公开(公告)号：US09259391B2

公开(公告)日：2016-02-16

申请号：US12802621

申请日：2010-06-10

申请人： Diana Shu-Lian Chow ,  Pranav Gupta ,  Yulan Qi ,  Dong Liang

发明人： Diana Shu-Lian Chow ,  Pranav Gupta ,  Yulan Qi ,  Dong Liang

IPC分类号： A61K31/4184 ,  A61K9/107 ,  A61P33/10 ,  A61P33/12 ,  A61K9/00

CPC分类号： A61K9/1075 ,  A61K9/0019 ,  A61K9/0095 ,  A61K31/4184

摘要： Provided herein are drug delivery systems, such as self-nanoemulsifying drug delivery systems, self-emulsifying drug delivery systems and parenteral microemulsion formulations, suitable for parenteral or oral delivery to a subject. The drug delivery systems may comprise a benzimidazole derivative, e.g., mebendazole, an oil, a surfactant, a cosurfactant and a dipolar aprotic solvent in a microemulsion formulation. Also provided are methods for improving the bioavailability of a benzimidazole derivative during treatment of a pathophysiological condition by using a formulation combining a particular emulsion droplet diameter and ratio of the surfactant:cosurfactant therein, for increasing concentration and retention of a benzimidazole derivative in the lung via a parenterally administerable microemulsion with droplet size of about 35 nm to less than 100 nm and for defining hemolytically safe microemulsions of a benzimidazole derivative during a therapeutic treatment via a parenterally administerable microemulsion with a surfactant:cosurfactant content by weight of about 6% to 48%.

公开(公告)号：US09259390B2

公开(公告)日：2016-02-16

申请号：US12220374

申请日：2008-07-24

申请人： Diana Shu-Lian Chow ,  Pranav Gupta ,  Yulan Qi ,  Dong Liang

发明人： Diana Shu-Lian Chow ,  Pranav Gupta ,  Yulan Qi ,  Dong Liang

IPC分类号： A61K31/4184 ,  A61K9/107 ,  A61K9/00

CPC分类号： A61K9/1075 ,  A61K9/0019 ,  A61K9/0095 ,  A61K31/4184

摘要： Provided herein are drug delivery systems, such as self-nanoemulsifying drug delivery systems, self-emulsifying drug delivery systems and parenteral microemulsion formulations, suitable for parenteral or oral delivery to a subject. The drug delivery systems may comprise a benzimidazole derivative, e.g., mebendazole, an oil, a surfactant, a cosurfactant and a dipolar aprotic solvent in a microemulsion formulation. Also provided are methods for improving the bioavailability of a benzimidazole derivative during treatment of a pathophysiological condition by using a formulation combining a particular emulsion droplet diameter and ratio of the surfactant:cosurfactant therein, for increasing concentration and retention of a benzimidazole derivative in the lung via a parenterally administerable microemulsion with droplet size of about 35 nm to less than 100 nm and for defining hemolytically safe microemulsions of a benzimidazole derivative during a therapeutic treatment via a parenterally administerable microemulsion with a surfactant:cosurfactant content by weight of about 6% to 48%.

公开(公告)号：US20100310611A1

公开(公告)日：2010-12-09

申请号：US12802621

申请日：2010-06-10

申请人： Diana Shu-Lian Chow ,  Pranav Gupta ,  Yulan Qi ,  Dong Liang

发明人： Diana Shu-Lian Chow ,  Pranav Gupta ,  Yulan Qi ,  Dong Liang

IPC分类号： A61K31/4184 ,  A61K9/107 ,  A61P33/10 ,  A61P33/12

CPC分类号： A61K9/1075 ,  A61K9/0019 ,  A61K9/0095 ,  A61K31/4184

摘要： Provided herein are drug delivery systems, such as self-nanoemulsifying drug delivery systems, self-emulsifying drug delivery systems and parenteral microemulsion formulations, suitable for parenteral or oral delivery to a subject. The drug delivery systems may comprise a benzimidazole derivative, e.g., mebendazole, an oil, a surfactant, a cosurfactant and a dipolar aprotic solvent in a microemulsion formulation. Also provided are methods for improving the bioavailability of a benzimidazole derivative during treatment of a pathophysiological condition by using a formulation combining a particular emulsion droplet diameter and ratio of the surfactant:cosurfactant therein, for increasing concentration and retention of a benzimidazole derivative in the lung via a parenterally administerable microemulsion with droplet size of about 35 nm to less than 100 nm and for defining hemolytically safe microemulsions of a benzimidazole derivative during a therapeutic treatment via a parenterally administerable microemulsion with a surfactant:cosurfactant content by weight of about 6% to 48%.

