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公开(公告)号：US5246698A
公开(公告)日：1993-09-21
申请号：US811139
申请日：1991-12-20
IPC分类号： A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61L27/20 , A61L27/52 , A61L31/04 , A61L31/14 , C08L5/08 , H04B10/155
CPC分类号： A61K9/0019 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61L27/20 , A61L27/52 , A61L31/042 , A61L31/145 , C08L5/08 , H04B10/50 , Y10S514/944 , Y10S530/813
摘要： Disclosed are biocompatible viscoelastic gel slurries formed from a polymeric gel, preferably a hyaluronan or a derivative thereof such as hylan swollen in an aqueous medium and a fluid phase which is an aqueous solution of a polymer which may also but not necessarily be a hyaluronan or derivative thereof. Also disclosed are methods of making such slurries, controlling their rheological properties and the uses thereof.
摘要翻译： 公开了由聚合物凝胶，优选透明质酸或其衍生物形成的生物相容性粘弹性凝胶浆液，例如在水性介质中溶胀的果胶，和作为聚合物的水溶液的流体相，该聚合物也可以但不一定是透明质酸或衍生物 其中。 还公开了制备这种浆料，控制其流变性质及其用途的方法。
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公开(公告)号：US5143724A
公开(公告)日：1992-09-01
申请号：US550287
申请日：1990-07-09
IPC分类号： A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61L27/00 , A61L27/20 , A61L27/52 , A61L31/00 , A61L31/04 , A61L31/14 , C08L5/00 , C08L5/08 , C08L101/00 , H04B10/155
CPC分类号： A61K9/0019 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61L27/20 , A61L27/52 , A61L31/042 , A61L31/145 , C08L5/08 , H04B10/50 , Y10S514/944 , Y10S530/813
摘要： Disclosed are biocompatible viscoelastic gel slurries formed from a polymeric gel, preferably a hyaluronan or a derivative thereof such as hylan swollen in an aqueous medium and a fluid phase which is an aqueous solution of a polymer which may also but not necessarily be a hyaluronan or derivative thereof. Also disclosed are methods of making such slurries, controlling their rheological properties and the uses thereof.
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公开(公告)号：US5399351A
公开(公告)日：1995-03-21
申请号：US80629
申请日：1993-06-24
IPC分类号： A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61L27/20 , A61L27/52 , A61L31/04 , A61L31/14 , C08L5/08 , H04B10/155 , A61K31/74 , A61K31/715 , A61K31/79
CPC分类号： A61K9/0019 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61L27/20 , A61L27/52 , A61L31/042 , A61L31/145 , C08L5/08 , H04B10/50 , Y10S514/944 , Y10S530/813
摘要： Disclosed are biocompatible viscoelastic gel slurries formed from a polymeric gel, preferably a hyaluronan or a derivative thereof such as hylan swollen in an aqueous medium and a fluid phase which is an aqueous solution of a polymer which may also but not necessarily be a hyaluronan or derivative thereof. Also disclosed are methods of making such slurries, controlling their rheological properties and the uses thereof.
摘要翻译： 公开了由聚合物凝胶，优选透明质酸或其衍生物形成的生物相容性粘弹性凝胶浆液，例如在水性介质中溶胀的果胶，和作为聚合物的水溶液的流体相，该聚合物也可以但不一定是透明质酸或衍生物 其中。 还公开了制备这种浆料，控制其流变性质及其用途的方法。
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4.发明授权Chemically modified hyaluronic acid preparation and method of recovery thereof from animal tissues 失效化学修饰的透明质酸制剂及其从动物组织中回收的方法
公开(公告)号：US4713448A
公开(公告)日：1987-12-15
申请号：US710929
申请日：1985-03-12
CPC分类号： C08B37/0072
摘要： Disclosed is hylan, a chemically modified hyaluronic acid preparation characterized by the presence of small amounts (0.005-0.05% by weight) of aldehyde cross-linking groups covalently bonded to the hyaluronic acid molecular chains. Also disclosed is a method of obtaining hylan comprising treating hyaluronic acid in situ in animal tissues containing same with a treatment mixture including a reagent (typically an aldehyde) which is reactive towards hyaluronic acid and the proteins contained in the animal tissue.
