摘要:
A multi-path access control device for an integrated system is presented which allows simultaneous access to multiple external devices coupled thereto by multiple functional units. The multiple functional units are coupled to the shared access control device across two or more high speed, shared data buses. The control device includes multiple bus ports, each coupled to a different data bus, and a non-blocking crossbar switch coupled to the bus ports for controlling forwarding, with zero cycle latency, of requests from the functional units. Multiple external device ports are coupled to the non-blocking crossbar switch for receiving requests forwarded by the crossbar switch, and each external device is coupled to a different external device port. The crossbar switch allows multiple requests at the bus ports directed to different external devices to be forwarded to different external device ports for simultaneous accessing of different external devices coupled thereto pursuant to the multiple requests.
摘要:
The invention relates to the treatment or prevention of an inflammatory skin disease, disorder or condition, by modulating a protein that is normally regulated by caspase-8 in the skin or by increasing caspase-8 activity or level in the skin. Another aspect of the invention relates to methods for diagnosing an inflammatory skin disease, disorder or condition or a predisposition to develop said disease disorder or condition in an individual. Further aspects of the invention relate to methods for identifying target proteins involved in the course or pathology of an inflammatory skin disease, disorder or condition and to methods of screening a candidate compound for treating said disease, disorder or condition. In particular, the invention relates to inflammatory skin diseases such as atopic dermatitis and psoriasis.
摘要:
An isolated DNA molecule has the sequence of encoding a fragment of encoding Tumor Necrosis Factor (TNF) Binding Protein II. It has a length sufficient to serve as an immunogen for raising antibodies against a polypeptide that is a fragment of TNF Binding Protein II. The DNA may be used to produce replicable expression vehicles and prokaryotic or eukaryotic expression host cells. Such host cells may be used to produce polypeptides encoded by such DNA molecules.
摘要:
A DNA sequence encoding a protein capable of binding to a tumor necrosis factor receptor-associated factor (TRAF) molecule, TRAF-binding proteins, their isoforms, analogs, fragments and derivatives encoded by the DNA sequence, their methods for the production of the DNA sequences and proteins, and the uses for the DNA sequence and proteins.
摘要:
A method of treating a disease associated with NF-κB activity. The method is effected by providing to a subject in need thereof a therapeutically effective amount of an agent capable of modulating NIK-HC8 binding.
摘要:
A DNA sequence encoding a protein capable of binding to a tumor necrosis factor receptor-associated factor (TRAF) molecule, TRAF-binding proteins, their isoforms, analogs, fragments and derivatives encoded by the DNA sequence, their methods for the production of the DNA sequences and proteins, and the uses for the DNA sequence and proteins.
摘要:
This invention relates to the use of the IL-2 common gamma chain (cγc) and related molecules for the modulation of signal activities controlled by NIK, and some new such molecules.