摘要翻译： 本文提供了药物递送系统，例如适合于向对象的肠胃外或口服递送的自 - 纳米乳化药物递送系统，自乳化药物递送系统和胃肠外微乳剂制剂。 药物递送系统可以在微乳液制剂中包含苯并咪唑衍生物，例如甲苯达唑，油，表面活性剂，辅助表面活性剂和偶极非质子溶剂。 还提供了通过使用组合特定乳剂液滴直径的组合物和其中表面活性剂：助表面活性剂的比例来改善治疗病理生理状况期间苯并咪唑衍生物的生物利用度的方法，用于增加苯并咪唑衍生物在肺中的浓度和保留通过 具有约35nm至小于100nm的液滴尺寸的肠胃外可施用的微乳液，并且在通过具有表面活性剂的肠胃外可施用的微乳液的治疗性治疗期间限定苯并咪唑衍生物的溶血安全微乳液：辅助表面活性剂含量为约6％至48％ 。

公开(公告)号：US20090048322A1

公开(公告)日：2009-02-19

申请号：US12220374

申请日：2008-07-24

申请人： Diana Shu-Lian Chow ,  Pranav Gupta ,  Yulan Qi ,  Dong Liang

发明人： Diana Shu-Lian Chow ,  Pranav Gupta ,  Yulan Qi ,  Dong Liang

IPC分类号： A61K31/4184

CPC分类号： A61K9/1075 ,  A61K9/0019 ,  A61K9/0095 ,  A61K31/4184

摘要： Provided herein are drug delivery systems, such as self-nanoemulsifying drug delivery systems, self-emulsifying drug delivery systems and parenteral microemulsion formulations, suitable for parenteral or oral delivery to a subject. The drug delivery systems may comprise a benzimidazole derivative, e.g., mebendazole, an oil, a surfactant, a cosurfactant and a dipolar aprotic solvent in a microemulsion formulation. Also provided are methods for improving the bioavailability of a benzimidazole derivative during treatment of a pathophysiological condition by using a formulation combining a particular emulsion droplet diameter and ratio of the surfactant:cosurfactant therein, for increasing concentration and retention of a benzimidazole derivative in the lung via a parenterally administerable microemulsion with droplet size of about 35 nm to less than 100 nm and for defining hemolytically safe microemulsions of a benzimidazole derivative during a therapeutic treatment via a parenterally administerable microemulsion with a surfactant:cosurfactant content by weight of about 6% to 48%.

摘要翻译： 本文提供了药物递送系统，例如适合于向对象的肠胃外或口服递送的自 - 纳米乳化药物递送系统，自乳化药物递送系统和胃肠外微乳剂制剂。 药物递送系统可以在微乳液制剂中包含苯并咪唑衍生物，例如甲苯达唑，油，表面活性剂，辅助表面活性剂和偶极非质子溶剂。 还提供了通过使用组合特定乳剂液滴直径的组合物和其中表面活性剂：助表面活性剂的比例来改善治疗病理生理状况期间苯并咪唑衍生物的生物利用度的方法，用于增加苯并咪唑衍生物在肺中的浓度和保留通过 具有约35nm至小于100nm的液滴尺寸的肠胃外可施用的微乳液，并且在通过具有表面活性剂的肠胃外可施用的微乳液的治疗性治疗期间限定苯并咪唑衍生物的溶血安全微乳液：辅助表面活性剂含量为约6％至48％ 。

公开(公告)号：US07419996B2

公开(公告)日：2008-09-02

申请号：US10640467

申请日：2003-08-13

申请人： Diana Shu-Lian Chow ,  Dong Liang

发明人： Diana Shu-Lian Chow ,  Dong Liang

IPC分类号： A61K31/4439 ,  A61K31/418

CPC分类号： A61K9/0019 ,  A61K9/0095 ,  A61K9/1075 ,  A61K31/4184

摘要： Pharmaceutical compositions of a benzimidazole or a benzimidazole derivative are disclosed. For example, in certain embodiments the pharmaceutical compositions include a benzimidazole, PEG 400, and a dipolar aprotic solvent. In other embodiments, pharmaceutical compositions include a benzimidazole, an oil, a dipolar aproptic solvent, and a surfactant. In certain embodiments, the benzimidazole is mebendezole. The pharmaceutical compositions are formulated for delivery to a subject by any means, and include formulations for oral and parenteral delivery.

