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    Multi-well plate with tailored chambers
    1.
    发明授权
    Multi-well plate with tailored chambers 有权
    多孔板与定制的房间

    公开(公告)号：US08808647B2

    公开(公告)日：2014-08-19

    申请号：US12556925

    申请日：2009-09-10

    申请人： Claudio Cherubini ,  Nicole Gwerder ,  Martin Kopp ,  Edwin Oosterbroek ,  Emad Sarofim

    发明人： Claudio Cherubini ,  Nicole Gwerder ,  Martin Kopp ,  Edwin Oosterbroek ,  Emad Sarofim

    IPC分类号： B01L3/00

    CPC分类号： B01L3/50851 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2300/0858

    摘要： Systems, methods and multi-well plates comprising an array of wells for thermal treatment of chemical or biological samples are disclosed. Each of the wells comprises a bottom opening, an upper opening, inner side walls extending from the bottom opening to the upper opening, a protrusion extending from the inner side walls into the well with a first cross-sectional area and located at a height from the bottom opening which is smaller than the height from the upper opening. A sample chamber with a second cross-sectional area is formed between the bottom opening and the protrusion. An upper chamber with a third cross-sectional area is formed between the protrusion and the upper opening, and in which the first cross-sectional area is smaller than the third cross-sectional area and smaller than or equal to the second cross-sectional area.

    摘要翻译： 公开了包括用于化学或生物样品的热处理的孔阵列的系统，方法和多孔板。 每个孔包括底部开口，上部开口，从底部开口延伸到上部开口的内侧壁，从内侧壁延伸进入井的突起，其具有第一横截面积并且位于与 底部开口小于从上部开口的高度。 具有第二横截面积的样品室形成在底部开口和突起之间。 在所述突起与所述上部开口之间形成具有第三横截面积的上部腔室，其中，所述第一横截面积小于所述第三横截面积，并且小于或等于所述第二横截面积 。

    System And Method For Dispensing Fluids
    2.
    发明申请
    System And Method For Dispensing Fluids 审中-公开
    液体分配系统及方法

    公开(公告)号：US20110127292A1

    公开(公告)日：2011-06-02

    申请号：US12786709

    申请日：2010-05-25

    申请人： Emad Sarofim ,  Martin Kopp ,  Claudio Cherubini

    发明人： Emad Sarofim ,  Martin Kopp ,  Claudio Cherubini

    IPC分类号： B67D7/06 ,  B01L3/02 ,  B01L9/00

    CPC分类号： G01N35/1083 ,  B01L9/52 ,  B01L9/523 ,  B01L2300/0829 ,  G01N35/1065

    摘要： A system for dispensing one or more fluids into wells of a target multi-well plate, a holder and a method thereof are disclosed. The system provides the holder which holds the multi-well plate in a predefined holding position, the plate having a well region provided with wells for accommodating the fluids and an edge region surrounding the well region. The holder includes: a contact area which contacts the edge region to form a sealing zone which air-tightly seals a void formed between the holder and the plate; a supporting face which supports the well region in a planar condition; and a duct which connects to a pump to generate a negative pressure in the void so as to draw the well region onto the supporting face.

    摘要翻译： 公开了一种用于将一种或多种流体分配到目标多孔板的孔中的系统，保持器及其方法。 该系统提供将多孔板保持在预定的保持位置的保持器，该板具有设置有用于容纳流体的井的井区域和围绕井区域的边缘区域。 保持器包括：接触区域，其接触边缘区域以形成气密密封形成在保持器和板之间的空隙的密封区域; 在平坦状态下支撑井区的支撑面; 以及连接到泵以在空隙中产生负压以将阱区域拉到支撑面上的管道。

    MULTI-WELL PLATE WITH TAILORED CHAMBERS
    3.
    发明申请
    MULTI-WELL PLATE WITH TAILORED CHAMBERS 有权
    多层板，配有定制座椅

    公开(公告)号：US20100064781A1

    公开(公告)日：2010-03-18

    申请号：US12556925

    申请日：2009-09-10

    申请人： Claudio Cherubini ,  Nicole Gwerder ,  Martin Kopp ,  Edwin Oosterbroek ,  Emad Sarofim

    发明人： Claudio Cherubini ,  Nicole Gwerder ,  Martin Kopp ,  Edwin Oosterbroek ,  Emad Sarofim

