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公开(公告)号：US20120270273A1
公开(公告)日：2012-10-25
申请号：US13353662
申请日：2012-01-19
申请人： Feng Zhang , Le Cong , Sriram Kosuri , George M. Church
发明人： Feng Zhang , Le Cong , Sriram Kosuri , George M. Church
CPC分类号： C07K14/195 , C07K14/4705 , C07K2319/00 , C07K2319/09 , C07K2319/60 , C07K2319/80 , C12P19/34
摘要： Provided herein are compositions, kits and methods useful in the construction of designer transcription activator-like effector (dTALE) polypeptides.
摘要翻译： 本文提供了可用于构建设计者转录激活子样效应子（dTALE）多肽的组合物，试剂盒和方法。
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公开(公告)号：US09499592B2
公开(公告)日：2016-11-22
申请号：US13353662
申请日：2012-01-19
申请人： Feng Zhang , Le Cong , Sriram Kosuri , George M. Church
发明人： Feng Zhang , Le Cong , Sriram Kosuri , George M. Church
IPC分类号： C07K14/195 , C07K14/47
CPC分类号： C07K14/195 , C07K14/4705 , C07K2319/00 , C07K2319/09 , C07K2319/60 , C07K2319/80 , C12P19/34
摘要： Provided herein are compositions, kits and methods useful in the construction of designer transcription activator-like effector (dTALE) polypeptides.
摘要翻译： 本文提供了可用于构建设计者转录激活子样效应子（dTALE）多肽的组合物，试剂盒和方法。
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公开(公告)号：US20140045728A1
公开(公告)日：2014-02-13
申请号：US13880824
申请日：2011-10-20
IPC分类号： C12N15/10
CPC分类号： C12N15/1031 , B01J2219/00529 , B01J2219/00592 , B01J2219/00608 , C12Q1/6834 , C40B50/14
摘要： Methods and compositions for synthesizing nucleic acid sequences of interest from heterogeneous mixtures of oligonucleotide sequences are provided.
摘要翻译： 提供了用于从寡核苷酸序列的异源混合物合成目标核酸序列的方法和组合物。
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4.发明申请Engineered CO2 Fixing Microorganisms Producing Carbon-Based Products of Interest 有权工程化的CO2固定微生物生产碳基产品公开(公告)号：US20110008861A1
公开(公告)日：2011-01-13
申请号：US12867738
申请日：2009-03-03
申请人： David A. Berry , Dan E. Robertson , Frank A. Skraly , Brian D. Green , Christian P. Ridley , Sriram Kosuri , Nikos B. Reppas , Martha Sholl , Noubar B. Afeyan
发明人： David A. Berry , Dan E. Robertson , Frank A. Skraly , Brian D. Green , Christian P. Ridley , Sriram Kosuri , Nikos B. Reppas , Martha Sholl , Noubar B. Afeyan
CPC分类号： C12P7/065 , C12N1/20 , C12N9/00 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/0083 , C12N9/1007 , C12N9/1029 , C12N9/88 , C12N15/74 , C12P1/04 , C12P5/00 , C12P5/02 , C12P5/026 , C12P7/00 , C12P7/6409 , C12P7/6427 , C12P7/6436 , C12P7/6463 , C12P7/6472 , C12P7/649 , C12P13/04 , C12R1/01 , C12Y103/03006 , Y02E50/13 , Y02E50/17 , Y02E50/18 , Y02E50/343
摘要： The present disclosure identifies pathways and mechanisms to confer production of carbon-based products of interest such as ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof in photoautotrophic organisms such that these organisms efficiently convert carbon dioxide and light into carbon-based products of interest, and in particular the use of such organisms for the commercial production of ethanol, ethylene, chemicals, polymers, alkanes, isoprenoids, pharmaceutical products or intermediates thereof.