摘要翻译： 公开了苯并咪唑或苯并咪唑衍生物的药物组合物。 例如，在某些实施方案中，药物组合物包括苯并咪唑，PEG400和偶极非质子溶剂。 在其它实施方案中，药物组合物包括苯并咪唑，油，偶极亲和溶剂和表面活性剂。 在某些实施方案中，苯并咪唑是mebendezole。 将药物组合物配制成通过任何方式递送到受试者，并且包括用于口服和胃肠外递送的制剂。

公开(公告)号：US20130249134A1

公开(公告)日：2013-09-26

申请号：US13885917

申请日：2011-11-15

申请人： Andre Kamm ,  Dong Liang ,  ZhiZhong Tang ,  LiHua Hu

发明人： Andre Kamm ,  Dong Liang ,  ZhiZhong Tang ,  LiHua Hu

IPC分类号： B29C44/02 ,  C08G18/06

CPC分类号： B29C44/02 ,  B29C44/10 ,  C08G18/06 ,  C08G18/10 ,  C08G18/42 ,  C08G18/4238 ,  C08G18/6633 ,  C08G18/664 ,  C08G77/46 ,  C08G2101/00 ,  C08G2410/00 ,  C08J9/0061 ,  C08J9/14 ,  C08J9/141 ,  C08J2375/04 ,  C08J2409/00 ,  C08J2423/00 ,  C08J2433/00 ,  C08J2483/04

摘要： The present invention relates to a process for producing polyurethane foam moldings where the density of the molding is at most 500 g/L, by mixing the following to give a reaction mixture: a) organic polyisocyanates with b) polyesterols, c) blowing agents, d) cell-opening additives selected from the group consisting of homo- or copolymers based on ethylhexyl acrylate, on polybutadiene, on polyisobutene, and on diorganosilicones, or a mixture of two or more of said antifoams, e) silicone-based cell stabilizers and optionally f) chain extenders and/or crosslinking agents, g) catalysts, and h) other auxiliaries and/or additives, and charging the materials to a mold, and permitting them to complete a reaction to give a polyurethane foam molding. The present invention further relates to polyurethane moldings obtainable by this process, and to the use of said moldings as shoe sole, steering wheel, seat, or armrest.

摘要翻译： 本发明涉及通过混合以下物质来制备反应混合物：a）有机多异氰酸酯与b）聚酯醇的制备聚乙烯泡沫塑料模制品的方法，其中成型体的密度为至多500g / L，c）发泡剂， d）选自基于丙烯酸乙基己酯的均聚物或共聚物，聚丁二烯，聚异丁烯和二有机硅氧烷上的开孔添加剂，或两种或更多种所述消泡剂的混合物，e）硅氧烷基电池稳定剂和 任选地，f）扩链剂和/或交联剂，g）催化剂，和h）其它助剂和/或添加剂，并将该材料装入模具中，并允许它们完成反应以得到聚氨酯泡沫模塑。 本发明还涉及可通过该方法获得的聚氨酯模制品，以及所述模制品作为鞋底，方向盘，座椅或扶手的用途。

公开(公告)号：US08224252B2

公开(公告)日：2012-07-17

申请号：US12796484

申请日：2010-06-08

申请人： Minghai Feng ,  Xiaoming She ,  Lan Chen ,  Wenbo Wang ,  Mugen Peng ,  Dong Liang ,  Song Zhu

发明人： Minghai Feng ,  Xiaoming She ,  Lan Chen ,  Wenbo Wang ,  Mugen Peng ,  Dong Liang ,  Song Zhu

IPC分类号： H04B15/00 ,  H04W24/00

CPC分类号： H04W72/082 ,  H04W72/0406 ,  H04W92/20

摘要： An inter-cell interference coordination method comprises: measuring an interference over thermal noise of a first subcarrier resource block in an uplink direction and obtaining an interference over thermal noise measurement value by a first base station; judging whether a first high interference indicating message is received from a second base station when the interference over thermal noise measurement value is larger than a first preset threshold value by the first base station; sending an overload indicator message to the second base station which has sent the high interference indicating message or shielding the first subcarrier resource block by the first base station when the first high interference indicating message is received; and sending the overload indicator message to base stations to which all the neighboring cells belong by the first base station when the first high interference indicating message is not received. The overhead at X2 interface is reduced according to the present invention.

