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1.发明申请Ubiquitin or gamma-crystalline conjugates for use in therapy, diagnosis and chromatography 有权泛素或γ-结晶共轭物，用于治疗，诊断和色谱公开(公告)号：US20070248536A1
公开(公告)日：2007-10-25
申请号：US11732632
申请日：2007-04-04
申请人： Erik Fiedler , Hilmar Ebersbach , Thomas Hey , Ulrike Fiedler
发明人： Erik Fiedler , Hilmar Ebersbach , Thomas Hey , Ulrike Fiedler
摘要： The present invention relates to conjugates containing a covalent linkage between one or more polypeptide molecules based on gamma-crystallin or ubiquitin and one or more functional components. Furthermore, the present invention relates to a method for the preparation of such a conjugate as well as to the use of the conjugate in diagnostics, therapy and chromatography.
摘要翻译： 本发明涉及含有基于γ-晶状蛋白或泛素的一种或多种多肽分子和一种或多种功能组分之间的共价键的缀合物。 此外，本发明涉及制备这种缀合物的方法以及在诊断，治疗和层析中使用该缀合物。
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2.发明授权Ubiquitin or gamma-crystalline conjugates for use in therapy, diagnosis and chromatography 有权泛素或γ-结晶共轭物，用于治疗，诊断和色谱公开(公告)号：US07838629B2
公开(公告)日：2010-11-23
申请号：US11732632
申请日：2007-04-04
申请人： Erik Fiedler , Hilmar Ebersbach , Thomas Hey , Ulrike Fiedler
发明人： Erik Fiedler , Hilmar Ebersbach , Thomas Hey , Ulrike Fiedler
IPC分类号： C07K14/00
摘要： The present invention relates to conjugates containing a covalent linkage between one or more polypeptide molecules based on gamma-crystallin or ubiquitin and one or more functional components. Furthermore, the present invention relates to a method for the preparation of such a conjugate as well as to the use of the conjugate in diagnostics, therapy and chromatography.
摘要翻译： 本发明涉及含有基于γ-晶状蛋白或泛素的一种或多种多肽分子和一种或多种功能组分之间的共价键的缀合物。 此外，本发明涉及制备这种缀合物的方法以及在诊断，治疗和层析中使用该缀合物。
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公开(公告)号：US20100143387A1
公开(公告)日：2010-06-10
申请号：US12525902
申请日：2008-02-11
申请人： Ralf Kraehmer , Frank Leenders , Erik Fiedler , Thomas Hey , Ulrike Fiedler , Markus Fiedler
发明人： Ralf Kraehmer , Frank Leenders , Erik Fiedler , Thomas Hey , Ulrike Fiedler , Markus Fiedler
IPC分类号： A61K39/395 , C07D403/14 , C07C235/06 , C07K2/00 , C07K14/475 , C07H21/00 , C07K16/00 , A61K38/00 , A61K31/7088 , A61K31/4025 , A61K31/16
摘要： The present invention is directed to a multimeric agent and a multimeric conjugate formed from this multimeric agent and a biologically active agent. Said multimeric conjugates have a longer life time in vivo and an increased avidity compared to the unmodified biologically agent. The present invention is further directed to a pharmaceutical or diagnostic composition containing said conjugate as well as to a method of its production. The invention additionally provides the use of said conjugates for the detection, determination, separation and/or isolation of a specific binding partner and for the diagnosis, prophylaxis and treatment of diseases in which the specific binding partner is directly or indirectly involved.
摘要翻译： 本发明涉及由该多聚体试剂和生物活性剂形成的多聚体试剂和多聚体缀合物。 所述多聚体缀合物与未修饰的生物学试剂相比在体内具有更长的使用寿命和更高的亲合力。 本发明还涉及含有所述缀合物的药物或诊断组合物以及其制备方法。 本发明还提供所述缀合物用于特异性结合配偶体的检测，测定，分离和/或分离以及用于诊断，预防和治疗特异性结合配偶体直接或间接参与的疾病的用途。
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公开(公告)号：US08426357B2
公开(公告)日：2013-04-23
申请号：US12525902
申请日：2008-02-11
申请人： Ralf Kraehmer , Frank Leenders , Erik Fiedler , Thomas Hey , Ulrike Fiedler , Markus Fiedler
发明人： Ralf Kraehmer , Frank Leenders , Erik Fiedler , Thomas Hey , Ulrike Fiedler , Markus Fiedler
IPC分类号： A61K38/18 , A61K38/00 , A61K39/11 , A61K35/00 , A61K47/30 , C08G63/00 , C08G71/00 , C08G69/00 , C08G75/00 , C08G73/00 , C07K17/02 , C07K17/08
摘要： The present invention is directed to a multimeric agent and a multimeric conjugate formed from this multimeric agent and a biologically active agent. Said multimeric conjugates have a longer life time in vivo and an increased avidity compared to the unmodified biologically agent. The present invention is further directed to a pharmaceutical or diagnostic composition containing said conjugate as well as to a method of its production. The invention additionally provides the use of said conjugates for the detection, determination, separation and/or isolation of a specific binding partner and for the diagnosis, prophylaxis and treatment of diseases in which the specific binding partner is directly or indirectly involved.
