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公开(公告)号：US08383366B2
公开(公告)日：2013-02-26
申请号：US13356572
申请日：2012-01-23
摘要： The present invention provides cells that have been genetically manipulated to have an altered capacity to produce expressed proteins. In particular, the present invention relates to Gram-positive microorganisms, such as Bacillus species having enhanced expression of a protein of interest, wherein one or more chromosomal genes have been inactivated, and preferably wherein one or more chromosomal genes have been deleted from the Bacillus chromosome. In some further embodiments, one or more indigenous chromosomal regions have been deleted from a corresponding wild-type Bacillus host chromosome.
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公开(公告)号：US20120183995A1
公开(公告)日：2012-07-19
申请号：US13356572
申请日：2012-01-23
IPC分类号： C12P21/00 , C12N1/21 , C12N9/50 , C12N9/42 , C12N9/14 , C12N9/24 , C12N9/20 , C12N9/90 , C12N9/10 , C12N9/12 , C12N15/75 , C12N9/26
摘要： The present invention provides cells that have been genetically manipulated to have an altered capacity to produce expressed proteins. In particular, the present invention relates to Gram-positive microorganisms, such as Bacillus species having enhanced expression of a protein of interest, wherein one or more chromosomal genes have been inactivated, and preferably wherein one or more chromosomal genes have been deleted from the Bacillus chromosome. In some further embodiments, one or more indigenous chromosomal regions have been deleted from a corresponding wild-type Bacillus host chromosome.
摘要翻译： 本发明提供已被遗传操作以具有改变产生表达蛋白质的能力的细胞。 特别地，本发明涉及革兰氏阳性微生物，例如具有增强的感兴趣蛋白表达的芽孢杆菌属物种，其中一个或多个染色体基因已被灭活，并且优选其中一个或多个染色体基因已经从芽孢杆菌中缺失 染色体。 在一些另外的实施方案中，一个或多个本征染色体区已经从相应的野生型芽孢杆菌宿主染色体中缺失。
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公开(公告)号：US08124399B2
公开(公告)日：2012-02-28
申请号：US10507720
申请日：2003-03-28
摘要： The present invention provides cells that have been genetically manipulated to have an altered capacity to produce expressed proteins. In particular, the present invention relates to Gram-positive microorganisms, such as Bacillus species having enhanced expression of a protein of interest, wherein one or more chromosomal genes have been inactivated, and preferably wherein one or more chromosomal genes have been deleted from the Bacillus chromosome. In some further embodiments, one or more indigenous chromosomal regions have been deleted from a corresponding wild-type Bacillus host chromosome.
摘要翻译： 本发明提供已被遗传操作以具有改变产生表达蛋白质的能力的细胞。 特别地，本发明涉及革兰氏阳性微生物，例如具有增强的感兴趣蛋白表达的芽孢杆菌属物种，其中一个或多个染色体基因已被灭活，并且优选其中一个或多个染色体基因已经从芽孢杆菌中缺失 染色体。 在一些另外的实施方案中，一个或多个本征染色体区已经从相应的野生型芽孢杆菌宿主染色体中缺失。
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4.发明授权Metabolically engineered bacterial strains having non-functional endogenous gluconate transporters 有权具有非功能性内源葡萄糖酸盐转运蛋白的代谢改造的细菌菌株公开(公告)号：US08034583B2
公开(公告)日：2011-10-11
申请号：US12141522
申请日：2008-06-18
IPC分类号： C12P21/06
摘要： The present invention relates to engineering metabolic pathways in bacterial host cells which results in enhanced carbon flow for the production of ascorbic acid (ASA) intermediates. In particular, the invention relates to increasing the production of ASA intermediates in bacterial cells by enhancing the availability of gluconate resulting from the inactivation of endogenous gluconate transporter genes.
