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公开(公告)号：US08338376B2
公开(公告)日：2012-12-25
申请号：US12560257
申请日：2009-09-15
IPC分类号： A61K38/00 , A61K38/16 , A61K45/00 , C12P21/06 , C12P21/04 , C12N15/00 , C12N5/00 , C07H21/04 , C07K1/00 , C07K14/00
CPC分类号： C07K14/70578 , A61K38/00 , C07K2319/30
摘要： This invention relates to methods of treating disease with soluble inhibitors of the lymphotoxin pathway having improved properties. This invention also relates to improved LTBR-Ig fusion proteins, and pharmaceutical compositions thereof.
摘要翻译： 本发明涉及用具有改进性质的淋巴毒素途径的可溶性抑制剂治疗疾病的方法。 本发明还涉及改良的LTBR-Ig融合蛋白及其药物组合物。
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公开(公告)号：US20100111952A1
公开(公告)日：2010-05-06
申请号：US12560257
申请日：2009-09-15
IPC分类号： A61K39/395 , C07K14/00 , A61K38/16 , C07H21/00 , C12N15/63 , C12N5/07 , C12P21/00 , A61P37/02
CPC分类号： C07K14/70578 , A61K38/00 , C07K2319/30
摘要： Methods of treating disease with soluble inhibitors of the lymphotoxin pathway having improved properties. Improved LTBR-Ig fusion proteins, and pharmaceutical compositions thereof, are also described.
摘要翻译： 用可改善性质的淋巴毒素途径的可溶性抑制剂治疗疾病的方法。 还描述了改进的LTBR-Ig融合蛋白及其药物组合物。
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3.发明授权Neonatal Fc receptor (FcRn)-binding polypeptide variants, dimeric Fc binding proteins and methods related thereto 失效新生儿Fc受体（FcRn）结合多肽变体，二聚Fc结合蛋白及其相关方法公开(公告)号：US08618252B2
公开(公告)日：2013-12-31
申请号：US12966541
申请日：2010-12-13
申请人： Graham K. Farrington , Alexey Alexandrovich Lugovskoy , Werner Meier , John K. Eldredge , Ellen Garber
发明人： Graham K. Farrington , Alexey Alexandrovich Lugovskoy , Werner Meier , John K. Eldredge , Ellen Garber
CPC分类号： C07K16/00 , C07K2317/24 , C07K2317/52 , C07K2317/71 , C07K2317/72
摘要： The compositions and methods of the present invention are based, in part, on our discovery that an effector function mediated by an Fc-containing polypeptide can be altered by modifying one or more amino acid residues within the polypeptide (by, for example, electrostatic optimization). The polypeptides that can be generated according to the methods of the invention are highly variable, and they can include antibodies and fusion proteins that contain an Fc region or a biologically active portion thereof.
摘要翻译： 本发明的组合物和方法部分地基于我们的发现，即可以通过修饰多肽内的一个或多个氨基酸残基来改变由含Fc多肽介导的效应子功能（通过例如静电优化 ）。 可以根据本发明的方法产生的多肽是高度可变的，并且它们可以包括含有Fc区或其生物活性部分的抗体和融合蛋白。
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4.发明授权Compositions and methods for treating cellulose containing fabrics using truncated cellulase enzyme compositions 失效用截短的纤维素酶组合物处理含纤维素织物的组合物和方法公开(公告)号：US06294366B1
公开(公告)日：2001-09-25
申请号：US09136574
申请日：1998-08-19
申请人： Graham K. Farrington , Paige Anderson , Peter Bergquist , Roy Daniels , Moreland David Gibbs , Hugh Morgan , Diane P. Williams
发明人： Graham K. Farrington , Paige Anderson , Peter Bergquist , Roy Daniels , Moreland David Gibbs , Hugh Morgan , Diane P. Williams
IPC分类号： C12N942
CPC分类号： C12N9/2437 , C11D3/38645 , C12Y302/01004 , D06M16/003 , D06P5/02 , D06P5/13 , D06P5/15
摘要： Alkalophilic and thermophilic cellulases having high stability to elevated temperatures and pH have been isolated from an organism of unknown species, which most closely resembles those in the Caldicellulosiruptor genus and which has been called by us, Tok7B.1, These cellulases have been cloned and expressed in a recombinant system, so that they can be produced in quantity. These are particularly useful in treating cellulosic materials including cotton-containing fabrics, as detergent additives, and in aqueous compositions. We also provide genomic DNA which can be used in recombinant expression vectors and expression systems to produce enhanced alkali and/or temperature stability properties in cellulases other than those specifically described.
