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1.发明申请Platelet Activation Markers and Predictors of Desease and of Response to Therapy and for Monitoring Therapeutic Progress 有权血小板激活标志物和预测因子和对治疗和监测治疗进展的反应公开(公告)号：US20080311606A1
公开(公告)日：2008-12-18
申请号：US11658367
申请日：2005-07-26
申请人： E. Sabrinah Chapman- Montgomery , David Okrongly , Andrew McGregor Grant , Charaf E. Ahnadi , Alan Wu , Andre Gervais
发明人： E. Sabrinah Chapman- Montgomery , David Okrongly , Andrew McGregor Grant , Charaf E. Ahnadi , Alan Wu , Andre Gervais
CPC分类号： G01N33/56972 , G01N2333/4737 , G01N2800/324 , G01N2800/52
摘要： Methods for assessing patient risk for platelet-affected disease states are disclosed. Also disclosed are methods for predicting the appropriateness of platelet antagonist therapy, and for monitoring patients during therapeutic intervention or during a combined regimen of therapy and angioplasty.
摘要翻译： 公开了评估血小板受影响疾病状态患者风险的方法。 还公开了用于预测血小板拮抗剂治疗的适当性以及用于在治疗性干预期间或在治疗和血管成形术的组合方案期间监测患者的方法。
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2.发明申请公开(公告)号：US20100173339A1
公开(公告)日：2010-07-08
申请号：US12728760
申请日：2010-03-22
申请人： E. Sabrinah Chapman-Montgomery , David Okrongly , Andrew McGregor Grant , Charaf E. Ahnadi , Alan Wu , Andre Gervais
发明人： E. Sabrinah Chapman-Montgomery , David Okrongly , Andrew McGregor Grant , Charaf E. Ahnadi , Alan Wu , Andre Gervais
CPC分类号： G01N33/56972 , G01N2333/4737 , G01N2800/324 , G01N2800/52
摘要： Methods for determining the appropriateness of anti-platelet therapy in a patient with a platelet-affected disease. The Mean Platelet Component value in a patient blood sample is determined corresponding to the patient's platelet activation status. A high platelet activation status indicates the appropriateness of anti-platelet therapy.
摘要翻译： 确定患有血小板疾病的患者抗血小板治疗适宜性的方法。 根据患者的血小板活化状态确定患者血液样品中的平均血小板成分值。 高血小板活化状态表明抗血小板治疗的适宜性。
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3.发明授权Methods for monitoring patients for efficacy of an antiplatelet therapy regimen 有权监测患者抗血小板治疗方案疗效的方法公开(公告)号：US07723064B2
公开(公告)日：2010-05-25
申请号：US11658367
申请日：2005-07-26
申请人： E. Sabrinah Chapman-Montgomery , David Okrongly , Andrew McGregor Grant , Charaf E. Ahnadi , Alan Wu , Andre Gervais
发明人： E. Sabrinah Chapman-Montgomery , David Okrongly , Andrew McGregor Grant , Charaf E. Ahnadi , Alan Wu , Andre Gervais
IPC分类号： C12Q1/56
CPC分类号： G01N33/56972 , G01N2333/4737 , G01N2800/324 , G01N2800/52
摘要： Methods are disclosed for monitoring patients utilizing Mean Platelet Component values during therapeutic intervention.
摘要翻译： 公开了在治疗干预期间利用平均血小板成分值监测患者的方法。
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4.发明申请公开(公告)号：US20140227720A1
公开(公告)日：2014-08-14
申请号：US14124807
申请日：2012-06-08
申请人： David Wilson , David C. Duffy , David Hanlon , David Okrongly
发明人： David Wilson , David C. Duffy , David Hanlon , David Okrongly
IPC分类号： G01N33/574
CPC分类号： G01N33/57434 , C07K16/3069 , G01N2333/96455 , G01N2800/52 , G01N2800/54 , G01N2800/56
摘要： The present invention generally relates, in some embodiments, to methods of determining a patient's prognosis for recurrence of prostate cancer and/or determining a course of treatment for prostate cancer following a radical prostatectomy.
摘要翻译： 在一些实施方案中，本发明一般涉及确定患者对前列腺癌复发的预后和/或在根治性前列腺切除术后确定前列腺癌治疗过程的方法。
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公开(公告)号：US5286789A
公开(公告)日：1994-02-15
申请号：US041901
申请日：1993-04-02
申请人： David Okrongly , Brian R. Clark , Jack Spesard
发明人： David Okrongly , Brian R. Clark , Jack Spesard
CPC分类号： C07K1/042 , B01J2219/00315 , B01J2219/00364 , B01J2219/00511 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00617 , B01J2219/00626 , B01J2219/00659 , B01J2219/00725 , C40B40/10 , C40B60/14 , Y10S530/815 , Y10S530/816
摘要： Methods and compositions are provided, where oligopeptides are produced on a transparent surface while retaining transparency by the cyclical addition of protected monomers. Reagents are specifically selected to allow for efficient reproducible addition, while maintaining transparency of the support. Linkers are provided which permit retention of the oligopeptide to the surface or release of the oligopeptide at completion of the preparation of the oligopeptide. The oligopeptide bound to the support finds use in diagnostic assays, as well as other application, while the free oligopeptides may be used in a variety of ways.
摘要翻译： 提供了方法和组合物，其中在透明表面上产生寡肽，同时通过循环添加受保护的单体来保持透明性。 具体选择试剂以允许有效的可重复添加，同时保持载体的透明度。 提供接头，其在寡肽的制备完成时允许寡肽保留至表面或释放寡肽。 与支持物结合的寡肽可用于诊断测定以及其他应用，而游离寡肽可以以各种方式使用。
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公开(公告)号：US4933410A
公开(公告)日：1990-06-12
申请号：US330207
申请日：1989-03-29
申请人： David Okrongly
发明人： David Okrongly
IPC分类号： C12M1/24 , C08F8/30 , C08J7/12 , C12M1/34 , G01N33/543 , G01N33/545
CPC分类号： G01N33/54353 , C08F8/30
摘要： Uncrosslinked polystyrene surfaces are derivatized under Friedel-Crafts conditions in a tetramethylenesulfone solvent using a substituted N-hydroymethyl acetamide derivatizing agent. The substitutent is subject to nucleophilic substitution to allow for the binding of a wide variety of molecules, particularly specific binding pair members, to the surface. Clarity is maintained for monitoring observation of events on the surface through the polystyrene.
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