摘要翻译： 公开了一种化学修饰的透明质酸制剂，其特征在于存在少量（0.005-0.05重量％）共价键合到透明质酸分子链上的醛交联基团。 还公开了一种获得hylan的方法，其包括在含有其的动物组织中的原位处理透明质酸，所述处理混合物包括对透明质酸反应的试剂（通常为醛）和动物组织中所含的蛋白质。
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5.发明授权
公开(公告)号：US5099013A
公开(公告)日：1992-03-24
申请号：US616706
申请日：1990-11-16
IPC分类号： C08B37/08
CPC分类号： C08B37/0072
摘要： Disclosed is hylan, a chemically modified hyaluronan preparation characterized by the presence of small amounts (0.0002-0.05% by weight) of aldehyde cross-linking groups covalently bonded to the hyaluronan molecular chains. Also disclosed is an improved method of obtaining hylan comprising treating hyaluronan in situ in animal tissues containing same with a treatment mixture including an aldehyde which is reactive towards hyaluronic acid and the proteins contained in the animal tissue. Treatment is effected at temperatures below about 16.degree. C. at very high pH, e.g., 8-14 whereby the overall yield is increased while maintaining the high molecular weight of the hylan.
摘要翻译： 公开了一种化学改性的透明质酸制剂，其特征在于存在少量（0.0002-0.05重量％）共价结合到透明质酸分子链上的醛交联基团。 还公开了一种获得hylan的改进方法，其包括用包含对透明质酸和包含在动物组织中的蛋白质具有反应性的醛的处理混合物在原位处理透明质酸的动物组织。 在非常高的pH（例如8-14）下，在低于约16℃的温度下进行处理，由此总体收率提高同时保持高分子量的木聚糖。
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6.发明授权Drug delivery systems based on hyaluronans derivatives thereof and their salts and methods of producing same 失效基于透明质酸衍生物及其盐的药物递送系统及其制备方法
公开(公告)号：US5128326A
公开(公告)日：1992-07-07
申请号：US559413
申请日：1990-07-23
CPC分类号： A61K9/0014 , A61K47/36 , A61K47/4823 , A61K9/0019 , C08B37/0072 , C08L5/08 , A61K9/0048 , A61K9/7007
摘要： Disclosed are drug delivery systems based on a polymeric component which is soluble or insoluble (cross-linked) hyaluronan or hyaluronan copolymerized with another hydrophilic polymer or hylan and one or more substances having biological or pharmacological activity and methods of preparing same.
摘要翻译： 公开了基于聚合物组分的药物递送系统，其是可溶性或不溶性（交联）的透明质酸或透明质酸与另一种亲水性聚合物或hylan共聚的一种或多种具有生物或药理学活性的物质及其制备方法。
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7.发明授权
公开(公告)号：US4795741A
公开(公告)日：1989-01-03
申请号：US47419
申请日：1987-05-06
IPC分类号： A61L31/00 , A61K9/00 , A61K47/00 , A61K47/36 , A61K49/04 , A61L24/00 , A61L24/08 , A61L33/00 , C08F8/00 , C08G79/08
CPC分类号： A61K9/0019 , A61K47/36 , A61K49/04 , A61L24/0073 , A61L24/08 , A61L2430/36
摘要： Percutaneous emboli are formed for therapeutic and/or corrective reasons by using a composition which includes crosslinked gells of hyaluronic acid (HA), hylan (HY) or mixed crosslinked gels of HA or HY with other materials, thrombin and cationic substances containing quaternary ammonium groups. Other optional materials include fillers and radio-opaque substances.
