利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

204 条记录 (耗时 0.017 秒)

    Process for the preparation of N-10 alpha-methoxyl-lumilysergol and esters, thereof, and intermediates for their preparation
    4.
    发明授权
    Process for the preparation of N-10 alpha-methoxyl-lumilysergol and esters, thereof, and intermediates for their preparation 失效
    制备N-10α-甲氧基 - 亮片糊精及其酯及其制备方法

    公开(公告)号：US4980475A

    公开(公告)日：1990-12-25

    申请号：US716501

    申请日：1985-03-26

    申请人： Ezio Bombardelli ,  Giuseppe Mustich

    发明人： Ezio Bombardelli ,  Giuseppe Mustich

    IPC分类号： C07D457/02

    CPC分类号： C07D457/02

    摘要： Processes for the preparation of esters of N.sub.1 -methyl-10.alpha.-methoxylumilysergol are described, in which lysergol esters are subjected to N-methylation and subsequently to photochemical reaction with methanol/H.sub.2 SO.sub.4. The esters of N.sub.1 -methyl-10-methoxylumilysergol obtained in this way can then be saponified or converted directly into other esters.

    摘要翻译： 描述了制备N1-甲基-10α-甲氧基甘露醇的酯的方法，其中将莱赛尔酯进行N-甲基化，随后用甲醇/ H 2 SO 4进行光化学反应。 然后可以将以这种方式得到的N1-甲基-10-甲氧基甘露醇的酯类皂化或直接转化成其他酯。

    Extracts of Ginkgo biloba and their methods of preparation
    6.
    发明授权
    Extracts of Ginkgo biloba and their methods of preparation 失效
    银杏提取物及其制备方法

    公开(公告)号：US5637302A

    公开(公告)日：1997-06-10

    申请号：US445916

    申请日：1995-05-22

    申请人： Ezio Bombardelli ,  Giuseppe Mustich ,  Marco Bertani

    发明人： Ezio Bombardelli ,  Giuseppe Mustich ,  Marco Bertani

    IPC分类号： A61K31/70 ,  A61K36/16 ,  A61K31/685

    CPC分类号： A61K36/16 ,  A61K31/70

    摘要： A process is provided for producing a purified extract from Ginkgo biloba leaves by solvent extraction with selected solvents. In the process, a crude or partially purified extract is subjected to solvent extraction with a solvent comprising toluene and n-butanol. Pharmaceutical. compositions comprising dimeric flavones and/or polyphenols are also described.

    摘要翻译： 提供了通过溶剂萃取用选择的溶剂从银杏生产纯化提取物的方法。 在此过程中，将粗制或部分纯化的提取物用包含甲苯和正丁醇的溶剂进行溶剂萃取。 制药。 还描述了包含二聚黄酮和/或多酚的组合物。

    Bilobalide derivatives, their applications and formulations containing them
    8.
    发明授权
    Bilobalide derivatives, their applications and formulations containing them 失效
    BILOBALIDE衍生物，其应用和包含它们的制剂

    公开(公告)号：US5202313A

    公开(公告)日：1993-04-13

    申请号：US651598

    申请日：1991-02-06

    申请人： Ezio Bombardelli ,  Giuseppe Mustich

    发明人： Ezio Bombardelli ,  Giuseppe Mustich

    IPC分类号： A61K8/55 ,  A61K8/00 ,  A61K8/04 ,  A61K8/58 ,  A61K8/96 ,  A61K9/127 ,  A61K31/366 ,  A61K31/685 ,  A61P17/00 ,  A61P25/02 ,  A61P29/00 ,  A61Q19/00 ,  C07D493/14 ,  C07D493/20 ,  C07F9/10

    CPC分类号： C07D493/20 ,  A61K9/127 ,  C07F9/106

    摘要： Complexes between natural or synthetic phospholipids and bilobalide, a sesquiterpene extracted from the leaves of Gingko biloba, are disclosed, as well as the preparation thereof and their therapeutic application as antiinflammatory agents and as agents for the treatment of disorders associated with inflammatory or traumatic neuritic processes. These new compounds, which exhibit a different bioavailability compared with free bilobalide, are suitable for incorporation into pharmaceutical formulations for systemic and topical administration: the latter route has been found to be particularly useful for the treatment of common peripheral disorders associated with inflammatory or neurodystrophic alterations.

    摘要翻译： 公开了天然的或合成的磷脂和碧花苜蓿之间的复合物，从银杏叶提取的倍半萜，以及其制备方法及其作为抗炎剂的治疗应用以及用于治疗与炎性或创伤性神经突过程相关的病症 。 这些新的化合物与游离的碧绿苷相比表现出不同的生物利用度，适合于并入用于全身和局部给药的药物制剂中：后一种途径特别可用于治疗与炎性或神经营养不良变化相关的常见周围疾病 。