    IPC分类号： G01N21/00 ,  B01L3/00 ,  G01N1/44

    CPC分类号： B01L3/50851 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2300/0858

    摘要： Systems, methods and multi-well plates comprising an array of wells for thermal treatment of chemical or biological samples are disclosed. Each of the wells comprises a bottom opening, an upper opening, inner side walls extending from the bottom opening to the upper opening, a protrusion extending from the inner side walls into the well with a first cross-sectional area and located at a height from the bottom opening which is smaller than the height from the upper opening. A sample chamber with a second cross-sectional area is formed between the bottom opening and the protrusion. An upper chamber with a third cross-sectional area is formed between the protrusion and the upper opening, and in which the first cross-sectional area is smaller than the third cross-sectional area and smaller than or equal to the second cross-sectional area.

    摘要翻译： 公开了包括用于化学或生物样品的热处理的孔阵列的系统，方法和多孔板。 每个孔包括底部开口，上部开口，从底部开口延伸到上部开口的内侧壁，从内侧壁延伸进入井的突起，其具有第一横截面积并且位于与 底部开口小于从上部开口的高度。 具有第二横截面积的样品室形成在底部开口和突起之间。 在所述突起与所述上部开口之间形成具有第三横截面积的上部腔室，其中，所述第一横截面积小于所述第三横截面积，并且小于或等于所述第二横截面积 。

    METHOD, STRUCTURE, DEVICE, KIT AND SYSTEM FOR THE AUTOMATED ANALYSIS OF LIQUID SAMPLES
    4.
    发明申请
    METHOD, STRUCTURE, DEVICE, KIT AND SYSTEM FOR THE AUTOMATED ANALYSIS OF LIQUID SAMPLES 有权
    液体样品自动分析的方法，结构，装置，工具包和系统

    公开(公告)号：US20110250695A1

    公开(公告)日：2011-10-13

    申请号：US12903492

    申请日：2010-10-13

    申请人： Emad Sarofim ,  Edwin Oosterbroek ,  Claudio Cherubini ,  Nenad Milicevic

    发明人： Emad Sarofim ,  Edwin Oosterbroek ,  Claudio Cherubini ,  Nenad Milicevic

    IPC分类号： G01N35/00 ,  G01N33/00 ,  C12M1/34 ,  B01L3/00

    CPC分类号： G01N35/00029 ,  B01L3/502738 ,  B01L7/52 ,  B01L2200/0642 ,  B01L2200/0673 ,  B01L2300/0829 ,  B01L2300/0864 ,  B01L2400/0409 ,  B01L2400/0677 ,  G01N21/07 ,  G01N2021/0325 ,  G01N2035/00099 ,  G01N2035/00495

    摘要： A method for the automated analysis of liquid samples using at least one microfluidic structure is disclosed as well as microfluidic structures, a device having at least one of the microfluidic structures, a kit and a system including such microfluidic device. In one embodiment, the method may comprise: transferring said sample into a first fluid reservoir which is in fluid communication with a second fluid reservoir by a flow channel; spinning said microfluidic structure so as to transport said sample into one or more dead-end recesses or chambers; transferring a control fluid into the structure which generates a barrier to flow and diffusion of said sample contained in said one or more dead-end recesses or chambers; and analyzing said sample contained in said one or more dead-end recesses or chambers.

    摘要翻译： 公开了使用至少一个微流体结构自动分析液体样品的方法，以及微流体结构，具有至少一个微流体结构的装置，试剂盒和包括这种微流体装置的系统。 在一个实施例中，该方法可以包括：将所述样品转移到通过流动通道与第二流体储存器流体连通的第一流体储存器中; 旋转所述微流体结构以将所述样品输送到一个或多个死端凹部或腔室中; 将控制流体转移到所述结构中，所述结构产生所述一个或多个死端凹部或室中容纳的所述样品的流动和扩散的阻挡层; 并分析包含在所述一个或多个死端凹部或腔室中的所述样品。

    Method for the automated analysis of liquid samples using centrifugal force in a microfluidic structure
    5.
    发明授权
    Method for the automated analysis of liquid samples using centrifugal force in a microfluidic structure 有权
    在微流体结构中使用离心力自动分析液体样品的方法