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公开(公告)号：US4500676A
公开(公告)日：1985-02-19
申请号：US561816
申请日：1983-12-15
申请人： Endre A. Balazs , Adolf Leshchiner
发明人： Endre A. Balazs , Adolf Leshchiner
IPC分类号： C08L101/00 , A61L27/00 , A61L27/26 , A61L33/06 , C08F8/00 , C08G18/00 , C08G85/00 , C08J3/20 , C08J7/04 , C08J7/14 , C08L1/00 , C08L5/08 , C08L23/00 , C08L27/00 , C08L67/00 , C08L75/00 , C08L77/00
CPC分类号： C08G85/004 , A61L27/26 , A61L33/062 , C08F8/00 , A61F2/16 , Y10T428/31591 , Y10T428/31663 , Y10T428/31772 , Y10T428/3179 , Y10T428/3188
摘要： Polymeric materials (and articles made therefrom) including polyurethanes, polyesters, polyolefins, polyamides, polysiloxanes, vinylic and acrylic polymers are rendered biocompatible by including with the polymeric material hyaluronic acid or a salt thereof. The hyaluronic acid may be coated onto the surface of the polymeric material, dispersed throughout the body of the polymeric material, or both. The hyaluronic acid on the surface of the polymeric material may optionally be cross-linked. The biocompatible polymeric materials are used in the making of various prosthetic devices including heart valves, intraocular lenses, vascular grafts, pacemaker leads and the like.
摘要翻译： 包括聚氨酯，聚酯，聚烯烃，聚酰胺，聚硅氧烷，乙烯基和丙烯酸类聚合物在内的聚合材料（和由其制成的制品）通过用聚合物透明质酸或其盐包括而形成生物相容性。 透明质酸可以涂覆在聚合物材料的表面上，分散在整个聚合物材料的主体中，或者两者。 聚合物材料表面上的透明质酸可以任选地交联。 生物相容性聚合物材料用于制造各种假体装置，包括心脏瓣膜，人工晶状体，血管移植物，起搏器引线等。
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公开(公告)号：US4487865A
公开(公告)日：1984-12-11
申请号：US561817
申请日：1983-12-15
IPC分类号： C08L5/00 , A61L27/16 , A61L27/18 , A61L27/54 , A61L33/00 , C08F8/00 , C08L33/00 , C08L33/04 , C08L33/14 , C08L75/04
摘要： Polymeric materials (and articles made therefrom) including polyurethanes, polyesters, polyolefins, polyamides, polysiloxanes, vinylic and acrylic polymers are rendered biocompatible by including with the polymeric material hyaluronic acid or a salt thereof. The hyaluronic acid may be coated onto the surface of the polymeric material, dispersed throughout the body of the polymeric material, or both. The hyaluronic acid on the surface of the polymeric material may optionally be cross-linked. The biocompatible polymeric materials are used in the making of various prosthetic devices including heart valves, intraocular lenses, vascular grafts, pacemaker leads and the like.
摘要翻译： 包括聚氨酯，聚酯，聚烯烃，聚酰胺，聚硅氧烷，乙烯基和丙烯酸类聚合物在内的聚合材料（和由其制成的制品）通过用聚合物透明质酸或其盐包括而形成生物相容性。 透明质酸可以涂覆在聚合物材料的表面上，分散在整个聚合物材料的主体中，或者两者。 聚合物材料表面上的透明质酸可以任选地交联。 生物相容性聚合物材料用于制造各种假体装置，包括心脏瓣膜，人工晶状体，血管移植物，起搏器引线等。
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公开(公告)号：US5266563A
公开(公告)日：1993-11-30
申请号：US464583
申请日：1990-01-11
申请人： Endre A. Balazs , Adolf Leshchiner
发明人： Endre A. Balazs , Adolf Leshchiner
IPC分类号： A61K8/73 , A61K8/86 , A61K9/00 , A61K47/36 , A61Q19/00 , C08L5/08 , A61K7/15 , A61K7/48 , A61K31/70
CPC分类号： A61K8/86 , A61K47/36 , A61K8/735 , A61K9/0048 , A61Q19/00 , C08L5/08 , A61Q9/02 , Y10S514/844 , Y10S514/846 , Y10S514/912 , Y10S514/914
摘要： Disclosed are water based, viscoelastic compositions comprising a mixture of high molecular weights hyaluronic acid salts and water soluble poly(ethylene oxides). Also disclosed are cosmetic formulations including said compositions.
摘要翻译： 公开了包含高分子量透明质酸盐和水溶性聚（环氧乙烷）的混合物的水基粘弹性组合物。 还公开了包含所述组合物的化妆品制剂。
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