摘要翻译： 本发明涉及在细菌宿主细胞中工程代谢途径，其导致用于生产抗坏血酸（ASA）中间体的增强的碳流。 特别地，本发明涉及通过增加由内源性葡萄糖酸转运蛋白基因失活产生的葡萄糖酸盐的可利用性来增加细菌细胞中ASA中间体的产生。
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公开(公告)号：US20080293124A1
公开(公告)日：2008-11-27
申请号：US11872890
申请日：2007-10-16
摘要： The present invention concerns multimeric oxidoreductase complexes which function in the enzymatic conversion of a carbon substrate, said complexes having a dehydrogenase subunit and a cytochrome C subunit. The invention further relates to polynucleotides coding for the multimeric complexes and methods of use thereof.
摘要翻译： 本发明涉及在碳底物的酶促转化中起作用的多聚体氧化还原酶复合物，所述复合物具有脱氢酶亚基和细胞色素C亚基。 本发明还涉及编码多聚体复合物的多核苷酸及其使用方法。
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公开(公告)号：US08349599B2
公开(公告)日：2013-01-08
申请号：US13228758
申请日：2011-09-09
摘要： Described are multimeric oxidoreductase complexes which function in the enzymatic conversion of a carbon substrate. The complexes having a dehydrogenase subunit and a cytochrome C subunit. Also described are polynucleotides coding for the multimeric complexes and methods of use thereof.
摘要翻译： 描述了在碳底物的酶转化中起作用的多聚体氧化还原酶复合物。 具有脱氢酶亚基和细胞色素C亚基的复合物。 还描述了编码多聚体复合物的多核苷酸及其使用方法。
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公开(公告)号：US20110003353A1
公开(公告)日：2011-01-06
申请号：US12857480
申请日：2010-08-16
摘要： The present invention concerns multimeric oxidoreductase complexes which function in the enzymatic conversion of a carbon substrate, said complexes having a dehydrogenase subunit and a cytochrome C subunit. The invention further relates to polynucleotides coding for the multimeric complexes and methods of use thereof.
摘要翻译： 本发明涉及在碳底物的酶促转化中起作用的多聚体氧化还原酶复合物，所述复合物具有脱氢酶亚基和细胞色素C亚基。 本发明还涉及编码多聚体复合物的多核苷酸及其使用方法。
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8.发明授权Metabolically engineered bacterial strains having non-functional endogenous gluconate transporters 失效具有非功能性内源葡萄糖酸盐转运蛋白的代谢改造的细菌菌株公开(公告)号：US07419795B2
公开(公告)日：2008-09-02
申请号：US10842929
申请日：2004-05-10
IPC分类号： G01N33/53
摘要： The present invention relates to engineering metabolic pathways in bacterial host cells which results in enhanced carbon flow for the production of ascorbic acid (ASA) intermediates. In particular, the invention relates to increasing the production of ASA intermediates in bacterial cells by enhancing the availability of gluconate resulting from the inactivation of endogenous gluconate transporter genes.
摘要翻译： 本发明涉及在细菌宿主细胞中工程代谢途径，其导致用于生产抗坏血酸（ASA）中间体的增强的碳流。 特别地，本发明涉及通过增加由内源性葡萄糖酸转运蛋白基因失活产生的葡萄糖酸盐的可利用性来增加细菌细胞中ASA中间体的产生。
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公开(公告)号：US20120094357A1
公开(公告)日：2012-04-19
申请号：US13323291
申请日：2011-12-12
IPC分类号： C12N9/96
CPC分类号： B82Y5/00 , A61K47/6899 , A61K2039/505 , C07K16/30 , C07K2317/622
摘要： The present invention relates to TAB molecules, ADEPT constructs directed against TAG-72, and their use in therapy.
摘要翻译： 本发明涉及TAB分子，针对TAG-72的ADEPT构建体及其在治疗中的应用。
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公开(公告)号：US20120064586A1
公开(公告)日：2012-03-15
申请号：US13228758
申请日：2011-09-09
摘要： The present invention concerns multimeric oxidoreductase complexes which function in the enzymatic conversion of a carbon substrate, said complexes having a dehydrogenase subunit and a cytochrome C subunit. The invention further relates to polynucleotides coding for the multimeric complexes and methods of use thereof.
摘要翻译： 本发明涉及在碳底物的酶促转化中起作用的多聚体氧化还原酶复合物，所述复合物具有脱氢酶亚基和细胞色素C亚基。 本发明还涉及编码多聚体复合物的多核苷酸及其使用方法。
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