公开(公告)号：US20150352252A1

公开(公告)日：2015-12-10

申请号：US14836504

申请日：2015-08-26

Applicant: FUJIFILM CORPORATION

Inventor： Kentaro NAKAMURA ,  Reiko IWAZAWA ,  Hayato MIYOSHI ,  Kazuhiro YAMAGUCHI ,  Hideo FUSHIMI

IPC: A61L27/22 ,  A61L27/38 ,  A61L27/36

CPC classification number: A61L27/222 ,  A61L27/3604 ,  A61L27/3608 ,  A61L27/38 ,  A61L27/3834 ,  A61L27/3886 ,  A61L27/56 ,  A61L27/58 ,  A61L2300/64 ,  A61L2430/22 ,  C12N5/0068 ,  Y10T428/2982

Abstract: It is an object of the present invention to provide a cell construct for cell transplantation that does not contain a substance having cytotoxicity, such as glutaraldehyde, and suppresses the necrosis of the transplanted cells in the construct (namely, having a high cell survival rate). The present invention provides a cell construct for cell transplantation comprising biocompatible polymer blocks that do not contain glutaraldehyde and at least one type of cells, wherein a plurality of biocompatible polymer blocks are disposed in gaps among a plurality of cells, and wherein the biocompatible polymer blocks have a tap density of 10 mg/cm3 or more and 500 mg/cm3 or less, or the value of the square root of the cross-sectional area/boundary length in the two-dimensional sectional image of the polymer block is 0.01 or more and 0.13 or less.

Abstract translation: 本发明的目的是提供一种不含有细胞毒性的物质的细胞移植用细胞构建体，例如戊二醛，抑制构建体中移植细胞的坏死（即具有高细胞存活率） 。 本发明提供了一种用于细胞移植的细胞构建体，其包含不含戊二醛和至少一种类型细胞的生物相容性聚合物嵌段，其中多个生物相容性聚合物嵌段设置在多个细胞之间的间隙中，并且其中生物相容性聚合物嵌段 具有10毫克/厘米3以上至500毫克/厘米3以下的振实密度，或聚合物嵌段的二维截面图中的截面积/边界长度的平方根的值为0.01以上 和0.13以下。

公开(公告)号：US20140378662A1

公开(公告)日：2014-12-25

申请号：US14484838

申请日：2014-09-12

Applicant: FUJIFILM CORPORATION

Inventor： Shoji OYA ,  Hidekazu SAKAI ,  Ai KAWAKAMI ,  Takahiro HIRATSUKA ,  Hideo FUSHIMI ,  Kazuhiro YAMAGUCHI ,  Ichiro NISHIMURA ,  Yoshitaka OONO ,  Izumi OGURA

IPC: A61L27/22 ,  A61L27/54

CPC classification number: A61L27/222 ,  A61L27/52 ,  A61L27/54 ,  A61L2430/02 ,  A61L2430/34 ,  A61L2430/40

Abstract: A method of producing a tissue repair material, the method including: (a) obtaining a gelatin-containing intermediate that contains a gelatin and has a mesh structure, using a gelatin solution in which the gelatin is dissolved in an aqueous medium; (b) drying the gelatin-containing intermediate; and (c) cross-linking the gelatin before or after the drying of the gelatin-containing intermediate.

Abstract translation: 一种生产组织修复材料的方法，所述方法包括：（a）使用其中明胶溶于水性介质中的明胶溶液获得含有明胶并具有网状结构的含明胶的中间体; （b）干燥含明胶的中间体; 和（c）在含明胶的中间体的干燥之前或之后交联明胶。

公开(公告)号：US20150290359A1

公开(公告)日：2015-10-15

申请号：US14751511

申请日：2015-06-26

Applicant: FUJIFILM CORPORATION ,  JAPAN TISSUE ENGINEERING CO., LTD.