摘要翻译： 本发明公开了确定感兴趣的碳基产物如乙醇，乙烯，化学品，聚合物，正烷烃，类异戊二烯，药物产品或其中间体在光自养生物体中生产的途径和机制，使得这些生物有效地转化二氧化碳和 特别是利用这些生物来商业生产乙醇，乙烯，化学品，聚合物，烷烃，类异戊二烯，药物产品或其中间体。
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公开(公告)号：US20090203070A1
公开(公告)日：2009-08-13
申请号：US12268406
申请日：2008-11-10
申请人： Eric James Devroe , Sriram Kosuri , David Arthur Berry , Noubar Boghos Afeyan , Frank Anthony Skraly , Dan Eric Robertson , Brian Green , Christian Perry Ridley
发明人： Eric James Devroe , Sriram Kosuri , David Arthur Berry , Noubar Boghos Afeyan , Frank Anthony Skraly , Dan Eric Robertson , Brian Green , Christian Perry Ridley
CPC分类号： C12N15/74 , C12N9/1007 , C12N15/52 , C12P7/6409 , C12P7/6436 , C12P7/6463 , C12P7/649 , C12Y111/01006 , Y02E50/13 , Y02P60/247
摘要： The present disclosure identifies pathways and mechanisms to confer improved industrial fitness on engineered organisms. It also discloses engineered organisms having improved industrial fitness. Synthetic biologic engineering modules are disclosed that provide for light capture, carbon dioxide fixation, NADH production, NADPH production, thermotolerance, pH tolerance, flue gas tolerance, salt tolerance, nutrient independence and near infrared absorbance. The disclosed engineered organisms can include one or more of these modules. Also provided are methods of using the engineered organism to produce carbon-based products of interest, biomass or pharmaceutical agents.
摘要翻译： 本公开确定了赋予工程生物体的改善的工业适应性的途径和机制。 它还公开了具有改善的工业适应性的工程生物。 公开了合成生物工程模块，其提供轻捕获，二氧化碳固定，NADH生产，NADPH生产，耐热性，pH耐受性，烟气耐受性，耐盐性，营养独立性和近红外吸光度。 所公开的工程生物体可以包括这些模块中的一个或多个。 还提供了使用工程生物体产生感兴趣的碳基产物，生物质或药剂的方法。
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6.发明授权Engineered CO2 fixing microorganisms producing carbon-based products of interest 有权工程化的二氧化碳固定微生物生产碳基产品公开(公告)号：US08227237B2
公开(公告)日：2012-07-24
申请号：US13174580
申请日：2011-06-30
申请人： Nikos B. Reppas , Martha Sholl , Sriram Kosuri , Brian D. Green , Christian P. Ridley , Frank A. Skraly , Dan E. Robertson , David A. Berry , Noubar B. Afeyan
发明人： Nikos B. Reppas , Martha Sholl , Sriram Kosuri , Brian D. Green , Christian P. Ridley , Frank A. Skraly , Dan E. Robertson , David A. Berry , Noubar B. Afeyan
CPC分类号： C12P7/065 , C12N1/20 , C12N9/00 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/0083 , C12N9/1007 , C12N9/1029 , C12N9/88 , C12N15/74 , C12P1/04 , C12P5/00 , C12P5/02 , C12P5/026 , C12P7/00 , C12P7/6409 , C12P7/6427 , C12P7/6436 , C12P7/6463 , C12P7/6472 , C12P7/649 , C12P13/04 , C12R1/01 , C12Y103/03006 , Y02E50/13 , Y02E50/17 , Y02E50/18 , Y02E50/343
摘要： The present disclosure identifies pathways and mechanisms to confer production of carbon-based products of interest such as ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof in photoautotrophic organisms such that these organisms efficiently convert carbon dioxide and light into carbon-based products of interest, and in particular the use of such organisms for the commercial production of ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof.
