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11 条记录 (耗时 0.019 秒)

    Modified hydrophilic polymers containing hydrophobic groups
    7.
    发明授权
    Modified hydrophilic polymers containing hydrophobic groups 有权
    含疏水基团的改性亲水性聚合物

    公开(公告)号：US08247390B2

    公开(公告)日：2012-08-21

    申请号：US12586716

    申请日：2009-09-28

    申请人： Adelya K. Leshchiner ,  Nancy E. Larsen ,  Edward G. Parent

    发明人： Adelya K. Leshchiner ,  Nancy E. Larsen ,  Edward G. Parent

    IPC分类号： A01N43/04 ,  A61K31/715

    CPC分类号： A61Q17/04 ,  A61K8/735

    摘要： Disclosed are hydrophilic polymers such as polysaccharides, including hyaluronic acid of any origin, modified by reaction with epoxy-functional-silicones. Hydrophobic silicon, which contains chemically active groups covalently attach to the backbone of the hydrophilic polymer and gives these new, modified polymers the ability to dissolve hydrophobic compounds including oils, drugs, and vitamins, while maintaining the hydrophilic properties and benefits of the unmodified polymer. With respect to topical applications these polymers substantially increase the stability of formulations and provide for ease of preparation. The properties and advantages of the original polymer are maintained while other properties are augmented, namely the ability to combine with or dissolve hydrophobic and hydrophilic drugs. The products can be used alone or in combination with other substances for various applications including cosmetic, medical, and drug delivery applications. Also disclosed are methods for preparing them.

    摘要翻译： 公开了亲水性聚合物，例如多糖，包括任何来源的透明质酸，通过与环氧官能聚硅氧烷反应而改性。 含有化学活性基团的疏水硅共价连接到亲水性聚合物的骨架上，并且使这些新的改性聚合物具有溶解疏水化合物（包括油，药物和维生素）的能力，同时保持未改性聚合物的亲水性质和益处。 关于局部应用，这些聚合物基本上增加制剂的稳定性并提供易于制备。 保持原始聚合物的性质和优点，而其他性能得到增强，即与疏水性和亲水性药物结合或溶解的能力。 该产品可以单独使用或与其他物质组合使用，用于各种应用，包括化妆品，医药和药物输送应用。 还公开了制备它们的方法。

    Modified hydrophilic polymers containing hydrophobic groups
    8.
    发明申请
    Modified hydrophilic polymers containing hydrophobic groups 有权
    含疏水基团的改性亲水性聚合物

    公开(公告)号：US20110076243A1

    公开(公告)日：2011-03-31

    申请号：US12586716

    申请日：2009-09-28

    申请人： Adelya K. Leshchiner ,  Nancy E. Larsen ,  Edward G. Parent

    发明人： Adelya K. Leshchiner ,  Nancy E. Larsen ,  Edward G. Parent

    IPC分类号： A61K8/73 ,  A61K31/715 ,  A61K31/727 ,  A61Q17/04 ,  A61P17/00

    CPC分类号： A61Q17/04 ,  A61K8/735

    摘要： Disclosed are hydrophilic polymers such as polysaccharides, including hyaluronic acid of any origin, modified by reaction with epoxy-functional-silicones. Hydrophobic silicon, which contains chemically active groups covalently attach to the backbone of the hydrophilic polymer and gives these new, modified polymers the ability to dissolve hydrophobic compounds including oils, drugs, and vitamins, while maintaining the hydrophilic properties and benefits of the unmodified polymer. With respect to topical applications these polymers substantially increase the stability of formulations and provide for ease of preparation. The properties and advantages of the original polymer are maintained while other properties are augmented, namely the ability to combine with or dissolve hydrophobic and hydrophilic drugs. The products can be used alone or in combination with other substances for various applications including cosmetic, medical, and drug delivery applications. Also disclosed are methods for preparing them.

    摘要翻译： 公开了亲水性聚合物，例如多糖，包括任何来源的透明质酸，通过与环氧官能聚硅氧烷反应而改性。 含有化学活性基团的疏水硅共价连接到亲水性聚合物的骨架上，并且使这些新的改性聚合物具有溶解疏水化合物（包括油，药物和维生素）的能力，同时保持未改性聚合物的亲水性质和益处。 关于局部应用，这些聚合物基本上增加制剂的稳定性并提供易于制备。 保持原始聚合物的性质和优点，而其他性能得到增强，即与疏水性和亲水性药物结合或溶解的能力。 该产品可以单独使用或与其他物质组合使用，用于各种应用，包括化妆品，医药和药物输送应用。 还公开了制备它们的方法。

    Hydrophilic biopolymer-drug conjugates, their preparation and use
    9.
    发明授权
    Hydrophilic biopolymer-drug conjugates, their preparation and use 有权
    亲水生物聚合物 - 药物共轭物，其制备和用途

    公开(公告)号：US07034127B2

    公开(公告)日：2006-04-25

    申请号：US10611439

    申请日：2003-07-01

    申请人： Edward G. Parent ,  Nancy E. Larsen

    发明人： Edward G. Parent ,  Nancy E. Larsen

    IPC分类号： C07K1/00 ,  C07K14/00 ,  C07K16/00 ,  C07K17/00

    CPC分类号： A61K38/4833 ,  A61K31/716 ,  A61K31/737 ,  A61K38/14 ,  A61K38/212 ,  A61K38/41 ,  A61K47/61 ,  C08B37/0072

    摘要： Disclosed are methods of conjugating biologically active substances, particularly, alpha-interferon, with a hyaluronan or a mixture of a hyaluronan with at least one other hydrophilic polymer having a functional group capable of reacting with divinyl sulfone. Also disclosed are stable intermediates formed by partially reacting a hyaluronan with divinyl sulfone and stopping the reaction before completion to leave free, or reactive vinyl groups on the hyaluronan molecule available for conjugation with the biologically active substance.

    摘要翻译： 公开了将生物活性物质，特别是α-干扰素与透明质酸或透明质酸与至少一种具有能够与二乙烯基砜反应的官能团的其它亲水性聚合物的混合物缀合的方法。 还公开了通过使透明质酸与二乙烯基砜部分反应并在完成之前停止反应而在可用于与生物活性物质缀合的透明质酸分子上留下游离的或反应性乙烯基而形成的稳定的中间体。