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    Depth Filters For Disposable Biotechnological Processes
    2.
    发明申请
    Depth Filters For Disposable Biotechnological Processes 审中-公开

    公开(公告)号：US20180345173A1

    公开(公告)日：2018-12-06

    申请号：US16058258

    申请日：2018-08-08

    Applicant: EMD Millipore Corporation

    Inventor： Nripen Singh ,  Kwok-Shun Cheng

    IPC: B01D15/12 ,  C07K1/34 ,  C02F1/00 ,  B01D15/38 ,  C02F1/52 ,  C02F1/56 ,  C02F103/34

    Abstract: A process for the primary clarification of feeds, including chemically treated flocculated feeds, containing the target biomolecules of interest such as mAbs, mammalian cell cultures, or bacterial cell cultures, using a primary clarification depth filtration device without the use of a primary clarification centrifugation step or a primary clarification tangential flow microfiltration step. The primary clarification depth filtration device contains a porous depth filter having graded porous layers of varying pore ratings. The primary clarification depth filtration device filters fluid feeds, including chemically treated flocculated feeds containing flocculated cellular debris and colloidal particulates having a particle size distribution of approximately about 0.5 μm to 200 μm, at a flow rate of about 10 litres/m2/hr to about 100 litres/m2/hr. Kits and methods of using and making the same are also provided.

    High capacity composite depth filter media with low extractables
    6.
    发明授权
    High capacity composite depth filter media with low extractables 有权

    公开(公告)号：US11590439B2

    公开(公告)日：2023-02-28

    申请号：US14890774

    申请日：2014-09-02

    Applicant: EMD Millipore Corporation

    Inventor： Maybelle Woo ,  David Yavorksy ,  John Amara ,  Nripen Singh ,  Kwok-Shun Cheng

    IPC: B01D39/16 ,  B01D29/66

    Abstract: A depth filtration device for the clarification of biological fluids including a composite depth filter media having a nonwoven first layer integral with a second layer containing a polyaeryionitrile (PAN) fibers, a filter aid, and a wet-strength resin. The depth filter media exhibits increased creased binding capacity for soluble impurities such as DNA and host eel! proteins from biological/cell culture feed-streams during secondary clarification and low-level impurity clearance of harvested cell culture fluids, such as those used for the manufacture of monoclonal antibodies. The depth filter media additionally exhibits significantly lower flushing requirements, resulting in lower levels of organic, inorganic and bioburden extractables released, high dirt holding capacities and good chemical and/or radiation resistance.

    Depth filters for disposable biotechnological processes
    7.
    发明授权
    Depth filters for disposable biotechnological processes 有权

    公开(公告)号：US11504646B2

    公开(公告)日：2022-11-22

    申请号：US17008690

    申请日：2020-09-01

    Applicant: EMD Millipore Corporation

    Inventor： Nripen Singh ,  Kwok-Shun Cheng

    IPC: B01D15/12 ,  B01D15/38 ,  C02F1/00 ,  C02F1/52 ,  C07K1/34 ,  C02F1/56 ,  C02F103/34

    Abstract: A process for the primary clarification of feeds, including chemically treated flocculated feeds, containing the target biomolecules of interest such as mAbs, mammalian cell cultures, or bacterial cell cultures, using a primary clarification depth filtration device without the use of a primary clarification centrifugation step or a primary clarification tangential flow microfiltration step. The primary clarification depth filtration device contains a porous depth filter having graded porous layers of varying pore ratings. The primary clarification depth filtration device filters fluid feeds, including chemically treated flocculated feeds containing flocculated cellular debris and colloidal particulates having a particle size distribution of approximately about 0.5 μm to 200 μm, at a flow rate of about 10 litres/m2/hr to about 100 litres/m2/hr. Kits and methods of using and making the same are also provided.

    High capacity composite depth filter media with low extractables
    8.
    发明授权
    High capacity composite depth filter media with low extractables 有权

    公开(公告)号：US11439933B2

    公开(公告)日：2022-09-13

    申请号：US16720102

    申请日：2019-12-19

    Applicant: EMD Millipore Corporation

    Inventor： Maybelle Woo ,  David Yavorsky ,  John Amara ,  Nripen Singh ,  Kwok-Shun Cheng

    IPC: B01D39/16 ,  B01D29/66

    Abstract: A depth filtration device for the clarification of biological fluids including a composite depth filter media having a nonwoven first layer integral with a second layer containing a polyacrylonitrile (PAN) fibers, a filter aid, and a wet-strength resin. The depth filter media exhibits increased binding capacity for soluble impurities such as DNA and host cell proteins from biological/cell culture feedstreams during secondary clarification and low-level impurity clearance of harvested cell culture fluids, such as those used for the manufacture of monoclonal antibodies. The depth filter media additionally exhibits significantly lower flushing requirements, resulting in lower levels of organic, inorganic and bioburden extractables released, high dirt holding capacities and good chemical and/or radiation resistance.

    HIGH CAPACITY COMPOSITE DEPTH FILTER MEDIA WITH LOW EXTRACTABLES
    10.
    发明申请
    HIGH CAPACITY COMPOSITE DEPTH FILTER MEDIA WITH LOW EXTRACTABLES 有权

    公开(公告)号：US20220387917A1

    公开(公告)日：2022-12-08

    申请号：US17819969

    申请日：2022-08-16

    Applicant: EMD Millipore Corporation

    Inventor： Maybelle Woo ,  David Yavorsky ,  John Amara ,  Nripen Singh ,  Kwok-Shun Cheng

    IPC: B01D39/16 ,  B01D29/66

    Abstract: A depth filtration device for the clarification of biological fluids including a composite depth filter media having a nonwoven first layer integral with a second layer containing a polyacrylonitrile (PAN) fibers, a filter aid, and a wet-strength resin. The depth filter media exhibits increased binding capacity for soluble impurities such as DNA and host cell proteins from biological/cell culture feedstreams during secondary clarification and low-level impurity clearance of harvested cell culture fluids, such as those used for the manufacture of monoclonal antibodies. The depth filter media additionally exhibits significantly lower flushing requirements, resulting in lower levels of organic, inorganic and bioburden extractables released, high dirt holding capacities and good chemical and/or radiation resistance.

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