摘要翻译： 本发明公开了确定感兴趣的碳基产物如乙醇，乙烯，化学品，聚合物，正烷烃，类异戊二烯，药物产品或其中间体在光自养生物体中生产的途径和机制，使得这些生物有效地转化二氧化碳和 特别是利用这些有机物用于商业生产乙醇，乙烯，化学品，聚合物，正烷烃，类异戊二烯，药物产品或其中间体。
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7.发明授权Engineered CO2 fixing microorganisms producing carbon-based products of interest 有权工程化的二氧化碳固定微生物生产碳基产品公开(公告)号：US07981647B2
公开(公告)日：2011-07-19
申请号：US12867738
申请日：2009-03-03
申请人： David A. Berry , Dan E. Robertson , Frank A. Skraly , Brian D. Green , Christian P. Ridley , Sriram Kosuri , Nikos B. Reppas , Martha Sholl , Noubar B. Afeyan
发明人： David A. Berry , Dan E. Robertson , Frank A. Skraly , Brian D. Green , Christian P. Ridley , Sriram Kosuri , Nikos B. Reppas , Martha Sholl , Noubar B. Afeyan
CPC分类号： C12P7/065 , C12N1/20 , C12N9/00 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/0083 , C12N9/1007 , C12N9/1029 , C12N9/88 , C12N15/74 , C12P1/04 , C12P5/00 , C12P5/02 , C12P5/026 , C12P7/00 , C12P7/6409 , C12P7/6427 , C12P7/6436 , C12P7/6463 , C12P7/6472 , C12P7/649 , C12P13/04 , C12R1/01 , C12Y103/03006 , Y02E50/13 , Y02E50/17 , Y02E50/18 , Y02E50/343
摘要： The present disclosure identifies pathways and mechanisms to confer production of carbon-based products of interest such as ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof in photoautotrophic organisms such that these organisms efficiently convert carbon dioxide and light into carbon-based products of interest, and in particular the use of such organisms for the commercial production of ethanol, ethylene, chemicals, polymers, alkanes, isoprenoids, pharmaceutical products or intermediates thereof.
摘要翻译： 本发明公开了确定感兴趣的碳基产物如乙醇，乙烯，化学品，聚合物，正烷烃，类异戊二烯，药物产品或其中间体在光自养生物体中生产的途径和机制，使得这些生物有效地转化二氧化碳和 特别是利用这些生物来商业生产乙醇，乙烯，化学品，聚合物，烷烃，类异戊二烯，药物产品或其中间体。
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公开(公告)号：US07785861B2
公开(公告)日：2010-08-31
申请号：US12268406
申请日：2008-11-10
申请人： Eric James Devroe , Sriram Kosuri , David Arthur Berry , Noubar Boghos Afeyan , Frank Anthony Skraly , Dan Eric Robertson , Brian Green , Christian Perry Ridley
发明人： Eric James Devroe , Sriram Kosuri , David Arthur Berry , Noubar Boghos Afeyan , Frank Anthony Skraly , Dan Eric Robertson , Brian Green , Christian Perry Ridley
CPC分类号： C12N15/74 , C12N9/1007 , C12N15/52 , C12P7/6409 , C12P7/6436 , C12P7/6463 , C12P7/649 , C12Y111/01006 , Y02E50/13 , Y02P60/247
摘要： The present disclosure identifies pathways and mechanisms to confer improved industrial fitness on engineered organisms. It also discloses engineered organisms having improved industrial fitness. Synthetic biologic engineering modules are disclosed that provide for light capture, carbon dioxide fixation, NADH production, NADPH production, thermotolerance, pH tolerance, flue gas tolerance, salt tolerance, nutrient independence and near infrared absorbance. The disclosed engineered organisms can include one or more of these modules. Also provided are methods of using the engineered organism to produce carbon-based products of interest, biomass or pharmaceutical agents.
