-
公开(公告)号：US6039557A
公开(公告)日：2000-03-21
申请号：US833489
申请日：1997-04-07
IPC分类号： A61K49/00 , A61B5/055 , A61B8/00 , A61J3/00 , A61K8/14 , A61K8/70 , A61K9/127 , A61K41/00 , A61K47/48 , A61K49/18 , A61K49/22 , A61M5/31 , A61Q19/00 , B01F3/04 , B01F11/00 , B01F15/00 , B01J13/02
CPC分类号： A61K49/22 , A61K41/0028 , A61K41/0052 , A61K49/1815 , A61K49/223 , A61K49/227 , A61K9/127 , A61K9/1277 , A61K9/1278 , B01F11/0025 , B01F13/0033 , A61J3/00 , A61K2800/87 , A61M5/3145 , B01F15/00435 , B01F3/04099 , Y10S366/605
摘要： A method and apparatus for making vesicles suitable for use as contrast agents in which a container containing an aqueous suspension phase and a separate gas phase is shaken using reciprocating motion. The reciprocating motion is produced by a shaker arm that moves the container in two, substantially perpendicular directions, with the motion in the first direction being along an arcuate path. The overall path of the motion occurs in a figure-8 eight pattern. The frequency of shaking is at least approximately 2800 RPM, the length of the shaker arm is at least approximately 6 cm, and the angle through which the shaker arm rotates in the first direction is at least approximately 3.degree.. The total length of travel around the figure-8 pattern is at least 0.7 cm.
摘要翻译： 用于制造适合用作造影剂的囊泡的方法和装置，其中使用往复运动使含有水悬浮相和单独气相的容器摇动。 往复运动由摇动臂产生，摇动臂使容器沿两个大致垂直的方向移动，第一方向的运动沿着弧形路径移动。 运动的总体路径以图8八种模式发生。 振动频率至少约为2800RPM，摇臂的长度至少约为6厘米，摇臂在第一方向上的旋转角度至少约为3度。 图8周围的旅行总长度至少为0.7厘米。
-
公开(公告)号：US5656211A
公开(公告)日：1997-08-12
申请号：US482294
申请日：1995-06-07
IPC分类号： A61K49/00 , A61B5/055 , A61B8/00 , A61J3/00 , A61K8/14 , A61K8/70 , A61K9/127 , A61K41/00 , A61K47/48 , A61K49/18 , A61K49/22 , A61M5/31 , A61Q19/00 , B01F3/04 , B01F11/00 , B01F15/00 , B01J13/02 , B01J13/04 , B01J13/20 , B01J13/22
CPC分类号： A61K49/22 , A61K41/0028 , A61K41/0052 , A61K49/1815 , A61K49/223 , A61K49/227 , A61K9/127 , A61K9/1277 , A61K9/1278 , B01F11/0025 , B01F13/0033 , A61J3/00 , A61K2800/87 , A61M5/3145 , B01F15/00435 , B01F3/04099 , Y10S366/605
摘要： A method and apparatus for making vesicles suitable for use as contrast agents in which a container containing an aqueous suspension phase and a separate gas phase is shaken using reciprocating motion. The reciprocating motion is produced by a shaker arm that moves the container in two, substantially perpendicular directions, with the motion in the first direction being along an arcuate path. The overall path of the motion occurs in a figure-8 eight pattern. The frequency of shaking is at least approximately 2800 RPM, the length of the shaker arm is at least approximately 6 cm, and the angle through which the shaker arm rotates in the first direction is at least approximately 3.degree.. The total length of travel around the figure-8 pattern is at least 0.7 cm.
摘要翻译： 用于制造适合用作造影剂的囊泡的方法和装置，其中使用往复运动使含有水悬浮相和单独气相的容器摇动。 往复运动由摇动臂产生，摇动臂使容器沿两个大致垂直的方向移动，第一方向的运动沿着弧形路径移动。 运动的总体路径以图8八种模式发生。 振动频率至少约为2800RPM，摇臂的长度至少约为6厘米，摇臂在第一方向上的旋转角度至少约为3度。 图8周围的旅行总长度至少为0.7厘米。
-
公开(公告)号：US20050163716A1
公开(公告)日：2005-07-28
申请号：US11036834
申请日：2005-01-14
申请人： Evan Unger , Thomas Fritz , Terry Matsunaga , Varadarajan Ramaswami , David Yellowhair , Guanli Wu
发明人： Evan Unger , Thomas Fritz , Terry Matsunaga , Varadarajan Ramaswami , David Yellowhair , Guanli Wu
CPC分类号： A61K9/127 , A61K9/1277 , A61K9/1278 , A61K41/0028 , A61K41/0052 , A61K47/6925 , A61K49/223 , A61K49/227 , A61M5/3145
摘要： Methods of and apparatus for preparing gas-filled microspheres are described. Gas-filled microspheres prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.
