Polypeptide originating in haemophilus paragallinarum and process for producing the same
    2.
    发明授权
    Polypeptide originating in haemophilus paragallinarum and process for producing the same 失效
    源自嗜血杆菌的多肽及其制备方法

    公开(公告)号:US06544519B1

    公开(公告)日:2003-04-08

    申请号:US09077098

    申请日:1998-05-19

    IPC分类号: A61K3938

    摘要: A novel peptide obtained from Haemophilus paragallinarum has been found useful for preventing avian infectious coryza. This polypeptide induces production of hemagglutination-inhibition antibody and prevents infection and onset of avian infectious coryza. The invention further provides a gene coding for the polypeptide, a recombinant vector for expression of this gene, a host transformed with this vector, a process for preparing the polypeptide in a host, a vaccine for avian infectious coryza comprising the polypeptide as an active ingredient, a monoclonal antibody obtained using the polypeptide as an immunogen, and a diagnostic agent and a therapeutic agent for avian infectious coryza using the peptide and the antibody.

    摘要翻译: 已经发现从嗜血杆菌获得的新肽可用于预防禽传染性鼻炎。 该多肽诱导血细胞凝集抑制抗体的产生并防止禽传染性鼻炎的感染和发作。 本发明还提供了编码该多肽的基因,用于表达该基因的重组载体,用该载体转化的宿主,在宿主中制备该多肽的方法,用于禽传染性鼻炎的疫苗,其包含该多肽作为活性成分 ,使用该多肽作为免疫原获得的单克隆抗体,以及使用该肽和抗体的诊断剂和禽类感染性鼻炎的治疗剂。

    Process for preparing variant of Erysipelothrix rhusiopathiae surface protective antigen in E. coli
    3.
    发明授权
    Process for preparing variant of Erysipelothrix rhusiopathiae surface protective antigen in E. coli 有权
    在大肠杆菌中制备欧洲白喉病毒性表皮保护性抗原变异体的方法

    公开(公告)号:US08277820B2

    公开(公告)日:2012-10-02

    申请号:US10590896

    申请日:2005-02-08

    摘要: A variant of Erysipelothrix rhusiopathiae surface protective antigen SpaA protein or of a shortened form of SpaA (ΔSpaA) in which a portion of SpaA protein is deleted for protection from Erysipelothrix rhusiopathiae infection and a process for preparing the same are provided. Introduction of amino acid substitution at a specific site in the amino acid sequence of SpaA or ΔSpaA protein provides a variant of SpaA or ΔSpaA protein which is immunogenic and is expressed in E. coli as inclusion bodies. The variant of SpaA or ΔSpaA protein of the present invention may easily be recovered and purified since it is expressed in E. coli as inclusion bodies.

    摘要翻译: 提供了Erysillolothrix rhasiopathiae表面保护性抗原SpaA蛋白或SpaA(&Dgr。SpaA)的缩写形式的一种变体,其中一部分SpaA蛋白被缺失以防止欧莱氏杆菌性鼻病毒感染及其制备方法。 在SpaA或&Dgr; SpaA蛋白的氨基酸序列中的特定位点引入氨基酸取代提供了SPAA或&Dgr; SpaA蛋白的变体,其是免疫原性的并且在大肠杆菌中以包涵体表达。 本发明的SpaA或&Dgr; SpaA蛋白质的变体可以容易地回收和纯化,因为其在大肠杆菌中作为包涵体表达。

    Process for Preparing Variant of Erysipelothrix Rhusiopathiae Surface Protective Antigen in E. Coli
    4.
    发明申请
    Process for Preparing Variant of Erysipelothrix Rhusiopathiae Surface Protective Antigen in E. Coli 有权
    大肠杆菌表皮保护性抗原的制备方法

    公开(公告)号:US20080286309A1

    公开(公告)日:2008-11-20

    申请号:US10590896

    申请日:2005-02-08

    摘要: A variant of Erysipelothrix rhusiopathiae surface protective antigen SpaA protein or of a shortened form of SpaA (ΔSpaA) in which a portion of SpaA protein is deleted for protection from Erysipelothrix rhusiopathiae infection and a process for preparing the same are provided. Introduction of amino acid substitution at a specific site in the amino acid sequence of SpaA or ΔSpaA protein provides a variant of SpaA or ΔSpaA protein which is immunogenic and is expressed in E. coli as inclusion bodies. The variant of SpaA or ΔSpaA protein of the present invention may easily be recovered and purified since it is expressed in E. coli as inclusion bodies.