摘要翻译： 本发明涉及由该多聚体试剂和生物活性剂形成的多聚体试剂和多聚体缀合物。 所述多聚体缀合物与未修饰的生物学试剂相比在体内具有更长的使用寿命和更高的亲合力。 本发明还涉及含有所述缀合物的药物或诊断组合物以及其制备方法。 本发明还提供所述缀合物用于特异性结合配偶体的检测，测定，分离和/或分离以及用于诊断，预防和治疗特异性结合配偶体直接或间接参与的疾病的用途。
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公开(公告)号：US09492572B2
公开(公告)日：2016-11-15
申请号：US14126358
申请日：2012-06-15
IPC分类号： C07K19/00 , A61K51/08 , C12N1/14 , C12N15/62 , C12N15/63 , C12N1/16 , C12N1/20 , C07K14/47 , C07K14/00 , G01N33/68
CPC分类号： A61K51/08 , C07K14/00 , C07K14/47 , C07K2319/00 , C07K2319/33 , C07K2319/95 , C12N1/14 , C12N1/16 , C12N1/20 , C12N15/62 , C12N15/63 , G01N33/6803
摘要： The present invention refers to novel dimeric proteins obtained from modified ubiquitin capable of binding targets with high affinity. The novel dimeric binding proteins comprise a combination of amino acid substitutions and at least one insertion of amino acids in one of the monomers. The invention is further directed to the use of said proteins in medical diagnosis or treatment methods.
摘要翻译： 本发明涉及从能够以高亲和力结合靶的修饰的泛素获得的新型二聚体蛋白质。 新型二聚结合蛋白包含氨基酸取代和至少一个氨基酸插入单体之一的组合。 本发明进一步涉及所述蛋白质在医学诊断或治疗方法中的用途。
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公开(公告)号：US20140127129A1
公开(公告)日：2014-05-08
申请号：US14126358
申请日：2012-06-15
CPC分类号： A61K51/08 , C07K14/00 , C07K14/47 , C07K2319/00 , C07K2319/33 , C07K2319/95 , C12N1/14 , C12N1/16 , C12N1/20 , C12N15/62 , C12N15/63 , G01N33/6803
摘要： The present invention refers to novel dimeric proteins obtained from modified ubiquitin capable of binding targets with high affinity. The novel dimeric binding proteins comprise a combination of amino acid substitutions and at least one insertion of amino acids in one of the monomers. The invention is further directed to the use of said proteins in medical diagnosis or treatment methods.
摘要翻译： 本发明涉及从能够以高亲和力结合靶的修饰的泛素获得的新型二聚体蛋白质。 新型二聚结合蛋白包含氨基酸取代和至少一个氨基酸插入单体之一的组合。 本发明进一步涉及所述蛋白质在医学诊断或治疗方法中的用途。
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公开(公告)号：US08791238B2
公开(公告)日：2014-07-29
申请号：US12072959
申请日：2008-02-29
申请人： Markus Fiedler , Ulrike Fiedler , Rainer Rudolph
发明人： Markus Fiedler , Ulrike Fiedler , Rainer Rudolph
CPC分类号： C12N15/1044 , C07K14/00 , C07K2319/00 , C12N15/1037 , C40B40/02 , G01N33/6872
摘要： The invention relates to modified proteins of the superfamily of “ubiquitin-like proteins”, proteins that have a ubiquitin-like fold and fragments or fusion proteins thereof. As a result of said modification, the proteins have a binding affinity with respect to a predetermined binding partner that did not exist previously. The invention also relates to a method for the production and utilization of said proteins.
摘要翻译： 本发明涉及“遍在蛋白样蛋白”的超家族的修饰蛋白质，具有泛素样折叠的蛋白质及其片段或融合蛋白质。 作为所述修饰的结果，蛋白质相对于先前不存在的预定结合配偶体具有结合亲合力。 本发明还涉及生产和利用所述蛋白质的方法。
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公开(公告)号：US08592144B2
公开(公告)日：2013-11-26
申请号：US11656646
申请日：2007-01-23
申请人： Ulrike Fiedler , Rainer Rudolph
发明人： Ulrike Fiedler , Rainer Rudolph
IPC分类号： C12Q1/68
CPC分类号： C07K14/00 , C07K14/435 , C07K14/47 , Y02A90/26
摘要： The present invention describes novel beta-sheet proteins having specific binding properties and catalytic properties and also methods for preparing these proteins.
摘要翻译： 本发明描述了具有特异性结合特性和催化性质的新型β-折叠蛋白以及制备这些蛋白质的方法。
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公开(公告)号：US20070111287A1
公开(公告)日：2007-05-17
申请号：US11656646
申请日：2007-01-23
申请人： Ulrike Fiedler , Rainer Rudolph
发明人： Ulrike Fiedler , Rainer Rudolph
CPC分类号： C07K14/00 , C07K14/435 , C07K14/47 , Y02A90/26
摘要： The present invention describes novel beta-sheet proteins having specific binding properties and catalytic properties and also methods for preparing these proteins.
摘要翻译： 本发明描述了具有特异性结合特性和催化性质的新型β-折叠蛋白以及制备这些蛋白质的方法。
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10.发明申请公开(公告)号：US20060099686A1
公开(公告)日：2006-05-11
申请号：US11283332
申请日：2005-11-18
申请人： Markus Fiedler , Ulrike Fiedler , Rainer Rudolph
发明人： Markus Fiedler , Ulrike Fiedler , Rainer Rudolph
CPC分类号： C12N15/1044 , C07K14/00 , C07K2319/00 , C12N15/1037 , C40B40/02 , G01N33/6872
摘要： The invention relates to modified proteins of the superfamily of “ubiguitin-like proteins”, proteins that have a ubiguitin-like fold and fragments or fusion proteins thereof. As a result of said modification, the proteins have a binding affinity with respect to a predetermined binding partner that did not exist previously. The invention also relates to a method for the production and utilization of said proteins.
摘要翻译： 本发明涉及“ubiguitin样蛋白”的超家族的修饰蛋白质，具有ubiguitin样折叠的蛋白质及其片段或融合蛋白质。 作为所述修饰的结果，蛋白质相对于先前不存在的预定结合配偶体具有结合亲合力。 本发明还涉及生产和利用所述蛋白质的方法。
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