摘要翻译： 描述了制备充气微球的方法和装置。 通过这些方法制备的充气微球在例如超声成像应用和治疗药物递送系统中是特别有用的。
-
公开(公告)号：US5770222A
公开(公告)日：1998-06-23
申请号：US472305
申请日：1995-06-07
申请人： Evan C. Unger , Thomas A. Fritz , Terry Matsunaga , VaradaRajan Ramaswami , David Yellowhair , Guanli Wu
发明人： Evan C. Unger , Thomas A. Fritz , Terry Matsunaga , VaradaRajan Ramaswami , David Yellowhair , Guanli Wu
IPC分类号： A61B8/00 , A61K8/14 , A61K9/127 , A61K31/70 , A61K39/395 , A61K41/00 , A61K47/48 , A61K49/18 , A61K49/22 , A61M5/31 , A61Q19/00
CPC分类号： A61K49/22 , A61K41/0028 , A61K41/0052 , A61K47/48869 , A61K49/1815 , A61K49/223 , A61K49/227 , A61K9/127 , A61K9/1277 , A61K9/1278 , A61M5/3145 , Y10S436/829 , Y10S977/801 , Y10S977/907 , Y10S977/915
摘要： Therapeutic drug delivery systems comprising gas-filled microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic drug delivery applications are also provided. Drug delivery systems comprising gas-filled liposomes having encapsulated therein a drug are preferred. Methods of and apparatus for preparing such liposomes and methods for employing such liposomes in drug delivery applications are also disclosed.
-
公开(公告)号：US5469854A
公开(公告)日：1995-11-28
申请号：US76239
申请日：1993-06-11
申请人： Evan C. Unger , Thomas A. Fritz , Terry Matsunaga , VaradaRajan Ramaswami , David Yellowhair , Guanli Wu
发明人： Evan C. Unger , Thomas A. Fritz , Terry Matsunaga , VaradaRajan Ramaswami , David Yellowhair , Guanli Wu
IPC分类号： A61B8/00 , A61K8/14 , A61K9/127 , A61K41/00 , A61K47/48 , A61K48/00 , A61K49/00 , A61K49/18 , A61K49/22 , A61M5/31 , A61Q19/00 , B01J13/02 , A61K9/66
CPC分类号： A61K9/1278 , A61K41/0028 , A61K41/0052 , A61K47/48869 , A61K49/1815 , A61K49/22 , A61K49/223 , A61K49/227 , A61K9/127 , A61K9/1277 , A61M5/3145 , Y10S977/795 , Y10S977/801 , Y10S977/905 , Y10S977/906 , Y10S977/907 , Y10S977/927 , Y10S977/929 , Y10S977/962
摘要： Methods of and apparatus for preparing gas-filled liposomes are described. Gas-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.
摘要翻译： 描述了制备充气脂质体的方法和装置。 通过这些方法制备的充气脂质体在例如超声成像应用和治疗药物递送系统中是特别有用的。
-
公开(公告)号：US6071495A
公开(公告)日：2000-06-06
申请号：US942862
申请日：1997-10-02
申请人： Evan C. Unger , Thomas A. Fritz , Terry Matsunaga , VaradaRajan Ramaswami , David Yellowhair , Guanli Wu
发明人： Evan C. Unger , Thomas A. Fritz , Terry Matsunaga , VaradaRajan Ramaswami , David Yellowhair , Guanli Wu
IPC分类号： A61B8/00 , A61K8/14 , A61K9/127 , A61K41/00 , A61K47/48 , A61K49/00 , A61K49/18 , A61K49/22 , A61M5/31 , A61Q19/00 , A61K49/04
CPC分类号： A61K49/227 , A61K41/0028 , A61K41/0052 , A61K49/1815 , A61K49/22 , A61K49/223 , A61K9/127 , A61K9/1277 , A61K9/1278 , A61M5/3145 , Y10S424/812 , Y10S436/829 , Y10S977/907 , Y10S977/915 , Y10S977/927 , Y10S977/929
摘要： Methods of and apparatus for preparing temperature activated gaseous precursor-filled liposomes are described. Gaseous precursor-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.
摘要翻译： 描述了制备温度活化气态前体填充脂质体的方法和装置。 通过这些方法制备的气态前体填充脂质体在例如超声成像应用和治疗药物递送系统中是特别有用的。
-
7.发明授权Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles 失效气体和气体前体填充的微球作为局部和皮下递送载体
公开(公告)号：US5733572A
公开(公告)日：1998-03-31
申请号：US346426
申请日：1994-11-29
IPC分类号： A61K8/00 , A61K8/11 , A61K8/14 , A61K8/21 , A61K8/25 , A61K8/31 , A61K8/33 , A61K8/34 , A61K8/36 , A61K8/368 , A61K8/37 , A61K8/39 , A61K8/40 , A61K8/41 , A61K8/42 , A61K8/44 , A61K8/46 , A61K8/49 , A61K8/60 , A61K8/64 , A61K8/65 , A61K8/66 , A61K8/70 , A61K8/73 , A61K8/86 , A61K8/92 , A61K8/97 , A61K9/127 , A61K9/50 , A61K41/00 , A61K47/48 , A61K49/18 , A61K49/22 , A61M5/31 , A61Q1/00 , A61Q1/10 , A61Q19/00
CPC分类号： A61K9/1271 , A61K41/0028 , A61K41/0052 , A61K47/48869 , A61K49/1815 , A61K49/22 , A61K49/223 , A61K49/227 , A61K8/14 , A61K8/70 , A61K9/127 , A61K9/1277 , A61K9/1278 , A61Q19/00 , A61K2800/87 , A61M5/3145 , Y10S436/829
摘要： Gas and gaseous precursor filled microspheres, and foams thereof, provide novel topical and subcutaneous delivery vehicles for various active ingredients, including drugs and cosmetics.