    摘要翻译: 提供了Erysillolothrix rhusiopathiae表面保护性抗原SpaA蛋白质或缩短形式的SpaA(DeltaSpaA)的变体,其中一部分SpaA蛋白质被缺失以防止欧洲白喉病毒性鼻炎病毒感染及其制备方法。 在SpaA或DeltaSpaA蛋白的氨基酸序列中的特定位点处引入氨基酸取代提供了SPAA或DeltaSpaA蛋白的变体,其是免疫原性的并且在大肠杆菌中作为包涵体表达。 本发明的SpaA或DeltaSpaA蛋白的变体可以容易地被回收和纯化,因为它作为包涵体在大肠杆菌中表达。

    PROCESS FOR PREPARING VARIANT OF ERYSIPELOTHRIX RHUSIOPATHIAE SURFACE PROTECTIVE ANTIGEN IN E. COLI
    5.
    发明申请
    PROCESS FOR PREPARING VARIANT OF ERYSIPELOTHRIX RHUSIOPATHIAE SURFACE PROTECTIVE ANTIGEN IN E. COLI 有权
    在大肠杆菌中制备抗坏血酸表面抗原的变体的方法

    公开(公告)号:US20110059021A1

    公开(公告)日:2011-03-10

    申请号:US12949606

    申请日:2010-11-18

    摘要: A variant of Erysipelothrix rhusiopathiae surface protective antigen SpaA protein or of a shortened form of SpaA (ΔSpaA) in which a portion of SpaA protein is deleted for protection from Erysipelothrix rhusiopathiae infection and a process for preparing the same are provided. Introduction of amino acid substitution at a specific site in the amino acid sequence of SpaA or ΔSpaA protein provides a variant of SpaA or ΔSpaA protein which is immunogenic and is expressed in E. coli as inclusion bodies. The variant of SpaA or ΔSpaA protein of the present invention may easily be recovered and purified since it is expressed in E. coli as inclusion bodies.

    摘要翻译: 提供了Erysillolothrix rhasiopathiae表面保护性抗原SpaA蛋白或SpaA(&Dgr。SpaA)的缩写形式的一种变体,其中一部分SpaA蛋白被缺失以防止欧莱氏杆菌性鼻病毒感染及其制备方法。 在SpaA或&Dgr; SpaA蛋白的氨基酸序列中的特定位点引入氨基酸取代提供了SPAA或&Dgr; SpaA蛋白的变体,其是免疫原性的并且在大肠杆菌中以包涵体表达。 本发明的SpaA或&Dgr; SpaA蛋白质的变体可以容易地回收和纯化,因为其在大肠杆菌中作为包涵体表达。

    In ovo vaccination of marek's disease type I virus
    6.
    发明授权
    In ovo vaccination of marek's disease type I virus 失效
    在ovo接种马立克氏病I型病毒

    公开(公告)号:US06410222B1

    公开(公告)日:2002-06-25

    申请号:US09622093

    申请日:2000-08-11

    IPC分类号: C12Q170

    摘要: The preset invention provides a method for immunizing chickens which comprises inoculating into growing egg a composition comprising either cell-free attenuated viruses of Marek's disease type 1 or cells infected with attenuated viruses of Marek's disease type 1 capable of producing cell-free viruses. The present invention also provides a method for immunizing chickens which comprises inoculating into growing egg a mixed vaccine comprising said composition plus another vaccine from at least one microorganisms selected from the group consisting of viruses other than virus of Marek's disease type 1, bacteria and protozoan.

    摘要翻译: 本发明提供了一种用于免疫鸡的方法,其包括将生长的卵中的一种组合物接种到生长中的鸡中,所述组合物包含1型马立克氏病的无细胞减毒病毒或能够产生无细胞病毒的1型马立克氏病减毒病毒感染的细胞。 本发明还提供了一种免疫鸡的方法,其包括将包含所述组合物的混合疫苗和来自至少一种选自除了马立克氏病1型病毒以外的病毒的细菌和细菌和原生动物的至少一种微生物接种到生长的鸡蛋中。

    Process for preparing variant of Erysipelothrix rhusiopathiae surface protective antigen in E. coli
    7.
    发明授权
    Process for preparing variant of Erysipelothrix rhusiopathiae surface protective antigen in E. coli 有权
    在大肠杆菌中制备欧洲白喉病毒性表皮保护性抗原变异体的方法

    公开(公告)号:US08361749B2

    公开(公告)日:2013-01-29

    申请号:US12949606

    申请日:2010-11-18

    摘要: A variant of Erysipelothrix rhusiopathiae surface protective antigen SpaA protein or of a shortened form of SpaA (ΔSpaA) in which a portion of SpaA protein is deleted for protection from Erysipelothrix rhusiopathiae infection and a process for preparing the same are provided. Introduction of amino acid substitution at a specific site in the amino acid sequence of SpaA or ΔSpaA protein provides a variant of SpaA or ΔSpaA protein which is immunogenic and is expressed in E. coli as inclusion bodies. The variant of SpaA or ΔSpaA protein of the present invention may easily be recovered and purified since it is expressed in E. coli as inclusion bodies.

    摘要翻译: 提供了Erysillolothrix rhasiopathiae表面保护性抗原SpaA蛋白或SpaA(&Dgr。SpaA)的缩写形式的一种变体,其中一部分SpaA蛋白被缺失以防止欧莱氏杆菌性鼻病毒感染及其制备方法。 在SpaA或&Dgr; SpaA蛋白的氨基酸序列中的特定位点引入氨基酸取代提供了SPAA或&Dgr; SpaA蛋白的变体,其是免疫原性的并且在大肠杆菌中以包涵体表达。 本发明的SpaA或&Dgr; SpaA蛋白质的变体可以容易地回收和纯化,因为其在大肠杆菌中作为包涵体表达。