摘要翻译： 已经从未知物种的生物体中分离出对升高的温度和pH具有高稳定性的嗜碱性和嗜热纤维素酶，其与Caldicellulosiruptor属中的那些非常相似，并且被我们称之为Tok7B.1。这些纤维素酶已被克隆和表达 在重组体系中，使得它们可以量产。 这些在处理包括含棉织物，作为洗涤剂添加剂的纤维素材料和水性组合物中特别有用。 我们还提供可用于重组表达载体和表达系统的基因组DNA，以在除了具体描述的纤维素酶之外的纤维素酶中产生增强的碱和/或温度稳定性。
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5.发明申请Single-chain Fc (scFc) regions, binding polypeptides comprising same, and methods related thereto 审中-公开单链Fc（scFc）区，包含其的结合多肽及其相关方法公开(公告)号：US20090252729A1
公开(公告)日：2009-10-08
申请号：US12152622
申请日：2008-05-14
CPC分类号： C07K16/2875 , A61K47/65 , A61K47/6835 , A61K47/6881 , C07K14/565 , C07K2317/41 , C07K2317/52 , C07K2317/622 , C07K2318/10 , C07K2319/30
摘要： The present invention features inter alia polypeptides comprising an Fc region comprising genetically-fused Fc moieties. In addition, the instant invention provides, e.g., methods for treating or preventing a disease or disorder in subject by administering the binding polypeptides of the invention to said subject.
摘要翻译： 本发明尤其是包含含有遗传融合的Fc部分的Fc区的多肽。 此外，本发明提供了例如通过向所述受试者施用本发明的结合多肽来治疗或预防受试者的疾病或病症的方法。
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公开(公告)号：US08734795B2
公开(公告)日：2014-05-27
申请号：US12610204
申请日：2009-10-30
申请人： Xinzhong Wang , Veronique Bailly , Alexey Lugovskoy , Graham K. Farrington , Christilyn Graff , Scott Glaser
发明人： Xinzhong Wang , Veronique Bailly , Alexey Lugovskoy , Graham K. Farrington , Christilyn Graff , Scott Glaser
CPC分类号： C07K16/32 , A61K38/00 , A61K2039/505 , C07K14/525 , C07K16/2851 , C07K16/2869 , C07K2317/21 , C07K2317/55 , C07K2317/74 , C07K2317/77 , C07K2319/00 , C07K2319/32
摘要： LIGHT-targeting molecules (e.g., LIGHT fusion molecules), anti-HER2 antibody molecules, compositions, e.g., pharmaceutical compositions thereof, are disclosed. Methods of using these molecules to treat, prevent and/or diagnose hyperproliferative, e.g., neoplastic, diseases or conditions, including, but not limited to, cancer and metastasis are also provided.
摘要翻译： 公开了光靶向分子（例如LIGHT融合分子），抗HER2抗体分子，组合物，例如其药物组合物。 还提供了使用这些分子来治疗，预防和/或诊断过度增殖，例如肿瘤性疾病或病症（包括但不限于癌症和转移）的方法。
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公开(公告)号：US20100119511A1
公开(公告)日：2010-05-13
申请号：US12610204
申请日：2009-10-30
IPC分类号： A61K39/395 , C07K16/00 , C12N15/13 , C12N5/00 , C12N15/63 , C12P21/00 , A61P35/00 , G01N33/53
CPC分类号： C07K16/32 , A61K38/00 , A61K2039/505 , C07K14/525 , C07K16/2851 , C07K16/2869 , C07K2317/21 , C07K2317/55 , C07K2317/74 , C07K2317/77 , C07K2319/00 , C07K2319/32
摘要： LIGHT-targeting molecules (e.g., LIGHT fusion molecules), anti-HER2 antibody molecules, compositions, e.g., pharmaceutical compositions thereof, are disclosed. Methods of using these molecules to treat, prevent and/or diagnose hyperproliferative, e.g., neoplastic, diseases or conditions, including, but not limited to, cancer and metastasis are also provided.
摘要翻译： 公开了光靶向分子（例如LIGHT融合分子），抗HER2抗体分子，组合物，例如其药物组合物。 还提供了使用这些分子来治疗，预防和/或诊断过度增殖，例如肿瘤性疾病或病症（包括但不限于癌症和转移）的方法。
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