摘要翻译： 气体和气体前体填充的微球及其泡沫为各种活性成分（包括药物和化妆品）提供新的局部和皮下递送载体。
-
公开(公告)号：US5580575A
公开(公告)日：1996-12-03
申请号：US76250
申请日：1993-06-11
申请人： Evan C. Unger , Thomas A. Fritz , Terry Matsunaga , VaradaRajan Ramaswami , David Yellowhair , Guanli Wu
发明人： Evan C. Unger , Thomas A. Fritz , Terry Matsunaga , VaradaRajan Ramaswami , David Yellowhair , Guanli Wu
IPC分类号： A61B8/00 , A61K8/14 , A61K9/127 , A61K31/70 , A61K39/395 , A61K41/00 , A61K47/48 , A61K49/18 , A61K49/22 , A61M5/31 , A61Q19/00
CPC分类号： A61K49/22 , A61K41/0028 , A61K41/0052 , A61K47/48869 , A61K49/1815 , A61K49/223 , A61K49/227 , A61K9/127 , A61K9/1277 , A61K9/1278 , A61M5/3145 , Y10S436/829 , Y10S977/801 , Y10S977/907 , Y10S977/915
摘要： Therapeutic drug delivery systems comprising gas-filled microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic drug delivery applications are also provided. Drug delivery systems comprising gas-filled liposomes having encapsulated therein a drug are preferred. Methods of and apparatus for preparing such liposomes and methods for employing such liposomes in drug delivery applications are also disclosed.
摘要翻译： 描述包含含有治疗剂的充气微球的治疗药物递送系统。 还提供了在治疗药物递送应用中使用这种微球的方法。 药物递送系统包括其中封装有药物的充气脂质体。 还公开了制备这种脂质体的方法和装置以及在药物递送应用中使用这种脂质体的方法。
-
公开(公告)号：US07083572B2
公开(公告)日：2006-08-01
申请号：US10108284
申请日：2002-03-26
申请人： Evan C. Unger , Thomas A. Fritz , Terry Matsunaga , VaradaRajan Ramaswami , David Yellowhair , Guanli Wu
发明人： Evan C. Unger , Thomas A. Fritz , Terry Matsunaga , VaradaRajan Ramaswami , David Yellowhair , Guanli Wu
CPC分类号： A61K9/127 , A61K9/1277 , A61K9/1278 , A61K41/0028 , A61K41/0052 , A61K47/6925 , A61K49/223 , A61K49/227 , A61M5/3145
摘要： Targeted therapeutic delivery systems comprising gas- or gaseous precursor-filled lipid microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic delivery applications are also provided.Targeted therapeutic delivery systems comprising gas- or gaseous precursor-filled liposomes having a drug encapsulated therein are preferred. Methods of and apparatus for preparing such liposomes and methods for employing such liposomes in therapeutic delivery applications are also disclosed.
摘要翻译： 描述了包含含有治疗剂的气体或气体前体填充的脂质微球的靶向治疗递送系统。 还提供了在治疗性递送应用中使用这种微球的方法。 包含气体或气态前体填充的脂质体的靶向治疗递送系统是优选的。 还公开了制备这种脂质体的方法和装置以及在治疗性递送应用中使用这种脂质体的方法。
-
公开(公告)号：US5776429A
公开(公告)日：1998-07-07
申请号：US643070
申请日：1996-04-30
申请人： Evan C. Unger , Thomas A. Fritz , Terry Matsunaga , VaradaRajan Ramaswami , David Yellowhair , Guanli Wu
发明人： Evan C. Unger , Thomas A. Fritz , Terry Matsunaga , VaradaRajan Ramaswami , David Yellowhair , Guanli Wu
IPC分类号： A61B8/08 , A61K8/14 , A61K9/127 , A61K41/00 , A61K47/30 , A61K47/48 , A61K49/00 , A61K49/04 , A61K49/18 , A61K49/22 , A61M5/31 , A61Q19/00 , B01J13/02 , G01R33/28 , A61B8/13
CPC分类号： A61K9/1277 , A61K41/0028 , A61K41/0052 , A61K49/22 , A61K49/223 , A61K49/227 , A61K9/127 , A61K9/1271 , A61K9/1278 , G01R33/5601 , A61M5/3145
摘要： Lyophilized lipid compositions, as well as methods for their preparation, are embodied by the present invention. Gas-filled microspheres prepared using the lyophilized lipid composition are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.
摘要翻译： 冻干脂质组合物及其制备方法由本发明体现。 使用冻干的脂质组合物制备的充气微球在例如超声成像应用和治疗药物递送系统中是特别有用的。
-
-
-
-
-
-
-
-
-
搜索结果
22 条记录 (耗时 0.041 秒)