Inventor： Kazutaka OGIWARA ,  Kazuhiro YAMAGUCHI ,  Tasuku SASAKI ,  Eiko GOTO ,  Katsura SUGAWARA ,  Ken-ichiro HATA

IPC: A61L27/22 ,  A61F2/10 ,  A61L27/58 ,  A61L27/60 ,  A61L27/56

CPC classification number: A61L27/222 ,  A61F2/105 ,  A61F2210/0076 ,  A61L27/56 ,  A61L27/58 ,  A61L27/60 ,  A61L2430/34

Abstract: Artificial dermis for transplantation includes a wound contact layer that includes a porous sheet consisting of a biodegradable material, the porous sheet satisfying the following Equation, Equation: X2/X1≦0.8. In the porous sheet, when a line parallel to a wound contact face and a line perpendicular to a wound contact face of equal length are drawn, X1 represents a number of points of intersection between the line parallel to the wound contact face and pore walls; and X2 represents a number of points of intersection between the line perpendicular to the wound contact face and pore walls.

Abstract translation: 用于移植的人造真皮包括伤口接触层，其包括由可生物降解材料组成的多孔片，满足以下等式的多孔片，等式：X2 / X1＆N1; 0.8。 在多孔片材中，当绘制平行于伤口接触面的线和垂直于相同长度的伤口接触面的线时，X1表示平行于伤口接触面的线与孔壁之间的交点数; X2表示与伤口接触面垂直的线与孔壁的交点数。

公开(公告)号：US20160303282A1

公开(公告)日：2016-10-20

申请号：US15080827

申请日：2016-03-25

Applicant: FUJIFILM Corporation

Inventor： Kentaro NAKAMURA ,  Reiko IWAZAWA ,  Kazuhiro YAMAGUCHI

IPC: A61L27/22 ,  A61L27/58 ,  F26B5/06 ,  A61L27/54 ,  A61L27/38 ,  C07K14/78 ,  A61L27/56

CPC classification number: A61L27/222 ,  A61L27/3808 ,  A61L27/3834 ,  A61L27/3886 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L2300/412 ,  A61L2300/604 ,  A61L2300/64 ,  C07K14/78 ,  F26B5/06

Abstract: An object of the present invention is to provide a biocompatible macromolecular porous body, which enables provision of a cell structure showing a high number of cells and a high number of blood vessels; a method for producing the same; and a biocompatible macromolecular block and a cell structure. According to the present invention, there is provided: a method for producing a biocompatible macromolecular porous body which includes a step (a) of cooling a solution of biocompatible macromolecules to be in an unfrozen state, the difference between a temperature of a portion at the highest liquid temperature within the solution and a temperature of a portion at the lowest liquid temperature within the solution being lower than or equal to 2.5° C. and the temperature of the portion at the highest liquid temperature within the solution being lower than or equal to a melting point of a solvent, a step (b) of freezing the solution of biocompatible macromolecules obtained in the step (a), and a step (c) of freeze-drying the frozen biocompatible macromolecules obtained in the step (b); the biocompatible macromolecular porous body; a biocompatible macromolecular block; and a cell structure.

Abstract translation: 本发明的目的是提供一种生物相容性大分子多孔体，其能够提供显示大量细胞和大量血管的细胞结构; 其制造方法; 和生物相容性大分子嵌段和细胞结构。 根据本发明，提供了一种生物相容性高分子多孔体的制​​造方法，其特征在于，包括将生物体相容性大分子的溶液冷却至未冷冻状态的工序（a） 溶液中最高的液体温度，溶液中最低液温下的一部分的温度低于或等于2.5℃，溶液中最高液体温度下的部分的温度低于或等于 溶剂的熔点，步骤（b），使步骤（a）中获得的生物相容性大分子的溶液冷冻;以及步骤（c），冷冻干燥步骤（b）中得到的冷冻生物相容性大分子; 生物相容性大分子多孔体; 生物相容性大分子嵌段; 和细胞结构。