    公开(公告)号：US08580567B2

    公开(公告)日：2013-11-12

    申请号：US12903492

    申请日：2010-10-13

    申请人： Emad Sarofim ,  Edwin Oosterbroek ,  Claudio Cherubini ,  Nenad Milicevic

    发明人： Emad Sarofim ,  Edwin Oosterbroek ,  Claudio Cherubini ,  Nenad Milicevic

    IPC分类号： G01N21/07

    CPC分类号： G01N35/00029 ,  B01L3/502738 ,  B01L7/52 ,  B01L2200/0642 ,  B01L2200/0673 ,  B01L2300/0829 ,  B01L2300/0864 ,  B01L2400/0409 ,  B01L2400/0677 ,  G01N21/07 ,  G01N2021/0325 ,  G01N2035/00099 ,  G01N2035/00495

    摘要： A method for the automated analysis of liquid samples using at least one microfluidic structure is disclosed as well as microfluidic structures, a device having at least one of the microfluidic structures, a kit and a system including such microfluidic device. In one embodiment, the method may comprise: transferring a sample into a first fluid reservoir which is in fluid communication with a second fluid reservoir by a flow channel; spinning the microfluidic structure so as to transport the sample into one or more dead-end recesses or chambers; transferring a control fluid into the structure which generates a barrier to flow and diffusion of the sample contained in the one or more dead-end recesses or chambers; and analyzing the sample contained in the one or more dead-end recesses or chambers.

    摘要翻译： 公开了使用至少一个微流体结构自动分析液体样品的方法，以及微流体结构，具有至少一个微流体结构的装置，试剂盒和包括这种微流体装置的系统。 在一个实施例中，该方法可以包括：将样品转移到通过流动通道与第二流体储存器流体连通的第一流体储存器中; 旋转微流体结构以将样品输送到一个或多个死端凹部或腔室中; 将控制流体转移到所述结构中，所述结构产生包含在所述一个或多个死端凹部或腔室中的样品的流动和扩散的阻挡层; 并分析包含在一个或多个死端凹部或腔室中的样品。

    System And Method For Cycling Liquid Samples Through A Series Of Temperature Excursions
    7.
    发明申请
    System And Method For Cycling Liquid Samples Through A Series Of Temperature Excursions 审中-公开
    通过一系列温度漂移循环液体样品的系统和方法

    公开(公告)号：US20110136109A1

    公开(公告)日：2011-06-09

    申请号：US12963169

    申请日：2010-12-08

    申请人： Andreas Drechsler ,  Emad Sarofim ,  Claudio Cherubini ,  Stephan Korner

    发明人： Andreas Drechsler ,  Emad Sarofim ,  Claudio Cherubini ,  Stephan Korner

    IPC分类号： C12Q1/68 ,  C12M1/34 ,  C12M1/00

    CPC分类号： B01L7/52 ,  B01L3/5085 ,  B01L2300/168 ,  B01L2300/1827

    摘要： A system and method for cycling liquid samples through a series of temperature excursions are disclosed. Provided are open-top reaction vessels for containing the samples, which may be enclosed by one or more covers. A temperature-controlled block for generating or adsorbing heat is coupled thermally to the reaction vessels. A detection arrangement is disposed in an emission beam path to detect radiation emitted from the samples through the covers. A heating arrangement for generating heat includes a heating element that is both disposed between the reaction vessels and the detection arrangement and coupled thermally to the covers. The heating element includes an optically transparent substrate provided with one or more opaque heating lines, the heating lines being disposed in the emission beam path in a manner to obtain a predetermined minimum optical transmission of the heating element. A controller, set up to control cycling of the samples, is provided.

    摘要翻译： 公开了通过一系列温度偏移来循环液体样品的系统和方法。 提供用于容纳样品的敞开式反应容器，其可以由一个或多个盖子包围。 用于产生或吸附热量的温度控制块热耦合到反应容器。 检测装置设置在发射光束路径中以检测从样品通过盖发射的辐射。 用于产生热的加热装置包括加热元件，其均设置在反应容器和检测装置之间并且热耦合到盖子。 加热元件包括设置有一个或多个不透明加热线的光学透明基板，加热线以获得加热元件的预定最小光传输的方式设置在发射光束路径中。 提供了一个设置用于控制样品循环的控制器。