摘要翻译： 本公开确定了赋予工程生物体的改善的工业适应性的途径和机制。 它还公开了具有改善的工业适应性的工程生物。 公开了合成生物工程模块，其提供轻捕获，二氧化碳固定，NADH生产，NADPH生产，耐热性，pH耐受性，烟气耐受性，耐盐性，营养独立性和近红外吸光度。 所公开的工程生物体可以包括这些模块中的一个或多个。 还提供了使用工程生物体产生感兴趣的碳基产物，生物质或药剂的方法。
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9.发明申请ENGINEERED CO2 FIXING MICROORGANISMS PRODUCING CARBON-BASED PRODUCTS OF INTEREST 有权工程化二氧化碳固定微生物生产基于碳的产品公开(公告)号：US20110262975A1
公开(公告)日：2011-10-27
申请号：US13174580
申请日：2011-06-30
申请人： David A. Berry , Dan E. Robertson , Frank A. Skraly , Brian D. Green , Christian P. Ridley , Sriram Kosuri , Nikos B. Reppas , Martha Sholl , Noubar B. Afeyan
发明人： David A. Berry , Dan E. Robertson , Frank A. Skraly , Brian D. Green , Christian P. Ridley , Sriram Kosuri , Nikos B. Reppas , Martha Sholl , Noubar B. Afeyan
CPC分类号： C12P7/065 , C12N1/20 , C12N9/00 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/0083 , C12N9/1007 , C12N9/1029 , C12N9/88 , C12N15/74 , C12P1/04 , C12P5/00 , C12P5/02 , C12P5/026 , C12P7/00 , C12P7/6409 , C12P7/6427 , C12P7/6436 , C12P7/6463 , C12P7/6472 , C12P7/649 , C12P13/04 , C12R1/01 , C12Y103/03006 , Y02E50/13 , Y02E50/17 , Y02E50/18 , Y02E50/343
摘要： The present disclosure identifies pathways and mechanisms to confer production of carbon-based products of interest such as ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof in photoautotrophic organisms such that these organisms efficiently convert carbon dioxide and light into carbon-based products of interest, and in particular the use of such organisms for the commercial production of ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof.
摘要翻译： 本发明公开了确定感兴趣的碳基产物如乙醇，乙烯，化学品，聚合物，正烷烃，类异戊二烯，药物产品或其中间体在光自养生物体中生产的途径和机制，使得这些生物有效地转化二氧化碳和 特别是利用这些有机物用于商业生产乙醇，乙烯，化学品，聚合物，正烷烃，类异戊二烯，药物产品或其中间体。
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公开(公告)号：US20110124073A1
公开(公告)日：2011-05-26
申请号：US12860799
申请日：2010-08-20
申请人： Eric James Devroe , Sriram Kosuri , David Arthur Berry , Noubar Boghos Afeyan , Frank Anthony Skraly , Dan Eric Robertson , Brian Green , Christian Perry Ridley
发明人： Eric James Devroe , Sriram Kosuri , David Arthur Berry , Noubar Boghos Afeyan , Frank Anthony Skraly , Dan Eric Robertson , Brian Green , Christian Perry Ridley
CPC分类号： C12N15/74 , C12N9/1007 , C12N15/52 , C12P7/6409 , C12P7/6436 , C12P7/6463 , C12P7/649 , C12Y111/01006 , Y02E50/13 , Y02P60/247
摘要： The present disclosure identifies pathways and mechanisms to confer improved industrial fitness on engineered organisms. It also discloses engineered organisms having improved industrial fitness. Synthetic biologic engineering modules are disclosed that provide for light capture, carbon dioxide fixation, NADH production, NADPH production, thermotolerance, pH tolerance, flue gas tolerance, salt tolerance, nutrient independence and near infrared absorbance. The disclosed engineered organisms can include one or more of these modules. Also provided are methods of using the engineered organism to produce carbon-based products of interest, biomass or pharmaceutical agents.
摘要翻译： 本公开确定了赋予工程生物体的改善的工业适应性的途径和机制。 它还公开了具有改善的工业适应性的工程生物。 公开了合成生物工程模块，其提供轻捕获，二氧化碳固定，NADH生产，NADPH生产，耐热性，pH耐受性，烟气耐受性，耐盐性，营养独立性和近红外吸光度。 所公开的工程生物体可以包括这些模块中的一个或多个。 还提供了使用工程生物体产生感兴趣的碳基产物，生物质或药剂的方法。
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