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    Method for testing a substance which is potentially active in the field of lipolysis and its mainly cosmetic use
    1.
    发明授权
    Method for testing a substance which is potentially active in the field of lipolysis and its mainly cosmetic use 失效
    用于测试在脂肪分解领域潜在活性物质的方法，其主要是化妆品用途

    公开(公告)号：US08741359B2

    公开(公告)日：2014-06-03

    申请号：US13536342

    申请日：2012-06-28

    申请人： Eric Perrier ,  Delphine Rival ,  Valérie Lamy

    发明人： Eric Perrier ,  Delphine Rival ,  Valérie Lamy

    IPC分类号： A01N65/00

    CPC分类号： A61K36/752 ,  A61K36/03 ,  A61K36/04 ,  A61K36/07 ,  A61K36/355 ,  A61K36/38 ,  A61K36/42 ,  A61K36/74 ,  A61K36/81 ,  A61K36/88 ,  A61K36/899 ,  A61Q19/06 ,  C12Q1/44

    摘要： A method of testing a substance potentially active in the field of lipolysis comprising: preparing a substrate containing at least one triacylglycerol; placing this substrate in contact with a substance potentially active in the field of lipolysis, and with a lipoprotein lipase, in the presence of a cofactor of lipoprotein lipase, for a period of time sufficient to release at least in part one fatty acid of the triacylglycerol; and determining the capacity of inhibition of the release of the fatty acid resulting from the activity of the lipoprotein lipase, under the action of said potentially active substance, and evaluating the result of the inhibition which is either compared to the result obtained in the absence of the potentially active substance tested or compared with the result obtained in the presence of a known inhibitor acting as reference. Cosmetic and pharmaceutical uses are described.

    摘要翻译： 一种测试在脂肪分解领域潜在有活性的物质的方法，包括：制备含有至少一种三酰基甘油的底物; 将该底物置于与脂解作用中潜在有活性的物质接触，并在脂蛋白脂肪酶辅助因子存在下与脂蛋白脂肪酶接触足以释放三酰基甘油的至少一部分脂肪酸的时间 ; 并确定在所述潜在活性物质的作用下抑制由脂蛋白脂肪酶的活性引起的脂肪酸的释放的能力，并评估抑制结果，其与在不存在 所测定的潜在活性物质与作为参考的已知抑制剂存在下获得的结果进行比较。 描述了化妆品和药物用途。

    Method for Testing a Substance Which is Potentially Active in the Field of Lipolysis and its Mainly Cosmetic Use
    2.
    发明申请
    Method for Testing a Substance Which is Potentially Active in the Field of Lipolysis and its Mainly Cosmetic Use 失效
    在脂肪分解领域潜在活性物质的测试方法及其主要化妆品用途

    公开(公告)号：US20120269910A1

    公开(公告)日：2012-10-25

    申请号：US13536342

    申请日：2012-06-28

    申请人： Eric Perrier ,  Delphine Rival ,  Valérie Lamy

    发明人： Eric Perrier ,  Delphine Rival ,  Valérie Lamy

    IPC分类号： A61K8/97 ,  A61P3/00 ,  A61K36/74 ,  A61Q19/00 ,  C12Q1/44 ,  A61K36/38

    CPC分类号： A61K36/752 ,  A61K36/03 ,  A61K36/04 ,  A61K36/07 ,  A61K36/355 ,  A61K36/38 ,  A61K36/42 ,  A61K36/74 ,  A61K36/81 ,  A61K36/88 ,  A61K36/899 ,  A61Q19/06 ,  C12Q1/44

    摘要： A method of testing a substance potentially active in the field of lipolysis comprising: preparing a substrate containing at least one triacylglycerol; placing this substrate in contact with a substance potentially active in the field of lipolysis, and with a lipoprotein lipase, in the presence of a cofactor of lipoprotein lipase, for a period of time sufficient to release at least in part one fatty acid of the triacylglycerol; and determining the capacity of inhibition of the release of the fatty acid resulting from the activity of the lipoprotein lipase, under the action of said potentially active substance, and evaluating the result of the inhibition which is either compared to the result obtained in the absence of the potentially active substance tested or compared with the result obtained in the presence of a known inhibitor acting as reference. Cosmetic and pharmaceutical uses are described.

    摘要翻译： 一种测试在脂肪分解领域潜在有活性的物质的方法，包括：制备含有至少一种三酰基甘油的底物; 将该底物置于与脂解作用潜在活性的物质接触，并在脂蛋白脂肪酶辅助因子存在下与脂蛋白脂肪酶接触足以释放三酰基甘油的至少一部分脂肪酸的时间 ; 并确定在所述潜在活性物质的作用下抑制由脂蛋白脂肪酶的活性引起的脂肪酸的释放的能力，并评估抑制结果，其与在不存在 所测定的潜在活性物质与作为参考的已知抑制剂存在下获得的结果进行比较。 描述了化妆品和药物用途。

    USE OF RHODIOLA CRENULATA EXTRACT VIA THE TOPICAL ROUTE
    3.
    发明申请
    USE OF RHODIOLA CRENULATA EXTRACT VIA THE TOPICAL ROUTE 审中-公开
    RHODIOLA CRENULATA萃取物通过主题路线的使用

    公开(公告)号：US20120107425A1

    公开(公告)日：2012-05-03

    申请号：US13169601

    申请日：2011-06-27

    申请人： Eric Perrier ,  Sébastien Bonnet ,  Delphine Rival ,  Patrice Andre ,  Nancy About

    发明人： Eric Perrier ,  Sébastien Bonnet ,  Delphine Rival ,  Patrice Andre ,  Nancy About

    IPC分类号： A61K36/41 ,  A61P17/10 ,  A61P17/00

    CPC分类号： A61K36/41 ,  A61K8/97 ,  A61K9/0014 ,  A61K2800/28 ,  A61Q19/02 ,  A61Q19/08

    摘要： The invention relates to the use of a Rhodiola crenulata extract, via the topical route, for increasing the energy metabolism of the cutaneous tissues of a subject.The invention relates notably to topical compositions which comprise an active agent for increasing the energy metabolism of the cutaneous tissues of a subject, said active agent being a Rhodiola crenulata extract.The present invention enables making a cosmetic care such as: fighting against, or slowing down or preventing the loosening of the cutaneous tissue, increasing the plasticity of the cutaneous tissue, exerting an anti-wrinkle effect or slowing down or preventing the appearance of wrinkles, fighting against, slowing down or preventing the appearance of acne, exerting a depigmenting effect of the cutaneous tissue, in particular of the skin, and promoting desquamation of the cutaneous tissue (or “peeling”).

    摘要翻译： 本发明涉及红景天提取物通过局部途径用于增加受试者皮肤组织的能量代谢的用途。 本发明特别涉及包含用于增加受试者的皮肤组织的能量代谢的活性剂的局部组合物，所述活性剂是红景天提取物。 本发明能够进行美容护理，例如：防止或减缓或防止皮肤组织的松动，增加皮肤组织的可塑性，发挥抗皱作用或减缓或防止皱纹的出现， 防止，减缓或防止痤疮的出现，发挥皮肤组织，特别是皮肤的脱色作用，促进皮肤组织脱皮（或“剥离”）。