 ,  A23K20/137

摘要： An animal feed containing 0.00002 to 0.1% by weight of:2-methyl-7-methoxy-4'-nitroisoflavone,7-[hydroxyethoxy]-2-methylisoflavone,7-carbethoxy-2-methylisoflavone,7-ethoxyisoflavone,7-n-benzyloxy-2-methylisoflavone,7-p-nitrobenzyloxyisoflavone,7-p-nitrobenzyloxy-2-methylisoflavone,7-p-chlorobenzyloxyisoflavone,7-cetyloxy-2-methylisoflavone,7-(2-octyloxy)-isoflavone,7-benzyloxy-3',4'-dimethoxyisoflavone, and7-hexadecyloxyisoflavoneAs a weight-gain promoting anabolic ingredient.

摘要翻译： 含有0.00002至0.1重量％的动物饲料：

公开(公告)号：US4599327A

公开(公告)日：1986-07-08

申请号：US557629

申请日：1983-12-02

申请人： Mihaly Nogradi ,  Dezso Korbonits ,  Agnes Gottsegen ,  Sandor Antus ,  Zsuzsa Furst ,  Jozsef Knoll ,  Jozsef Szejtli ,  Agnes Stadler ,  Gabor Kovacs ,  Katalin Marmarosi

发明人： Mihaly Nogradi ,  Dezso Korbonits ,  Agnes Gottsegen ,  Sandor Antus ,  Zsuzsa Furst ,  Jozsef Knoll ,  Jozsef Szejtli ,  Agnes Stadler ,  Gabor Kovacs ,  Katalin Marmarosi

IPC分类号： A61K31/35 ,  A61K31/352 ,  A61K31/715 ,  A61P1/08 ,  A61P23/00 ,  A61P23/02 ,  A61P25/02 ,  A61P25/04 ,  C07C43/178 ,  C07C43/205 ,  C07C43/23 ,  C07C59/68 ,  C07D221/12 ,  C07D311/78 ,  C07D311/80 ,  C07D311/92 ,  C07D493/10 ,  C08B37/00 ,  C08B37/16 ,  A61K31/70

CPC分类号： C07D493/10 ,  C07C309/00 ,  C07C43/1782 ,  C07C43/1785 ,  C07C43/2055 ,  C07C43/23 ,  C07C59/68 ,  C07D221/12 ,  C07D311/78 ,  C07D311/80 ,  C08B37/0015

摘要： 2,6-di-O-methyl-beta-cyclodextrin complexes of compounds of the formula (1a) ##STR1## wherein R.sup.2' stands for C.sub.1 to C.sub.12 alkyl or a group of the formula ##STR2## in which R.sup.11 is C.sub.1 to C.sub.4 alkyl;R.sup.12 is hydrogen or C.sub.1 to C.sub.4 alkyl;n is 0 or 1;p is 1 to 4;r is 1 to 4; andR.sup.3' and R.sup.4' are each C.sub.1 to C.sub.4 alkyl, or pharmaceutically salts thereof are disclosed, having analgesic activity.

摘要翻译： 式（1a）化合物的2,6-二-O-甲基-β-环糊精复合物其中R 2'代表C 1至C 12烷基或其中R 11为C 1至C 4的式 烷基; R 12是氢或C 1至C 4烷基; n为0或1; p为1〜4; r为1〜4; 和R 3'和R 4'各自为C1至C4烷基，或其药学上可接受的盐，具有止痛活性。

公开(公告)号：US4163746A

公开(公告)日：1979-08-07

申请号：US845680

申请日：1977-10-26

申请人： Laszlo Feuer ,  Lorand Farkas ,  Mihaly Nogradi ,  Borbala Vermes ,  Agnes Gottsegen ,  Andras Wolfner

发明人： Laszlo Feuer ,  Lorand Farkas ,  Mihaly Nogradi ,  Borbala Vermes ,  Agnes Gottsegen ,  Andras Wolfner

IPC分类号： A23K1/16 ,  A23K1/18 ,  A61K31/35 ,  A61K31/352 ,  A61P3/00 ,  C07D311/36 ,  C07D311/02

CPC分类号： C07D311/36 ,  A23K20/121 ,  A23K50/30

摘要： Nonestrogenic 5-methyl-alkoxy-isoflavone, namely, 5-methyl-7-methoxy-isoflavone, 5-methyl-7-ethoxy-isoflavone, 5-methyl-7-isopropoxy-isoflavone, and 5-methyl-7-(2-hydroxy-ethoxy)-isoflavone are useful as weight-gain promoters in feeds from which the 7-methoxy and 7-ethoxy isoflavones have been excluded because of estrogenic effects. They are more effective than 7-isopropoxy-isoflavone as well.