摘要翻译： 小区间干扰协调方法包括：测量上行链路方向上的第一子载波资源块的热噪声干扰，并获得第一基站对热噪声测量值的干扰; 当所述第一基站的干扰超过热噪声测量值大于第一预设阈值时，判断是否从第二基站接收到第一高干扰指示消息; 当接收到所述第一高干扰指示消息时，向已经发送高干扰指示消息的第二基站或第一基站屏蔽第一子载波资源块的过载指示消息发送; 以及当没有接收到所述第一高干扰指示消息时，将所述过载指示符消息发送到所有相邻小区属于所述第一基站的基站。 根据本发明，X2接口的开销减小了。

公开(公告)号：US20120144732A1

公开(公告)日：2012-06-14

申请号：US13390876

申请日：2010-03-16

申请人： Depo Yang ,  Miaoling Huang ,  Dong Liang ,  Zhuoxue Li ,  Wenzhe Yang

发明人： Depo Yang ,  Miaoling Huang ,  Dong Liang ,  Zhuoxue Li ,  Wenzhe Yang

IPC分类号： C10L1/00

CPC分类号： C11C3/003 ,  C11B1/10 ,  C11B3/10 ,  C11B3/12 ,  C11B13/00 ,  C11C3/10 ,  Y02E50/13 ,  Y02W30/74

摘要： A method for preparing biodiesel includes the steps of: by using larvae or pupae of complete metamorphosis insect as raw materials, extracting insect oil by solvent process, conducting transesterification or pre-esterification-transesterification respectively of the low-acid-value (acid value≦2) insect oil or the high-acid-value (acid value>2) insect oil to get crude biodiesel after stratification; and purifying and processing the crude biodiesel by using adsorption clarification technic, molecular distillation techinic, and freezing (low temperature) separation technic to get refined biodiesel. The advantages of the method include wide variety of raw materials, easy to breeding, and low cost of production. The present invention provides a new technical way of producing biodiesel, and on the other hand, it also provides a new way of exploiting insects.

摘要翻译： 制备生物柴油的方法包括以下步骤：以完全变态昆虫的幼虫或蛹为原料，通过溶剂法提取昆虫油，分别进行酯交换或酯化前酯交换反应（酸值＆nlE; 2）昆虫油或高酸值（酸值> 2）昆虫油分层后得到粗生物柴油; 通过吸附澄清技术，分子蒸馏技术和冷冻（低​​温）分离技术对粗生物柴油进行纯化和处理，得到精制生物柴油。 该方法的优点包括原料种类繁多，养殖方便，生产成本低。 本发明提供了生产生物柴油的新的技术方法，另一方面也提供了开发昆虫的新途径。

公开(公告)号：US07527719B2

公开(公告)日：2009-05-05

申请号：US10500180

申请日：2002-11-29

申请人： Peng Liu ,  Wanli Xing ,  Dong Liang ,  Jing Cheng

发明人： Peng Liu ,  Wanli Xing ,  Dong Liang ,  Jing Cheng

IPC分类号： G01N27/453

CPC分类号： G01N27/44791

摘要： The present invention provides a capillary electrophoresis chip apparatus for detecting nucleotide polymorphism or single nucleotide polymorphism belonging to capillary electrophoresis apparatuses. The apparatus comprises an upper channel layer comprising a one-, two-, or multi-dimensional microfluid channel and an electrode aperture structure for loading sample, a middle electrode layer for sealing the microfluid channel to form an intact capillary and providing the needed voltage for electrophoresis; and a lower heating layer for providing a stable temperature gradient for electrophoresis. The upper, middle and lower layers are thermal conductive and adhesive to each other.

摘要翻译： 本发明提供一种用于检测属于毛细管电泳装置的核苷酸多态性或单核苷酸多态性的毛细管电泳芯片装置。 该装置包括上通道层，其包括一维，二维或多维微流体通道和用于装载样品的电极孔结构，用于密封微流体通道以形成完整毛细管的中间电极层，并提供所需电压 电泳; 以及用于提供电泳的稳定温度梯度的较低加热层。 上，中，下层相互导热，粘合。

公开(公告)号：US20070125206A1

公开(公告)日：2007-06-07

申请号：US11387920

申请日：2006-03-24

申请人： Guo-Wei Zhang ,  Rui Zhang ,  Dong Liang

发明人： Guo-Wei Zhang ,  Rui Zhang ,  Dong Liang

IPC分类号： B25B23/157 ,  B25B23/14

CPC分类号： B25B23/141

摘要： A torque regulating assembly includes a first tubular shell having at least one groove disposed along the longitudinal axis of the first tubular shell and a second tubular shell having at least one aperture, wherein the first tubular shell is screwed into the second tubular shell with threads, making the aperture corresponding to the groove. A torque regulating ring having at least one screw hole is put around the second tubular shell. A screwing element is screwed into the screw hole, and the front tip of the screwing element passes through the aperture and moves toward the groove, so that a position of the second tubular shell relative to the first tubular shell is fixed. Then a maximum torque value transmitted by a torque transmitting mechanism disposed inside the first tubular shell and the second tubular shell is regulated.