摘要翻译： 非雌激素5-甲基 - 烷氧基异黄酮，即5-甲基-7-甲氧基异黄酮，5-甲基-7-乙氧基异黄酮，5-甲基-7-异丙氧基异黄酮和5-甲基-7-（2 - 羟基 - 乙氧基） - 异黄酮可用作饲料中的体重增加启动子，由于雌激素作用，已经排除了7-甲氧基和7-乙氧基异黄酮。 它们也比7-异丙氧基异黄酮更有效。

公开(公告)号：US4092346A

公开(公告)日：1978-05-30

申请号：US746350

申请日：1976-12-01

申请人： Lorand Farkas ,  Mihaly Nogradi ,  Todor Pfliegel ,  Sandor Antus ,  Agnes Gottsegen

发明人： Lorand Farkas ,  Mihaly Nogradi ,  Todor Pfliegel ,  Sandor Antus ,  Agnes Gottsegen

IPC分类号： A23L27/30 ,  C07C309/11 ,  C07C143/24 ,  A23L1/236

CPC分类号： C07C309/11 ,  A23L27/30

摘要： Compounds of the formula (1), or their salts, ##STR1## are prepared as follows: (A) A COMPOUND OF THE FORMULA (II) ##STR2## is reduced; or (B) A COMPOUND OF THE FORMULA (III) ##STR3## is reacted, e.g. after protecting the phenolic hydroxy group attached to position 3 of the ring, with a compound of the formula (IV), ##STR4## or (C) GROUP R.sup.1 of a compound of the formula (V) ##STR5## is removed in an acidic medium, AND, IF DESIRED, THE COMPOUND OF THE FORMULA (I) is converted into salt, or a salt of a compound of the formula (I) is converted into the free acid or another salt thereof.The compounds of the formula (I) and their salts are valuable artificial sweetening agents.In the above formulae"alkyl" is a C.sub.1-4 alkyl group,R is hydrogen or a protecting group capable of splitting off upon hydrogenolysis, preferably benzyl or benzyloxycarbonyl,M+ is a proton or another cation,X is a group of the general formula O.sup.- M.sup.+,Y is halogen, orX and Y together represent an oxygen atom, andR.sup.1 is a protecting group capable of splitting off in acidic media, such as 2-tetrahydropyranyl or 1-ethoxyethyl.

摘要翻译： 式（1）化合物或其盐，如下制备：

公开(公告)号：US3956375A

公开(公告)日：1976-05-11

申请号：US311666

申请日：1972-12-04

申请人： Lorant Farkas ,  Mihaly Nogradi ,  Agnes Gottsegen ,  Sandor Antus

发明人： Lorant Farkas ,  Mihaly Nogradi ,  Agnes Gottsegen ,  Sandor Antus

IPC分类号： A23L27/30 ,  C07C45/00 ,  C07C45/62 ,  C07C49/76 ,  C07C49/82 ,  C07C49/83 ,  C07C49/84 ,  C07C51/00 ,  C07C59/125 ,  C07C59/64 ,  C07C59/90 ,  C07C65/40 ,  C07C67/00 ,  C07C69/712 ,  C07C69/716 ,  C07C225/22 ,  C07C309/44 ,  C07C65/20

CPC分类号： C07C59/90 ,  C07C309/00 ,  C07C45/62 ,  C07C49/84

摘要： A sweetening agent in the form of a 1,3-diphenyl-propanone-1 derivative of the formula ##SPC1##Wherein R is hydrogen, hydroxyl, alkoxy or carboxyl-substituted, sulphonyl-substituted, phosphonyl-substituted, dialkylamino-substituted, trialkyl ammonium-substituted alkoxy; R.sup.1 is hydrogen or a hydrophylic group but both R and R.sup.1 are not both hydrogen; R.sup.2 and R.sup.3 are hydroxyl or alkoxy.

摘要翻译： 式WHEREIN R的1,3-二苯基 - 丙酮-1-衍生物形式的甜味剂为氢，羟基，烷氧基或羧基取代的磺酰基取代的，膦酰基取代的，二烷基氨基取代的三烷基铵取代的 烷氧基 R1是氢或亲水基，但R和R1都不是氢; R2和R3是羟基或烷氧基。

公开(公告)号：US3949085A

公开(公告)日：1976-04-06

申请号：US497644

申请日：1974-08-15

申请人： Laszlo Feuer ,  Mihaly Nogradi ,  Agnes Gottsegen ,  Borbala Vermes ,  Janos Streliszky ,  Andreas Wolfner ,  Lorant Farkas ,  Sandor Antus ,  Maria Kovaks

发明人： Laszlo Feuer ,  Mihaly Nogradi ,  Agnes Gottsegen ,  Borbala Vermes ,  Janos Streliszky ,  Andreas Wolfner ,  Lorant Farkas ,  Sandor Antus ,  Maria Kovaks

IPC分类号： A23K1/16 ,  C07D311/36 ,  A61K31/35

CPC分类号： C07D311/36 ,  A23K20/121 ,  A23K20/137

摘要： A method of anabolic treatment in humans comprises administering a compound of the following formula: ##SPC1##Wherein R is halosubstituted, nitrosubstituted, or unsubstituted benzyl, R.sup.2 is hydrogen, methyl or carboxy, and R.sup.3 and R.sup.4 are hydrogen, methoxy or nitro. Pharmaceutical compositions are also disclosed.

摘要翻译： 人的合成代谢治疗方法包括施用下式的化合物：